CXB5_HUMAN 2019

Gene Name CXB5

Description Gap junction beta-5 protein

Length 273

9606

Sequence

>sp|O95377|CXB5_HUMAN Gap junction beta-5 protein
MNWSIFEGLLSGVNKYSTAFGRIWLSLVFIFRVLVYLVTAERVWSDDHKDFDCNTRQPGCSNVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREVQEKRHREAHGENSGRLYLNPGKKRGGLWWTYVCSLVFKASVDIAFLYVFHSFYPKYILPPVVKCHADPCPNIVDCFISKPSEKNIFTLFMVATAAICILLNLVELIYLVSKRCHECLAARKAQAMCTGHHPHGTTSSCKQDDLLSGDLIFLGSDSHPPLLPDRPRDHVKKTIL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

PLM_HUMAN

Phospholemman

0.267

SN_HUMAN

Sialoadhesin

0.267

O10A5_HUMAN

Olfactory receptor 10A5

0.277

INAR2_HUMAN

Interferon alpha/beta receptor 2

0.277

TM52B_HUMAN

Transmembrane protein 52B

0.277

BPIB4_HUMAN

BPI fold-containing family B member 4

0.277

ACRBP_HUMAN

Acrosin-binding protein

0.277

PRIO_HUMAN

Major prion protein

0.277

TREM2_HUMAN

Triggering receptor expressed on myeloid cells 2

0.277

CD8A_HUMAN

T-cell surface glycoprotein CD8 alpha chain

0.277

PSPC_HUMAN

Pulmonary surfactant-associated protein C

0.277

O11A1_HUMAN

Olfactory receptor 11A1

0.277

MYOZ3_HUMAN

Myozenin-3

0.277

OPT_HUMAN

Opticin

0.277

MISP_HUMAN

Mitotic interactor and substrate of PLK1

0.365

IL6_HUMAN

Interleukin-6

0.365

INY2B_HUMAN

Protein INSYN2B

0.365

PKHS1_HUMAN

Pleckstrin homology domain-containing family S member 1

0.365

RB8NL_HUMAN

RBBP8 N-terminal-like protein

0.365

TRI47_HUMAN

E3 ubiquitin-protein ligase TRIM47

0.378

INGR1_HUMAN

Interferon gamma receptor 1

0.378

CO8A1_HUMAN

Collagen alpha-1(VIII) chain

0.378

BRNP2_HUMAN

BMP/retinoic acid-inducible neural-specific protein 2

0.378

ZN654_HUMAN

Zinc finger protein 654

0.378

RAI3_HUMAN

Retinoic acid-induced protein 3

0.378

LNP1_HUMAN

Leukemia NUP98 fusion partner 1

0.378

ICAM5_HUMAN

Intercellular adhesion molecule 5

0.378

LPAR5_HUMAN

Lysophosphatidic acid receptor 5

0.378

CNCG_HUMAN

Retinal cone rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit gamma

0.378

IL22_HUMAN

Interleukin-22

0.378

HMGN2_HUMAN

Non-histone chromosomal protein HMG-17

0.378

INGR2_HUMAN

Interferon gamma receptor 2

0.378

IGSF1_HUMAN

Immunoglobulin superfamily member 1

0.378

TAF1D_HUMAN

TATA box-binding protein-associated factor RNA polymerase I subunit D

0.378

TRI29_HUMAN

Tripartite motif-containing protein 29

0.378

IRAK2_HUMAN

Interleukin-1 receptor-associated kinase-like 2

0.378

AKAP8_HUMAN

A-kinase anchor protein 8

0.378

RILP_HUMAN

Rab-interacting lysosomal protein

0.378

NPVF_HUMAN

Pro-FMRFamide-related neuropeptide VF

0.378

CD80_HUMAN

T-lymphocyte activation antigen CD80

0.392

IFNL3_HUMAN

Interferon lambda-3

0.392

IL9R_HUMAN

Interleukin-9 receptor

0.392

NPS_HUMAN

Neuropeptide S

0.392

CD72_HUMAN

B-cell differentiation antigen CD72

0.392

GKN2_HUMAN

Gastrokine-2

0.392

DMB_HUMAN

HLA class II histocompatibility antigen, DM beta chain

0.392

TM140_HUMAN

Transmembrane protein 140

0.392

PDCD1_HUMAN

Programmed cell death protein 1

0.392

GSDMA_HUMAN

Gasdermin-A

0.392

RESF1_HUMAN

Retroelement silencing factor 1

0.392

BASP1_HUMAN

Brain acid soluble protein 1

0.392

S10AB_HUMAN

Protein S100-A11

0.392

NFAM1_HUMAN

NFAT activation molecule 1

0.392

C3AR_HUMAN

C3a anaphylatoxin chemotactic receptor

0.392

DMA_HUMAN

HLA class II histocompatibility antigen, DM alpha chain

0.392

AKAP5_HUMAN

A-kinase anchor protein 5

0.392

CENPA_HUMAN

Histone H3-like centromeric protein A

0.392

MALL_HUMAN

MAL-like protein

0.392

NXPH3_HUMAN

Neurexophilin-3

0.392

K1C23_HUMAN

Keratin, type I cytoskeletal 23

0.392

O5AR1_HUMAN

Olfactory receptor 5AR1

0.392

OSTP_HUMAN

Osteopontin

0.392

VEXIN_HUMAN

Vexin

0.392

M4A15_HUMAN

Membrane-spanning 4-domains subfamily A member 15

0.392

OR6B1_HUMAN

Olfactory receptor 6B1

0.392

CLBA1_HUMAN

Uncharacterized protein CLBA1

0.392

MTCP1_HUMAN

Protein p13 MTCP-1

0.392

CO062_HUMAN

Uncharacterized protein C15orf62, mitochondrial

0.392

LY6E_HUMAN

Lymphocyte antigen 6E

0.392

IL15_HUMAN

Interleukin-15

0.392

TB182_HUMAN

182 kDa tankyrase-1-binding protein

0.392

IFNL1_HUMAN

Interferon lambda-1

0.392

ZN639_HUMAN

Zinc finger protein 639

0.392

CD5_HUMAN

T-cell surface glycoprotein CD5

0.392

SPERT_HUMAN

Spermatid-associated protein

0.392

I10R1_HUMAN

Interleukin-10 receptor subunit alpha

0.392

TNFL8_HUMAN

Tumor necrosis factor ligand superfamily member 8

0.392

MROH7_HUMAN

Maestro heat-like repeat-containing protein family member 7

0.392

ZPBP1_HUMAN

Zona pellucida-binding protein 1

0.392

FYB2_HUMAN

FYN-binding protein 2

0.392

MISSL_HUMAN

MAPK-interacting and spindle-stabilizing protein-like

0.392

HRG_HUMAN

Histidine-rich glycoprotein

0.392

CF132_HUMAN

Uncharacterized protein C6orf132

0.392

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

BPIB4_HUMAN

BPI fold-containing family B member 4

0.378

THY1_HUMAN

Thy-1 membrane glycoprotein

0.392

INGR2_HUMAN

Interferon gamma receptor 2

0.395

S10AB_HUMAN

Protein S100-A11

0.395

TREM2_HUMAN

Triggering receptor expressed on myeloid cells 2

0.395

VEXIN_HUMAN

Vexin

0.397

CD28_HUMAN

T-cell-specific surface glycoprotein CD28

0.398

MO2R1_HUMAN

Cell surface glycoprotein CD200 receptor 1

0.398

PRIO_HUMAN

Major prion protein

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 13 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy