PNPO_HUMAN 2019

Gene Name PNPO

Description Pyridoxine-5-phosphate oxidase

Length 261

9606

Sequence

>sp|Q9NVS9|PNPO_HUMAN Pyridoxine-5-phosphate oxidase
MTCWLRGVTATFGRPAEWPGYLSHLCGRSAAMDLGPMRKSYRGDREAFEETHLTSLDPVKQFAAWFEEAVQCPDIGEANAMCLATCTRDGKPSARMLLLKGFGKDGFRFFTNFESRKGKELDSNPFASLVFYWEPLNRQVRVEGPVKKLPEEEAECYFHSRPKSSQIGAVVSHQSSVIPDREYLRKKNEELEQLYQDQEVPKPKSWGGYVLYPQVMEFWQGQTNRLHDRIVFRRGLPTGDSPLGPMTHRGEEDWLYERLAP

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.329

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.336

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.343

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.343

VIGLN_HUMAN

Vigilin

0.346

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.350

GOLP3_HUMAN

Golgi phosphoprotein 3

0.352

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.352

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.353

CC14A_HUMAN

Dual specificity protein phosphatase CDC14A

0.353

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.356

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.356

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.356

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.356

ZNT1_HUMAN

Zinc transporter 1

0.356

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.357

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.359

SURF4_HUMAN

Surfeit locus protein 4

0.359

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.363

DOCK5_HUMAN

Dedicator of cytokinesis protein 5

0.365

NPRL2_HUMAN

GATOR complex protein NPRL2

0.367

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.369

CUL1_HUMAN

Cullin-1

0.369

SOS1_HUMAN

Son of sevenless homolog 1

0.369

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.371

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.372

S2536_HUMAN

Solute carrier family 25 member 36

0.372

DPP4_HUMAN

Dipeptidyl peptidase 4

0.372

SEPR_HUMAN

Prolyl endopeptidase FAP

0.374

PB1_HUMAN

Protein polybromo-1

0.374

SRF_HUMAN

Serum response factor

0.374

STRP1_HUMAN

Striatin-interacting protein 1

0.375

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.376

DOCK3_HUMAN

Dedicator of cytokinesis protein 3

0.377

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.377

GDE_HUMAN

Glycogen debranching enzyme

0.377

HIP1_HUMAN

Huntingtin-interacting protein 1

0.379

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.380

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.380

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.381

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.381

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.381

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.381

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.381

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.381

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.382

DPP6_HUMAN

Dipeptidyl aminopeptidase-like protein 6

0.383

RDHE2_HUMAN

Epidermal retinol dehydrogenase 2

0.383

CBPA1_HUMAN

Carboxypeptidase A1

0.384

PBDC1_HUMAN

Protein PBDC1

0.384

CNDP2_HUMAN

Cytosolic non-specific dipeptidase

0.384

PAN2_HUMAN

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

0.385

MPIP1_HUMAN

M-phase inducer phosphatase 1

0.385

DOCK2_HUMAN

Dedicator of cytokinesis protein 2

0.385

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.385

CBPB1_HUMAN

Carboxypeptidase B

0.387

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.387

SEPT7_HUMAN

Septin-7

0.388

S39A9_HUMAN

Zinc transporter ZIP9

0.388

DOCK1_HUMAN

Dedicator of cytokinesis protein 1

0.388

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.389

SOS2_HUMAN

Son of sevenless homolog 2

0.389

DYR_HUMAN

Dihydrofolate reductase

0.391

EP15R_HUMAN

Epidermal growth factor receptor substrate 15-like 1

0.391

S2533_HUMAN

Solute carrier family 25 member 33

0.392

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.392

MPIP2_HUMAN

M-phase inducer phosphatase 2

0.392

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.392

H33_HUMAN

Histone H3.3

0.392

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.392

ASM_HUMAN

Sphingomyelin phosphodiesterase

0.393

SNX12_HUMAN

Sorting nexin-12

0.393

CACP_HUMAN

Carnitine O-acetyltransferase

0.394

MOT12_HUMAN

Monocarboxylate transporter 12

0.394

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.394

DOCK4_HUMAN

Dedicator of cytokinesis protein 4

0.395

TRM44_HUMAN

Probable tRNA (uracil-O(2)-)-methyltransferase

0.396

ATP9A_HUMAN

Probable phospholipid-transporting ATPase IIA

0.396

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.397

PAXI_HUMAN

Paxillin

0.397

DOP1_HUMAN

Protein dopey-1

0.397

CCHL_HUMAN

Cytochrome c-type heme lyase

0.398

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.398

C560_HUMAN

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

0.399

HID1_HUMAN

Protein HID1

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 100 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy