KLH33_HUMAN 2019

Gene Name KLH33

Description Kelch-like protein 33

Length 533

9606

Sequence

>sp|A6NCF5|KLH33_HUMAN Kelch-like protein 33
MLLSGMRESQGTEVSLRTISTQDLRLLVSFAYSGVVRARWPGLLRAAQAALQYQSSSCLDLCQKGLARGLSPARCLALFPMAEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAARCWLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDLLHQLMVEADVPGQERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTLPRPRAEMPACILTLPAVQHIALVPTPHQTKPAG

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

CBARP_HUMAN

Voltage-dependent calcium channel beta subunit-associated regulatory protein

0.387

CMYA5_HUMAN

Cardiomyopathy-associated protein 5

0.387

CCD71_HUMAN

Coiled-coil domain-containing protein 71

0.387

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ZBT20_HUMAN

Zinc finger and BTB domain-containing protein 20

0.372

TM182_HUMAN

Transmembrane protein 182

0.372

F171B_HUMAN

Protein FAM171B

0.374

KLH42_HUMAN

Kelch-like protein 42

0.382

TF_HUMAN

Tissue factor

0.384

PTHR_HUMAN

Parathyroid hormone-related protein

0.384

ABEC2_HUMAN

C->U-editing enzyme APOBEC-2

0.384

CCR7_HUMAN

C-C chemokine receptor type 7

0.384

ZN335_HUMAN

Zinc finger protein 335

0.384

ZBT18_HUMAN

Zinc finger and BTB domain-containing protein 18

0.384

CXD2_HUMAN

Gap junction delta-2 protein

0.384

LYRIC_HUMAN

Protein LYRIC

0.384

VCAM1_HUMAN

Vascular cell adhesion protein 1

0.384

FMOD_HUMAN

Fibromodulin

0.384

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.384

ZBTB1_HUMAN

Zinc finger and BTB domain-containing protein 1

0.384

CXCR4_HUMAN

C-X-C chemokine receptor type 4

0.384

CLD11_HUMAN

Claudin-11

0.384

TEFF1_HUMAN

Tomoregulin-1

0.384

CKLF3_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 3

0.384

FPRP_HUMAN

Prostaglandin F2 receptor negative regulator

0.384

ESM1_HUMAN

Endothelial cell-specific molecule 1

0.386

CABP1_HUMAN

Calcium-binding protein 1

0.386

ZBT41_HUMAN

Zinc finger and BTB domain-containing protein 41

0.386

SYNCI_HUMAN

Syncoilin

0.386

KDF1_HUMAN

Keratinocyte differentiation factor 1

0.388

VTM2A_HUMAN

V-set and transmembrane domain-containing protein 2A

0.388

ANDR_HUMAN

Androgen receptor

0.388

FASTK_HUMAN

Fas-activated serine/threonine kinase

0.388

CCR9_HUMAN

C-C chemokine receptor type 9

0.390

ZN131_HUMAN

Zinc finger protein 131

0.395

LEG1_HUMAN

Galectin-1

0.395

MFA3L_HUMAN

Microfibrillar-associated protein 3-like

0.395

ZN644_HUMAN

Zinc finger protein 644

0.395

NEXMI_HUMAN

Neurite extension and migration factor

0.395

CO8A_HUMAN

Complement component C8 alpha chain

0.395

VSTM4_HUMAN

V-set and transmembrane domain-containing protein 4

0.395

GHR_HUMAN

Growth hormone receptor

0.395

PENK_HUMAN

Proenkephalin-A

0.395

SGO1_HUMAN

Shugoshin 1

0.395

PDGFC_HUMAN

Platelet-derived growth factor C

0.395

OCLN_HUMAN

Occludin

0.395

NPY_HUMAN

Pro-neuropeptide Y

0.395

MYZAP_HUMAN

Myocardial zonula adherens protein

0.395

MERB1_HUMAN

bMERB domain-containing protein 1

0.395

SYBU_HUMAN

Syntabulin

0.395

ADNP_HUMAN

Activity-dependent neuroprotector homeobox protein

0.395

ZPLD1_HUMAN

Zona pellucida-like domain-containing protein 1

0.395

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.395

PRL_HUMAN

Prolactin

0.395

P33MX_HUMAN

Putative monooxygenase p33MONOX

0.395

CAVN2_HUMAN

Caveolae-associated protein 2

0.397

GPC5C_HUMAN

G-protein coupled receptor family C group 5 member C

0.397

SOGA1_HUMAN

Protein SOGA1

0.397

SHSA6_HUMAN

Protein shisa-6

0.397

ERRFI_HUMAN

ERBB receptor feedback inhibitor 1

0.397

TSN1_HUMAN

Tetraspanin-1

0.397

MFR1L_HUMAN

Mitochondrial fission regulator 1-like

0.397

F222B_HUMAN

Protein FAM222B

0.397

KBTB3_HUMAN

Kelch repeat and BTB domain-containing protein 3

0.397

HECAM_HUMAN

Hepatocyte cell adhesion molecule

0.397

OLFM4_HUMAN

Olfactomedin-4

0.397

PEPL_HUMAN

Periplakin

0.397

MRAP2_HUMAN

Melanocortin-2 receptor accessory protein 2

0.397

F180A_HUMAN

Protein FAM180A

0.397

IKIP_HUMAN

Inhibitor of nuclear factor kappa-B kinase-interacting protein

0.397

SCF_HUMAN

Kit ligand

0.397

AGR2_HUMAN

Anterior gradient protein 2 homolog

0.397

OLFL3_HUMAN

Olfactomedin-like protein 3

0.397

K1107_HUMAN

AP2-interacting clathrin-endocytosis protein

0.397

MIME_HUMAN

Mimecan

0.397

GDF9_HUMAN

Growth/differentiation factor 9

0.397

HBEGF_HUMAN

Proheparin-binding EGF-like growth factor

0.397

REST_HUMAN

RE1-silencing transcription factor

0.397

CCPG1_HUMAN

Cell cycle progression protein 1

0.397

F131A_HUMAN

Protein FAM131A

0.397

NRN1_HUMAN

Neuritin

0.399

CLUL1_HUMAN

Clusterin-like protein 1

0.399

VTM2L_HUMAN

V-set and transmembrane domain-containing protein 2-like protein

0.399

FGF19_HUMAN

Fibroblast growth factor 19

0.399

CMYA5_HUMAN

Cardiomyopathy-associated protein 5

0.399

TRADD_HUMAN

Tumor necrosis factor receptor type 1-associated DEATH domain protein

0.399

LRC38_HUMAN

Leucine-rich repeat-containing protein 38

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 20 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy