TNNC2_HUMAN 2019

Gene Name TNNC2

Description Troponin C, skeletal muscle

Length 160

9606

Sequence

>sp|P02585|TNNC2_HUMAN Troponin C, skeletal muscle
MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDPEELAEIFRASGEHVTDEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

PHLA1_HUMAN

Pleckstrin homology-like domain family A member 1

0.333

CLD19_HUMAN

Claudin-19

0.387

AINX_HUMAN

Alpha-internexin

0.387

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

TNNC1_HUMAN

Troponin C, slow skeletal and cardiac muscles

0.281

FABP6_HUMAN

Gastrotropin

0.346

BORG2_HUMAN

Cdc42 effector protein 3

0.372

NECT3_HUMAN

Nectin-3

0.372

CXB1_HUMAN

Gap junction beta-1 protein

0.372

STXB6_HUMAN

Syntaxin-binding protein 6

0.372

PCOC2_HUMAN

Procollagen C-endopeptidase enhancer 2

0.372

MMP9_HUMAN

Matrix metalloproteinase-9

0.374

STYK1_HUMAN

Tyrosine-protein kinase STYK1

0.374

MYPC3_HUMAN

Myosin-binding protein C, cardiac-type

0.374

CXB6_HUMAN

Gap junction beta-6 protein

0.376

STC1_HUMAN

Stanniocalcin-1

0.383

NEXN_HUMAN

Nexilin

0.383

NECT1_HUMAN

Nectin-1

0.383

CD166_HUMAN

CD166 antigen

0.385

IKZF2_HUMAN

Zinc finger protein Helios

0.385

ZN142_HUMAN

Zinc finger protein 142

0.385

FBLN7_HUMAN

Fibulin-7

0.385

CXG1_HUMAN

Gap junction gamma-1 protein

0.385

MYPC1_HUMAN

Myosin-binding protein C, slow-type

0.385

CEP55_HUMAN

Centrosomal protein of 55 kDa

0.385

T150A_HUMAN

Transmembrane protein 150A

0.385

FMOD_HUMAN

Fibromodulin

0.387

CKLF3_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 3

0.387

CLD11_HUMAN

Claudin-11

0.387

F131B_HUMAN

Protein FAM131B

0.387

CCR7_HUMAN

C-C chemokine receptor type 7

0.387

ZN335_HUMAN

Zinc finger protein 335

0.387

CXD2_HUMAN

Gap junction delta-2 protein

0.387

CLD10_HUMAN

Claudin-10

0.387

PCD10_HUMAN

Protocadherin-10

0.389

DHX32_HUMAN

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32

0.389

IBP2_HUMAN

Insulin-like growth factor-binding protein 2

0.389

ZN711_HUMAN

Zinc finger protein 711

0.389

PCD12_HUMAN

Protocadherin-12

0.391

RIC3_HUMAN

Protein RIC-3

0.396

STC2_HUMAN

Stanniocalcin-2

0.396

ZBT44_HUMAN

Zinc finger and BTB domain-containing protein 44

0.396

NFL_HUMAN

Neurofilament light polypeptide

0.396

SH3B4_HUMAN

SH3 domain-binding protein 4

0.396

ZPLD1_HUMAN

Zona pellucida-like domain-containing protein 1

0.398

PCD19_HUMAN

Protocadherin-19

0.398

VSTM4_HUMAN

V-set and transmembrane domain-containing protein 4

0.398

CO7_HUMAN

Complement component C7

0.398

CALD1_HUMAN

Caldesmon

0.398

JAM3_HUMAN

Junctional adhesion molecule C

0.398

PENK_HUMAN

Proenkephalin-A

0.398

FAKD2_HUMAN

FAST kinase domain-containing protein 2, mitochondrial

0.398

LEG1_HUMAN

Galectin-1

0.398

OCLN_HUMAN

Occludin

0.398

NEXMI_HUMAN

Neurite extension and migration factor

0.398

PRL_HUMAN

Prolactin

0.398

MYZAP_HUMAN

Myocardial zonula adherens protein

0.398

NPY_HUMAN

Pro-neuropeptide Y

0.398

PDGFC_HUMAN

Platelet-derived growth factor C

0.398

ZN131_HUMAN

Zinc finger protein 131

0.398

SYBU_HUMAN

Syntabulin

0.398

MERB1_HUMAN

bMERB domain-containing protein 1

0.398

ADNP_HUMAN

Activity-dependent neuroprotector homeobox protein

0.398

MFA3L_HUMAN

Microfibrillar-associated protein 3-like

0.398

CRBB1_HUMAN

Beta-crystallin B1

0.398

CBLN4_HUMAN

Cerebellin-4

0.398

GHR_HUMAN

Growth hormone receptor

0.398

P33MX_HUMAN

Putative monooxygenase p33MONOX

0.398

EPYC_HUMAN

Epiphycan

0.398

ZN644_HUMAN

Zinc finger protein 644

0.398

K1107_HUMAN

AP2-interacting clathrin-endocytosis protein

0.400

PATZ1_HUMAN

POZ-, AT hook-, and zinc finger-containing protein 1

0.400

F222B_HUMAN

Protein FAM222B

0.400

ZBT20_HUMAN

Zinc finger and BTB domain-containing protein 20

0.400

GPC5C_HUMAN

G-protein coupled receptor family C group 5 member C

0.400

SLIK1_HUMAN

SLIT and NTRK-like protein 1

0.400

BSPRY_HUMAN

B box and SPRY domain-containing protein

0.400

AGTR1_HUMAN

Type-1 angiotensin II receptor

0.400

PEPL_HUMAN

Periplakin

0.400

CAVN2_HUMAN

Caveolae-associated protein 2

0.400

ERRFI_HUMAN

ERBB receptor feedback inhibitor 1

0.400

CC126_HUMAN

Coiled-coil domain-containing protein 126

0.400

GDF9_HUMAN

Growth/differentiation factor 9

0.400

TSN1_HUMAN

Tetraspanin-1

0.400

ZN652_HUMAN

Zinc finger protein 652

0.400

DLK2_HUMAN

Protein delta homolog 2

0.400

TNMD_HUMAN

Tenomodulin

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 17 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy