S45A2_HUMAN 2019

Gene Name S45A2

Description Membrane-associated transporter protein

Length 530

9606

Sequence

>sp|Q9UMX9|S45A2_HUMAN Membrane-associated transporter protein
MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEAPLTEVAKGIPPQQTPQDPPLSSDGMYEYGSIEKVKNGYVNPELAMQGAKNKNHAEQTRRAMTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEFLIYERGVEVGCWGLCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPNVYSTLVLCSLFGVMSSTLYTVPFNLITEYHREEEKERQQAPGGDPDNSVRGKGMDCATLTCMVQLAQILVGGGLGFLVNTAGTVVVVVITASAVALIGCCFVALFVRYVD

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

S45A4_HUMAN

Solute carrier family 45 member 4

0.289

ECD_HUMAN

Protein ecdysoneless homolog

0.326

ACLY_HUMAN

ATP-citrate synthase

0.352

S45A3_HUMAN

Solute carrier family 45 member 3

0.356

UVRAG_HUMAN

UV radiation resistance-associated gene protein

0.357

NSE1_HUMAN

Non-structural maintenance of chromosomes element 1 homolog

0.358

CSN7B_HUMAN

COP9 signalosome complex subunit 7b

0.361

ACSF2_HUMAN

Acyl-CoA synthetase family member 2, mitochondrial

0.365

CSN1_HUMAN

COP9 signalosome complex subunit 1

0.366

RINT1_HUMAN

RAD50-interacting protein 1

0.367

TPC10_HUMAN

Trafficking protein particle complex subunit 10

0.369

IPO11_HUMAN

Importin-11

0.370

RAD1_HUMAN

Cell cycle checkpoint protein RAD1

0.373

TSNAX_HUMAN

Translin-associated protein X

0.373

STRAP_HUMAN

Serine-threonine kinase receptor-associated protein

0.374

GCDH_HUMAN

Glutaryl-CoA dehydrogenase, mitochondrial

0.374

CSN7A_HUMAN

COP9 signalosome complex subunit 7a

0.375

CSN4_HUMAN

COP9 signalosome complex subunit 4

0.376

RIC1_HUMAN

RAB6A-GEF complex partner protein 1

0.378

EIF3E_HUMAN

Eukaryotic translation initiation factor 3 subunit E

0.378

SYF2_HUMAN

Pre-mRNA-splicing factor SYF2

0.378

TMM19_HUMAN

Transmembrane protein 19

0.379

EIF3D_HUMAN

Eukaryotic translation initiation factor 3 subunit D

0.383

GPTC1_HUMAN

G patch domain-containing protein 1

0.383

CAND1_HUMAN

Cullin-associated NEDD8-dissociated protein 1

0.383

ARMC8_HUMAN

Armadillo repeat-containing protein 8

0.386

PPT1_HUMAN

Palmitoyl-protein thioesterase 1

0.386

ARP8_HUMAN

Actin-related protein 8

0.386

XRCC5_HUMAN

X-ray repair cross-complementing protein 5

0.387

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.388

MOCOS_HUMAN

Molybdenum cofactor sulfurase

0.388

NDUV1_HUMAN

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

0.388

PUR2_HUMAN

Trifunctional purine biosynthetic protein adenosine-3

0.388

DNJC3_HUMAN

DnaJ homolog subfamily C member 3

0.388

EIF3M_HUMAN

Eukaryotic translation initiation factor 3 subunit M

0.388

MMSA_HUMAN

Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

0.388

UBP10_HUMAN

Ubiquitin carboxyl-terminal hydrolase 10

0.389

MCCB_HUMAN

Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

0.389

TTI1_HUMAN

TELO2-interacting protein 1 homolog

0.389

RBM8A_HUMAN

RNA-binding protein 8A

0.389

NADK_HUMAN

NAD kinase

0.390

NDUV2_HUMAN

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

0.390

HAOX1_HUMAN

Hydroxyacid oxidase 1

0.391

CCD12_HUMAN

Coiled-coil domain-containing protein 12

0.392

PPWD1_HUMAN

Peptidylprolyl isomerase domain and WD repeat-containing protein 1

0.393

DCUP_HUMAN

Uroporphyrinogen decarboxylase

0.393

TSN_HUMAN

Translin

0.393

INO80_HUMAN

Chromatin-remodeling ATPase INO80

0.395

STABP_HUMAN

STAM-binding protein

0.395

NIT2_HUMAN

Omega-amidase NIT2

0.395

STALP_HUMAN

AMSH-like protease

0.395

ARP5_HUMAN

Actin-related protein 5

0.396

HMGCL_HUMAN

Hydroxymethylglutaryl-CoA lyase, mitochondrial

0.396

NDUA8_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

0.396

KHDC4_HUMAN

KH homology domain-containing protein 4

0.396

PUR9_HUMAN

Bifunctional purine biosynthesis protein PURH

0.396

PLPP4_HUMAN

Phospholipid phosphatase 4

0.396

CSN2_HUMAN

COP9 signalosome complex subunit 2

0.397

PIMT_HUMAN

Protein-L-isoaspartate(D-aspartate) O-methyltransferase

0.397

PPOX_HUMAN

Protoporphyrinogen oxidase

0.397

PRDX6_HUMAN

Peroxiredoxin-6

0.397

IF4E2_HUMAN

Eukaryotic translation initiation factor 4E type 2

0.397

CSN3_HUMAN

COP9 signalosome complex subunit 3

0.397

RANB9_HUMAN

Ran-binding protein 9

0.397

HEM6_HUMAN

Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

0.398

COPE_HUMAN

Coatomer subunit epsilon

0.398

GNAI2_HUMAN

Guanine nucleotide-binding protein G(i) subunit alpha-2

0.398

PUR1_HUMAN

Amidophosphoribosyltransferase

0.398

IVD_HUMAN

Isovaleryl-CoA dehydrogenase, mitochondrial

0.398

PPIL2_HUMAN

RING-type E3 ubiquitin-protein ligase PPIL2

0.399

CHDH_HUMAN

Choline dehydrogenase, mitochondrial

0.399

MET16_HUMAN

RNA N6-adenosine-methyltransferase METTL16

0.399

PPID_HUMAN

Peptidyl-prolyl cis-trans isomerase D

0.399

IPO9_HUMAN

Importin-9

0.399

ACO13_HUMAN

Acyl-coenzyme A thioesterase 13

0.399

PIGS_HUMAN

GPI transamidase component PIG-S

0.400

UBR7_HUMAN

Putative E3 ubiquitin-protein ligase UBR7

0.400

XYLB_HUMAN

Xylulose kinase

0.400

U5S1_HUMAN

116 kDa U5 small nuclear ribonucleoprotein component

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 110 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy