SMCO3_HUMAN 2019

Gene Name SMCO3

Description Single-pass membrane and coiled-coil domain-containing protein 3

Length 225

9606

Sequence

>sp|A2RU48|SMCO3_HUMAN Single-pass membrane and coiled-coil domain-containing protein 3
MAQSDFLYPENPKRREEVNRLHQQLLDCLSDSFDVTNKLTEVLNMHLGCRLASIEMKRDGTIKENCDLIIQAIMKIQKELQKVDEALKDKLEPTLYRKLQDIKEKETDKIAIVQKVISVILGEATSAASAVAVKLVGSNVTTGIINKLVTVLAQIGASLLGSIGVAVLGLGIDMIVRAILGAVEKTQLQAAIKSYEKHLVEFKSASEKYNHAITEVINTVKHQMK

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

CD47_HUMAN

Leukocyte surface antigen CD47

0.000

SNTAN_HUMAN

Sentan

0.000

TPO_HUMAN

Thrombopoietin

0.000

CAMP_HUMAN

Cathelicidin antimicrobial peptide

0.000

AKND1_HUMAN

Protein AKNAD1

0.277

GIMD1_HUMAN

GTPase IMAP family member GIMD1

0.277

ICOSL_HUMAN

ICOS ligand

0.277

INGR2_HUMAN

Interferon gamma receptor 2

0.277

CNCG_HUMAN

Retinal cone rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit gamma

0.277

LNP1_HUMAN

Leukemia NUP98 fusion partner 1

0.277

IFNK_HUMAN

Interferon kappa

0.277

BCAS1_HUMAN

Breast carcinoma-amplified sequence 1

0.277

SPERT_HUMAN

Spermatid-associated protein

0.289

BASP1_HUMAN

Brain acid soluble protein 1

0.289

IL15_HUMAN

Interleukin-15

0.289

K1C23_HUMAN

Keratin, type I cytoskeletal 23

0.289

MTCP1_HUMAN

Protein p13 MTCP-1

0.289

M4A15_HUMAN

Membrane-spanning 4-domains subfamily A member 15

0.289

CD4_HUMAN

T-cell surface glycoprotein CD4

0.289

VEXIN_HUMAN

Vexin

0.289

FYB2_HUMAN

FYN-binding protein 2

0.289

AKAP5_HUMAN

A-kinase anchor protein 5

0.289

A1AG2_HUMAN

Alpha-1-acid glycoprotein 2

0.289

IL9R_HUMAN

Interleukin-9 receptor

0.289

MROH7_HUMAN

Maestro heat-like repeat-containing protein family member 7

0.289

NPS_HUMAN

Neuropeptide S

0.289

CO062_HUMAN

Uncharacterized protein C15orf62, mitochondrial

0.289

TNFL8_HUMAN

Tumor necrosis factor ligand superfamily member 8

0.289

GSDMA_HUMAN

Gasdermin-A

0.289

MISSL_HUMAN

MAPK-interacting and spindle-stabilizing protein-like

0.289

NFAM1_HUMAN

NFAT activation molecule 1

0.289

TB182_HUMAN

182 kDa tankyrase-1-binding protein

0.289

CD5_HUMAN

T-cell surface glycoprotein CD5

0.289

PML_HUMAN

Protein PML

0.289

OSTP_HUMAN

Osteopontin

0.289

GKN2_HUMAN

Gastrokine-2

0.289

ZPBP1_HUMAN

Zona pellucida-binding protein 1

0.289

CF132_HUMAN

Uncharacterized protein C6orf132

0.289

PIANP_HUMAN

PILR alpha-associated neural protein

0.378

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.378

IL18_HUMAN

Interleukin-18

0.378

MSLN_HUMAN

Mesothelin

0.378

TRI14_HUMAN

Tripartite motif-containing protein 14

0.378

VWCE_HUMAN

von Willebrand factor C and EGF domain-containing protein

0.378

I12R1_HUMAN

Interleukin-12 receptor subunit beta-1

0.378

ARMD4_HUMAN

Armadillo-like helical domain-containing protein 4

0.378

RBM43_HUMAN

RNA-binding protein 43

0.378

BID_HUMAN

BH3-interacting domain death agonist

0.378

PARM1_HUMAN

Prostate androgen-regulated mucin-like protein 1

0.378

LRAD1_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 1

0.378

PLM_HUMAN

Phospholemman

0.378

KCD18_HUMAN

BTB/POZ domain-containing protein KCTD18

0.378

CLD16_HUMAN

Claudin-16

0.378

PRIO_HUMAN

Major prion protein

0.392

CLC2D_HUMAN

C-type lectin domain family 2 member D

0.392

L37A1_HUMAN

Leucine-rich repeat-containing protein 37A

0.392

PCDB2_HUMAN

Protocadherin beta-2

0.392

LYPD2_HUMAN

Ly6/PLAUR domain-containing protein 2

0.392

A0A087X1L8_HUMAN

Uncharacterized protein

0.392

IQCJ_HUMAN

IQ domain-containing protein J

0.392

PDZD9_HUMAN

PDZ domain-containing protein 9

0.392

ACRBP_HUMAN

Acrosin-binding protein

0.392

MYOZ3_HUMAN

Myozenin-3

0.392

TM52B_HUMAN

Transmembrane protein 52B

0.392

TR13B_HUMAN

Tumor necrosis factor receptor superfamily member 13B

0.392

MB214_HUMAN

Protein mab-21-like 4

0.392

BPIB4_HUMAN

BPI fold-containing family B member 4

0.392

PCDB5_HUMAN

Protocadherin beta-5

0.392

EGLN_HUMAN

Endoglin

0.392

INAR2_HUMAN

Interferon alpha/beta receptor 2

0.392

PCDBC_HUMAN

Protocadherin beta-12

0.392

CD8A_HUMAN

T-cell surface glycoprotein CD8 alpha chain

0.392

SACA1_HUMAN

Sperm acrosome membrane-associated protein 1

0.392

O11A1_HUMAN

Olfactory receptor 11A1

0.392

PCDBF_HUMAN

Protocadherin beta-15

0.392

I22R1_HUMAN

Interleukin-22 receptor subunit alpha-1

0.392

ODFP1_HUMAN

Outer dense fiber protein 1

0.392

OPT_HUMAN

Opticin

0.392

A0A0G2JMZ2_HUMAN

Uncharacterized protein

0.392

TREM2_HUMAN

Triggering receptor expressed on myeloid cells 2

0.392

SIAL_HUMAN

Bone sialoprotein 2

0.392

L37A3_HUMAN

Leucine-rich repeat-containing protein 37A3

0.392

VSIG4_HUMAN

V-set and immunoglobulin domain-containing protein 4

0.392

GPR15_HUMAN

G-protein coupled receptor 15

0.392

PCDB4_HUMAN

Protocadherin beta-4

0.392

L37A2_HUMAN

Leucine-rich repeat-containing protein 37A2

0.392

PSPC_HUMAN

Pulmonary surfactant-associated protein C

0.392

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

SPERT_HUMAN

Spermatid-associated protein

0.333

CD47_HUMAN

Leukocyte surface antigen CD47

0.349

ODFP1_HUMAN

Outer dense fiber protein 1

0.351

VEXIN_HUMAN

Vexin

0.370

GKN2_HUMAN

Gastrokine-2

0.373

CF132_HUMAN

Uncharacterized protein C6orf132

0.383

SNTAN_HUMAN

Sentan

0.386

TNFL8_HUMAN

Tumor necrosis factor ligand superfamily member 8

0.386

LRAD1_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 1

0.386

CAMP_HUMAN

Cathelicidin antimicrobial peptide

0.386

EGLN_HUMAN

Endoglin

0.386

ODF2L_HUMAN

Protein BCAP

0.388

TPO_HUMAN

Thrombopoietin

0.388

IL15_HUMAN

Interleukin-15

0.388

CD019_HUMAN

Uncharacterized protein C4orf19

0.391

OSTP_HUMAN

Osteopontin

0.391

SHLD1_HUMAN

Shieldin complex subunit 1

0.394

MTCP1_HUMAN

Protein p13 MTCP-1

0.394

SHPS1_HUMAN

Tyrosine-protein phosphatase non-receptor type substrate 1

0.397

INGR2_HUMAN

Interferon gamma receptor 2

0.400

MFAP5_HUMAN

Microfibrillar-associated protein 5

0.400

TREM2_HUMAN

Triggering receptor expressed on myeloid cells 2

0.400

ACRBP_HUMAN

Acrosin-binding protein

0.400

I22R1_HUMAN

Interleukin-22 receptor subunit alpha-1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 12 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy