YLAT1_HUMAN 2019

Gene Name YLAT1

Description Y+L amino acid transporter 1

Length 511

9606

Sequence

>sp|Q9UM01|YLAT1_HUMAN Y+L amino acid transporter 1
MVDSTEYEVASQPEVETSPLGDGASPGPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVIWAVGGLFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAIIAITFANYMVQPLFPSCFAPYAASRLLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIVAGIVRLGQGASTHFENSFEGSSFAVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYTVLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGHLPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWKEPDRPRPLKLSVFFPIVFCLCTIFLVAVPLYSDTINSLIGIAIALSGLPFYFLIIRVPEHKRPLYLRRIVGSATRYLQVLCMSVAAEMDLEDGGEMPKQRDPKSN

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

YLAT2_HUMAN

Y+L amino acid transporter 2

0.214

LAT2_HUMAN

Large neutral amino acids transporter small subunit 2

0.291

LAT1_HUMAN

Large neutral amino acids transporter small subunit 1

0.328

VIGLN_HUMAN

Vigilin

0.333

GOLP3_HUMAN

Golgi phosphoprotein 3

0.335

BAT1_HUMAN

b(0,+)-type amino acid transporter 1

0.335

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.343

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.344

SEPR_HUMAN

Prolyl endopeptidase FAP

0.344

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.344

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.345

SURF4_HUMAN

Surfeit locus protein 4

0.346

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.347

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.349

DPP4_HUMAN

Dipeptidyl peptidase 4

0.350

CACP_HUMAN

Carnitine O-acetyltransferase

0.350

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.351

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.352

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.353

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.353

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.354

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.354

SOS1_HUMAN

Son of sevenless homolog 1

0.354

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.354

STRP1_HUMAN

Striatin-interacting protein 1

0.356

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.356

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.357

SOS2_HUMAN

Son of sevenless homolog 2

0.358

RHOA_HUMAN

Transforming protein RhoA

0.358

PBDC1_HUMAN

Protein PBDC1

0.362

S39A9_HUMAN

Zinc transporter ZIP9

0.363

CUL1_HUMAN

Cullin-1

0.363

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.364

NPRL2_HUMAN

GATOR complex protein NPRL2

0.365

PLPL6_HUMAN

Neuropathy target esterase

0.366

SEPT7_HUMAN

Septin-7

0.367

DOCK4_HUMAN

Dedicator of cytokinesis protein 4

0.367

DOCK3_HUMAN

Dedicator of cytokinesis protein 3

0.368

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.369

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.370

CLAT_HUMAN

Choline O-acetyltransferase

0.371

GDE_HUMAN

Glycogen debranching enzyme

0.371

DOCK5_HUMAN

Dedicator of cytokinesis protein 5

0.372

SRF_HUMAN

Serum response factor

0.372

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.372

GATA4_HUMAN

Transcription factor GATA-4

0.372

DOCK2_HUMAN

Dedicator of cytokinesis protein 2

0.373

ZNT1_HUMAN

Zinc transporter 1

0.373

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.374

S2536_HUMAN

Solute carrier family 25 member 36

0.376

STRP2_HUMAN

Striatin-interacting protein 2

0.377

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.377

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.378

RCC1_HUMAN

Regulator of chromosome condensation

0.379

SNX12_HUMAN

Sorting nexin-12

0.379

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.379

LMA2L_HUMAN

VIP36-like protein

0.379

HIP1_HUMAN

Huntingtin-interacting protein 1

0.379

PLPL7_HUMAN

Patatin-like phospholipase domain-containing protein 7

0.379

DOCK1_HUMAN

Dedicator of cytokinesis protein 1

0.379

COR1C_HUMAN

Coronin-1C

0.380

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.380

HYAS3_HUMAN

Hyaluronan synthase 3

0.380

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.381

XCT_HUMAN

Cystine/glutamate transporter

0.382

MOT12_HUMAN

Monocarboxylate transporter 12

0.383

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.383

CEGT_HUMAN

Ceramide glucosyltransferase

0.383

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.383

TRM44_HUMAN

Probable tRNA (uracil-O(2)-)-methyltransferase

0.384

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.384

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.384

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.384

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.384

PYC_HUMAN

Pyruvate carboxylase, mitochondrial

0.385

ASM_HUMAN

Sphingomyelin phosphodiesterase

0.385

DYR_HUMAN

Dihydrofolate reductase

0.385

GATA6_HUMAN

Transcription factor GATA-6

0.386

RHOC_HUMAN

Rho-related GTP-binding protein RhoC

0.386

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.386

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.386

DPP6_HUMAN

Dipeptidyl aminopeptidase-like protein 6

0.387

CCHL_HUMAN

Cytochrome c-type heme lyase

0.387

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.387

HYAS2_HUMAN

Hyaluronan synthase 2

0.387

LMAN2_HUMAN

Vesicular integral-membrane protein VIP36

0.388

AT133_HUMAN

Probable cation-transporting ATPase 13A3

0.388

DCPS_HUMAN

m7GpppX diphosphatase

0.388

ARGI2_HUMAN

Arginase-2, mitochondrial

0.388

RRAGB_HUMAN

Ras-related GTP-binding protein B

0.388

S2533_HUMAN

Solute carrier family 25 member 33

0.389

IQGA1_HUMAN

Ras GTPase-activating-like protein IQGAP1

0.389

SNX3_HUMAN

Sorting nexin-3

0.389

DIC_HUMAN

Mitochondrial dicarboxylate carrier

0.390

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.390

PB1_HUMAN

Protein polybromo-1

0.390

MTAP_HUMAN

S-methyl-5-thioadenosine phosphorylase

0.390

STAM1_HUMAN

Signal transducing adapter molecule 1

0.391

CORO6_HUMAN

Coronin-6

0.391

GATA5_HUMAN

Transcription factor GATA-5

0.392

PAXI_HUMAN

Paxillin

0.392

COR1A_HUMAN

Coronin-1A

0.392

PCBP2_HUMAN

Poly(rC)-binding protein 2

0.392

QPCT_HUMAN

Glutaminyl-peptide cyclotransferase

0.392

PP2BC_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

0.393

GGPPS_HUMAN

Geranylgeranyl pyrophosphate synthase

0.394

ARGI1_HUMAN

Arginase-1

0.394

GATA3_HUMAN

Trans-acting T-cell-specific transcription factor GATA-3

0.394

ARMT1_HUMAN

Protein-glutamate O-methyltransferase

0.395

IDH3G_HUMAN

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

0.395

PEX13_HUMAN

Peroxisomal membrane protein PEX13

0.396

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.396

PCBP3_HUMAN

Poly(rC)-binding protein 3

0.396

CNDP2_HUMAN

Cytosolic non-specific dipeptidase

0.396

ERGI2_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 2

0.398

GATA2_HUMAN

Endothelial transcription factor GATA-2

0.398

RDHE2_HUMAN

Epidermal retinol dehydrogenase 2

0.398

DOP2_HUMAN

Protein dopey-2

0.399

QPCTL_HUMAN

Glutaminyl-peptide cyclotransferase-like protein

0.399

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.399

COQ7_HUMAN

5-demethoxyubiquinone hydroxylase, mitochondrial

0.399

TSC2_HUMAN

Tuberin

0.400

PCBP1_HUMAN

Poly(rC)-binding protein 1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 88 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy