FOXH1_HUMAN 2019

Gene Name FOXH1

Description Forkhead box protein H1

Length 365

9606

Sequence

>sp|O75593|FOXH1_HUMAN Forkhead box protein H1
MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKPPYTYLAMIALVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNGGARGAFAKDLGPYVLHGRPYRPPSPPPPPSEGFSIKSLLGGSGEGAPWPGLAPQSSPVPAGTGNSGEEAVPTPPLPSSERPLWPLCPLPGPTRVEGETVQGGAIGPSTLSPEPRAWPLHLLQGTAVPGGRSSGGHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSCPQCPSTSPAYWGVAPETRGPPGLLCDLDALFQGVPPNKSIYDVWVSHPRDLAAPGPGWLLSWCSL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

T150B_HUMAN

Modulator of macroautophagy TMEM150B

0.229

CLD4_HUMAN

Claudin-4

0.229

CLD10_HUMAN

Claudin-10

0.309

TM121_HUMAN

Transmembrane protein 121

0.309

CXA1_HUMAN

Gap junction alpha-1 protein

0.309

CXA8_HUMAN

Gap junction alpha-8 protein

0.309

ZBT44_HUMAN

Zinc finger and BTB domain-containing protein 44

0.309

MYPC3_HUMAN

Myosin-binding protein C, cardiac-type

0.309

FABP6_HUMAN

Gastrotropin

0.309

CXB1_HUMAN

Gap junction beta-1 protein

0.309

FLRT2_HUMAN

Leucine-rich repeat transmembrane protein FLRT2

0.309

CXA10_HUMAN

Gap junction alpha-10 protein

0.309

CXG1_HUMAN

Gap junction gamma-1 protein

0.309

CLD8_HUMAN

Claudin-8

0.309

MYPC1_HUMAN

Myosin-binding protein C, slow-type

0.309

IKZF2_HUMAN

Zinc finger protein Helios

0.309

TNNC1_HUMAN

Troponin C, slow skeletal and cardiac muscles

0.309

DESM_HUMAN

Desmin

0.309

CLD19_HUMAN

Claudin-19

0.316

SPEG_HUMAN

Striated muscle preferentially expressed protein kinase

0.316

MA7D1_HUMAN

MAP7 domain-containing protein 1

0.316

LURA1_HUMAN

Leucine rich adaptor protein 1

0.324

MBD1_HUMAN

Methyl-CpG-binding domain protein 1

0.324

CC106_HUMAN

Coiled-coil domain-containing protein 106

0.324

INKA1_HUMAN

PAK4-inhibitor INKA1

0.324

HEMO_HUMAN

Hemopexin

0.324

DHX32_HUMAN

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32

0.324

F1712_HUMAN

Protein FAM171A2

0.324

CLD15_HUMAN

Claudin-15

0.324

FIBG_HUMAN

Fibrinogen gamma chain

0.369

NEXN_HUMAN

Nexilin

0.369

CAD15_HUMAN

Cadherin-15

0.369

IKZF5_HUMAN

Zinc finger protein Pegasus

0.369

CXB6_HUMAN

Gap junction beta-6 protein

0.378

CLD14_HUMAN

Claudin-14

0.378

ZN142_HUMAN

Zinc finger protein 142

0.378

CXA3_HUMAN

Gap junction alpha-3 protein

0.378

GPC5B_HUMAN

G-protein coupled receptor family C group 5 member B

0.378

IKZF4_HUMAN

Zinc finger protein Eos

0.378

FBLN7_HUMAN

Fibulin-7

0.378

CALD1_HUMAN

Caldesmon

0.378

FIL1L_HUMAN

Filamin A-interacting protein 1-like

0.378

EPYC_HUMAN

Epiphycan

0.378

GT2D1_HUMAN

General transcription factor II-I repeat domain-containing protein 1

0.378

SLIK6_HUMAN

SLIT and NTRK-like protein 6

0.378

JAM3_HUMAN

Junctional adhesion molecule C

0.378

STXB6_HUMAN

Syntaxin-binding protein 6

0.378

RL3R1_HUMAN

Relaxin-3 receptor 1

0.378

IKZF1_HUMAN

DNA-binding protein Ikaros

0.378

NECT2_HUMAN

Nectin-2

0.378

AKAP2_HUMAN

A-kinase anchor protein 2

0.378

MUC18_HUMAN

Cell surface glycoprotein MUC18

0.378

T150A_HUMAN

Transmembrane protein 150A

0.378

EFNA5_HUMAN

Ephrin-A5

0.378

BORG2_HUMAN

Cdc42 effector protein 3

0.378

SEM3F_HUMAN

Semaphorin-3F

0.378

CD166_HUMAN

CD166 antigen

0.378

DLK2_HUMAN

Protein delta homolog 2

0.378

ZN827_HUMAN

Zinc finger protein 827

0.378

FLIP1_HUMAN

Filamin-A-interacting protein 1

0.378

SLIK5_HUMAN

SLIT and NTRK-like protein 5

0.378

ARTN_HUMAN

Artemin

0.387

GPC5C_HUMAN

G-protein coupled receptor family C group 5 member C

0.387

CK2N2_HUMAN

Calcium/calmodulin-dependent protein kinase II inhibitor 2

0.387

CLUS_HUMAN

Clusterin

0.387

CNRG_HUMAN

Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit gamma

0.387

EPOR_HUMAN

Erythropoietin receptor

0.387

FA83C_HUMAN

Protein FAM83C

0.387

MYPC2_HUMAN

Myosin-binding protein C, fast-type

0.387

PERF_HUMAN

Perforin-1

0.387

CX038_HUMAN

Uncharacterized protein CXorf38

0.387

CAD26_HUMAN

Cadherin-like protein 26

0.387

PRR35_HUMAN

Proline-rich protein 35

0.387

HEG1_HUMAN

Protein HEG homolog 1

0.387

CALCB_HUMAN

Calcitonin gene-related peptide 2

0.387

K1C14_HUMAN

Keratin, type I cytoskeletal 14

0.387

PDYN_HUMAN

Proenkephalin-B

0.387

ZN217_HUMAN

Zinc finger protein 217

0.387

CSH2_HUMAN

Chorionic somatomammotropin hormone 2

0.387

INHA_HUMAN

Inhibin alpha chain

0.387

SOMA_HUMAN

Somatotropin

0.387

CSH1_HUMAN

Chorionic somatomammotropin hormone 1

0.387

SCAR3_HUMAN

Scavenger receptor class A member 3

0.387

SPRY4_HUMAN

SPRY domain-containing protein 4

0.387

UIMC1_HUMAN

BRCA1-A complex subunit RAP80

0.387

UFO_HUMAN

Tyrosine-protein kinase receptor UFO

0.387

ESAM_HUMAN

Endothelial cell-selective adhesion molecule

0.387

CART_HUMAN

Cocaine- and amphetamine-regulated transcript protein

0.387

IL2RG_HUMAN

Cytokine receptor common subunit gamma

0.387

T178A_HUMAN

Transmembrane protein 178A

0.387

OCSTP_HUMAN

Osteoclast stimulatory transmembrane protein

0.387

T150C_HUMAN

Transmembrane protein 150C

0.387

ASC_HUMAN

Apoptosis-associated speck-like protein containing a CARD

0.387

VTM2L_HUMAN

V-set and transmembrane domain-containing protein 2-like protein

0.387

SOM2_HUMAN

Growth hormone variant

0.387

CEAM5_HUMAN

Carcinoembryonic antigen-related cell adhesion molecule 5

0.387

SIG15_HUMAN

Sialic acid-binding Ig-like lectin 15

0.387

TOR4A_HUMAN

Torsin-4A

0.387

EMP3_HUMAN

Epithelial membrane protein 3

0.387

GPR17_HUMAN

Uracil nucleotide/cysteinyl leukotriene receptor

0.387

LSR_HUMAN

Lipolysis-stimulated lipoprotein receptor

0.387

MAG_HUMAN

Myelin-associated glycoprotein

0.387

TRI44_HUMAN

Tripartite motif-containing protein 44

0.397

CRBG1_HUMAN

Beta/gamma crystallin domain-containing protein 1

0.397

SRRM4_HUMAN

Serine/arginine repetitive matrix protein 4

0.397

RHBD3_HUMAN

Rhomboid domain-containing protein 3

0.397

CXB2_HUMAN

Gap junction beta-2 protein

0.397

TELT_HUMAN

Telethonin

0.397

APOE_HUMAN

Apolipoprotein E

0.397

EFNA1_HUMAN

Ephrin-A1

0.397

GPR25_HUMAN

Probable G-protein coupled receptor 25

0.397

ECM1_HUMAN

Extracellular matrix protein 1

0.397

F131C_HUMAN

Protein FAM131C

0.397

GPBAR_HUMAN

G-protein coupled bile acid receptor 1

0.397

SE6L2_HUMAN

Seizure 6-like protein 2

0.397

CLC11_HUMAN

C-type lectin domain family 11 member A

0.397

CXB3_HUMAN

Gap junction beta-3 protein

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CXB2_HUMAN

Gap junction beta-2 protein

0.364

IKZF4_HUMAN

Zinc finger protein Eos

0.374

EMP3_HUMAN

Epithelial membrane protein 3

0.376

RHBD3_HUMAN

Rhomboid domain-containing protein 3

0.380

NECT2_HUMAN

Nectin-2

0.389

SPRY4_HUMAN

SPRY domain-containing protein 4

0.391

ECM1_HUMAN

Extracellular matrix protein 1

0.393

CX038_HUMAN

Uncharacterized protein CXorf38

0.393

CC106_HUMAN

Coiled-coil domain-containing protein 106

0.396

EPO_HUMAN

Erythropoietin

0.398

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 19 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy