LDHD_HUMAN 2019

Gene Name LDHD

Description Probable D-lactate dehydrogenase, mitochondrial

Length 507

9606

Sequence

>sp|Q86WU2|LDHD_HUMAN Probable D-lactate dehydrogenase, mitochondrial
MARLLRSATWELFPWRGYCSQKAKGELCRDFVEALKAVVGGSHVSTAAVVREQHGRDESVHRCEPPDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTHMDRILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGADASLCGMAATGASGTNAVRYGTMRDNVLNLEVVLPDGRLLHTAGRGRHFRFGFWPEIPHHTAWYSPCVSLGRRKSAAGYNLTGLFVGSEGTLGLITATTLRLHPAPEATVAATCAFPSVQAAVDSTVHILQAAVPVARIEFLDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKEAEERSRLWTARHNAWYAALATRPGCKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSIVGHVGDGNFHCILLVNPDDAEELGRVKAFAEQLGRRALALHGTCTGEHGIGMGKRQLLQEEVGAVGVETMRQLKAVLDPQGLMNPGKVL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

GSHR_HUMAN

Glutathione reductase, mitochondrial

0.328

M3K2_HUMAN

Mitogen-activated protein kinase kinase kinase 2

0.334

TMCO4_HUMAN

Transmembrane and coiled-coil domain-containing protein 4

0.337

PPGB_HUMAN

Lysosomal protective protein

0.338

XPOT_HUMAN

Exportin-T

0.340

M3K3_HUMAN

Mitogen-activated protein kinase kinase kinase 3

0.340

NALD2_HUMAN

N-acetylated-alpha-linked acidic dipeptidase 2

0.343

CP51A_HUMAN

Lanosterol 14-alpha demethylase

0.351

DECR2_HUMAN

Peroxisomal 2,4-dienoyl-CoA reductase

0.352

FOLH1_HUMAN

Glutamate carboxypeptidase 2

0.352

ADCK2_HUMAN

Uncharacterized aarF domain-containing protein kinase 2

0.354

TKFC_HUMAN

Triokinase/FMN cyclase

0.355

THTM_HUMAN

3-mercaptopyruvate sulfurtransferase

0.357

SELO_HUMAN

Protein adenylyltransferase SelO, mitochondrial

0.358

DNPEP_HUMAN

Aspartyl aminopeptidase

0.359

SH3Y1_HUMAN

SH3 domain-containing YSC84-like protein 1

0.359

PIR_HUMAN

Pirin

0.360

MAOM_HUMAN

NAD-dependent malic enzyme, mitochondrial

0.361

MTHR_HUMAN

Methylenetetrahydrofolate reductase

0.362

FDFT_HUMAN

Squalene synthase

0.363

ERG7_HUMAN

Lanosterol synthase

0.363

S47A1_HUMAN

Multidrug and toxin extrusion protein 1

0.364

THIK_HUMAN

3-ketoacyl-CoA thiolase, peroxisomal

0.364

NSDHL_HUMAN

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

0.364

ERG1_HUMAN

Squalene monooxygenase

0.366

OTC_HUMAN

Ornithine carbamoyltransferase, mitochondrial

0.367

FADS2_HUMAN

Acyl-CoA 6-desaturase

0.367

CBWD3_HUMAN

COBW domain-containing protein 3

0.368

CBWD2_HUMAN

COBW domain-containing protein 2

0.368

CBWD1_HUMAN

COBW domain-containing protein 1

0.368

CBWD5_HUMAN

COBW domain-containing protein 5

0.368

NADC_HUMAN

Nicotinate-nucleotide pyrophosphorylase [carboxylating]

0.369

THTR_HUMAN

Thiosulfate sulfurtransferase

0.370

FMO5_HUMAN

Dimethylaniline monooxygenase [N-oxide-forming] 5

0.370

MSMO1_HUMAN

Methylsterol monooxygenase 1

0.372

SRR_HUMAN

Serine racemase

0.373

IDHP_HUMAN

Isocitrate dehydrogenase [NADP], mitochondrial

0.373

NUD12_HUMAN

Peroxisomal NADH pyrophosphatase NUDT12

0.374

MINY2_HUMAN

Ubiquitin carboxyl-terminal hydrolase MINDY-2

0.374

FADS1_HUMAN

Acyl-CoA (8-3)-desaturase

0.374

CBWD6_HUMAN

COBW domain-containing protein 6

0.375

SC5D_HUMAN

Lathosterol oxidase

0.375

DNJA2_HUMAN

DnaJ homolog subfamily A member 2

0.376

HLTF_HUMAN

Helicase-like transcription factor

0.377

SGPL1_HUMAN

Sphingosine-1-phosphate lyase 1

0.377

ARLY_HUMAN

Argininosuccinate lyase

0.377

AK1A1_HUMAN

Aldo-keto reductase family 1 member A1

0.378

PUR2_HUMAN

Trifunctional purine biosynthetic protein adenosine-3

0.379

FAHD1_HUMAN

Acylpyruvase FAHD1, mitochondrial

0.379

SPHK1_HUMAN

Sphingosine kinase 1

0.380

ETFA_HUMAN

Electron transfer flavoprotein subunit alpha, mitochondrial

0.381

MYCT_HUMAN

Proton myo-inositol cotransporter

0.381

ETFD_HUMAN

Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

0.382

MRS2_HUMAN

Magnesium transporter MRS2 homolog, mitochondrial

0.382

AOC1_HUMAN

Amiloride-sensitive amine oxidase [copper-containing]

0.382

MINY1_HUMAN

Ubiquitin carboxyl-terminal hydrolase MINDY-1

0.382

IAH1_HUMAN

Isoamyl acetate-hydrolyzing esterase 1 homolog

0.383

SERA_HUMAN

D-3-phosphoglycerate dehydrogenase

0.383

QCR1_HUMAN

Cytochrome b-c1 complex subunit 1, mitochondrial

0.383

KAT3_HUMAN

Kynurenine--oxoglutarate transaminase 3

0.383

ASSY_HUMAN

Argininosuccinate synthase

0.383

BCAT1_HUMAN

Branched-chain-amino-acid aminotransferase, cytosolic

0.384

GTR5_HUMAN

Solute carrier family 2, facilitated glucose transporter member 5

0.384

COQ4_HUMAN

Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

0.385

ATD2B_HUMAN

ATPase family AAA domain-containing protein 2B

0.385

ATAD2_HUMAN

ATPase family AAA domain-containing protein 2

0.385

ATAD1_HUMAN

ATPase family AAA domain-containing protein 1

0.385

KAT1_HUMAN

Kynurenine--oxoglutarate transaminase 1

0.385

PDS5B_HUMAN

Sister chromatid cohesion protein PDS5 homolog B

0.385

DCR1A_HUMAN

DNA cross-link repair 1A protein

0.385

NALDL_HUMAN

Aminopeptidase NAALADL1

0.386

VP26A_HUMAN

Vacuolar protein sorting-associated protein 26A

0.386

SMBP2_HUMAN

DNA-binding protein SMUBP-2

0.387

RPTOR_HUMAN

Regulatory-associated protein of mTOR

0.388

SSDH_HUMAN

Succinate-semialdehyde dehydrogenase, mitochondrial

0.388

ESTD_HUMAN

S-formylglutathione hydrolase

0.388

DCAM_HUMAN

S-adenosylmethionine decarboxylase proenzyme

0.388

CBS_HUMAN

Cystathionine beta-synthase

0.388

CBSL_HUMAN

Cystathionine beta-synthase-like protein

0.388

MRP2_HUMAN

Canalicular multispecific organic anion transporter 1

0.389

UMPS_HUMAN

Uridine 5-monophosphate synthase

0.389

CATA_HUMAN

Catalase

0.389

AL1A2_HUMAN

Retinal dehydrogenase 2

0.389

VPS41_HUMAN

Vacuolar protein sorting-associated protein 41 homolog

0.390

PUR9_HUMAN

Bifunctional purine biosynthesis protein PURH

0.390

HAOX1_HUMAN

Hydroxyacid oxidase 1

0.390

FANCM_HUMAN

Fanconi anemia group M protein

0.390

PROD_HUMAN

Proline dehydrogenase 1, mitochondrial

0.390

HDHD5_HUMAN

Haloacid dehalogenase-like hydrolase domain-containing 5

0.390

TALDO_HUMAN

Transaldolase

0.391

RAD21_HUMAN

Double-strand-break repair protein rad21 homolog

0.391

CMBL_HUMAN

Carboxymethylenebutenolidase homolog

0.391

D2HDH_HUMAN

D-2-hydroxyglutarate dehydrogenase, mitochondrial

0.391

PUR4_HUMAN

Phosphoribosylformylglycinamidine synthase

0.392

F263_HUMAN

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

0.392

UGGG1_HUMAN

UDP-glucose:glycoprotein glucosyltransferase 1

0.392

ALG3_HUMAN

Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

0.392

DHSO_HUMAN

Sorbitol dehydrogenase

0.393

ANKZ1_HUMAN

Ankyrin repeat and zinc finger domain-containing protein 1

0.393

SURF1_HUMAN

Surfeit locus protein 1

0.393

SPEE_HUMAN

Spermidine synthase

0.393

PAPS1_HUMAN

Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1

0.393

DCOR_HUMAN

Ornithine decarboxylase

0.394

COQ6_HUMAN

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

0.394

REV1_HUMAN

DNA repair protein REV1

0.394

NOL6_HUMAN

Nucleolar protein 6

0.394

ADHX_HUMAN

Alcohol dehydrogenase class-3

0.394

MDHM_HUMAN

Malate dehydrogenase, mitochondrial

0.394

PDS5A_HUMAN

Sister chromatid cohesion protein PDS5 homolog A

0.394

CGL_HUMAN

Cystathionine gamma-lyase

0.394

GCSP_HUMAN

Glycine dehydrogenase (decarboxylating), mitochondrial

0.394

FADS3_HUMAN

Fatty acid desaturase 3

0.394

IDH3A_HUMAN

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

0.394

PAQR2_HUMAN

Adiponectin receptor protein 2

0.394

GLNA_HUMAN

Glutamine synthetase

0.394

F262_HUMAN

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

0.394

F16P1_HUMAN

Fructose-1,6-bisphosphatase 1

0.394

TIPRL_HUMAN

TIP41-like protein

0.395

OPLA_HUMAN

5-oxoprolinase

0.395

ACD10_HUMAN

Acyl-CoA dehydrogenase family member 10

0.395

AAKG2_HUMAN

5-AMP-activated protein kinase subunit gamma-2

0.395

ODP2_HUMAN

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

0.395

NIPBL_HUMAN

Nipped-B-like protein

0.395

LETM2_HUMAN

LETM1 domain-containing protein LETM2, mitochondrial

0.395

MAON_HUMAN

NADP-dependent malic enzyme, mitochondrial

0.395

COX15_HUMAN

Cytochrome c oxidase assembly protein COX15 homolog

0.395

PSME4_HUMAN

Proteasome activator complex subunit 4

0.396

CNNM3_HUMAN

Metal transporter CNNM3

0.396

EFGM_HUMAN

Elongation factor G, mitochondrial

0.396

ACER3_HUMAN

Alkaline ceramidase 3

0.396

ATG9A_HUMAN

Autophagy-related protein 9A

0.396

DHB4_HUMAN

Peroxisomal multifunctional enzyme type 2

0.396

SSU72_HUMAN

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

0.397

MCAT_HUMAN

Mitochondrial carnitine/acylcarnitine carrier protein

0.397

PUR1_HUMAN

Amidophosphoribosyltransferase

0.397

FMO4_HUMAN

Dimethylaniline monooxygenase [N-oxide-forming] 4

0.397

NARF_HUMAN

Nuclear prelamin A recognition factor

0.397

HIBCH_HUMAN

3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

0.397

MD2L1_HUMAN

Mitotic spindle assembly checkpoint protein MAD2A

0.397

FMO1_HUMAN

Dimethylaniline monooxygenase [N-oxide-forming] 1

0.397

STK26_HUMAN

Serine/threonine-protein kinase 26

0.397

LIAS_HUMAN

Lipoyl synthase, mitochondrial

0.397

PAQR1_HUMAN

Adiponectin receptor protein 1

0.398

AZIN1_HUMAN

Antizyme inhibitor 1

0.398

GNAZ_HUMAN

Guanine nucleotide-binding protein G(z) subunit alpha

0.398

ANC2_HUMAN

Anaphase-promoting complex subunit 2

0.398

PGM1_HUMAN

Phosphoglucomutase-1

0.398

MPCP_HUMAN

Phosphate carrier protein, mitochondrial

0.398

GUAA_HUMAN

GMP synthase [glutamine-hydrolyzing]

0.398

HEAT1_HUMAN

HEAT repeat-containing protein 1

0.398

CKAP5_HUMAN

Cytoskeleton-associated protein 5

0.398

P5CS_HUMAN

Delta-1-pyrroline-5-carboxylate synthase

0.398

GNTK_HUMAN

Probable gluconokinase

0.398

NPCL1_HUMAN

NPC1-like intracellular cholesterol transporter 1

0.398

ABCG2_HUMAN

ATP-binding cassette sub-family G member 2

0.398

NB5R3_HUMAN

NADH-cytochrome b5 reductase 3

0.399

APT_HUMAN

Adenine phosphoribosyltransferase

0.399

F264_HUMAN

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

0.399

GATA_HUMAN

Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

0.399

MA1B1_HUMAN

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

0.399

UNG_HUMAN

Uracil-DNA glycosylase

0.399

DCAF7_HUMAN

DDB1- and CUL4-associated factor 7

0.399

COQ3_HUMAN

Ubiquinone biosynthesis O-methyltransferase, mitochondrial

0.399

STK24_HUMAN

Serine/threonine-protein kinase 24

0.399

GGT1_HUMAN

Glutathione hydrolase 1 proenzyme

0.399

ADT4_HUMAN

ADP/ATP translocase 4

0.399

DDX3X_HUMAN

ATP-dependent RNA helicase DDX3X

0.399

NFU1_HUMAN

NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

0.400

TOP1_HUMAN

DNA topoisomerase 1

0.400

BCS1_HUMAN

Mitochondrial chaperone BCS1

0.400

ERO1B_HUMAN

ERO1-like protein beta

0.400

CB39L_HUMAN

Calcium-binding protein 39-like

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 111 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy