MTA2_HUMAN 2019

Gene Name MTA2

Description Metastasis-associated protein MTA2

Length 668

9606

Sequence

>sp|O94776|MTA2_HUMAN Metastasis-associated protein MTA2
MAANMYRVGDYVYFENSSSNPYLVRRIEELNKTANGNVEAKVVCLFRRRDISSSLNSLADSNAREFEEESKQPGVSEQQRHQLKHRELFLSRQFESLPATHIRGKCSVTLLNETDILSQYLEKEDCFFYSLVFDPVQKTLLADQGEIRVGCKYQAEIPDRLVEGESDNRNQQKMEMKVWDPDNPLTDRQIDQFLVVARAVGTFARALDCSSSIRQPSLHMSAAAASRDITLFHAMDTLQRNGYDLAKAMSTLVPQGGPVLCRDEMEEWSASEAMLFEEALEKYGKDFNDIRQDFLPWKSLASIVQFYYMWKTTDRYIQQKRLKAAEADSKLKQVYIPTYTKPNPNQIISVGSKPGMNGAGFQKGLTCESCHTTQSAQWYAWGPPNMQCRLCASCWIYWKKYGGLKTPTQLEGATRGTTEPHSRGHLSRPEAQSLSPYTTSANRAKLLAKNRQTFLLQTTKLTRLARRMCRDLLQPRRAARRPYAPINANAIKAECSIRLPKAAKTPLKIHPLVRLPLATIVKDLVAQAPLKPKTPRGTKTPINRNQLSQNRGLGGIMVKRAYETMAGAGVPFSANGRPLASGIRSSSQPAAKRQKLNPADAPNPVVFVATKDTRALRKALTHLEMRRAARRPNLPLKVKPTLIAVRPPVPLPAPSHPASTNEPIVLED

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

NEB2_HUMAN

Neurabin-2

0.280

FERM2_HUMAN

Fermitin family homolog 2

0.336

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.336

FERM1_HUMAN

Fermitin family homolog 1

0.336

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.340

CPEB1_HUMAN

Cytoplasmic polyadenylation element-binding protein 1

0.340

PHF10_HUMAN

PHD finger protein 10

0.357

MTA1_HUMAN

Metastasis-associated protein MTA1

0.360

SNX6_HUMAN

Sorting nexin-6

0.360

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.360

RIMB2_HUMAN

RIMS-binding protein 2

0.363

BMP2_HUMAN

Bone morphogenetic protein 2

0.363

WLS_HUMAN

Protein wntless homolog

0.363

CPEB3_HUMAN

Cytoplasmic polyadenylation element-binding protein 3

0.363

TGFR1_HUMAN

TGF-beta receptor type-1

0.363

TSN5_HUMAN

Tetraspanin-5

0.367

SMAD9_HUMAN

Mothers against decapentaplegic homolog 9

0.367

ARFP1_HUMAN

Arfaptin-1

0.381

AFAD_HUMAN

Afadin

0.381

ECSIT_HUMAN

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

0.381

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.381

FGFR2_HUMAN

Fibroblast growth factor receptor 2

0.385

MTA3_HUMAN

Metastasis-associated protein MTA3

0.385

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.385

TRAM1_HUMAN

Translocating chain-associated membrane protein 1

0.385

ANKY2_HUMAN

Ankyrin repeat and MYND domain-containing protein 2

0.385

SYT1_HUMAN

Synaptotagmin-1

0.385

RUNX2_HUMAN

Runt-related transcription factor 2

0.385

BAF_HUMAN

Barrier-to-autointegration factor

0.385

FGFR1_HUMAN

Fibroblast growth factor receptor 1

0.385

MIGA1_HUMAN

Mitoguardin 1

0.385

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.389

RUND1_HUMAN

RUN domain-containing protein 1

0.389

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.389

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.389

HTF4_HUMAN

Transcription factor 12

0.389

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.389

APLP2_HUMAN

Amyloid-like protein 2

0.389

BMP4_HUMAN

Bone morphogenetic protein 4

0.389

WNT5A_HUMAN

Protein Wnt-5a

0.389

JIP3_HUMAN

C-Jun-amino-terminal kinase-interacting protein 3

0.389

JPH1_HUMAN

Junctophilin-1

0.389

BMP7_HUMAN

Bone morphogenetic protein 7

0.389

AT1B4_HUMAN

Protein ATP1B4

0.389

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.389

CPEB4_HUMAN

Cytoplasmic polyadenylation element-binding protein 4

0.389

E41L1_HUMAN

Band 4.1-like protein 1

0.392

URP2_HUMAN

Fermitin family homolog 3

0.396

C43BP_HUMAN

Collagen type IV alpha-3-binding protein

0.397

SPTN1_HUMAN

Spectrin alpha chain, non-erythrocytic 1

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ECSIT_HUMAN

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

0.351

TSN5_HUMAN

Tetraspanin-5

0.363

RUNX2_HUMAN

Runt-related transcription factor 2

0.364

BAF_HUMAN

Barrier-to-autointegration factor

0.364

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.366

ITB1_HUMAN

Integrin beta-1

0.366

FERM2_HUMAN

Fermitin family homolog 2

0.368

PHKG2_HUMAN

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

0.369

AT1B2_HUMAN

Sodium/potassium-transporting ATPase subunit beta-2

0.369

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.369

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.372

DVL2_HUMAN

Segment polarity protein dishevelled homolog DVL-2

0.373

BMP2_HUMAN

Bone morphogenetic protein 2

0.373

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.374

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.374

PLXA2_HUMAN

Plexin-A2

0.374

HINFP_HUMAN

Histone H4 transcription factor

0.374

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.374

AT1B4_HUMAN

Protein ATP1B4

0.374

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.374

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.374

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.374

TEF_HUMAN

Thyrotroph embryonic factor

0.375

AFAD_HUMAN

Afadin

0.376

MYL4_HUMAN

Myosin light chain 4

0.378

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.379

WLS_HUMAN

Protein wntless homolog

0.380

FERM1_HUMAN

Fermitin family homolog 1

0.380

MTA1_HUMAN

Metastasis-associated protein MTA1

0.380

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.380

TRIO_HUMAN

Triple functional domain protein

0.380

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.380

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.380

HLF_HUMAN

Hepatic leukemia factor

0.381

ACK1_HUMAN

Activated CDC42 kinase 1

0.382

CSKP_HUMAN

Peripheral plasma membrane protein CASK

0.383

3BP5L_HUMAN

SH3 domain-binding protein 5-like

0.383

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.384

NEB2_HUMAN

Neurabin-2

0.384

PICK1_HUMAN

PRKCA-binding protein

0.385

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.385

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.385

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.386

RSBN1_HUMAN

Lysine-specific demethylase 9

0.386

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.386

FGFR1_HUMAN

Fibroblast growth factor receptor 1

0.386

RIMB2_HUMAN

RIMS-binding protein 2

0.386

ARFP2_HUMAN

Arfaptin-2

0.386

NUMB_HUMAN

Protein numb homolog

0.386

TSN17_HUMAN

Tetraspanin-17

0.386

RUND1_HUMAN

RUN domain-containing protein 1

0.387

AT1B3_HUMAN

Sodium/potassium-transporting ATPase subunit beta-3

0.387

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.388

PAR6A_HUMAN

Partitioning defective 6 homolog alpha

0.389

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.389

CACB1_HUMAN

Voltage-dependent L-type calcium channel subunit beta-1

0.389

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.390

CBL_HUMAN

E3 ubiquitin-protein ligase CBL

0.390

ARFP1_HUMAN

Arfaptin-1

0.390

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.390

CACB4_HUMAN

Voltage-dependent L-type calcium channel subunit beta-4

0.391

MAPK2_HUMAN

MAP kinase-activated protein kinase 2

0.391

PP4P1_HUMAN

Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.391

MIGA1_HUMAN

Mitoguardin 1

0.392

MADD_HUMAN

MAP kinase-activating death domain protein

0.392

UNC79_HUMAN

Protein unc-79 homolog

0.393

PLXA4_HUMAN

Plexin-A4

0.393

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.393

BCL7B_HUMAN

B-cell CLL/lymphoma 7 protein family member B

0.393

RIPL1_HUMAN

RILP-like protein 1

0.393

H6ST1_HUMAN

Heparan-sulfate 6-O-sulfotransferase 1

0.394

PHKG1_HUMAN

Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

0.394

UNC5D_HUMAN

Netrin receptor UNC5D

0.394

SYT1_HUMAN

Synaptotagmin-1

0.394

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.394

IP3KC_HUMAN

Inositol-trisphosphate 3-kinase C

0.395

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.395

ACADV_HUMAN

Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

0.395

ITF2_HUMAN

Transcription factor 4

0.395

MIGA2_HUMAN

Mitoguardin 2

0.396

ITB3_HUMAN

Integrin beta-3

0.396

ONEC2_HUMAN

One cut domain family member 2

0.396

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.397

BMP4_HUMAN

Bone morphogenetic protein 4

0.397

RT25_HUMAN

28S ribosomal protein S25, mitochondrial

0.397

VAV2_HUMAN

Guanine nucleotide exchange factor VAV2

0.397

BICD1_HUMAN

Protein bicaudal D homolog 1

0.398

SMAD9_HUMAN

Mothers against decapentaplegic homolog 9

0.398

ANLN_HUMAN

Anillin

0.398

HTF4_HUMAN

Transcription factor 12

0.398

NDUAA_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

0.398

RB6I2_HUMAN

ELKS/Rab6-interacting/CAST family member 1

0.399

BMP7_HUMAN

Bone morphogenetic protein 7

0.399

MACOI_HUMAN

Macoilin

0.399

FA8A1_HUMAN

Protein FAM8A1

0.399

H6ST2_HUMAN

Heparan-sulfate 6-O-sulfotransferase 2

0.399

HS2ST_HUMAN

Heparan sulfate 2-O-sulfotransferase 1

0.399

IP3KB_HUMAN

Inositol-trisphosphate 3-kinase B

0.399

TFAP4_HUMAN

Transcription factor AP-4

0.399

PO4F3_HUMAN

POU domain, class 4, transcription factor 3

0.400

TAOK1_HUMAN

Serine/threonine-protein kinase TAO1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 48 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy