SH21B_HUMAN 2019

Gene Name SH21B

Description SH2 domain-containing protein 1B

Length 132

9606

Sequence

>sp|O14796|SH21B_HUMAN SH2 domain-containing protein 1B
MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRGLKLELETFVNSNSDYVDVLP

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

NANG2_HUMAN

Putative homeobox protein NANOG2

0.000

RBM44_HUMAN

RNA-binding protein 44

0.000

CSF1_HUMAN

Macrophage colony-stimulating factor 1

0.000

NANOG_HUMAN

Homeobox protein NANOG

0.000

NANP8_HUMAN

Homeobox protein NANOGP8

0.000

HMGN3_HUMAN

High mobility group nucleosome-binding domain-containing protein 3

0.250

CCL20_HUMAN

C-C motif chemokine 20

0.250

ERMIN_HUMAN

Ermin

0.250

ALPK2_HUMAN

Alpha-protein kinase 2

0.250

PODXL_HUMAN

Podocalyxin

0.250

IL7RA_HUMAN

Interleukin-7 receptor subunit alpha

0.250

CABP8_HUMAN

Calcium-binding protein 8

0.250

ZDBF2_HUMAN

DBF4-type zinc finger-containing protein 2

0.250

TSHB_HUMAN

Thyrotropin subunit beta

0.250

TOPZ1_HUMAN

Protein TOPAZ1

0.250

LRC41_HUMAN

Leucine-rich repeat-containing protein 41

0.250

GUC2A_HUMAN

Guanylin

0.250

ITPI1_HUMAN

Protein ITPRID1

0.250

MDFI2_HUMAN

MyoD family inhibitor domain-containing protein 2

0.250

CK016_HUMAN

Uncharacterized protein C11orf16

0.250

NEUT_HUMAN

Neurotensin/neuromedin N

0.250

RBM43_HUMAN

RNA-binding protein 43

0.258

PRIMA_HUMAN

Proline-rich membrane anchor 1

0.258

ARMD4_HUMAN

Armadillo-like helical domain-containing protein 4

0.258

SPXN_HUMAN

Spexin

0.258

LY86_HUMAN

Lymphocyte antigen 86

0.258

BSND_HUMAN

Barttin

0.258

CD244_HUMAN

Natural killer cell receptor 2B4

0.258

I12R1_HUMAN

Interleukin-12 receptor subunit beta-1

0.258

CCD9B_HUMAN

Coiled-coil domain-containing protein 9B

0.258

CD180_HUMAN

CD180 antigen

0.258

TAFA2_HUMAN

Chemokine-like protein TAFA-2

0.343

IHO1_HUMAN

Interactor of HORMAD1 protein 1

0.343

CD83_HUMAN

CD83 antigen

0.343

COX7B_HUMAN

Cytochrome c oxidase subunit 7B, mitochondrial

0.343

MANS1_HUMAN

MANSC domain-containing protein 1

0.343

F217B_HUMAN

Protein FAM217B

0.343

LUZP2_HUMAN

Leucine zipper protein 2

0.343

CF089_HUMAN

Bombesin receptor-activated protein C6orf89

0.343

IC1_HUMAN

Plasma protease C1 inhibitor

0.343

IGS10_HUMAN

Immunoglobulin superfamily member 10

0.343

B2MG_HUMAN

Beta-2-microglobulin

0.343

ETAA1_HUMAN

Ewings tumor-associated antigen 1

0.343

UBP18_HUMAN

Ubl carboxyl-terminal hydrolase 18

0.343

CPZIP_HUMAN

CapZ-interacting protein

0.343

FA83F_HUMAN

Protein FAM83F

0.343

CCGL_HUMAN

Voltage-dependent calcium channel gamma-like subunit

0.343

I20RB_HUMAN

Interleukin-20 receptor subunit beta

0.343

C1QA_HUMAN

Complement C1q subcomponent subunit A

0.343

MAL_HUMAN

Myelin and lymphocyte protein

0.343

GP119_HUMAN

Glucose-dependent insulinotropic receptor

0.343

MLIP_HUMAN

Muscular LMNA-interacting protein

0.343

CK024_HUMAN

Uncharacterized protein C11orf24

0.343

VTM2A_HUMAN

V-set and transmembrane domain-containing protein 2A

0.343

FANCG_HUMAN

Fanconi anemia group G protein

0.343

CTLA4_HUMAN

Cytotoxic T-lymphocyte protein 4

0.343

K1614_HUMAN

Uncharacterized protein KIAA1614

0.343

CAHM3_HUMAN

Calcium homeostasis modulator protein 3

0.343

IL2RB_HUMAN

Interleukin-2 receptor subunit beta

0.343

ZN365_HUMAN

Protein ZNF365

0.343

P2Y14_HUMAN

P2Y purinoceptor 14

0.354

BAALC_HUMAN

Brain and acute leukemia cytoplasmic protein

0.354

UPK3A_HUMAN

Uroplakin-3a

0.354

CD79B_HUMAN

B-cell antigen receptor complex-associated protein beta chain

0.354

EX3L4_HUMAN

Exocyst complex component 3-like protein 4

0.354

SYNPO_HUMAN

Synaptopodin

0.354

SGO2_HUMAN

Shugoshin 2

0.354

PRR7_HUMAN

Proline-rich protein 7

0.354

PERM1_HUMAN

PGC-1 and ERR-induced regulator in muscle protein 1

0.354

MAR1_HUMAN

Melanoma antigen recognized by T-cells 1

0.354

AMER3_HUMAN

APC membrane recruitment protein 3

0.354

MISP_HUMAN

Mitotic interactor and substrate of PLK1

0.354

PKHS1_HUMAN

Pleckstrin homology domain-containing family S member 1

0.354

RB8NL_HUMAN

RBBP8 N-terminal-like protein

0.354

ZN185_HUMAN

Zinc finger protein 185

0.354

SCG1_HUMAN

Secretogranin-1

0.354

TKNK_HUMAN

Tachykinin-3

0.365

BTLA_HUMAN

B- and T-lymphocyte attenuator

0.365

C16L2_HUMAN

CD164 sialomucin-like 2 protein

0.365

LNP1_HUMAN

Leukemia NUP98 fusion partner 1

0.365

ECSCR_HUMAN

Endothelial cell-specific chemotaxis regulator

0.365

IGSF6_HUMAN

Immunoglobulin superfamily member 6

0.365

IFNK_HUMAN

Interferon kappa

0.365

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

HMGN3_HUMAN

High mobility group nucleosome-binding domain-containing protein 3

0.398

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 15 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy