STAM2_HUMAN 2019

Gene Name STAM2

Description Signal transducing adapter molecule 2

Length 525

9606

Sequence

>sp|O75886|STAM2_HUMAN Signal transducing adapter molecule 2
MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKEEGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPVYIDEDKMDRALQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDRKHSELSELNVKVLEALELYNKLVNEAPVYSVYSKLHPPAHYPPASSGVPMQTYPVQSHGGNYMGQSIHQVTVAQSYSLGPDQIGPLRSLPPNVNSSVTAQPAQTSYLSTGQDTVSNPTYMNQNSNLQSATGTTAYTQQMGMSVDMSSYQNTTSNLPQLAGFPVTVPAHPVAQQHTNYHQQPLL

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

STAM1_HUMAN

Signal transducing adapter molecule 1

0.205

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

STAM1_HUMAN

Signal transducing adapter molecule 1

0.218

VIGLN_HUMAN

Vigilin

0.330

GOLP3_HUMAN

Golgi phosphoprotein 3

0.332

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.343

SOS1_HUMAN

Son of sevenless homolog 1

0.344

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.344

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.344

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.347

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.347

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.351

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.351

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.352

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.354

SURF4_HUMAN

Surfeit locus protein 4

0.354

STRP1_HUMAN

Striatin-interacting protein 1

0.356

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.357

SOS2_HUMAN

Son of sevenless homolog 2

0.359

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.361

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.365

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.366

PBDC1_HUMAN

Protein PBDC1

0.366

S2536_HUMAN

Solute carrier family 25 member 36

0.367

DPP4_HUMAN

Dipeptidyl peptidase 4

0.367

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.368

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.368

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.370

CUL1_HUMAN

Cullin-1

0.370

ZNT1_HUMAN

Zinc transporter 1

0.371

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.371

NPRL2_HUMAN

GATOR complex protein NPRL2

0.372

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.373

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.375

SEPR_HUMAN

Prolyl endopeptidase FAP

0.375

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.376

SNX12_HUMAN

Sorting nexin-12

0.376

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.376

HIP1_HUMAN

Huntingtin-interacting protein 1

0.377

SEPT7_HUMAN

Septin-7

0.377

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.377

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.377

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.378

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.378

GDE_HUMAN

Glycogen debranching enzyme

0.378

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.379

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.381

STRP2_HUMAN

Striatin-interacting protein 2

0.381

RHOA_HUMAN

Transforming protein RhoA

0.382

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.382

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.382

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.383

S39A9_HUMAN

Zinc transporter ZIP9

0.383

CACP_HUMAN

Carnitine O-acetyltransferase

0.383

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.385

PB1_HUMAN

Protein polybromo-1

0.385

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.385

DOCK5_HUMAN

Dedicator of cytokinesis protein 5

0.385

RCC1_HUMAN

Regulator of chromosome condensation

0.385

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.387

SNX3_HUMAN

Sorting nexin-3

0.387

SRF_HUMAN

Serum response factor

0.388

DYR_HUMAN

Dihydrofolate reductase

0.389

S2533_HUMAN

Solute carrier family 25 member 33

0.390

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.390

CCHL_HUMAN

Cytochrome c-type heme lyase

0.390

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.391

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.391

OGFD1_HUMAN

Prolyl 3-hydroxylase OGFOD1

0.391

COR1C_HUMAN

Coronin-1C

0.393

CLAT_HUMAN

Choline O-acetyltransferase

0.393

PEX13_HUMAN

Peroxisomal membrane protein PEX13

0.393

CDK9_HUMAN

Cyclin-dependent kinase 9

0.393

DPP6_HUMAN

Dipeptidyl aminopeptidase-like protein 6

0.393

HGS_HUMAN

Hepatocyte growth factor-regulated tyrosine kinase substrate

0.394

GATA4_HUMAN

Transcription factor GATA-4

0.395

M3K4_HUMAN

Mitogen-activated protein kinase kinase kinase 4

0.395

ERGI2_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 2

0.396

QPCT_HUMAN

Glutaminyl-peptide cyclotransferase

0.396

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.396

C560_HUMAN

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

0.397

CNDP2_HUMAN

Cytosolic non-specific dipeptidase

0.397

TRM44_HUMAN

Probable tRNA (uracil-O(2)-)-methyltransferase

0.397

AT133_HUMAN

Probable cation-transporting ATPase 13A3

0.397

PLPL6_HUMAN

Neuropathy target esterase

0.397

LMA2L_HUMAN

VIP36-like protein

0.398

CEGT_HUMAN

Ceramide glucosyltransferase

0.399

PP2BC_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 92 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy