PACRG_HUMAN 2019

Gene Name PACRG

Description Parkin coregulated gene protein

Length 296

9606

Sequence

>sp|Q96M98|PACRG_HUMAN Parkin coregulated gene protein
MVAEKETLSLNKCPDKMPKRTKLLAQQPLPVHQPHSLVSEGFTVKAMMKNSVVRGPPAAGAFKERPTKPTAFRKFYERGDFPIALEHDSKGNKIAWKVEIEKLDYHHYLPLFFDGLCEMTFPYEFFARQGIHDMLEHGGNKILPVLPQLIIPIKNALNLRNRQVICVTLKVLQHLVVSAEMVGKALVPYYRQILPVLNIFKNMNGSYSLPRLECSGAIMARCNLDHLGSSDPPTSASQVAEIIVNSGDGIDYSQQKRENIGDLIQETLEAFERYGGENAFINIKYVVPTYESCLLN

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

DRC4_HUMAN

Dynein regulatory complex subunit 4

0.266

IFT46_HUMAN

Intraflagellar transport protein 46 homolog

0.284

IDLC_HUMAN

Axonemal dynein light intermediate polypeptide 1

0.289

TT30B_HUMAN

Tetratricopeptide repeat protein 30B

0.302

TILB_HUMAN

Protein tilB homolog

0.305

EFHC1_HUMAN

EF-hand domain-containing protein 1

0.305

CFA57_HUMAN

Cilia- and flagella-associated protein 57

0.309

IFT52_HUMAN

Intraflagellar transport protein 52 homolog

0.318

TT30A_HUMAN

Tetratricopeptide repeat protein 30A

0.320

WDR19_HUMAN

WD repeat-containing protein 19

0.322

IFT57_HUMAN

Intraflagellar transport protein 57 homolog

0.322

DRC11_HUMAN

Dynein regulatory complex protein 11

0.327

CLUA1_HUMAN

Clusterin-associated protein 1

0.337

IFT56_HUMAN

Intraflagellar transport protein 56

0.339

IF122_HUMAN

Intraflagellar transport protein 122 homolog

0.339

CFA52_HUMAN

Cilia- and flagella-associated protein 52

0.343

IQUB_HUMAN

IQ and ubiquitin-like domain-containing protein

0.343

WDR63_HUMAN

WD repeat-containing protein 63

0.345

CF206_HUMAN

Cilia- and flagella-associated protein 206

0.345

MIPT3_HUMAN

TRAF3-interacting protein 1

0.354

ZMY10_HUMAN

Zinc finger MYND domain-containing protein 10

0.354

IF140_HUMAN

Intraflagellar transport protein 140 homolog

0.356

IF172_HUMAN

Intraflagellar transport protein 172 homolog

0.356

WDR35_HUMAN

WD repeat-containing protein 35

0.356

DAAF5_HUMAN

Dynein assembly factor 5, axonemal

0.358

KIFA3_HUMAN

Kinesin-associated protein 3

0.358

DRC7_HUMAN

Dynein regulatory complex subunit 7

0.360

CCD39_HUMAN

Coiled-coil domain-containing protein 39

0.362

IFT80_HUMAN

Intraflagellar transport protein 80 homolog

0.371

DNAI2_HUMAN

Dynein intermediate chain 2, axonemal

0.374

DNAL1_HUMAN

Dynein light chain 1, axonemal

0.376

CB5D1_HUMAN

Cytochrome b5 domain-containing protein 1

0.378

RSH4A_HUMAN

Radial spoke head protein 4 homolog A

0.378

CE104_HUMAN

Centrosomal protein of 104 kDa

0.382

DNAI1_HUMAN

Dynein intermediate chain 1, axonemal

0.389

WDR92_HUMAN

WD repeat-containing protein 92

0.390

ENKUR_HUMAN

Enkurin

0.391

CFA45_HUMAN

Cilia- and flagella-associated protein 45

0.393

DRC1_HUMAN

Dynein regulatory complex protein 1

0.393

SPEF1_HUMAN

Sperm flagellar protein 1

0.393

CFA43_HUMAN

Cilia- and flagella-associated protein 43

0.393

CCD42_HUMAN

Coiled-coil domain-containing protein 42

0.396

TT21B_HUMAN

Tetratricopeptide repeat protein 21B

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

DRC4_HUMAN

Dynein regulatory complex subunit 4

0.266

IFT46_HUMAN

Intraflagellar transport protein 46 homolog

0.284

IDLC_HUMAN

Axonemal dynein light intermediate polypeptide 1

0.289

TT30B_HUMAN

Tetratricopeptide repeat protein 30B

0.302

TILB_HUMAN

Protein tilB homolog

0.305

EFHC1_HUMAN

EF-hand domain-containing protein 1

0.305

CFA57_HUMAN

Cilia- and flagella-associated protein 57

0.309

IFT52_HUMAN

Intraflagellar transport protein 52 homolog

0.318

TT30A_HUMAN

Tetratricopeptide repeat protein 30A

0.320

WDR19_HUMAN

WD repeat-containing protein 19

0.322

IFT57_HUMAN

Intraflagellar transport protein 57 homolog

0.322

DRC11_HUMAN

Dynein regulatory complex protein 11

0.327

CLUA1_HUMAN

Clusterin-associated protein 1

0.337

IFT56_HUMAN

Intraflagellar transport protein 56

0.339

IF122_HUMAN

Intraflagellar transport protein 122 homolog

0.339

CFA52_HUMAN

Cilia- and flagella-associated protein 52

0.343

IQUB_HUMAN

IQ and ubiquitin-like domain-containing protein

0.343

WDR63_HUMAN

WD repeat-containing protein 63

0.345

CF206_HUMAN

Cilia- and flagella-associated protein 206

0.345

MIPT3_HUMAN

TRAF3-interacting protein 1

0.354

ZMY10_HUMAN

Zinc finger MYND domain-containing protein 10

0.354

IF140_HUMAN

Intraflagellar transport protein 140 homolog

0.356

IF172_HUMAN

Intraflagellar transport protein 172 homolog

0.356

WDR35_HUMAN

WD repeat-containing protein 35

0.356

DAAF5_HUMAN

Dynein assembly factor 5, axonemal

0.358

KIFA3_HUMAN

Kinesin-associated protein 3

0.358

DRC7_HUMAN

Dynein regulatory complex subunit 7

0.360

CCD39_HUMAN

Coiled-coil domain-containing protein 39

0.362

IFT80_HUMAN

Intraflagellar transport protein 80 homolog

0.371

DNAI2_HUMAN

Dynein intermediate chain 2, axonemal

0.374

DNAL1_HUMAN

Dynein light chain 1, axonemal

0.376

CB5D1_HUMAN

Cytochrome b5 domain-containing protein 1

0.378

RSH4A_HUMAN

Radial spoke head protein 4 homolog A

0.378

CE104_HUMAN

Centrosomal protein of 104 kDa

0.382

DNAI1_HUMAN

Dynein intermediate chain 1, axonemal

0.389

WDR92_HUMAN

WD repeat-containing protein 92

0.390

ENKUR_HUMAN

Enkurin

0.391

CFA45_HUMAN

Cilia- and flagella-associated protein 45

0.393

DRC1_HUMAN

Dynein regulatory complex protein 1

0.393

SPEF1_HUMAN

Sperm flagellar protein 1

0.393

CFA43_HUMAN

Cilia- and flagella-associated protein 43

0.393

CCD42_HUMAN

Coiled-coil domain-containing protein 42

0.396

TT21B_HUMAN

Tetratricopeptide repeat protein 21B

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 82 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy