AIP_HUMAN 2019

Gene Name AIP

Description AH receptor-interacting protein

Length 330

9606

Sequence

>sp|O00170|AIP_HUMAN AH receptor-interacting protein
MADIIARLREDGIQKRVIQEGRGELPDFQDGTKATFHYRTLHSDDEGTVLDDSRARGKPMELIIGKKFKLPVWETIVCTMREGEIAQFLCDIKHVVLYPLVAKSLRNIAVGKDPLEGQRHCCGVAQMREHSSLGHADLDALQQNPQPLIFHMEMLKVESPGTYQQDPWAMTDEEKAKAVPLIHQEGNRLYREGHVKEAAAKYYDAIACLKNLQMKEQPGSPEWIQLDQQITPLLLNYCQCKLVVEEYYEVLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELQALEARIRQKDEEDKARFRGIFSH

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

AIPL1_HUMAN

Aryl-hydrocarbon-interacting protein-like 1

0.187

VINC_HUMAN

Vinculin

0.381

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

AIPL1_HUMAN

Aryl-hydrocarbon-interacting protein-like 1

0.204

PICK1_HUMAN

PRKCA-binding protein

0.345

ZC4H2_HUMAN

Zinc finger C4H2 domain-containing protein

0.354

VINC_HUMAN

Vinculin

0.355

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.356

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.361

BMP2_HUMAN

Bone morphogenetic protein 2

0.368

MIGA2_HUMAN

Mitoguardin 2

0.369

RT22_HUMAN

28S ribosomal protein S22, mitochondrial

0.370

BMP4_HUMAN

Bone morphogenetic protein 4

0.370

PARVA_HUMAN

Alpha-parvin

0.372

HS2ST_HUMAN

Heparan sulfate 2-O-sulfotransferase 1

0.373

PCX1_HUMAN

Pecanex-like protein 1

0.374

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.375

ARFP1_HUMAN

Arfaptin-1

0.375

CBL_HUMAN

E3 ubiquitin-protein ligase CBL

0.375

TNIK_HUMAN

TRAF2 and NCK-interacting protein kinase

0.375

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.375

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.375

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.381

AT1B4_HUMAN

Protein ATP1B4

0.381

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.381

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.381

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.381

NUMB_HUMAN

Protein numb homolog

0.381

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.381

ITB1_HUMAN

Integrin beta-1

0.384

PDC10_HUMAN

Programmed cell death protein 10

0.386

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.386

TLN2_HUMAN

Talin-2

0.386

MAPK2_HUMAN

MAP kinase-activated protein kinase 2

0.386

OFUT1_HUMAN

GDP-fucose protein O-fucosyltransferase 1

0.386

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.386

WLS_HUMAN

Protein wntless homolog

0.386

CACB4_HUMAN

Voltage-dependent L-type calcium channel subunit beta-4

0.386

TRIO_HUMAN

Triple functional domain protein

0.386

MIGA1_HUMAN

Mitoguardin 1

0.387

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.388

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.388

WDFY2_HUMAN

WD repeat and FYVE domain-containing protein 2

0.389

JIP3_HUMAN

C-Jun-amino-terminal kinase-interacting protein 3

0.389

ILK_HUMAN

Integrin-linked protein kinase

0.389

CSKP_HUMAN

Peripheral plasma membrane protein CASK

0.390

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.390

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.390

MAGI3_HUMAN

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

0.390

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.391

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.391

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.391

WDFY1_HUMAN

WD repeat and FYVE domain-containing protein 1

0.391

PLXA2_HUMAN

Plexin-A2

0.391

ANKL2_HUMAN

Ankyrin repeat and LEM domain-containing protein 2

0.391

HINFP_HUMAN

Histone H4 transcription factor

0.391

RIMB2_HUMAN

RIMS-binding protein 2

0.392

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.392

BTBDA_HUMAN

BTB/POZ domain-containing protein 10

0.392

MAPK3_HUMAN

MAP kinase-activated protein kinase 3

0.392

ARFP2_HUMAN

Arfaptin-2

0.392

TTC17_HUMAN

Tetratricopeptide repeat protein 17

0.393

TSN5_HUMAN

Tetraspanin-5

0.393

TM39A_HUMAN

Transmembrane protein 39A

0.393

TEF_HUMAN

Thyrotroph embryonic factor

0.393

RUND1_HUMAN

RUN domain-containing protein 1

0.393

AFAD_HUMAN

Afadin

0.394

IP3KB_HUMAN

Inositol-trisphosphate 3-kinase B

0.394

EPHB3_HUMAN

Ephrin type-B receptor 3

0.395

CREL1_HUMAN

Cysteine-rich with EGF-like domain protein 1

0.395

PO4F3_HUMAN

POU domain, class 4, transcription factor 3

0.395

CREL2_HUMAN

Cysteine-rich with EGF-like domain protein 2

0.395

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.395

MPDZ_HUMAN

Multiple PDZ domain protein

0.395

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.396

TAOK3_HUMAN

Serine/threonine-protein kinase TAO3

0.396

TRAM1_HUMAN

Translocating chain-associated membrane protein 1

0.397

FERM2_HUMAN

Fermitin family homolog 2

0.397

FERM1_HUMAN

Fermitin family homolog 1

0.397

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.397

MTA1_HUMAN

Metastasis-associated protein MTA1

0.397

TM39B_HUMAN

Transmembrane protein 39B

0.398

PLXA4_HUMAN

Plexin-A4

0.399

STON1_HUMAN

Stonin-1

0.399

CSTN1_HUMAN

Calsyntenin-1

0.399

UNC79_HUMAN

Protein unc-79 homolog

0.399

ACK1_HUMAN

Activated CDC42 kinase 1

0.400

CAPS1_HUMAN

Calcium-dependent secretion activator 1

0.400

SNRK_HUMAN

SNF-related serine/threonine-protein kinase

0.400

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 55 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy