MRS2_HUMAN 2019

Gene Name MRS2

Description Magnesium transporter MRS2 homolog, mitochondrial

Length 443

9606

Sequence

>sp|Q9HD23|MRS2_HUMAN Magnesium transporter MRS2 homolog, mitochondrial
MECLRSLPCLLPRAMRLPRRTLCALALDVTSVGPPVAACGRRANLIGRSRAAQLCGPDRLRVAGEVHRFRTSDVSQATLASVAPVFTVTKFDKQGNVTSFERKKTELYQELGLQARDLRFQHVMSITVRNNRIIMRMEYLKAVITPECLLILDYRNLNLEQWLFRELPSQLSGEGQLVTYPLPFEFRAIEALLQYWINTLQGKLSILQPLILETLDALVDPKHSSVDRSKLHILLQNGKSLSELETDIKIFKESILEILDEEELLEELCVSKWSDPQVFEKSSAGIDHAEEMELLLENYYRLADDLSNAARELRVLIDDSQSIIFINLDSHRNVMMRLNLQLTMGTFSLSLFGLMGVAFGMNLESSLEEDHRIFWLITGIMFMGSGLIWRRLLSFLGRQLEAPLPPMMASLPKKTLLADRSMELKNSLRLDGLGSGRSILTNR

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

SH3Y1_HUMAN

SH3 domain-containing YSC84-like protein 1

0.315

GTR5_HUMAN

Solute carrier family 2, facilitated glucose transporter member 5

0.316

CP51A_HUMAN

Lanosterol 14-alpha demethylase

0.324

GTR9_HUMAN

Solute carrier family 2, facilitated glucose transporter member 9

0.327

GNAZ_HUMAN

Guanine nucleotide-binding protein G(z) subunit alpha

0.329

HLTF_HUMAN

Helicase-like transcription factor

0.329

ERG1_HUMAN

Squalene monooxygenase

0.330

CBWD5_HUMAN

COBW domain-containing protein 5

0.330

CBWD1_HUMAN

COBW domain-containing protein 1

0.330

CBWD3_HUMAN

COBW domain-containing protein 3

0.330

CBWD2_HUMAN

COBW domain-containing protein 2

0.330

THIK_HUMAN

3-ketoacyl-CoA thiolase, peroxisomal

0.331

FDFT_HUMAN

Squalene synthase

0.334

STXB3_HUMAN

Syntaxin-binding protein 3

0.336

ERG7_HUMAN

Lanosterol synthase

0.337

CBWD6_HUMAN

COBW domain-containing protein 6

0.338

OTC_HUMAN

Ornithine carbamoyltransferase, mitochondrial

0.338

AMPD1_HUMAN

AMP deaminase 1

0.343

MSMO1_HUMAN

Methylsterol monooxygenase 1

0.344

LETM2_HUMAN

LETM1 domain-containing protein LETM2, mitochondrial

0.345

TBA8_HUMAN

Tubulin alpha-8 chain

0.345

DECR2_HUMAN

Peroxisomal 2,4-dienoyl-CoA reductase

0.346

GNAT1_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-1

0.346

GNAT2_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-2

0.347

NSDHL_HUMAN

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

0.349

VPP3_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 3

0.350

TRUB1_HUMAN

Probable tRNA pseudouridine synthase 1

0.352

CATE_HUMAN

Cathepsin E

0.355

AOC3_HUMAN

Membrane primary amine oxidase

0.355

AOC1_HUMAN

Amiloride-sensitive amine oxidase [copper-containing]

0.358

GTR11_HUMAN

Solute carrier family 2, facilitated glucose transporter member 11

0.359

M3K2_HUMAN

Mitogen-activated protein kinase kinase kinase 2

0.361

TBB6_HUMAN

Tubulin beta-6 chain

0.361

CMBL_HUMAN

Carboxymethylenebutenolidase homolog

0.361

M3K3_HUMAN

Mitogen-activated protein kinase kinase kinase 3

0.363

ACTC_HUMAN

Actin, alpha cardiac muscle 1

0.364

S47A1_HUMAN

Multidrug and toxin extrusion protein 1

0.365

KCC4_HUMAN

Calcium/calmodulin-dependent protein kinase type IV

0.365

VPP2_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 2

0.366

GSHR_HUMAN

Glutathione reductase, mitochondrial

0.367

AOC2_HUMAN

Retina-specific copper amine oxidase

0.367

AMPD3_HUMAN

AMP deaminase 3

0.368

DNPEP_HUMAN

Aspartyl aminopeptidase

0.369

AL1A3_HUMAN

Aldehyde dehydrogenase family 1 member A3

0.369

QCR1_HUMAN

Cytochrome b-c1 complex subunit 1, mitochondrial

0.369

ADCK2_HUMAN

Uncharacterized aarF domain-containing protein kinase 2

0.370

PIR_HUMAN

Pirin

0.371

NADC_HUMAN

Nicotinate-nucleotide pyrophosphorylase [carboxylating]

0.373

SERC5_HUMAN

Serine incorporator 5

0.373

NPCL1_HUMAN

NPC1-like intracellular cholesterol transporter 1

0.373

TMCO4_HUMAN

Transmembrane and coiled-coil domain-containing protein 4

0.375

SC5D_HUMAN

Lathosterol oxidase

0.376

SELO_HUMAN

Protein adenylyltransferase SelO, mitochondrial

0.378

HEM3_HUMAN

Porphobilinogen deaminase

0.380

TBB3_HUMAN

Tubulin beta-3 chain

0.381

LDHD_HUMAN

Probable D-lactate dehydrogenase, mitochondrial

0.382

MAOM_HUMAN

NAD-dependent malic enzyme, mitochondrial

0.382

CLPB_HUMAN

Caseinolytic peptidase B protein homolog

0.384

CSK22_HUMAN

Casein kinase II subunit alpha

0.384

XPOT_HUMAN

Exportin-T

0.384

WDR76_HUMAN

WD repeat-containing protein 76

0.384

VP26A_HUMAN

Vacuolar protein sorting-associated protein 26A

0.384

GNAT3_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-3

0.385

VA0D2_HUMAN

V-type proton ATPase subunit d 2

0.386

CD123_HUMAN

Cell division cycle protein 123 homolog

0.386

ERG28_HUMAN

Probable ergosterol biosynthetic protein 28

0.387

AL1A2_HUMAN

Retinal dehydrogenase 2

0.388

ACTA_HUMAN

Actin, aortic smooth muscle

0.388

IAH1_HUMAN

Isoamyl acetate-hydrolyzing esterase 1 homolog

0.389

PPGB_HUMAN

Lysosomal protective protein

0.390

RANG_HUMAN

Ran-specific GTPase-activating protein

0.391

IDHP_HUMAN

Isocitrate dehydrogenase [NADP], mitochondrial

0.391

PLPP4_HUMAN

Phospholipid phosphatase 4

0.391

DCUP_HUMAN

Uroporphyrinogen decarboxylase

0.393

GDC_HUMAN

Graves disease carrier protein

0.393

UBP4_HUMAN

Ubiquitin carboxyl-terminal hydrolase 4

0.393

ACER3_HUMAN

Alkaline ceramidase 3

0.394

AL1A1_HUMAN

Retinal dehydrogenase 1

0.395

MSH3_HUMAN

DNA mismatch repair protein Msh3

0.395

MRP2_HUMAN

Canalicular multispecific organic anion transporter 1

0.395

HEM2_HUMAN

Delta-aminolevulinic acid dehydratase

0.395

FHIT_HUMAN

Bis(5-adenosyl)-triphosphatase

0.396

TBA4A_HUMAN

Tubulin alpha-4A chain

0.398

ARLY_HUMAN

Argininosuccinate lyase

0.398

IPO11_HUMAN

Importin-11

0.398

DNJA2_HUMAN

DnaJ homolog subfamily A member 2

0.399

THTM_HUMAN

3-mercaptopyruvate sulfurtransferase

0.399

AIFM2_HUMAN

Apoptosis-inducing factor 2

0.399

APEX2_HUMAN

DNA-(apurinic or apyrimidinic site) lyase 2

0.399

THTR_HUMAN

Thiosulfate sulfurtransferase

0.399

ASNS_HUMAN

Asparagine synthetase [glutamine-hydrolyzing]

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 109 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy