CRGD_HUMAN 2019

Gene Name CRGD

Description Gamma-crystallin D

Length 174

9606

Sequence

>sp|P07320|CRGD_HUMAN Gamma-crystallin D
MGKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRRGDYADHQQWMGLSDSVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNEIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

CRBA4_HUMAN

Beta-crystallin A4

0.229

LRC38_HUMAN

Leucine-rich repeat-containing protein 38

0.316

CRGB_HUMAN

Gamma-crystallin B

0.316

ZBT8B_HUMAN

Zinc finger and BTB domain-containing protein 8B

0.316

BRNP3_HUMAN

BMP/retinoic acid-inducible neural-specific protein 3

0.316

CRBB1_HUMAN

Beta-crystallin B1

0.316

S3TC2_HUMAN

SH3 domain and tetratricopeptide repeat-containing protein 2

0.316

TGFA_HUMAN

Protransforming growth factor alpha

0.316

STYK1_HUMAN

Tyrosine-protein kinase STYK1

0.316

TRBM_HUMAN

Thrombomodulin

0.324

FOXR1_HUMAN

Forkhead box protein R1

0.324

TMM25_HUMAN

Transmembrane protein 25

0.324

LGI3_HUMAN

Leucine-rich repeat LGI family member 3

0.324

FOXR2_HUMAN

Forkhead box protein R2

0.324

PHF6_HUMAN

PHD finger protein 6

0.369

CRBA1_HUMAN

Beta-crystallin A3

0.378

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.378

TSN18_HUMAN

Tetraspanin-18

0.378

RAMP3_HUMAN

Receptor activity-modifying protein 3

0.378

T255A_HUMAN

Transmembrane protein 255A

0.378

PTN_HUMAN

Pleiotrophin

0.378

ZN148_HUMAN

Zinc finger protein 148

0.378

GAK1B_HUMAN

Golgi-associated kinase 1B

0.378

RFXAP_HUMAN

Regulatory factor X-associated protein

0.378

SCG3_HUMAN

Secretogranin-3

0.378

CCDC3_HUMAN

Coiled-coil domain-containing protein 3

0.378

LGI2_HUMAN

Leucine-rich repeat LGI family member 2

0.378

GP153_HUMAN

Probable G-protein coupled receptor 153

0.378

TNIP2_HUMAN

TNFAIP3-interacting protein 2

0.378

EDNRB_HUMAN

Endothelin receptor type B

0.378

LARGN_HUMAN

Protein Largen

0.378

HBAZ_HUMAN

Hemoglobin subunit zeta

0.378

EDNRA_HUMAN

Endothelin-1 receptor

0.378

I10R2_HUMAN

Interleukin-10 receptor subunit beta

0.378

PGBD5_HUMAN

PiggyBac transposable element-derived protein 5

0.378

TPA_HUMAN

Tissue-type plasminogen activator

0.378

PCLI1_HUMAN

PTB-containing, cubilin and LRP1-interacting protein

0.378

PRLHR_HUMAN

Prolactin-releasing peptide receptor

0.378

PRLR_HUMAN

Prolactin receptor

0.378

EFCC1_HUMAN

EF-hand and coiled-coil domain-containing protein 1

0.378

RLF_HUMAN

Zinc finger protein Rlf

0.378

R4RL1_HUMAN

Reticulon-4 receptor-like 1

0.378

C2C4C_HUMAN

C2 calcium-dependent domain-containing protein 4C

0.378

EURL_HUMAN

Protein EURL homolog

0.378

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.378

LRAD3_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 3

0.378

GAK1A_HUMAN

Golgi-associated kinase 1A

0.387

CX038_HUMAN

Uncharacterized protein CXorf38

0.387

CAD26_HUMAN

Cadherin-like protein 26

0.387

SPRY4_HUMAN

SPRY domain-containing protein 4

0.387

ZN438_HUMAN

Zinc finger protein 438

0.387

CRGC_HUMAN

Gamma-crystallin C

0.387

MAG_HUMAN

Myelin-associated glycoprotein

0.387

PCD19_HUMAN

Protocadherin-19

0.387

AKIP1_HUMAN

A-kinase-interacting protein 1

0.387

SE6L1_HUMAN

Seizure 6-like protein

0.387

RN214_HUMAN

RING finger protein 214

0.387

CAVN4_HUMAN

Caveolae-associated protein 4

0.387

F222A_HUMAN

Protein FAM222A

0.387

CLUS_HUMAN

Clusterin

0.387

CN028_HUMAN

Uncharacterized protein C14orf28

0.387

PDYN_HUMAN

Proenkephalin-B

0.387

ESAM_HUMAN

Endothelial cell-selective adhesion molecule

0.387

LSR_HUMAN

Lipolysis-stimulated lipoprotein receptor

0.387

CPLX3_HUMAN

Complexin-3

0.387

EPOR_HUMAN

Erythropoietin receptor

0.387

SCAR3_HUMAN

Scavenger receptor class A member 3

0.387

CCD30_HUMAN

Coiled-coil domain-containing protein 30

0.387

SIG15_HUMAN

Sialic acid-binding Ig-like lectin 15

0.387

ZN513_HUMAN

Zinc finger protein 513

0.387

K2C8_HUMAN

Keratin, type II cytoskeletal 8

0.387

CALCB_HUMAN

Calcitonin gene-related peptide 2

0.387

HIC2_HUMAN

Hypermethylated in cancer 2 protein

0.387

OCSTP_HUMAN

Osteoclast stimulatory transmembrane protein

0.387

P3IP1_HUMAN

Phosphoinositide-3-kinase-interacting protein 1

0.387

GPR17_HUMAN

Uracil nucleotide/cysteinyl leukotriene receptor

0.387

ASC_HUMAN

Apoptosis-associated speck-like protein containing a CARD

0.387

RHNO1_HUMAN

RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

0.387

K1671_HUMAN

Uncharacterized protein KIAA1671

0.387

BTC_HUMAN

Probetacellulin

0.387

BSPRY_HUMAN

B box and SPRY domain-containing protein

0.387

K1C14_HUMAN

Keratin, type I cytoskeletal 14

0.387

MYP0_HUMAN

Myelin protein P0

0.387

HXA13_HUMAN

Homeobox protein Hox-A13

0.387

BRNP1_HUMAN

BMP/retinoic acid-inducible neural-specific protein 1

0.387

PERF_HUMAN

Perforin-1

0.387

CYTL1_HUMAN

Cytokine-like protein 1

0.387

PAR2_HUMAN

Proteinase-activated receptor 2

0.387

EMID1_HUMAN

EMI domain-containing protein 1

0.397

PPR35_HUMAN

Protein phosphatase 1 regulatory subunit 35

0.397

TELT_HUMAN

Telethonin

0.397

CRGA_HUMAN

Gamma-crystallin A

0.397

CING_HUMAN

Cingulin

0.397

1A68_HUMAN

HLA class I histocompatibility antigen, A-68 alpha chain

0.397

T179B_HUMAN

Transmembrane protein 179B

0.397

FGFP1_HUMAN

Fibroblast growth factor-binding protein 1

0.397

FSD2_HUMAN

Fibronectin type III and SPRY domain-containing protein 2

0.397

APOE_HUMAN

Apolipoprotein E

0.397

CXE1_HUMAN

Putative gap junction epsilon-1 protein

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

EPOR_HUMAN

Erythropoietin receptor

0.312

LSR_HUMAN

Lipolysis-stimulated lipoprotein receptor

0.331

CRGC_HUMAN

Gamma-crystallin C

0.335

SPRY4_HUMAN

SPRY domain-containing protein 4

0.347

CC136_HUMAN

Coiled-coil domain-containing protein 136

0.349

MAG_HUMAN

Myelin-associated glycoprotein

0.362

CN028_HUMAN

Uncharacterized protein C14orf28

0.364

ASC_HUMAN

Apoptosis-associated speck-like protein containing a CARD

0.380

MEDAG_HUMAN

Mesenteric estrogen-dependent adipogenesis protein

0.383

K2C8_HUMAN

Keratin, type II cytoskeletal 8

0.387

TTC22_HUMAN

Tetratricopeptide repeat protein 22

0.389

GPR4_HUMAN

G-protein coupled receptor 4

0.390

EMP3_HUMAN

Epithelial membrane protein 3

0.391

CING_HUMAN

Cingulin

0.391

IL27B_HUMAN

Interleukin-27 subunit beta

0.391

SCN1B_HUMAN

Sodium channel subunit beta-1

0.393

TPSN_HUMAN

Tapasin

0.393

TELT_HUMAN

Telethonin

0.393

TRI27_HUMAN

Zinc finger protein RFP

0.396

RHBD3_HUMAN

Rhomboid domain-containing protein 3

0.396

NYAP1_HUMAN

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

0.396

TRI44_HUMAN

Tripartite motif-containing protein 44

0.396

T179B_HUMAN

Transmembrane protein 179B

0.398

A0A0G2JMH6_HUMAN

HLA-DRA

0.399

BRNP3_HUMAN

BMP/retinoic acid-inducible neural-specific protein 3

0.399

DRA_HUMAN

HLA class II histocompatibility antigen, DR alpha chain

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 76 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy