HYAS2_HUMAN 2019

Gene Name HYAS2

Description Hyaluronan synthase 2

Length 552

9606

Sequence

>sp|Q92819|HYAS2_HUMAN Hyaluronan synthase 2
MHCERFLCILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQSLFAFLEHRKMKKSLETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVVMVIDGNSEDDLYMMDIFSEVMGRDKSATYIWKNNFHEKGPGETDESHKESSQHVTQLVLSNKSICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVGGVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFVEDWYNQEFMGNQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPIEYLRWLNQQTRWSKSYFREWLYNAMWFHKHHLWMTYEAIITGFFPFFLIATVIQLFYRGKIWNILLFLLTVQLVGLIKSSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGTSGRKTIVVNFIGLIPVSVWFTILLGGVIFTIYKESKRPFSESKQTVLIVGTLLYACYWVMLLTLYVVLINKCGRRKKGQQYDMVLDV

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

HYAS3_HUMAN

Hyaluronan synthase 3

0.333

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

HYAS3_HUMAN

Hyaluronan synthase 3

0.225

HYAS1_HUMAN

Hyaluronan synthase 1

0.284

IQGA1_HUMAN

Ras GTPase-activating-like protein IQGAP1

0.332

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.351

GATA4_HUMAN

Transcription factor GATA-4

0.353

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.353

GOLP3_HUMAN

Golgi phosphoprotein 3

0.356

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.356

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.358

VIGLN_HUMAN

Vigilin

0.360

GATA6_HUMAN

Transcription factor GATA-6

0.367

SEPT7_HUMAN

Septin-7

0.370

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.371

POMT2_HUMAN

Protein O-mannosyl-transferase 2

0.372

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.372

YLAT2_HUMAN

Y+L amino acid transporter 2

0.373

SURF4_HUMAN

Surfeit locus protein 4

0.373

GATA3_HUMAN

Trans-acting T-cell-specific transcription factor GATA-3

0.373

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.376

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.376

SEPR_HUMAN

Prolyl endopeptidase FAP

0.377

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.379

DPP4_HUMAN

Dipeptidyl peptidase 4

0.379

CACP_HUMAN

Carnitine O-acetyltransferase

0.379

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.380

MOT12_HUMAN

Monocarboxylate transporter 12

0.380

BAT1_HUMAN

b(0,+)-type amino acid transporter 1

0.380

IQGA3_HUMAN

Ras GTPase-activating-like protein IQGAP3

0.380

GATA2_HUMAN

Endothelial transcription factor GATA-2

0.380

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.382

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.382

MOT4_HUMAN

Monocarboxylate transporter 4

0.383

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.383

RHOA_HUMAN

Transforming protein RhoA

0.384

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.386

DOCK3_HUMAN

Dedicator of cytokinesis protein 3

0.387

DPP6_HUMAN

Dipeptidyl aminopeptidase-like protein 6

0.387

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.387

YLAT1_HUMAN

Y+L amino acid transporter 1

0.387

SUPT3_HUMAN

Transcription initiation protein SPT3 homolog

0.389

DYR_HUMAN

Dihydrofolate reductase

0.389

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.389

GATA5_HUMAN

Transcription factor GATA-5

0.389

LAT2_HUMAN

Large neutral amino acids transporter small subunit 2

0.390

DOCK4_HUMAN

Dedicator of cytokinesis protein 4

0.390

GDE_HUMAN

Glycogen debranching enzyme

0.390

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.391

GLP3L_HUMAN

Golgi phosphoprotein 3-like

0.391

SOS1_HUMAN

Son of sevenless homolog 1

0.391

HIP1_HUMAN

Huntingtin-interacting protein 1

0.392

MOT2_HUMAN

Monocarboxylate transporter 2

0.392

RCC1_HUMAN

Regulator of chromosome condensation

0.394

OGFD1_HUMAN

Prolyl 3-hydroxylase OGFOD1

0.394

PBDC1_HUMAN

Protein PBDC1

0.394

IQGA2_HUMAN

Ras GTPase-activating-like protein IQGAP2

0.394

ZNT1_HUMAN

Zinc transporter 1

0.395

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.395

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.396

SRF_HUMAN

Serum response factor

0.396

LAT1_HUMAN

Large neutral amino acids transporter small subunit 1

0.397

DOCK5_HUMAN

Dedicator of cytokinesis protein 5

0.397

S2536_HUMAN

Solute carrier family 25 member 36

0.397

CUL1_HUMAN

Cullin-1

0.397

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.397

S39A9_HUMAN

Zinc transporter ZIP9

0.398

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.398

NPRL2_HUMAN

GATOR complex protein NPRL2

0.398

ERGI2_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 2

0.398

XCT_HUMAN

Cystine/glutamate transporter

0.399

RAD52_HUMAN

DNA repair protein RAD52 homolog

0.399

SNX8_HUMAN

Sorting nexin-8

0.400

PLPL6_HUMAN

Neuropathy target esterase

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 78 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy