IAH1_HUMAN 2019

Gene Name IAH1

Description Isoamyl acetate-hydrolyzing esterase 1 homolog

Length 248

9606

Sequence

>sp|Q2TAA2|IAH1_HUMAN Isoamyl acetate-hydrolyzing esterase 1 homolog
MALCEAAGCGSALLWPRLLLFGDSITQFSFQQGGWGASLADRLVRKCDVLNRGFSGYNTRWAKIILPRLIRKGNSLDIPVAVTIFFGANDSALKDENPKQHIPLEEYAANLKSMVQYLKSVDIPENRVILITPTPLCETAWEEQCIIQGCKLNRLNSVVGEYANACLQVAQDCGTDVLDLWTLMQDSQDFSSYLSDGLHLSPKGNEFLFSHLWPLIEKKVSSLPLLLPYWRDVAEAKPELSLLGDGDH

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

SH3Y1_HUMAN

SH3 domain-containing YSC84-like protein 1

0.312

OTC_HUMAN

Ornithine carbamoyltransferase, mitochondrial

0.314

M3K2_HUMAN

Mitogen-activated protein kinase kinase kinase 2

0.322

M3K3_HUMAN

Mitogen-activated protein kinase kinase kinase 3

0.325

S47A1_HUMAN

Multidrug and toxin extrusion protein 1

0.326

THIK_HUMAN

3-ketoacyl-CoA thiolase, peroxisomal

0.336

ERG7_HUMAN

Lanosterol synthase

0.339

FDFT_HUMAN

Squalene synthase

0.342

CP51A_HUMAN

Lanosterol 14-alpha demethylase

0.342

SELO_HUMAN

Protein adenylyltransferase SelO, mitochondrial

0.344

CBWD2_HUMAN

COBW domain-containing protein 2

0.345

CBWD3_HUMAN

COBW domain-containing protein 3

0.345

CBWD5_HUMAN

COBW domain-containing protein 5

0.345

CBWD1_HUMAN

COBW domain-containing protein 1

0.345

HLTF_HUMAN

Helicase-like transcription factor

0.347

NADC_HUMAN

Nicotinate-nucleotide pyrophosphorylase [carboxylating]

0.348

CBWD6_HUMAN

COBW domain-containing protein 6

0.352

GTR5_HUMAN

Solute carrier family 2, facilitated glucose transporter member 5

0.352

DECR2_HUMAN

Peroxisomal 2,4-dienoyl-CoA reductase

0.353

ARLY_HUMAN

Argininosuccinate lyase

0.354

ERG1_HUMAN

Squalene monooxygenase

0.355

SC5D_HUMAN

Lathosterol oxidase

0.355

NSDHL_HUMAN

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

0.356

ASSY_HUMAN

Argininosuccinate synthase

0.364

PPGB_HUMAN

Lysosomal protective protein

0.365

PIR_HUMAN

Pirin

0.365

XPOT_HUMAN

Exportin-T

0.370

GSHR_HUMAN

Glutathione reductase, mitochondrial

0.374

ACER3_HUMAN

Alkaline ceramidase 3

0.374

MSMO1_HUMAN

Methylsterol monooxygenase 1

0.374

CMBL_HUMAN

Carboxymethylenebutenolidase homolog

0.375

GNAZ_HUMAN

Guanine nucleotide-binding protein G(z) subunit alpha

0.376

S47A2_HUMAN

Multidrug and toxin extrusion protein 2

0.377

ACD10_HUMAN

Acyl-CoA dehydrogenase family member 10

0.379

STXB3_HUMAN

Syntaxin-binding protein 3

0.381

CD123_HUMAN

Cell division cycle protein 123 homolog

0.381

NCLX_HUMAN

Mitochondrial sodium/calcium exchanger protein

0.381

AMPD1_HUMAN

AMP deaminase 1

0.382

CLPB_HUMAN

Caseinolytic peptidase B protein homolog

0.382

GDC_HUMAN

Graves disease carrier protein

0.382

LDHD_HUMAN

Probable D-lactate dehydrogenase, mitochondrial

0.383

PEX7_HUMAN

Peroxisomal targeting signal 2 receptor

0.383

HDHD5_HUMAN

Haloacid dehalogenase-like hydrolase domain-containing 5

0.384

DNPEP_HUMAN

Aspartyl aminopeptidase

0.384

MINY2_HUMAN

Ubiquitin carboxyl-terminal hydrolase MINDY-2

0.385

WDR76_HUMAN

WD repeat-containing protein 76

0.385

PLPP4_HUMAN

Phospholipid phosphatase 4

0.386

MAOM_HUMAN

NAD-dependent malic enzyme, mitochondrial

0.386

GTR9_HUMAN

Solute carrier family 2, facilitated glucose transporter member 9

0.386

QCR1_HUMAN

Cytochrome b-c1 complex subunit 1, mitochondrial

0.387

MRS2_HUMAN

Magnesium transporter MRS2 homolog, mitochondrial

0.389

HEM3_HUMAN

Porphobilinogen deaminase

0.390

TMCO4_HUMAN

Transmembrane and coiled-coil domain-containing protein 4

0.390

THTM_HUMAN

3-mercaptopyruvate sulfurtransferase

0.391

IDHP_HUMAN

Isocitrate dehydrogenase [NADP], mitochondrial

0.392

P5CS_HUMAN

Delta-1-pyrroline-5-carboxylate synthase

0.392

AMPD3_HUMAN

AMP deaminase 3

0.392

ORML3_HUMAN

ORM1-like protein 3

0.392

TRUB1_HUMAN

Probable tRNA pseudouridine synthase 1

0.392

HEM6_HUMAN

Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

0.393

AL1A3_HUMAN

Aldehyde dehydrogenase family 1 member A3

0.393

DCUP_HUMAN

Uroporphyrinogen decarboxylase

0.394

IPO11_HUMAN

Importin-11

0.394

GNAT1_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-1

0.394

LAAT1_HUMAN

Lysosomal amino acid transporter 1 homolog

0.395

GNAT2_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-2

0.395

DCR1A_HUMAN

DNA cross-link repair 1A protein

0.395

MINY1_HUMAN

Ubiquitin carboxyl-terminal hydrolase MINDY-1

0.395

DPOLL_HUMAN

DNA polymerase lambda

0.395

ORML1_HUMAN

ORM1-like protein 1

0.395

MGLL_HUMAN

Monoglyceride lipase

0.396

NADK_HUMAN

NAD kinase

0.396

AK1A1_HUMAN

Aldo-keto reductase family 1 member A1

0.396

AL1A2_HUMAN

Retinal dehydrogenase 2

0.397

DNJA2_HUMAN

DnaJ homolog subfamily A member 2

0.397

PUR2_HUMAN

Trifunctional purine biosynthetic protein adenosine-3

0.397

AOC1_HUMAN

Amiloride-sensitive amine oxidase [copper-containing]

0.399

EDEM1_HUMAN

ER degradation-enhancing alpha-mannosidase-like protein 1

0.399

NUD12_HUMAN

Peroxisomal NADH pyrophosphatase NUDT12

0.399

RANG_HUMAN

Ran-specific GTPase-activating protein

0.400

ADCK2_HUMAN

Uncharacterized aarF domain-containing protein kinase 2

0.400

LETM2_HUMAN

LETM1 domain-containing protein LETM2, mitochondrial

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 116 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy