PPM1D_HUMAN 2019

Gene Name PPM1D

Description Protein phosphatase 1D

Length 605

9606

Sequence

>sp|O15297|PPM1D_HUMAN Protein phosphatase 1D
MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRKTVCVC

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

TTC17_HUMAN

Tetratricopeptide repeat protein 17

0.348

OFUT1_HUMAN

GDP-fucose protein O-fucosyltransferase 1

0.365

ANKF1_HUMAN

Ankyrin repeat and fibronectin type-III domain-containing protein 1

0.367

CSKP_HUMAN

Peripheral plasma membrane protein CASK

0.368

AKA10_HUMAN

A-kinase anchor protein 10, mitochondrial

0.370

TEF_HUMAN

Thyrotroph embryonic factor

0.372

OFUT2_HUMAN

GDP-fucose protein O-fucosyltransferase 2

0.372

NUDT9_HUMAN

ADP-ribose pyrophosphatase, mitochondrial

0.372

PRIC2_HUMAN

Prickle-like protein 2

0.373

TSHR_HUMAN

Thyrotropin receptor

0.374

MPDZ_HUMAN

Multiple PDZ domain protein

0.375

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.375

WLS_HUMAN

Protein wntless homolog

0.376

SNX27_HUMAN

Sorting nexin-27

0.376

CTNA1_HUMAN

Catenin alpha-1

0.377

HLF_HUMAN

Hepatic leukemia factor

0.377

ZER1_HUMAN

Protein zer-1 homolog

0.379

KBRS2_HUMAN

NF-kappa-B inhibitor-interacting Ras-like protein 2

0.379

AGRL2_HUMAN

Adhesion G protein-coupled receptor L2

0.379

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.380

DDR2_HUMAN

Discoidin domain-containing receptor 2

0.380

KPCD3_HUMAN

Serine/threonine-protein kinase D3

0.380

BMP2_HUMAN

Bone morphogenetic protein 2

0.381

AKAP1_HUMAN

A-kinase anchor protein 1, mitochondrial

0.381

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.381

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.381

AT1B4_HUMAN

Protein ATP1B4

0.381

RBCC1_HUMAN

RB1-inducible coiled-coil protein 1

0.381

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.382

MAPK3_HUMAN

MAP kinase-activated protein kinase 3

0.382

BICD1_HUMAN

Protein bicaudal D homolog 1

0.383

CYLD_HUMAN

Ubiquitin carboxyl-terminal hydrolase CYLD

0.384

GALT1_HUMAN

Polypeptide N-acetylgalactosaminyltransferase 1

0.384

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.385

ITB1_HUMAN

Integrin beta-1

0.385

SAV1_HUMAN

Protein salvador homolog 1

0.386

DAB1_HUMAN

Disabled homolog 1

0.386

CBL_HUMAN

E3 ubiquitin-protein ligase CBL

0.386

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.386

PDC10_HUMAN

Programmed cell death protein 10

0.386

PTC1_HUMAN

Protein patched homolog 1

0.387

TRIO_HUMAN

Triple functional domain protein

0.387

MAPK2_HUMAN

MAP kinase-activated protein kinase 2

0.387

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.387

CACB4_HUMAN

Voltage-dependent L-type calcium channel subunit beta-4

0.387

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.387

RHG42_HUMAN

Rho GTPase-activating protein 42

0.388

BICD2_HUMAN

Protein bicaudal D homolog 2

0.388

APLP2_HUMAN

Amyloid-like protein 2

0.389

BCL7B_HUMAN

B-cell CLL/lymphoma 7 protein family member B

0.389

ATG13_HUMAN

Autophagy-related protein 13

0.390

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.390

PRIC1_HUMAN

Prickle-like protein 1

0.391

NID1_HUMAN

Nidogen-1

0.392

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.392

HINFP_HUMAN

Histone H4 transcription factor

0.392

ANKL2_HUMAN

Ankyrin repeat and LEM domain-containing protein 2

0.392

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.392

RYK_HUMAN

Tyrosine-protein kinase RYK

0.393

RIMB2_HUMAN

RIMS-binding protein 2

0.393

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.393

FOXO3_HUMAN

Forkhead box protein O3

0.393

NUMB_HUMAN

Protein numb homolog

0.393

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.393

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.393

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.393

BMP4_HUMAN

Bone morphogenetic protein 4

0.393

RT22_HUMAN

28S ribosomal protein S22, mitochondrial

0.393

ANLN_HUMAN

Anillin

0.394

MTCH2_HUMAN

Mitochondrial carrier homolog 2

0.394

TSN5_HUMAN

Tetraspanin-5

0.394

HTF4_HUMAN

Transcription factor 12

0.394

EPHA4_HUMAN

Ephrin type-A receptor 4

0.394

AFAD_HUMAN

Afadin

0.394

JKAMP_HUMAN

JNK1/MAPK8-associated membrane protein

0.395

MACOI_HUMAN

Macoilin

0.395

HS2ST_HUMAN

Heparan sulfate 2-O-sulfotransferase 1

0.395

RABE1_HUMAN

Rab GTPase-binding effector protein 1

0.396

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.396

TAOK1_HUMAN

Serine/threonine-protein kinase TAO1

0.396

KBRS1_HUMAN

NF-kappa-B inhibitor-interacting Ras-like protein 1

0.397

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.397

ARFP1_HUMAN

Arfaptin-1

0.397

PXDC2_HUMAN

Plexin domain-containing protein 2

0.398

FERM1_HUMAN

Fermitin family homolog 1

0.398

FERM2_HUMAN

Fermitin family homolog 2

0.398

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.398

DAG1_HUMAN

Dystroglycan

0.399

TPST1_HUMAN

Protein-tyrosine sulfotransferase 1

0.399

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.399

TET5A_HUMAN

Terminal nucleotidyltransferase 5A

0.399

RIPL1_HUMAN

RILP-like protein 1

0.400

UNC79_HUMAN

Protein unc-79 homolog

0.400

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.400

CSTN1_HUMAN

Calsyntenin-1

0.400

GIT2_HUMAN

ARF GTPase-activating protein GIT2

0.400

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.400

STIM2_HUMAN

Stromal interaction molecule 2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 52 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy