LAT2_HUMAN 2019

Gene Name LAT2

Description Large neutral amino acids transporter small subunit 2

Length 535

9606

Sequence

>sp|Q9UHI5|LAT2_HUMAN Large neutral amino acids transporter small subunit 2
MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEVERGSGTEEANEDMEEQQQPMYQPTPTKDKDVAGQPQP

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

LAT1_HUMAN

Large neutral amino acids transporter small subunit 1

0.284

YLAT1_HUMAN

Y+L amino acid transporter 1

0.291

YLAT2_HUMAN

Y+L amino acid transporter 2

0.298

VIGLN_HUMAN

Vigilin

0.349

GOLP3_HUMAN

Golgi phosphoprotein 3

0.352

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.356

SURF4_HUMAN

Surfeit locus protein 4

0.359

SOS1_HUMAN

Son of sevenless homolog 1

0.359

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.360

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.360

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.361

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.362

DPP4_HUMAN

Dipeptidyl peptidase 4

0.362

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.363

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.363

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.365

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.365

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.365

BAT1_HUMAN

b(0,+)-type amino acid transporter 1

0.366

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.366

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.366

SEPR_HUMAN

Prolyl endopeptidase FAP

0.367

PBDC1_HUMAN

Protein PBDC1

0.368

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.368

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.370

STRP1_HUMAN

Striatin-interacting protein 1

0.371

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.372

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.373

SOS2_HUMAN

Son of sevenless homolog 2

0.374

XCT_HUMAN

Cystine/glutamate transporter

0.375

CACP_HUMAN

Carnitine O-acetyltransferase

0.375

DPP6_HUMAN

Dipeptidyl aminopeptidase-like protein 6

0.376

GLP3L_HUMAN

Golgi phosphoprotein 3-like

0.377

DOCK3_HUMAN

Dedicator of cytokinesis protein 3

0.380

RHOA_HUMAN

Transforming protein RhoA

0.380

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.381

S2536_HUMAN

Solute carrier family 25 member 36

0.381

CUL1_HUMAN

Cullin-1

0.381

HIP1_HUMAN

Huntingtin-interacting protein 1

0.382

GATA3_HUMAN

Trans-acting T-cell-specific transcription factor GATA-3

0.382

ZNT1_HUMAN

Zinc transporter 1

0.382

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.382

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.382

GATA2_HUMAN

Endothelial transcription factor GATA-2

0.383

NPRL2_HUMAN

GATOR complex protein NPRL2

0.383

HYAS3_HUMAN

Hyaluronan synthase 3

0.383

DOCK5_HUMAN

Dedicator of cytokinesis protein 5

0.384

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.384

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.384

SEPT7_HUMAN

Septin-7

0.384

IQGA1_HUMAN

Ras GTPase-activating-like protein IQGAP1

0.385

PYC_HUMAN

Pyruvate carboxylase, mitochondrial

0.387

GATA4_HUMAN

Transcription factor GATA-4

0.387

PLPL6_HUMAN

Neuropathy target esterase

0.387

S39A9_HUMAN

Zinc transporter ZIP9

0.388

AT132_HUMAN

Cation-transporting ATPase 13A2

0.388

DOCK2_HUMAN

Dedicator of cytokinesis protein 2

0.388

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.389

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.389

GDE_HUMAN

Glycogen debranching enzyme

0.389

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.390

RCC1_HUMAN

Regulator of chromosome condensation

0.390

AAA1_HUMAN

Asc-type amino acid transporter 1

0.390

HYAS2_HUMAN

Hyaluronan synthase 2

0.390

AT133_HUMAN

Probable cation-transporting ATPase 13A3

0.390

SNX12_HUMAN

Sorting nexin-12

0.390

IQGA3_HUMAN

Ras GTPase-activating-like protein IQGAP3

0.391

CLAT_HUMAN

Choline O-acetyltransferase

0.392

STRP2_HUMAN

Striatin-interacting protein 2

0.392

DOCK4_HUMAN

Dedicator of cytokinesis protein 4

0.392

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.392

SRF_HUMAN

Serum response factor

0.392

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.393

ASM_HUMAN

Sphingomyelin phosphodiesterase

0.393

LMA2L_HUMAN

VIP36-like protein

0.393

PLPL7_HUMAN

Patatin-like phospholipase domain-containing protein 7

0.394

DYR_HUMAN

Dihydrofolate reductase

0.394

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.394

AT2C2_HUMAN

Calcium-transporting ATPase type 2C member 2

0.394

DOCK1_HUMAN

Dedicator of cytokinesis protein 1

0.394

SNX3_HUMAN

Sorting nexin-3

0.395

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.395

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.396

PP2BC_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

0.396

PB1_HUMAN

Protein polybromo-1

0.396

LMAN2_HUMAN

Vesicular integral-membrane protein VIP36

0.396

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.397

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.397

COR1C_HUMAN

Coronin-1C

0.397

S2533_HUMAN

Solute carrier family 25 member 33

0.397

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.397

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.398

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.398

MK14_HUMAN

Mitogen-activated protein kinase 14

0.398

STAM1_HUMAN

Signal transducing adapter molecule 1

0.399

ARGI2_HUMAN

Arginase-2, mitochondrial

0.399

RRAGB_HUMAN

Ras-related GTP-binding protein B

0.400

ARGI1_HUMAN

Arginase-1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 84 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy