TNF14_HUMAN 2019

Gene Name TNF14

Description Tumor necrosis factor ligand superfamily member 14

Length 240

9606

Sequence

>sp|O43557|TNF14_HUMAN Tumor necrosis factor ligand superfamily member 14
MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQLHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGLAFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

ARG33_HUMAN

Rho guanine nucleotide exchange factor 33

0.309

TTC22_HUMAN

Tetratricopeptide repeat protein 22

0.309

TALD3_HUMAN

Protein TALPID3

0.309

LRAT2_HUMAN

Protein LRATD2

0.316

TMM81_HUMAN

Transmembrane protein 81

0.324

SCN1B_HUMAN

Sodium channel subunit beta-1

0.324

CSF3R_HUMAN

Granulocyte colony-stimulating factor receptor

0.369

NDP_HUMAN

Norrin

0.369

CAR14_HUMAN

Caspase recruitment domain-containing protein 14

0.369

B2L13_HUMAN

Bcl-2-like protein 13

0.369

AKAP6_HUMAN

A-kinase anchor protein 6

0.369

TMPS4_HUMAN

Transmembrane protease serine 4

0.369

MK04_HUMAN

Mitogen-activated protein kinase 4

0.369

FA53B_HUMAN

Protein FAM53B

0.378

SMI19_HUMAN

Small integral membrane protein 19

0.378

CJ088_HUMAN

Uncharacterized protein C10orf88

0.378

ANR26_HUMAN

Ankyrin repeat domain-containing protein 26

0.378

COL12_HUMAN

Collectin-12

0.378

IPRI_HUMAN

Inositol 1,4,5-trisphosphate receptor-interacting protein

0.378

CFLAR_HUMAN

CASP8 and FADD-like apoptosis regulator

0.378

NTR1_HUMAN

Neurotensin receptor type 1

0.378

UR2R_HUMAN

Urotensin-2 receptor

0.378

EPOR_HUMAN

Erythropoietin receptor

0.387

CLUL1_HUMAN

Clusterin-like protein 1

0.387

S22AN_HUMAN

Solute carrier family 22 member 23

0.387

OCSTP_HUMAN

Osteoclast stimulatory transmembrane protein

0.387

F163A_HUMAN

Protein FAM163A

0.387

ASC_HUMAN

Apoptosis-associated speck-like protein containing a CARD

0.387

LYRIC_HUMAN

Protein LYRIC

0.387

SUSD5_HUMAN

Sushi domain-containing protein 5

0.387

CX038_HUMAN

Uncharacterized protein CXorf38

0.387

NRN1_HUMAN

Neuritin

0.387

CAD26_HUMAN

Cadherin-like protein 26

0.387

TAFA4_HUMAN

Chemokine-like protein TAFA-4

0.387

AGR2_HUMAN

Anterior gradient protein 2 homolog

0.387

CN028_HUMAN

Uncharacterized protein C14orf28

0.387

GPR17_HUMAN

Uracil nucleotide/cysteinyl leukotriene receptor

0.387

MAG_HUMAN

Myelin-associated glycoprotein

0.387

CALCB_HUMAN

Calcitonin gene-related peptide 2

0.387

SIG15_HUMAN

Sialic acid-binding Ig-like lectin 15

0.387

SYNCI_HUMAN

Syncoilin

0.387

PDYN_HUMAN

Proenkephalin-B

0.387

K1C14_HUMAN

Keratin, type I cytoskeletal 14

0.387

CD048_HUMAN

Neuropeptide-like protein C4orf48

0.387

PERF_HUMAN

Perforin-1

0.387

IAPP_HUMAN

Islet amyloid polypeptide

0.387

SHSA6_HUMAN

Protein shisa-6

0.387

SEM7A_HUMAN

Semaphorin-7A

0.387

AKIP1_HUMAN

A-kinase-interacting protein 1

0.387

CIART_HUMAN

Circadian-associated transcriptional repressor

0.387

GALA_HUMAN

Galanin peptides

0.387

LRTM1_HUMAN

Leucine-rich repeat and transmembrane domain-containing protein 1

0.387

CLUS_HUMAN

Clusterin

0.387

TMM71_HUMAN

Transmembrane protein 71

0.387

HBEGF_HUMAN

Proheparin-binding EGF-like growth factor

0.387

SCAR3_HUMAN

Scavenger receptor class A member 3

0.387

SPRY4_HUMAN

SPRY domain-containing protein 4

0.387

F171B_HUMAN

Protein FAM171B

0.387

ESAM_HUMAN

Endothelial cell-selective adhesion molecule

0.387

LSR_HUMAN

Lipolysis-stimulated lipoprotein receptor

0.387

ECM1_HUMAN

Extracellular matrix protein 1

0.397

CLC11_HUMAN

C-type lectin domain family 11 member A

0.397

T179B_HUMAN

Transmembrane protein 179B

0.397

SNPC2_HUMAN

snRNA-activating protein complex subunit 2

0.397

F131C_HUMAN

Protein FAM131C

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

EPOR_HUMAN

Erythropoietin receptor

0.327

SPRY4_HUMAN

SPRY domain-containing protein 4

0.327

IL27B_HUMAN

Interleukin-27 subunit beta

0.343

MAG_HUMAN

Myelin-associated glycoprotein

0.343

SCN1B_HUMAN

Sodium channel subunit beta-1

0.345

CN028_HUMAN

Uncharacterized protein C14orf28

0.345

LSR_HUMAN

Lipolysis-stimulated lipoprotein receptor

0.345

CIART_HUMAN

Circadian-associated transcriptional repressor

0.358

CC106_HUMAN

Coiled-coil domain-containing protein 106

0.364

RPA34_HUMAN

DNA-directed RNA polymerase I subunit RPA34

0.366

PRRT4_HUMAN

Proline-rich transmembrane protein 4

0.369

TTC22_HUMAN

Tetratricopeptide repeat protein 22

0.371

EMP3_HUMAN

Epithelial membrane protein 3

0.374

NYAP1_HUMAN

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

0.378

TRI44_HUMAN

Tripartite motif-containing protein 44

0.378

EX3L2_HUMAN

Exocyst complex component 3-like protein 2

0.378

RHBD3_HUMAN

Rhomboid domain-containing protein 3

0.378

SNPC2_HUMAN

snRNA-activating protein complex subunit 2

0.378

CLC11_HUMAN

C-type lectin domain family 11 member A

0.380

DRA_HUMAN

HLA class II histocompatibility antigen, DR alpha chain

0.382

A0A0G2JMH6_HUMAN

HLA-DRA

0.382

F131C_HUMAN

Protein FAM131C

0.383

HEMO_HUMAN

Hemopexin

0.387

NAR5_HUMAN

Ecto-ADP-ribosyltransferase 5

0.389

ASC_HUMAN

Apoptosis-associated speck-like protein containing a CARD

0.391

CC136_HUMAN

Coiled-coil domain-containing protein 136

0.391

ECM1_HUMAN

Extracellular matrix protein 1

0.391

CX038_HUMAN

Uncharacterized protein CXorf38

0.391

TESP1_HUMAN

Protein TESPA1

0.391

MEDAG_HUMAN

Mesenteric estrogen-dependent adipogenesis protein

0.393

CAR14_HUMAN

Caspase recruitment domain-containing protein 14

0.394

CCG6_HUMAN

Voltage-dependent calcium channel gamma-6 subunit

0.396

K2C8_HUMAN

Keratin, type II cytoskeletal 8

0.397

LMIP_HUMAN

Lens fiber membrane intrinsic protein

0.397

CXCR3_HUMAN

C-X-C chemokine receptor type 3

0.398

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 19 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy