BORG1_HUMAN 2019

Gene Name BORG1

Description Cdc42 effector protein 2

Length 210

9606

Sequence

>sp|O14613|BORG1_HUMAN Cdc42 effector protein 2
MSTKVPIYLKRGSRKGKKEKLRDLLSSDMISPPLGDFRHTIHIGSGGGSDMFGDISFLQGKFHLLPGTMVEGPEEDGTFDLPFQFTRTATVCGRELPDGPSPLLKNAISLPVIGGPQALTLPTAQAPPKPPRLHLETPQPSPQEGGSVDIWRIPETGSPNSGLTPESGAEEPFLSNASSLLSLHVDLGPSILDDVLQIMDQDLDSMQIPT

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

CRLF1_HUMAN

Cytokine receptor-like factor 1

0.324

FOXR1_HUMAN

Forkhead box protein R1

0.333

TMM25_HUMAN

Transmembrane protein 25

0.333

FOXR2_HUMAN

Forkhead box protein R2

0.333

DHX32_HUMAN

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32

0.333

GPC5B_HUMAN

G-protein coupled receptor family C group 5 member B

0.387

CXA3_HUMAN

Gap junction alpha-3 protein

0.387

AKAP2_HUMAN

A-kinase anchor protein 2

0.387

CALD1_HUMAN

Caldesmon

0.387

FLIP1_HUMAN

Filamin-A-interacting protein 1

0.387

DLK2_HUMAN

Protein delta homolog 2

0.387

SLIK5_HUMAN

SLIT and NTRK-like protein 5

0.387

CD166_HUMAN

CD166 antigen

0.387

MUC18_HUMAN

Cell surface glycoprotein MUC18

0.387

FBLN7_HUMAN

Fibulin-7

0.387

ZN142_HUMAN

Zinc finger protein 142

0.387

STXB6_HUMAN

Syntaxin-binding protein 6

0.387

SLIK6_HUMAN

SLIT and NTRK-like protein 6

0.387

EFNA5_HUMAN

Ephrin-A5

0.387

RL3R1_HUMAN

Relaxin-3 receptor 1

0.387

GT2D1_HUMAN

General transcription factor II-I repeat domain-containing protein 1

0.387

BORG2_HUMAN

Cdc42 effector protein 3

0.387

DCBD1_HUMAN

Discoidin, CUB and LCCL domain-containing protein 1

0.387

T150A_HUMAN

Transmembrane protein 150A

0.387

K1671_HUMAN

Uncharacterized protein KIAA1671

0.397

CCD30_HUMAN

Coiled-coil domain-containing protein 30

0.397

PERF_HUMAN

Perforin-1

0.397

HIC2_HUMAN

Hypermethylated in cancer 2 protein

0.397

TNMD_HUMAN

Tenomodulin

0.397

T150B_HUMAN

Modulator of macroautophagy TMEM150B

0.397

ASC_HUMAN

Apoptosis-associated speck-like protein containing a CARD

0.397

PDYN_HUMAN

Proenkephalin-B

0.397

PAR2_HUMAN

Proteinase-activated receptor 2

0.397

T178A_HUMAN

Transmembrane protein 178A

0.397

MRP_HUMAN

MARCKS-related protein

0.397

CYTL1_HUMAN

Cytokine-like protein 1

0.397

CLUS_HUMAN

Clusterin

0.397

GPR17_HUMAN

Uracil nucleotide/cysteinyl leukotriene receptor

0.397

ZN513_HUMAN

Zinc finger protein 513

0.397

CAVN4_HUMAN

Caveolae-associated protein 4

0.397

CAD26_HUMAN

Cadherin-like protein 26

0.397

SCAR3_HUMAN

Scavenger receptor class A member 3

0.397

CXL14_HUMAN

C-X-C motif chemokine 14

0.397

MAG_HUMAN

Myelin-associated glycoprotein

0.397

LSR_HUMAN

Lipolysis-stimulated lipoprotein receptor

0.397

SETBP_HUMAN

SET-binding protein

0.397

BSPRY_HUMAN

B box and SPRY domain-containing protein

0.397

T150C_HUMAN

Transmembrane protein 150C

0.397

AHDC1_HUMAN

AT-hook DNA-binding motif-containing protein 1

0.397

P3IP1_HUMAN

Phosphoinositide-3-kinase-interacting protein 1

0.397

EPOR_HUMAN

Erythropoietin receptor

0.397

F222A_HUMAN

Protein FAM222A

0.397

EMP3_HUMAN

Epithelial membrane protein 3

0.397

GLPC_HUMAN

Glycophorin-C

0.397

MYP0_HUMAN

Myelin protein P0

0.397

AKP8L_HUMAN

A-kinase anchor protein 8-like

0.397

HXA13_HUMAN

Homeobox protein Hox-A13

0.397

CN028_HUMAN

Uncharacterized protein C14orf28

0.397

CRBA4_HUMAN

Beta-crystallin A4

0.397

SYT13_HUMAN

Synaptotagmin-13

0.397

OCSTP_HUMAN

Osteoclast stimulatory transmembrane protein

0.397

PCD19_HUMAN

Protocadherin-19

0.397

GAK1A_HUMAN

Golgi-associated kinase 1A

0.397

CALCB_HUMAN

Calcitonin gene-related peptide 2

0.397

ZN438_HUMAN

Zinc finger protein 438

0.397

NDUV3_HUMAN

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

0.397

CPLX3_HUMAN

Complexin-3

0.397

SNN_HUMAN

Stannin

0.397

K1C14_HUMAN

Keratin, type I cytoskeletal 14

0.397

CX038_HUMAN

Uncharacterized protein CXorf38

0.397

R51A1_HUMAN

RAD51-associated protein 1

0.397

C2TA_HUMAN

MHC class II transactivator

0.397

F1892_HUMAN

Protein FAM189A2

0.397

JCAD_HUMAN

Junctional protein associated with coronary artery disease

0.397

RN214_HUMAN

RING finger protein 214

0.397

ESAM_HUMAN

Endothelial cell-selective adhesion molecule

0.397

SLIK2_HUMAN

SLIT and NTRK-like protein 2

0.397

SE6L1_HUMAN

Seizure 6-like protein

0.397

SPRY4_HUMAN

SPRY domain-containing protein 4

0.397

CO039_HUMAN

Uncharacterized protein C15orf39

0.397

ZN638_HUMAN

Zinc finger protein 638

0.397

UPK1A_HUMAN

Uroplakin-1a

0.397

SIG15_HUMAN

Sialic acid-binding Ig-like lectin 15

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

UPK1A_HUMAN

Uroplakin-1a

0.392

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 17 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy