MPIP2_HUMAN 2019

Gene Name MPIP2

Description M-phase inducer phosphatase 2

Length 580

9606

Sequence

>sp|P30305|MPIP2_HUMAN M-phase inducer phosphatase 2
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

MPIP3_HUMAN

M-phase inducer phosphatase 3

0.265

MPIP1_HUMAN

M-phase inducer phosphatase 1

0.307

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

MPIP3_HUMAN

M-phase inducer phosphatase 3

0.163

MPIP1_HUMAN

M-phase inducer phosphatase 1

0.224

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.349

CC14A_HUMAN

Dual specificity protein phosphatase CDC14A

0.354

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.356

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.356

AT133_HUMAN

Probable cation-transporting ATPase 13A3

0.360

SOS1_HUMAN

Son of sevenless homolog 1

0.363

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.363

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.366

RCC1_HUMAN

Regulator of chromosome condensation

0.366

SEPT7_HUMAN

Septin-7

0.366

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.369

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.369

VIGLN_HUMAN

Vigilin

0.369

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.370

RRAGB_HUMAN

Ras-related GTP-binding protein B

0.370

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.370

RHOA_HUMAN

Transforming protein RhoA

0.371

PP2BC_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

0.372

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.372

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.372

CC14B_HUMAN

Dual specificity protein phosphatase CDC14B

0.372

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.373

SYYC_HUMAN

Tyrosine--tRNA ligase, cytoplasmic

0.374

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.375

DCPS_HUMAN

m7GpppX diphosphatase

0.375

AT134_HUMAN

Probable cation-transporting ATPase 13A4

0.376

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.377

NPRL2_HUMAN

GATOR complex protein NPRL2

0.377

H33_HUMAN

Histone H3.3

0.377

STRP1_HUMAN

Striatin-interacting protein 1

0.377

GOLP3_HUMAN

Golgi phosphoprotein 3

0.378

PP2BB_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

0.378

PLPL6_HUMAN

Neuropathy target esterase

0.378

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.379

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.380

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.380

RMND1_HUMAN

Required for meiotic nuclear division protein 1 homolog

0.380

ATP9A_HUMAN

Probable phospholipid-transporting ATPase IIA

0.381

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.382

SYCC_HUMAN

Cysteine--tRNA ligase, cytoplasmic

0.382

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.382

SOS2_HUMAN

Son of sevenless homolog 2

0.383

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.383

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.383

SRF_HUMAN

Serum response factor

0.383

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.384

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.384

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.384

CUL1_HUMAN

Cullin-1

0.384

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.384

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.385

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.385

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.385

STRP2_HUMAN

Striatin-interacting protein 2

0.386

CBPB1_HUMAN

Carboxypeptidase B

0.387

CBPA1_HUMAN

Carboxypeptidase A1

0.387

S2536_HUMAN

Solute carrier family 25 member 36

0.387

PLK1_HUMAN

Serine/threonine-protein kinase PLK1

0.387

CNDP2_HUMAN

Cytosolic non-specific dipeptidase

0.387

GATA4_HUMAN

Transcription factor GATA-4

0.387

DPP4_HUMAN

Dipeptidyl peptidase 4

0.387

RHOC_HUMAN

Rho-related GTP-binding protein RhoC

0.388

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.388

CCHL_HUMAN

Cytochrome c-type heme lyase

0.389

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.390

SURF4_HUMAN

Surfeit locus protein 4

0.390

CBPA4_HUMAN

Carboxypeptidase A4

0.391

RDHE2_HUMAN

Epidermal retinol dehydrogenase 2

0.392

PNPO_HUMAN

Pyridoxine-5-phosphate oxidase

0.392

TBC20_HUMAN

TBC1 domain family member 20

0.392

PAN2_HUMAN

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

0.393

PLPL7_HUMAN

Patatin-like phospholipase domain-containing protein 7

0.393

AADAT_HUMAN

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

0.393

ZNT1_HUMAN

Zinc transporter 1

0.394

DOP1_HUMAN

Protein dopey-1

0.394

CBPA3_HUMAN

Mast cell carboxypeptidase A

0.394

CMC2_HUMAN

Calcium-binding mitochondrial carrier protein Aralar2

0.395

OGFD1_HUMAN

Prolyl 3-hydroxylase OGFOD1

0.395

CBPA2_HUMAN

Carboxypeptidase A2

0.396

TMED4_HUMAN

Transmembrane emp24 domain-containing protein 4

0.396

GATA3_HUMAN

Trans-acting T-cell-specific transcription factor GATA-3

0.396

AT135_HUMAN

Probable cation-transporting ATPase 13A5

0.397

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.397

ATP9B_HUMAN

Probable phospholipid-transporting ATPase IIB

0.397

GDE_HUMAN

Glycogen debranching enzyme

0.398

CBPA5_HUMAN

Carboxypeptidase A5

0.398

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.398

RABX5_HUMAN

Rab5 GDP/GTP exchange factor

0.398

CPSF4_HUMAN

Cleavage and polyadenylation specificity factor subunit 4

0.399

TMED9_HUMAN

Transmembrane emp24 domain-containing protein 9

0.399

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.399

COR1C_HUMAN

Coronin-1C

0.399

COR1A_HUMAN

Coronin-1A

0.400

IQGA1_HUMAN

Ras GTPase-activating-like protein IQGAP1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 111 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy