NUCG_HUMAN 2019

Gene Name NUCG

Description Endonuclease G, mitochondrial

Length 297

9606

Sequence

>sp|Q14249|NUCG_HUMAN Endonuclease G, mitochondrial
MRALRAGLTLASGAGLGAVVEGWRRRREDARAAPGLLGRLPVLPVAAAAELPPVPGGPRGPGELAKYGLPGLAQLKSRESYVLCYDPRTRGALWVVEQLRPERLRGDGDRRECDFREDDSVHAYHRATNADYRGSGFDRGHLAAAANHRWSQKAMDDTFYLSNVAPQVPHLNQNAWNNLEKYSRSLTRSYQNVYVCTGPLFLPRTEADGKSYVKYQVIGKNHVAVPTHFFKVLILEAAGGQIELRTYVMPNAPVDEAIPLERFLVPIESIERASGLLFVPNILARAGSLKAITAGSK

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.316

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.327

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.327

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.334

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.336

CNDP2_HUMAN

Cytosolic non-specific dipeptidase

0.342

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.343

TBC20_HUMAN

TBC1 domain family member 20

0.348

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.348

SYCC_HUMAN

Cysteine--tRNA ligase, cytoplasmic

0.350

CCHL_HUMAN

Cytochrome c-type heme lyase

0.350

PAN2_HUMAN

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

0.352

NPRL2_HUMAN

GATOR complex protein NPRL2

0.352

SOS1_HUMAN

Son of sevenless homolog 1

0.354

S2533_HUMAN

Solute carrier family 25 member 33

0.356

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.357

S2536_HUMAN

Solute carrier family 25 member 36

0.357

VIGLN_HUMAN

Vigilin

0.358

SYYC_HUMAN

Tyrosine--tRNA ligase, cytoplasmic

0.360

STRP1_HUMAN

Striatin-interacting protein 1

0.360

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.360

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.364

RCC1_HUMAN

Regulator of chromosome condensation

0.364

CC14A_HUMAN

Dual specificity protein phosphatase CDC14A

0.364

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.365

RMND1_HUMAN

Required for meiotic nuclear division protein 1 homolog

0.366

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.369

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.370

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.370

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.370

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.370

ARMT1_HUMAN

Protein-glutamate O-methyltransferase

0.371

COR1C_HUMAN

Coronin-1C

0.371

PYC_HUMAN

Pyruvate carboxylase, mitochondrial

0.373

CACP_HUMAN

Carnitine O-acetyltransferase

0.373

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.373

RRAGB_HUMAN

Ras-related GTP-binding protein B

0.374

CTDS1_HUMAN

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

0.374

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.374

SOS2_HUMAN

Son of sevenless homolog 2

0.375

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.376

PP2BC_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

0.376

CUL1_HUMAN

Cullin-1

0.376

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.378

GGPPS_HUMAN

Geranylgeranyl pyrophosphate synthase

0.379

PP2BB_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

0.379

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.380

CPSF4_HUMAN

Cleavage and polyadenylation specificity factor subunit 4

0.380

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.380

CTDSL_HUMAN

CTD small phosphatase-like protein

0.381

H33_HUMAN

Histone H3.3

0.381

AT133_HUMAN

Probable cation-transporting ATPase 13A3

0.382

PLPL6_HUMAN

Neuropathy target esterase

0.382

RABX5_HUMAN

Rab5 GDP/GTP exchange factor

0.382

ARGI2_HUMAN

Arginase-2, mitochondrial

0.382

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.382

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.383

TMED9_HUMAN

Transmembrane emp24 domain-containing protein 9

0.383

TMED4_HUMAN

Transmembrane emp24 domain-containing protein 4

0.383

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.383

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.383

GORS2_HUMAN

Golgi reassembly-stacking protein 2

0.384

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.384

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.384

C560_HUMAN

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

0.384

ASM_HUMAN

Sphingomyelin phosphodiesterase

0.385

GOLP3_HUMAN

Golgi phosphoprotein 3

0.385

MIO_HUMAN

GATOR complex protein MIOS

0.385

SEPT7_HUMAN

Septin-7

0.385

STRP2_HUMAN

Striatin-interacting protein 2

0.387

LMAN2_HUMAN

Vesicular integral-membrane protein VIP36

0.388

DCPS_HUMAN

m7GpppX diphosphatase

0.388

HID1_HUMAN

Protein HID1

0.388

DPP4_HUMAN

Dipeptidyl peptidase 4

0.388

SURF4_HUMAN

Surfeit locus protein 4

0.391

PLPL7_HUMAN

Patatin-like phospholipase domain-containing protein 7

0.391

NSMA_HUMAN

Sphingomyelin phosphodiesterase 2

0.391

COQ7_HUMAN

5-demethoxyubiquinone hydroxylase, mitochondrial

0.393

CORO6_HUMAN

Coronin-6

0.394

AADAT_HUMAN

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

0.394

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.395

OGFD1_HUMAN

Prolyl 3-hydroxylase OGFOD1

0.396

MTAP_HUMAN

S-methyl-5-thioadenosine phosphorylase

0.396

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.396

LMA2L_HUMAN

VIP36-like protein

0.397

SEPR_HUMAN

Prolyl endopeptidase FAP

0.398

KDM4A_HUMAN

Lysine-specific demethylase 4A

0.399

DC1I2_HUMAN

Cytoplasmic dynein 1 intermediate chain 2

0.399

SNX12_HUMAN

Sorting nexin-12

0.400

LBR_HUMAN

Delta(14)-sterol reductase

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 108 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy