FIBA_HUMAN 2019

Gene Name FIBA

Description Fibrinogen alpha chain

Length 866

9606

Sequence

>sp|P02671|FIBA_HUMAN Fibrinogen alpha chain
MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRNNSPYEIENGVVWVSFRGADYSLRAVRMKIRPLVTQ

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

AMER2_HUMAN

APC membrane recruitment protein 2

0.324

FIBB_HUMAN

Fibrinogen beta chain

0.369

ASGR1_HUMAN

Asialoglycoprotein receptor 1

0.378

OLFL3_HUMAN

Olfactomedin-like protein 3

0.378

COGA1_HUMAN

Collagen alpha-1(XVI) chain

0.387

IGSF3_HUMAN

Immunoglobulin superfamily member 3

0.387

PECA1_HUMAN

Platelet endothelial cell adhesion molecule

0.387

NUCKS_HUMAN

Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

0.387

EDN1_HUMAN

Endothelin-1

0.387

MAP9_HUMAN

Microtubule-associated protein 9

0.387

IL10_HUMAN

Interleukin-10

0.387

CXCR5_HUMAN

C-X-C chemokine receptor type 5

0.387

IL21R_HUMAN

Interleukin-21 receptor

0.387

AZI2_HUMAN

5-azacytidine-induced protein 2

0.387

CD44_HUMAN

CD44 antigen

0.387

APC16_HUMAN

Anaphase-promoting complex subunit 16

0.387

FGF23_HUMAN

Fibroblast growth factor 23

0.387

P2Y10_HUMAN

Putative P2Y purinoceptor 10

0.387

CMGA_HUMAN

Chromogranin-A

0.387

GOGB1_HUMAN

Golgin subfamily B member 1

0.387

MYNN_HUMAN

Myoneurin

0.387

CD3Z_HUMAN

T-cell surface glycoprotein CD3 zeta chain

0.387

SCN3B_HUMAN

Sodium channel subunit beta-3

0.387

C99L2_HUMAN

CD99 antigen-like protein 2

0.387

SHPS1_HUMAN

Tyrosine-protein phosphatase non-receptor type substrate 1

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

FIBB_HUMAN

Fibrinogen beta chain

0.333

AZI2_HUMAN

5-azacytidine-induced protein 2

0.366

ITGBL_HUMAN

Integrin beta-like protein 1

0.366

M3K8_HUMAN

Mitogen-activated protein kinase kinase kinase 8

0.366

F163A_HUMAN

Protein FAM163A

0.368

CR025_HUMAN

Uncharacterized protein C18orf25

0.368

IL12B_HUMAN

Interleukin-12 subunit beta

0.368

A0A0G2JMH6_HUMAN

HLA-DRA

0.370

DRA_HUMAN

HLA class II histocompatibility antigen, DR alpha chain

0.370

OCLN_HUMAN

Occludin

0.378

SYBU_HUMAN

Syntabulin

0.378

NPY_HUMAN

Pro-neuropeptide Y

0.378

VSTM4_HUMAN

V-set and transmembrane domain-containing protein 4

0.378

PDGFC_HUMAN

Platelet-derived growth factor C

0.378

CDHR1_HUMAN

Cadherin-related family member 1

0.378

PEDF_HUMAN

Pigment epithelium-derived factor

0.378

LEG1_HUMAN

Galectin-1

0.378

MYZAP_HUMAN

Myocardial zonula adherens protein

0.378

ZPLD1_HUMAN

Zona pellucida-like domain-containing protein 1

0.378

PRL_HUMAN

Prolactin

0.378

P33MX_HUMAN

Putative monooxygenase p33MONOX

0.378

GHR_HUMAN

Growth hormone receptor

0.378

NEXMI_HUMAN

Neurite extension and migration factor

0.378

ZN131_HUMAN

Zinc finger protein 131

0.378

ADNP_HUMAN

Activity-dependent neuroprotector homeobox protein

0.378

ZN644_HUMAN

Zinc finger protein 644

0.378

MFA3L_HUMAN

Microfibrillar-associated protein 3-like

0.378

PENK_HUMAN

Proenkephalin-A

0.378

MERB1_HUMAN

bMERB domain-containing protein 1

0.378

SCN3B_HUMAN

Sodium channel subunit beta-3

0.380

FNDC7_HUMAN

Fibronectin type III domain-containing protein 7

0.380

CMGA_HUMAN

Chromogranin-A

0.380

HBEGF_HUMAN

Proheparin-binding EGF-like growth factor

0.380

TSG6_HUMAN

Tumor necrosis factor-inducible gene 6 protein

0.380

F168B_HUMAN

Myelin-associated neurite-outgrowth inhibitor

0.380

REST_HUMAN

RE1-silencing transcription factor

0.380

MAL_HUMAN

Myelin and lymphocyte protein

0.380

CFAI_HUMAN

Complement factor I

0.380

UIF_HUMAN

UAP56-interacting factor

0.380

PGFRL_HUMAN

Platelet-derived growth factor receptor-like protein

0.380

CAHM1_HUMAN

Calcium homeostasis modulator protein 1

0.382

PECA1_HUMAN

Platelet endothelial cell adhesion molecule

0.382

I13R2_HUMAN

Interleukin-13 receptor subunit alpha-2

0.382

R51A1_HUMAN

RAD51-associated protein 1

0.384

VTNC_HUMAN

Vitronectin

0.389

GCR_HUMAN

Glucocorticoid receptor

0.389

CD166_HUMAN

CD166 antigen

0.389

TM206_HUMAN

Transmembrane protein 206

0.389

CEP55_HUMAN

Centrosomal protein of 55 kDa

0.389

PROS_HUMAN

Vitamin K-dependent protein S

0.389

CCD80_HUMAN

Coiled-coil domain-containing protein 80

0.389

ZN142_HUMAN

Zinc finger protein 142

0.389

F1711_HUMAN

Protein FAM171A1

0.391

MNAR1_HUMAN

Major intrinsically disordered Notch2-binding receptor 1

0.391

SKA3_HUMAN

Spindle and kinetochore-associated protein 3

0.391

EDAR_HUMAN

Tumor necrosis factor receptor superfamily member EDAR

0.391

NLRX1_HUMAN

NLR family member X1

0.391

ZP3_HUMAN

Zona pellucida sperm-binding protein 3

0.391

BFSP1_HUMAN

Filensin

0.391

CXCR4_HUMAN

C-X-C chemokine receptor type 4

0.391

CKLF3_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 3

0.391

CAD17_HUMAN

Cadherin-17

0.391

ANGT_HUMAN

Angiotensinogen

0.391

TF_HUMAN

Tissue factor

0.391

PHAG1_HUMAN

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

0.391

LUZP1_HUMAN

Leucine zipper protein 1

0.391

GDNF_HUMAN

Glial cell line-derived neurotrophic factor

0.391

RAG2_HUMAN

V(D)J recombination-activating protein 2

0.391

SMS_HUMAN

Somatostatin

0.391

ABEC2_HUMAN

C->U-editing enzyme APOBEC-2

0.391

CDCP1_HUMAN

CUB domain-containing protein 1

0.391

FMOD_HUMAN

Fibromodulin

0.391

PTHR_HUMAN

Parathyroid hormone-related protein

0.391

ZBTB1_HUMAN

Zinc finger and BTB domain-containing protein 1

0.391

NYAP2_HUMAN

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

0.391

ZBT16_HUMAN

Zinc finger and BTB domain-containing protein 16

0.391

CLD11_HUMAN

Claudin-11

0.391

LYRIC_HUMAN

Protein LYRIC

0.391

LUR1L_HUMAN

Leucine rich adaptor protein 1-like

0.391

ZBT18_HUMAN

Zinc finger and BTB domain-containing protein 18

0.391

SPIN1_HUMAN

Spindlin-1

0.391

CCSE2_HUMAN

Serine-rich coiled-coil domain-containing protein 2

0.391

TMM51_HUMAN

Transmembrane protein 51

0.391

TANK_HUMAN

TRAF family member-associated NF-kappa-B activator

0.391

ZN335_HUMAN

Zinc finger protein 335

0.391

CCR7_HUMAN

C-C chemokine receptor type 7

0.391

LEPR_HUMAN

Leptin receptor

0.391

AKA11_HUMAN

A-kinase anchor protein 11

0.391

PALMD_HUMAN

Palmdelphin

0.391

CXD2_HUMAN

Gap junction delta-2 protein

0.391

TEFF1_HUMAN

Tomoregulin-1

0.391

VCAM1_HUMAN

Vascular cell adhesion protein 1

0.391

FPRP_HUMAN

Prostaglandin F2 receptor negative regulator

0.391

F131B_HUMAN

Protein FAM131B

0.391

ZBTB2_HUMAN

Zinc finger and BTB domain-containing protein 2

0.391

PRDM5_HUMAN

PR domain zinc finger protein 5

0.391

MBP_HUMAN

Myelin basic protein

0.391

AICDA_HUMAN

Single-stranded DNA cytosine deaminase

0.393

NUCKS_HUMAN

Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

0.393

CLCF1_HUMAN

Cardiotrophin-like cytokine factor 1

0.393

ZN711_HUMAN

Zinc finger protein 711

0.393

C99L2_HUMAN

CD99 antigen-like protein 2

0.393

PD1L1_HUMAN

Programmed cell death 1 ligand 1

0.393

APC16_HUMAN

Anaphase-promoting complex subunit 16

0.393

IL2RB_HUMAN

Interleukin-2 receptor subunit beta

0.393

EDN1_HUMAN

Endothelin-1

0.393

AUGN_HUMAN

Augurin

0.393

TECTB_HUMAN

Beta-tectorin

0.393

SPI1_HUMAN

Transcription factor PU.1

0.395

LYVE1_HUMAN

Lymphatic vessel endothelial hyaluronic acid receptor 1

0.395

CRAD_HUMAN

Cancer-related regulator of actin dynamics

0.395

UBP18_HUMAN

Ubl carboxyl-terminal hydrolase 18

0.395

TMM82_HUMAN

Transmembrane protein 82

0.395

CD44_HUMAN

CD44 antigen

0.395

CXAR_HUMAN

Coxsackievirus and adenovirus receptor

0.400

RIC3_HUMAN

Protein RIC-3

0.400

BORG2_HUMAN

Cdc42 effector protein 3

0.400

EURL_HUMAN

Protein EURL homolog

0.400

CCG1_HUMAN

Voltage-dependent calcium channel gamma-1 subunit

0.400

LEGL_HUMAN

Galectin-related protein

0.400

GAK1B_HUMAN

Golgi-associated kinase 1B

0.400

STXB6_HUMAN

Syntaxin-binding protein 6

0.400

STC2_HUMAN

Stanniocalcin-2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 19 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy