PLPP2_HUMAN 2019

Gene Name PLPP2

Description Phospholipid phosphatase 2

Length 288

9606

Sequence

>sp|O43688|PLPP2_HUMAN Phospholipid phosphatase 2
MQRRWVFVLLDVLCLLVASLPFAILTLVNAPYKRGFYCGDDSIRYPYRPDTITHGLMAGVTITATVILVSAGEAYLVYTDRLYSRSDFNNYVAAVYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQLEKVCRGNPADVTEARLSFYSGHSSFGMYCMVFLALYVQARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTVCYISDFFKARPPQHCLKEEELERKPSLSLTLTLGEADHNHYGYPHSSS

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

PLPP1_HUMAN

Phospholipid phosphatase 1

0.322

PLPP3_HUMAN

Phospholipid phosphatase 3

0.344

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

PLPP1_HUMAN

Phospholipid phosphatase 1

0.341

PLPP3_HUMAN

Phospholipid phosphatase 3

0.353

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.360

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.362

TRIO_HUMAN

Triple functional domain protein

0.362

BMP2_HUMAN

Bone morphogenetic protein 2

0.367

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.368

HINFP_HUMAN

Histone H4 transcription factor

0.368

AT1B4_HUMAN

Protein ATP1B4

0.368

TSN5_HUMAN

Tetraspanin-5

0.369

ITB1_HUMAN

Integrin beta-1

0.371

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.374

WLS_HUMAN

Protein wntless homolog

0.374

RIPL1_HUMAN

RILP-like protein 1

0.375

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.377

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.377

CSKP_HUMAN

Peripheral plasma membrane protein CASK

0.377

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.379

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.380

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.380

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.380

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.380

BMP4_HUMAN

Bone morphogenetic protein 4

0.380

NUMB_HUMAN

Protein numb homolog

0.380

SNX6_HUMAN

Sorting nexin-6

0.380

SPON1_HUMAN

Spondin-1

0.380

AT1B3_HUMAN

Sodium/potassium-transporting ATPase subunit beta-3

0.381

AFAD_HUMAN

Afadin

0.381

MACOI_HUMAN

Macoilin

0.381

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.383

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.384

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.384

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.384

FERM1_HUMAN

Fermitin family homolog 1

0.385

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.385

MTA1_HUMAN

Metastasis-associated protein MTA1

0.385

FERM2_HUMAN

Fermitin family homolog 2

0.385

MADD_HUMAN

MAP kinase-activating death domain protein

0.386

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.386

CSTN1_HUMAN

Calsyntenin-1

0.386

STON1_HUMAN

Stonin-1

0.386

UNC79_HUMAN

Protein unc-79 homolog

0.386

JIP3_HUMAN

C-Jun-amino-terminal kinase-interacting protein 3

0.387

PHKG1_HUMAN

Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

0.387

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.389

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.390

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.390

ITB3_HUMAN

Integrin beta-3

0.390

MIGA2_HUMAN

Mitoguardin 2

0.390

DGCR8_HUMAN

Microprocessor complex subunit DGCR8

0.390

RT25_HUMAN

28S ribosomal protein S25, mitochondrial

0.390

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.390

NUDT9_HUMAN

ADP-ribose pyrophosphatase, mitochondrial

0.391

HTF4_HUMAN

Transcription factor 12

0.391

TEF_HUMAN

Thyrotroph embryonic factor

0.391

ANLN_HUMAN

Anillin

0.391

RUND1_HUMAN

RUN domain-containing protein 1

0.391

BICD1_HUMAN

Protein bicaudal D homolog 1

0.391

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.392

CSTN3_HUMAN

Calsyntenin-3

0.394

ARFP1_HUMAN

Arfaptin-1

0.394

CBL_HUMAN

E3 ubiquitin-protein ligase CBL

0.394

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.395

CACB4_HUMAN

Voltage-dependent L-type calcium channel subunit beta-4

0.395

AMD_HUMAN

Peptidyl-glycine alpha-amidating monooxygenase

0.396

BICD2_HUMAN

Protein bicaudal D homolog 2

0.396

TPST1_HUMAN

Protein-tyrosine sulfotransferase 1

0.396

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.396

HLF_HUMAN

Hepatic leukemia factor

0.396

TF3C1_HUMAN

General transcription factor 3C polypeptide 1

0.397

BCL7B_HUMAN

B-cell CLL/lymphoma 7 protein family member B

0.397

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.397

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.397

AHR_HUMAN

Aryl hydrocarbon receptor

0.398

APC_HUMAN

Adenomatous polyposis coli protein

0.398

KBRS2_HUMAN

NF-kappa-B inhibitor-interacting Ras-like protein 2

0.398

SNRK_HUMAN

SNF-related serine/threonine-protein kinase

0.398

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.399

LMNB2_HUMAN

Lamin-B2

0.400

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.400

RBCC1_HUMAN

RB1-inducible coiled-coil protein 1

0.400

PICK1_HUMAN

PRKCA-binding protein

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 54 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy