TM218_HUMAN 2019

Gene Name TM218

Description Transmembrane protein 218

Length 115

9606

Sequence

>sp|A2RU14|TM218_HUMAN Transmembrane protein 218
MAGTVLGVGAGVFILALLWVAVLLLCVLLSRASGAARFSVIFLFFGAVIITSVLLLFPRAGEFPAPEVEVKIVDDFFIGRYVLLAFLSAIFLGGLFLVLIHYVLEPIYAKPLHSY

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

CEAM5_HUMAN

Carcinoembryonic antigen-related cell adhesion molecule 5

0.236

RHBD3_HUMAN

Rhomboid domain-containing protein 3

0.243

NRG3_HUMAN

Pro-neuregulin-3, membrane-bound isoform

0.324

MPLKI_HUMAN

M-phase-specific PLK1-interacting protein

0.333

LURA1_HUMAN

Leucine rich adaptor protein 1

0.333

C5AR1_HUMAN

C5a anaphylatoxin chemotactic receptor 1

0.333

CLD15_HUMAN

Claudin-15

0.333

INKA1_HUMAN

PAK4-inhibitor INKA1

0.333

SLAP2_HUMAN

Src-like-adapter 2

0.333

F1712_HUMAN

Protein FAM171A2

0.333

CC106_HUMAN

Coiled-coil domain-containing protein 106

0.333

HEMO_HUMAN

Hemopexin

0.333

I17RC_HUMAN

Interleukin-17 receptor C

0.343

TCTA_HUMAN

T-cell leukemia translocation-altered gene protein

0.343

GPR12_HUMAN

G-protein coupled receptor 12

0.387

SYBU_HUMAN

Syntabulin

0.387

IBP1_HUMAN

Insulin-like growth factor-binding protein 1

0.387

IL17_HUMAN

Interleukin-17A

0.387

ATL2_HUMAN

ADAMTS-like protein 2

0.387

ESAM_HUMAN

Endothelial cell-selective adhesion molecule

0.397

SPRY4_HUMAN

SPRY domain-containing protein 4

0.397

PRR35_HUMAN

Proline-rich protein 35

0.397

CO039_HUMAN

Uncharacterized protein C15orf39

0.397

ZN638_HUMAN

Zinc finger protein 638

0.397

IL2RG_HUMAN

Cytokine receptor common subunit gamma

0.397

UPK1A_HUMAN

Uroplakin-1a

0.397

SIG15_HUMAN

Sialic acid-binding Ig-like lectin 15

0.397

CNRG_HUMAN

Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit gamma

0.397

PERF_HUMAN

Perforin-1

0.397

T150B_HUMAN

Modulator of macroautophagy TMEM150B

0.397

ASC_HUMAN

Apoptosis-associated speck-like protein containing a CARD

0.397

PDYN_HUMAN

Proenkephalin-B

0.397

MRP_HUMAN

MARCKS-related protein

0.397

CLUS_HUMAN

Clusterin

0.397

GPR17_HUMAN

Uracil nucleotide/cysteinyl leukotriene receptor

0.397

FA83C_HUMAN

Protein FAM83C

0.397

CAD26_HUMAN

Cadherin-like protein 26

0.397

SCAR3_HUMAN

Scavenger receptor class A member 3

0.397

CXL14_HUMAN

C-X-C motif chemokine 14

0.397

MAG_HUMAN

Myelin-associated glycoprotein

0.397

LSR_HUMAN

Lipolysis-stimulated lipoprotein receptor

0.397

SETBP_HUMAN

SET-binding protein

0.397

T150C_HUMAN

Transmembrane protein 150C

0.397

CART_HUMAN

Cocaine- and amphetamine-regulated transcript protein

0.397

CSH1_HUMAN

Chorionic somatomammotropin hormone 1

0.397

AHDC1_HUMAN

AT-hook DNA-binding motif-containing protein 1

0.397

EPOR_HUMAN

Erythropoietin receptor

0.397

DNHD1_HUMAN

Dynein heavy chain domain-containing protein 1

0.397

IBP2_HUMAN

Insulin-like growth factor-binding protein 2

0.397

CK2N2_HUMAN

Calcium/calmodulin-dependent protein kinase II inhibitor 2

0.397

GLPC_HUMAN

Glycophorin-C

0.397

UIMC1_HUMAN

BRCA1-A complex subunit RAP80

0.397

AKP8L_HUMAN

A-kinase anchor protein 8-like

0.397

INHA_HUMAN

Inhibin alpha chain

0.397

VTM2L_HUMAN

V-set and transmembrane domain-containing protein 2-like protein

0.397

SYT13_HUMAN

Synaptotagmin-13

0.397

OCSTP_HUMAN

Osteoclast stimulatory transmembrane protein

0.397

GAK1A_HUMAN

Golgi-associated kinase 1A

0.397

CALCB_HUMAN

Calcitonin gene-related peptide 2

0.397

GPC5C_HUMAN

G-protein coupled receptor family C group 5 member C

0.397

HEG1_HUMAN

Protein HEG homolog 1

0.397

ARTN_HUMAN

Artemin

0.397

SOMA_HUMAN

Somatotropin

0.397

CSH2_HUMAN

Chorionic somatomammotropin hormone 2

0.397

K1C14_HUMAN

Keratin, type I cytoskeletal 14

0.397

ZN217_HUMAN

Zinc finger protein 217

0.397

SNN_HUMAN

Stannin

0.397

CX038_HUMAN

Uncharacterized protein CXorf38

0.397

SOM2_HUMAN

Growth hormone variant

0.397

R51A1_HUMAN

RAD51-associated protein 1

0.397

C2TA_HUMAN

MHC class II transactivator

0.397

F1892_HUMAN

Protein FAM189A2

0.397

JCAD_HUMAN

Junctional protein associated with coronary artery disease

0.397

TOR4A_HUMAN

Torsin-4A

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

NRG3_HUMAN

Pro-neuregulin-3, membrane-bound isoform

0.395

ECM1_HUMAN

Extracellular matrix protein 1

0.397

CNST_HUMAN

Consortin

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 17 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy