GFRA3_HUMAN 2019

Gene Name GFRA3

Description GDNF family receptor alpha-3

Length 400

9606

Sequence

>sp|O60609|GFRA3_HUMAN GDNF family receptor alpha-3
MVRPLNPRPLPPVVLMLLLLLPPSPLPLAAGDPLPTESRLMNSCLQARRKCQADPTCSAAYHHLDSCTSSISTPLPSEEPSVPADCLEAAQQLRNSSLIGCMCHRRMKNQVACLDIYWTVHRARSLGNYELDVSPYEDTVTSKPWKMNLSKLNMLKPDSDLCLKFAMLCTLNDKCDRLRKAYGEACSGPHCQRHVCLRQLLTFFEKAAEPHAQGLLLCPCAPNDRGCGERRRNTIAPNCALPPVAPNCLELRRLCFSDPLCRSRLVDFQTHCHPMDILGTCATEQSRCLRAYLGLIGTAMTPNFVSNVNTSVALSCTCRGSGNLQEECEMLEGFFSHNPCLTEAIAAKMRFHSQLFSQDWPHPTFAVMAHQNENPAVRPQPWVPSLFSCTLPLILLLSLW

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

IL1A_HUMAN

Interleukin-1 alpha

0.311

ZKSC5_HUMAN

Zinc finger protein with KRAB and SCAN domains 5

0.311

FNDC8_HUMAN

Fibronectin type III domain-containing protein 8

0.331

TRML1_HUMAN

Trem-like transcript 1 protein

0.333

LAX1_HUMAN

Lymphocyte transmembrane adapter 1

0.333

ZNF18_HUMAN

Zinc finger protein 18

0.333

ZN202_HUMAN

Zinc finger protein 202

0.333

SPAT9_HUMAN

Spermatogenesis-associated protein 9

0.333

ZN496_HUMAN

Zinc finger protein 496

0.336

IL5_HUMAN

Interleukin-5

0.336

O13C7_HUMAN

Olfactory receptor 13C7

0.336

TMCO2_HUMAN

Transmembrane and coiled-coil domain-containing protein 2

0.336

LAT_HUMAN

Linker for activation of T-cells family member 1

0.336

CSF2_HUMAN

Granulocyte-macrophage colony-stimulating factor

0.336

PRS37_HUMAN

Probable inactive serine protease 37

0.336

IL2_HUMAN

Interleukin-2

0.336

DKKL1_HUMAN

Dickkopf-like protein 1

0.336

CD20_HUMAN

B-lymphocyte antigen CD20

0.354

S10A5_HUMAN

Protein S100-A5

0.354

GPC5D_HUMAN

G-protein coupled receptor family C group 5 member D

0.354

SPNDC_HUMAN

Spindlin interactor and repressor of chromatin-binding protein

0.354

GL6D1_HUMAN

Putative glycosyltransferase 6 domain-containing protein 1

0.354

TM219_HUMAN

Insulin-like growth factor-binding protein 3 receptor

0.356

RAGE_HUMAN

Advanced glycosylation end product-specific receptor

0.356

F186B_HUMAN

Protein FAM186B

0.356

ZKSC1_HUMAN

Zinc finger protein with KRAB and SCAN domains 1

0.356

CQ080_HUMAN

Uncharacterized protein C17orf80

0.356

DMKN_HUMAN

Dermokine

0.356

S10A8_HUMAN

Protein S100-A8

0.356

ZKSC2_HUMAN

Zinc finger protein with KRAB and SCAN domains 2

0.356

CC196_HUMAN

Putative coiled-coil domain-containing protein 196

0.356

ZN189_HUMAN

Zinc finger protein 189

0.359

CD70_HUMAN

CD70 antigen

0.359

ZN263_HUMAN

Zinc finger protein 263

0.359

ZN200_HUMAN

Zinc finger protein 200

0.359

DBND2_HUMAN

Dysbindin domain-containing protein 2

0.359

CC116_HUMAN

Coiled-coil domain-containing protein 116

0.359

OPALI_HUMAN

Opalin

0.359

CJ120_HUMAN

Uncharacterized protein C10orf120

0.359

G6B_HUMAN

Megakaryocyte and platelet inhibitory receptor G6b

0.359

F170A_HUMAN

Protein FAM170A

0.359

NGAL_HUMAN

Neutrophil gelatinase-associated lipocalin

0.359

TMC5A_HUMAN

Transmembrane and coiled-coil domain-containing protein 5A

0.359

TREM1_HUMAN

Triggering receptor expressed on myeloid cells 1

0.359

F229B_HUMAN

Protein FAM229B

0.359

AMTN_HUMAN

Amelotin

0.359

KRBA1_HUMAN

Protein KRBA1

0.359

ZFP1_HUMAN

Zinc finger protein 1 homolog

0.359

PRIC4_HUMAN

Prickle-like protein 4

0.372

T53G5_HUMAN

TP53-target gene 5 protein

0.372

ZSC20_HUMAN

Zinc finger and SCAN domain-containing protein 20

0.375

PA2GF_HUMAN

Group IIF secretory phospholipase A2

0.375

NAR3_HUMAN

Ecto-ADP-ribosyltransferase 3

0.375

ZN691_HUMAN

Zinc finger protein 691

0.378

ACTT3_HUMAN

Actin-related protein T3

0.378

ZSC10_HUMAN

Zinc finger and SCAN domain-containing protein 10

0.378

ZN184_HUMAN

Zinc finger protein 184

0.378

MEFV_HUMAN

Pyrin

0.378

TNF18_HUMAN

Tumor necrosis factor ligand superfamily member 18

0.378

BPIB1_HUMAN

BPI fold-containing family B member 1

0.378

BPIA1_HUMAN

BPI fold-containing family A member 1

0.378

CCL22_HUMAN

C-C motif chemokine 22

0.378

SPT25_HUMAN

Spermatogenesis-associated protein 25

0.378

TEX35_HUMAN

Testis-expressed protein 35

0.381

IL13_HUMAN

Interleukin-13

0.381

BEX3_HUMAN

Protein BEX3

0.381

IL33_HUMAN

Interleukin-33

0.381

PRR19_HUMAN

Proline-rich protein 19

0.381

TRIMM_HUMAN

Probable E3 ubiquitin-protein ligase TRIML2

0.381

ZN174_HUMAN

Zinc finger protein 174

0.381

MEPE_HUMAN

Matrix extracellular phosphoglycoprotein

0.381

ZNF48_HUMAN

Zinc finger protein 48

0.381

ETV2_HUMAN

ETS translocation variant 2

0.381

BPIA3_HUMAN

BPI fold-containing family A member 3

0.381

CAVN3_HUMAN

Caveolae-associated protein 3

0.381

IRGQ_HUMAN

Immunity-related GTPase family Q protein

0.381

ZSC25_HUMAN

Zinc finger and SCAN domain-containing protein 25

0.381

ZN445_HUMAN

Zinc finger protein 445

0.381

CB074_HUMAN

Uncharacterized protein C2orf74

0.381

MASTR_HUMAN

MEF2-activating motif and SAP domain-containing transcriptional regulator

0.381

ODAM_HUMAN

Odontogenic ameloblast-associated protein

0.381

CLD9_HUMAN

Claudin-9

0.381

CDSN_HUMAN

Corneodesmosin

0.381

F187B_HUMAN

Protein FAM187B

0.386

FSCN3_HUMAN

Fascin-3

0.386

ARM12_HUMAN

Armadillo repeat-containing protein 12

0.386

TROAP_HUMAN

Tastin

0.389

TBC21_HUMAN

TBC1 domain family member 21

0.389

DMRTD_HUMAN

Doublesex- and mab-3-related transcription factor C2

0.389

MSTRO_HUMAN

Protein maestro

0.392

CD27_HUMAN

CD27 antigen

0.392

CC121_HUMAN

Coiled-coil domain-containing protein 121

0.392

IL27A_HUMAN

Interleukin-27 subunit alpha

0.392

APOA2_HUMAN

Apolipoprotein A-II

0.392

SIT1_HUMAN

Signaling threshold-regulating transmembrane adapter 1

0.392

AKAP3_HUMAN

A-kinase anchor protein 3

0.392

CD14_HUMAN

Monocyte differentiation antigen CD14

0.395

RTBDN_HUMAN

Retbindin

0.395

MROH9_HUMAN

Maestro heat-like repeat-containing protein family member 9

0.395

ZSC29_HUMAN

Zinc finger and SCAN domain-containing protein 29

0.395

DPPA4_HUMAN

Developmental pluripotency-associated protein 4

0.395

ZN205_HUMAN

Zinc finger protein 205

0.395

CAGE1_HUMAN

Cancer-associated gene 1 protein

0.395

SHRM1_HUMAN

Protein Shroom1

0.398

SG3A2_HUMAN

Secretoglobin family 3A member 2

0.398

CXL16_HUMAN

C-X-C motif chemokine 16

0.398

IL7_HUMAN

Interleukin-7

0.398

CP090_HUMAN

Uncharacterized protein C16orf90

0.398

DPPA2_HUMAN

Developmental pluripotency-associated protein 2

0.398

PAHO_HUMAN

Pancreatic prohormone

0.398

ZN449_HUMAN

Zinc finger protein 449

0.398

F205A_HUMAN

Protein FAM205A

0.398

PRR3_HUMAN

Proline-rich protein 3

0.398

PTCA_HUMAN

Protein tyrosine phosphatase receptor type C-associated protein

0.398

GAST_HUMAN

Gastrin

0.398

TRML2_HUMAN

Trem-like transcript 2 protein

0.398

T126B_HUMAN

Complex I assembly factor TMEM126B, mitochondrial

0.398

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 10 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy