NSMA_HUMAN 2019

Gene Name NSMA

Description Sphingomyelin phosphodiesterase 2

Length 423

9606

Sequence

>sp|O60906|NSMA_HUMAN Sphingomyelin phosphodiesterase 2
MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.338

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.345

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.351

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.352

VIGLN_HUMAN

Vigilin

0.352

SOS1_HUMAN

Son of sevenless homolog 1

0.352

CACP_HUMAN

Carnitine O-acetyltransferase

0.355

DCPS_HUMAN

m7GpppX diphosphatase

0.355

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.356

STRP1_HUMAN

Striatin-interacting protein 1

0.357

GOLP3_HUMAN

Golgi phosphoprotein 3

0.358

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.358

SEPT7_HUMAN

Septin-7

0.359

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.359

DPP4_HUMAN

Dipeptidyl peptidase 4

0.362

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.363

NPRL2_HUMAN

GATOR complex protein NPRL2

0.363

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.363

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.364

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.364

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.364

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.364

S2536_HUMAN

Solute carrier family 25 member 36

0.365

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.365

COQ7_HUMAN

5-demethoxyubiquinone hydroxylase, mitochondrial

0.367

CCHL_HUMAN

Cytochrome c-type heme lyase

0.367

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.367

SURF4_HUMAN

Surfeit locus protein 4

0.368

RCC1_HUMAN

Regulator of chromosome condensation

0.368

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.368

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.368

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.368

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.369

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.369

SOS2_HUMAN

Son of sevenless homolog 2

0.370

PYC_HUMAN

Pyruvate carboxylase, mitochondrial

0.371

PLPL6_HUMAN

Neuropathy target esterase

0.371

AT133_HUMAN

Probable cation-transporting ATPase 13A3

0.371

ARGI2_HUMAN

Arginase-2, mitochondrial

0.371

CC14A_HUMAN

Dual specificity protein phosphatase CDC14A

0.371

SNX12_HUMAN

Sorting nexin-12

0.374

TBC20_HUMAN

TBC1 domain family member 20

0.374

CUL1_HUMAN

Cullin-1

0.374

CNDP2_HUMAN

Cytosolic non-specific dipeptidase

0.374

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.375

TRM44_HUMAN

Probable tRNA (uracil-O(2)-)-methyltransferase

0.376

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.377

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.377

S39A9_HUMAN

Zinc transporter ZIP9

0.377

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.378

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.378

COR1C_HUMAN

Coronin-1C

0.378

S2533_HUMAN

Solute carrier family 25 member 33

0.378

GORS2_HUMAN

Golgi reassembly-stacking protein 2

0.379

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.379

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.380

C560_HUMAN

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

0.380

GATA4_HUMAN

Transcription factor GATA-4

0.380

PAN2_HUMAN

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

0.380

PLPL7_HUMAN

Patatin-like phospholipase domain-containing protein 7

0.381

ZNT1_HUMAN

Zinc transporter 1

0.381

SYCC_HUMAN

Cysteine--tRNA ligase, cytoplasmic

0.381

CLAT_HUMAN

Choline O-acetyltransferase

0.382

SEPR_HUMAN

Prolyl endopeptidase FAP

0.382

RMND1_HUMAN

Required for meiotic nuclear division protein 1 homolog

0.382

PP2BC_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

0.383

PBDC1_HUMAN

Protein PBDC1

0.383

YLAT2_HUMAN

Y+L amino acid transporter 2

0.383

ARMT1_HUMAN

Protein-glutamate O-methyltransferase

0.384

SNX3_HUMAN

Sorting nexin-3

0.385

DIC_HUMAN

Mitochondrial dicarboxylate carrier

0.385

OGFD1_HUMAN

Prolyl 3-hydroxylase OGFOD1

0.386

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.386

LMAN2_HUMAN

Vesicular integral-membrane protein VIP36

0.386

SYYC_HUMAN

Tyrosine--tRNA ligase, cytoplasmic

0.387

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.387

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.387

OXDD_HUMAN

D-aspartate oxidase

0.388

STRP2_HUMAN

Striatin-interacting protein 2

0.388

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.388

ASM_HUMAN

Sphingomyelin phosphodiesterase

0.389

GGPPS_HUMAN

Geranylgeranyl pyrophosphate synthase

0.389

PP2BB_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

0.389

RNH1_HUMAN

Ribonuclease H1

0.389

CDK9_HUMAN

Cyclin-dependent kinase 9

0.391

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.391

MK14_HUMAN

Mitogen-activated protein kinase 14

0.391

NUCG_HUMAN

Endonuclease G, mitochondrial

0.391

PB1_HUMAN

Protein polybromo-1

0.391

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.392

TSC2_HUMAN

Tuberin

0.392

LMA2L_HUMAN

VIP36-like protein

0.392

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.393

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.393

GATA2_HUMAN

Endothelial transcription factor GATA-2

0.393

RDHE2_HUMAN

Epidermal retinol dehydrogenase 2

0.394

HID1_HUMAN

Protein HID1

0.395

RRAGB_HUMAN

Ras-related GTP-binding protein B

0.395

AADAT_HUMAN

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

0.396

HIP1_HUMAN

Huntingtin-interacting protein 1

0.396

GATA6_HUMAN

Transcription factor GATA-6

0.396

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.397

DPP6_HUMAN

Dipeptidyl aminopeptidase-like protein 6

0.397

SRF_HUMAN

Serum response factor

0.397

CAN7_HUMAN

Calpain-7

0.397

KDM4A_HUMAN

Lysine-specific demethylase 4A

0.398

CORO6_HUMAN

Coronin-6

0.398

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.398

SUPT3_HUMAN

Transcription initiation protein SPT3 homolog

0.399

H33_HUMAN

Histone H3.3

0.399

WDR59_HUMAN

GATOR complex protein WDR59

0.399

UB2G2_HUMAN

Ubiquitin-conjugating enzyme E2 G2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 90 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy