DLL1_HUMAN 2019

Gene Name DLL1

Description Delta-like protein 1

Length 723

9606

Sequence

>sp|O00548|DLL1_HUMAN Delta-like protein 1
MGSRCALALAVLSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREKDISVSIIGATQIKNTNKKADFHGDHSADKNGFKARYPAVDYNLVQDLKGDDTAVRDAHSKRDTKCQPQGSSGEEKGTPTTLRGGEASERKRPDSGCSTSKDTKYQSVYVISEEKDECVIATEV

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

SKIL_HUMAN

Ski-like protein

0.298

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.298

HXA1_HUMAN

Homeobox protein Hox-A1

0.302

TMCC3_HUMAN

Transmembrane and coiled-coil domain protein 3

0.302

HINFP_HUMAN

Histone H4 transcription factor

0.326

FABP7_HUMAN

Fatty acid-binding protein, brain

0.326

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.326

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.330

MED24_HUMAN

Mediator of RNA polymerase II transcription subunit 24

0.333

PRD16_HUMAN

Histone-lysine N-methyltransferase PRDM16

0.337

GNRHR_HUMAN

Gonadotropin-releasing hormone receptor

0.337

LEG8_HUMAN

Galectin-8

0.337

MTP_HUMAN

Microsomal triglyceride transfer protein large subunit

0.341

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.350

AT1B4_HUMAN

Protein ATP1B4

0.354

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.354

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.354

SKI_HUMAN

Ski oncogene

0.357

VAS1_HUMAN

V-type proton ATPase subunit S1

0.357

CSTN1_HUMAN

Calsyntenin-1

0.357

NR2C2_HUMAN

Nuclear receptor subfamily 2 group C member 2

0.357

NDUB5_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

0.361

SYDE2_HUMAN

Rho GTPase-activating protein SYDE2

0.361

FEZF1_HUMAN

Fez family zinc finger protein 1

0.361

DIRA2_HUMAN

GTP-binding protein Di-Ras2

0.361

NID1_HUMAN

Nidogen-1

0.361

PTF1A_HUMAN

Pancreas transcription factor 1 subunit alpha

0.361

PHC2_HUMAN

Polyhomeotic-like protein 2

0.361

S12A8_HUMAN

Solute carrier family 12 member 8

0.361

GATD1_HUMAN

GATA zinc finger domain-containing protein 1

0.361

NR1H3_HUMAN

Oxysterols receptor LXR-alpha

0.361

CEBPG_HUMAN

CCAAT/enhancer-binding protein gamma

0.361

BIG3_HUMAN

Brefeldin A-inhibited guanine nucleotide-exchange protein 3

0.365

BAKOR_HUMAN

Beclin 1-associated autophagy-related key regulator

0.365

RM39_HUMAN

39S ribosomal protein L39, mitochondrial

0.365

NEGR1_HUMAN

Neuronal growth regulator 1

0.365

TRIB2_HUMAN

Tribbles homolog 2

0.365

SCHI1_HUMAN

Schwannomin-interacting protein 1

0.369

CTCF_HUMAN

Transcriptional repressor CTCF

0.369

TMCC2_HUMAN

Transmembrane and coiled-coil domains protein 2

0.369

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.374

SPRE2_HUMAN

Sprouty-related, EVH1 domain-containing protein 2

0.374

IKKA_HUMAN

Inhibitor of nuclear factor kappa-B kinase subunit alpha

0.374

WLS_HUMAN

Protein wntless homolog

0.378

FGOP2_HUMAN

FGFR1 oncogene partner 2

0.378

GFI1_HUMAN

Zinc finger protein Gfi-1

0.378

NKX61_HUMAN

Homeobox protein Nkx-6.1

0.382

TSN5_HUMAN

Tetraspanin-5

0.382

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.382

VANG1_HUMAN

Vang-like protein 1

0.382

STON1_HUMAN

Stonin-1

0.382

RIPL1_HUMAN

RILP-like protein 1

0.382

SEM5B_HUMAN

Semaphorin-5B

0.382

NFIA_HUMAN

Nuclear factor 1 A-type

0.382

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.382

NFIB_HUMAN

Nuclear factor 1 B-type

0.382

ZO1_HUMAN

Tight junction protein ZO-1

0.382

PEBB_HUMAN

Core-binding factor subunit beta

0.386

HMX3_HUMAN

Homeobox protein HMX3

0.386

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.386

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.386

RXRA_HUMAN

Retinoic acid receptor RXR-alpha

0.386

AHR_HUMAN

Aryl hydrocarbon receptor

0.386

CUBN_HUMAN

Cubilin

0.386

NRCAM_HUMAN

Neuronal cell adhesion molecule

0.386

ZFHX3_HUMAN

Zinc finger homeobox protein 3

0.386

FBX25_HUMAN

F-box only protein 25

0.386

DAG1_HUMAN

Dystroglycan

0.386

ANLN_HUMAN

Anillin

0.386

RT30_HUMAN

39S ribosomal protein S30, mitochondrial

0.386

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.390

BNC2_HUMAN

Zinc finger protein basonuclin-2

0.390

HME2_HUMAN

Homeobox protein engrailed-2

0.390

SRCN1_HUMAN

SRC kinase signaling inhibitor 1

0.390

GRASP_HUMAN

General receptor for phosphoinositides 1-associated scaffold protein

0.390

HAND2_HUMAN

Heart- and neural crest derivatives-expressed protein 2

0.390

SKT_HUMAN

Sickle tail protein homolog

0.390

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.390

TSHR_HUMAN

Thyrotropin receptor

0.390

MCF2L_HUMAN

Guanine nucleotide exchange factor DBS

0.390

5HT1B_HUMAN

5-hydroxytryptamine receptor 1B

0.390

OPCM_HUMAN

Opioid-binding protein/cell adhesion molecule

0.390

SCMH1_HUMAN

Polycomb protein SCMH1

0.390

TXD11_HUMAN

Thioredoxin domain-containing protein 11

0.390

NR2C1_HUMAN

Nuclear receptor subfamily 2 group C member 1

0.390

TMCC1_HUMAN

Transmembrane and coiled-coil domains protein 1

0.394

PRD13_HUMAN

PR domain zinc finger protein 13

0.394

GDF11_HUMAN

Growth/differentiation factor 11

0.394

SALL1_HUMAN

Sal-like protein 1

0.394

AMOT_HUMAN

Angiomotin

0.394

IRS2_HUMAN

Insulin receptor substrate 2

0.394

AMOL2_HUMAN

Angiomotin-like protein 2

0.394

TJAP1_HUMAN

Tight junction-associated protein 1

0.394

CTNL1_HUMAN

Alpha-catulin

0.394

NEO1_HUMAN

Neogenin

0.394

RM51_HUMAN

39S ribosomal protein L51, mitochondrial

0.394

NKAI1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

0.399

NPAS4_HUMAN

Neuronal PAS domain-containing protein 4

0.399

AGRA3_HUMAN

Adhesion G protein-coupled receptor A3

0.399

DCC_HUMAN

Netrin receptor DCC

0.399

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.399

SPIR2_HUMAN

Protein spire homolog 2

0.399

SATB1_HUMAN

DNA-binding protein SATB1

0.399

RXFP1_HUMAN

Relaxin receptor 1

0.399

FA20C_HUMAN

Extracellular serine/threonine protein kinase FAM20C

0.399

TUTLB_HUMAN

Protein turtle homolog B

0.399

NCAM1_HUMAN

Neural cell adhesion molecule 1

0.399

T22D2_HUMAN

TSC22 domain family protein 2

0.399

RUNX2_HUMAN

Runt-related transcription factor 2

0.400

FERM1_HUMAN

Fermitin family homolog 1

0.400

SYT1_HUMAN

Synaptotagmin-1

0.400

FERM2_HUMAN

Fermitin family homolog 2

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

FGOP2_HUMAN

FGFR1 oncogene partner 2

0.340

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.345

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.349

ETS1_HUMAN

Protein C-ets-1

0.359

RM39_HUMAN

39S ribosomal protein L39, mitochondrial

0.369

SKIL_HUMAN

Ski-like protein

0.378

PAIRB_HUMAN

Plasminogen activator inhibitor 1 RNA-binding protein

0.390

SPRE2_HUMAN

Sprouty-related, EVH1 domain-containing protein 2

0.391

SPRE1_HUMAN

Sprouty-related, EVH1 domain-containing protein 1

0.391

MED24_HUMAN

Mediator of RNA polymerase II transcription subunit 24

0.396

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.398

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 43 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy