CFA52_HUMAN 2019

Gene Name CFA52

Description Cilia- and flagella-associated protein 52

Length 620

9606

Sequence

>sp|Q8N1V2|CFA52_HUMAN Cilia- and flagella-associated protein 52
MDNKISPEAQVAELELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFLQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELDLPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLTDVGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKPIKKIQLQGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPYTS

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

DRC4_HUMAN

Dynein regulatory complex subunit 4

0.221

CF206_HUMAN

Cilia- and flagella-associated protein 206

0.225

IDLC_HUMAN

Axonemal dynein light intermediate polypeptide 1

0.248

CFA57_HUMAN

Cilia- and flagella-associated protein 57

0.272

CB5D1_HUMAN

Cytochrome b5 domain-containing protein 1

0.276

RSH4A_HUMAN

Radial spoke head protein 4 homolog A

0.276

RSPH9_HUMAN

Radial spoke head protein 9 homolog

0.276

DRC11_HUMAN

Dynein regulatory complex protein 11

0.294

SPAG6_HUMAN

Sperm-associated antigen 6

0.294

DRC7_HUMAN

Dynein regulatory complex subunit 7

0.294

HYDIN_HUMAN

Hydrocephalus-inducing protein homolog

0.296

TILB_HUMAN

Protein tilB homolog

0.309

WDR63_HUMAN

WD repeat-containing protein 63

0.314

RSH6A_HUMAN

Radial spoke head protein 6 homolog A

0.320

ZMY10_HUMAN

Zinc finger MYND domain-containing protein 10

0.325

CCD39_HUMAN

Coiled-coil domain-containing protein 39

0.333

CFA43_HUMAN

Cilia- and flagella-associated protein 43

0.335

CC113_HUMAN

Coiled-coil domain-containing protein 113

0.338

CF251_HUMAN

Cilia- and flagella-associated protein 251

0.338

RSPH3_HUMAN

Radial spoke head protein 3 homolog

0.338

CFA44_HUMAN

Cilia- and flagella-associated protein 44

0.338

DRC3_HUMAN

Dynein regulatory complex subunit 3

0.341

IF122_HUMAN

Intraflagellar transport protein 122 homolog

0.343

IFT56_HUMAN

Intraflagellar transport protein 56

0.343

PACRG_HUMAN

Parkin coregulated gene protein

0.343

IQUB_HUMAN

IQ and ubiquitin-like domain-containing protein

0.347

DNAL1_HUMAN

Dynein light chain 1, axonemal

0.349

CFA58_HUMAN

Cilia- and flagella-associated protein 58

0.351

DRC5_HUMAN

Dynein regulatory complex subunit 5

0.356

CFA91_HUMAN

Cilia- and flagella-associated protein 91

0.356

IFT57_HUMAN

Intraflagellar transport protein 57 homolog

0.358

IF172_HUMAN

Intraflagellar transport protein 172 homolog

0.360

WDR35_HUMAN

WD repeat-containing protein 35

0.360

ENKUR_HUMAN

Enkurin

0.366

DRC1_HUMAN

Dynein regulatory complex protein 1

0.369

SPEF1_HUMAN

Sperm flagellar protein 1

0.369

CFA45_HUMAN

Cilia- and flagella-associated protein 45

0.369

CCD42_HUMAN

Coiled-coil domain-containing protein 42

0.371

CFA65_HUMAN

Cilia- and flagella-associated protein 65

0.371

KAD7_HUMAN

Adenylate kinase 7

0.371

CF299_HUMAN

Cilia- and flagella-associated protein 299

0.373

EFHC1_HUMAN

EF-hand domain-containing protein 1

0.374

IFT80_HUMAN

Intraflagellar transport protein 80 homolog

0.376

DNAI2_HUMAN

Dynein intermediate chain 2, axonemal

0.378

SSNA1_HUMAN

Sjoegren syndrome nuclear autoantigen 1

0.380

IFT46_HUMAN

Intraflagellar transport protein 46 homolog

0.384

CCD40_HUMAN

Coiled-coil domain-containing protein 40

0.385

CCD63_HUMAN

Coiled-coil domain-containing protein 63

0.385

WDR19_HUMAN

WD repeat-containing protein 19

0.387

CE104_HUMAN

Centrosomal protein of 104 kDa

0.387

IF140_HUMAN

Intraflagellar transport protein 140 homolog

0.389

CFA61_HUMAN

Cilia- and flagella-associated protein 61

0.390

DAAF5_HUMAN

Dynein assembly factor 5, axonemal

0.391

DNAI1_HUMAN

Dynein intermediate chain 1, axonemal

0.393

WDR92_HUMAN

WD repeat-containing protein 92

0.394

TT30B_HUMAN

Tetratricopeptide repeat protein 30B

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

DRC4_HUMAN

Dynein regulatory complex subunit 4

0.221

CF206_HUMAN

Cilia- and flagella-associated protein 206

0.225

IDLC_HUMAN

Axonemal dynein light intermediate polypeptide 1

0.248

CFA57_HUMAN

Cilia- and flagella-associated protein 57

0.272

CB5D1_HUMAN

Cytochrome b5 domain-containing protein 1

0.276

RSH4A_HUMAN

Radial spoke head protein 4 homolog A

0.276

RSPH9_HUMAN

Radial spoke head protein 9 homolog

0.276

DRC11_HUMAN

Dynein regulatory complex protein 11

0.294

SPAG6_HUMAN

Sperm-associated antigen 6

0.294

DRC7_HUMAN

Dynein regulatory complex subunit 7

0.294

HYDIN_HUMAN

Hydrocephalus-inducing protein homolog

0.296

TILB_HUMAN

Protein tilB homolog

0.309

WDR63_HUMAN

WD repeat-containing protein 63

0.314

RSH6A_HUMAN

Radial spoke head protein 6 homolog A

0.320

ZMY10_HUMAN

Zinc finger MYND domain-containing protein 10

0.325

CCD39_HUMAN

Coiled-coil domain-containing protein 39

0.333

CFA43_HUMAN

Cilia- and flagella-associated protein 43

0.335

CC113_HUMAN

Coiled-coil domain-containing protein 113

0.338

CF251_HUMAN

Cilia- and flagella-associated protein 251

0.338

RSPH3_HUMAN

Radial spoke head protein 3 homolog

0.338

CFA44_HUMAN

Cilia- and flagella-associated protein 44

0.338

DRC3_HUMAN

Dynein regulatory complex subunit 3

0.341

IF122_HUMAN

Intraflagellar transport protein 122 homolog

0.343

IFT56_HUMAN

Intraflagellar transport protein 56

0.343

PACRG_HUMAN

Parkin coregulated gene protein

0.343

IQUB_HUMAN

IQ and ubiquitin-like domain-containing protein

0.347

DNAL1_HUMAN

Dynein light chain 1, axonemal

0.349

CFA58_HUMAN

Cilia- and flagella-associated protein 58

0.351

DRC5_HUMAN

Dynein regulatory complex subunit 5

0.356

CFA91_HUMAN

Cilia- and flagella-associated protein 91

0.356

IFT57_HUMAN

Intraflagellar transport protein 57 homolog

0.358

IF172_HUMAN

Intraflagellar transport protein 172 homolog

0.360

WDR35_HUMAN

WD repeat-containing protein 35

0.360

ENKUR_HUMAN

Enkurin

0.366

DRC1_HUMAN

Dynein regulatory complex protein 1

0.369

SPEF1_HUMAN

Sperm flagellar protein 1

0.369

CFA45_HUMAN

Cilia- and flagella-associated protein 45

0.369

CCD42_HUMAN

Coiled-coil domain-containing protein 42

0.371

CFA65_HUMAN

Cilia- and flagella-associated protein 65

0.371

KAD7_HUMAN

Adenylate kinase 7

0.371

CF299_HUMAN

Cilia- and flagella-associated protein 299

0.373

EFHC1_HUMAN

EF-hand domain-containing protein 1

0.374

IFT80_HUMAN

Intraflagellar transport protein 80 homolog

0.376

DNAI2_HUMAN

Dynein intermediate chain 2, axonemal

0.378

SSNA1_HUMAN

Sjoegren syndrome nuclear autoantigen 1

0.380

IFT46_HUMAN

Intraflagellar transport protein 46 homolog

0.384

CCD40_HUMAN

Coiled-coil domain-containing protein 40

0.385

CCD63_HUMAN

Coiled-coil domain-containing protein 63

0.385

WDR19_HUMAN

WD repeat-containing protein 19

0.387

CE104_HUMAN

Centrosomal protein of 104 kDa

0.387

IF140_HUMAN

Intraflagellar transport protein 140 homolog

0.389

CFA61_HUMAN

Cilia- and flagella-associated protein 61

0.390

DAAF5_HUMAN

Dynein assembly factor 5, axonemal

0.391

DNAI1_HUMAN

Dynein intermediate chain 1, axonemal

0.393

WDR92_HUMAN

WD repeat-containing protein 92

0.394

TT30B_HUMAN

Tetratricopeptide repeat protein 30B

0.397

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 78 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy