K2C7_HUMAN 2019

Gene Name K2C7

Description Keratin, type II cytoskeletal 7

Length 469

9606

Sequence

>sp|P08729|K2C7_HUMAN Keratin, type II cytoskeletal 7
MSIHFSSPVFTSRSAAFSGRGAQVRLSSARPGGLGSSSLYGLGASRPRVAVRSAYGGPVGAGIREVTINQSLLAPLRLDADPSLQRVRQEESEQIKTLNNKFASFIDKVRFLEQQNKLLETKWTLLQEQKSAKSSRLPDIFEAQIAGLRGQLEALQVDGGRLEAELRSMQDVVEDFKNKYEDEINHRTAAENEFVVLKKDVDAAYMSKVELEAKVDALNDEINFLRTLNETELTELQSQISDTSVVLSMDNSRSLDLDGIIAEVKAQYEEMAKCSRAEAEAWYQTKFETLQAQAGKHGDDLRNTRNEISEMNRAIQRLQAEIDNIKNQRAKLEAAIAEAEERGELALKDARAKQEELEAALQRGKQDMARQLREYQELMSVKLALDIEIATYRKLLEGEESRLAGDGVGAVNISVMNSTGGSSSGGGIGLTLGGTMGSNALSFSSSAGPGLLKAYSIRTASASRRSARD

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

UFSP1_HUMAN

Inactive Ufm1-specific protease 1

0.378

K2C73_HUMAN

Keratin, type II cytoskeletal 73

0.378

CQ050_HUMAN

Uncharacterized protein C17orf50

0.378

K2C1B_HUMAN

Keratin, type II cytoskeletal 1b

0.378

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

S10A8_HUMAN

Protein S100-A8

0.291

ZN202_HUMAN

Zinc finger protein 202

0.316

TRML1_HUMAN

Trem-like transcript 1 protein

0.316

LAX1_HUMAN

Lymphocyte transmembrane adapter 1

0.316

TNF18_HUMAN

Tumor necrosis factor ligand superfamily member 18

0.319

ZN691_HUMAN

Zinc finger protein 691

0.319

CSF2_HUMAN

Granulocyte-macrophage colony-stimulating factor

0.319

IL2_HUMAN

Interleukin-2

0.319

DKKL1_HUMAN

Dickkopf-like protein 1

0.319

ZNF48_HUMAN

Zinc finger protein 48

0.322

SPNDC_HUMAN

Spindlin interactor and repressor of chromatin-binding protein

0.339

SIT1_HUMAN

Signaling threshold-regulating transmembrane adapter 1

0.339

CD20_HUMAN

B-lymphocyte antigen CD20

0.339

MSTRO_HUMAN

Protein maestro

0.339

S10A5_HUMAN

Protein S100-A5

0.339

GPC5D_HUMAN

G-protein coupled receptor family C group 5 member D

0.339

CAGE1_HUMAN

Cancer-associated gene 1 protein

0.342

ZKSC5_HUMAN

Zinc finger protein with KRAB and SCAN domains 5

0.342

CQ080_HUMAN

Uncharacterized protein C17orf80

0.342

RAGE_HUMAN

Advanced glycosylation end product-specific receptor

0.342

CC196_HUMAN

Putative coiled-coil domain-containing protein 196

0.342

DMKN_HUMAN

Dermokine

0.342

TM219_HUMAN

Insulin-like growth factor-binding protein 3 receptor

0.342

CD14_HUMAN

Monocyte differentiation antigen CD14

0.342

IL1A_HUMAN

Interleukin-1 alpha

0.342

ZKSC2_HUMAN

Zinc finger protein with KRAB and SCAN domains 2

0.342

TRML2_HUMAN

Trem-like transcript 2 protein

0.344

T126B_HUMAN

Complex I assembly factor TMEM126B, mitochondrial

0.344

PTCA_HUMAN

Protein tyrosine phosphatase receptor type C-associated protein

0.344

DBND2_HUMAN

Dysbindin domain-containing protein 2

0.344

ZN189_HUMAN

Zinc finger protein 189

0.344

F170A_HUMAN

Protein FAM170A

0.344

CP090_HUMAN

Uncharacterized protein C16orf90

0.344

ZFP1_HUMAN

Zinc finger protein 1 homolog

0.344

CXL16_HUMAN

C-X-C motif chemokine 16

0.344

CALY_HUMAN

Neuron-specific vesicular protein calcyon

0.347

CE046_HUMAN

Uncharacterized protein C5orf46

0.347

T53G5_HUMAN

TP53-target gene 5 protein

0.359

FNDC8_HUMAN

Fibronectin type III domain-containing protein 8

0.359

PA2GF_HUMAN

Group IIF secretory phospholipase A2

0.362

ZSC20_HUMAN

Zinc finger and SCAN domain-containing protein 20

0.362

ZNF18_HUMAN

Zinc finger protein 18

0.362

SPAT9_HUMAN

Spermatogenesis-associated protein 9

0.362

IL5_HUMAN

Interleukin-5

0.365

ZSC10_HUMAN

Zinc finger and SCAN domain-containing protein 10

0.365

CCL22_HUMAN

C-C motif chemokine 22

0.365

TMCO2_HUMAN

Transmembrane and coiled-coil domain-containing protein 2

0.365

BPIB1_HUMAN

BPI fold-containing family B member 1

0.365

CD19_HUMAN

B-lymphocyte antigen CD19

0.365

O13C7_HUMAN

Olfactory receptor 13C7

0.365

ZN496_HUMAN

Zinc finger protein 496

0.365

LAT_HUMAN

Linker for activation of T-cells family member 1

0.365

BPIA1_HUMAN

BPI fold-containing family A member 1

0.365

SPIN4_HUMAN

Spindlin-4

0.365

GPR3_HUMAN

G-protein coupled receptor 3

0.365

MEFV_HUMAN

Pyrin

0.365

PRS37_HUMAN

Probable inactive serine protease 37

0.365

BEX3_HUMAN

Protein BEX3

0.368

BPIA3_HUMAN

BPI fold-containing family A member 3

0.368

ZN445_HUMAN

Zinc finger protein 445

0.368

IRGQ_HUMAN

Immunity-related GTPase family Q protein

0.368

CB074_HUMAN

Uncharacterized protein C2orf74

0.368

ETV2_HUMAN

ETS translocation variant 2

0.368

MEPE_HUMAN

Matrix extracellular phosphoglycoprotein

0.368

F209A_HUMAN

Protein FAM209A

0.368

ZSC25_HUMAN

Zinc finger and SCAN domain-containing protein 25

0.368

ZN174_HUMAN

Zinc finger protein 174

0.368

SYNE4_HUMAN

Nesprin-4

0.368

IL33_HUMAN

Interleukin-33

0.368

IL13_HUMAN

Interleukin-13

0.368

TRIMM_HUMAN

Probable E3 ubiquitin-protein ligase TRIML2

0.368

ZN697_HUMAN

Zinc finger protein 697

0.371

BEX2_HUMAN

Protein BEX2

0.371

JSPR1_HUMAN

Junctional sarcoplasmic reticulum protein 1

0.375

FSCN3_HUMAN

Fascin-3

0.375

ARM12_HUMAN

Armadillo repeat-containing protein 12

0.375

TBC21_HUMAN

TBC1 domain family member 21

0.378

IL23A_HUMAN

Interleukin-23 subunit alpha

0.378

TROAP_HUMAN

Tastin

0.378

DMRTD_HUMAN

Doublesex- and mab-3-related transcription factor C2

0.378

KRT85_HUMAN

Keratin, type II cuticular Hb5

0.381

GL6D1_HUMAN

Putative glycosyltransferase 6 domain-containing protein 1

0.381

CC121_HUMAN

Coiled-coil domain-containing protein 121

0.381

IL27A_HUMAN

Interleukin-27 subunit alpha

0.381

S35G3_HUMAN

Solute carrier family 35 member G3

0.384

F186B_HUMAN

Protein FAM186B

0.384

ZKSC1_HUMAN

Zinc finger protein with KRAB and SCAN domains 1

0.384

MROH9_HUMAN

Maestro heat-like repeat-containing protein family member 9

0.384

RTBDN_HUMAN

Retbindin

0.384

ZN205_HUMAN

Zinc finger protein 205

0.384

SG3A2_HUMAN

Secretoglobin family 3A member 2

0.387

F229B_HUMAN

Protein FAM229B

0.387

KRBA1_HUMAN

Protein KRBA1

0.387

REL2_HUMAN

Prorelaxin H2

0.387

OPALI_HUMAN

Opalin

0.387

NGAL_HUMAN

Neutrophil gelatinase-associated lipocalin

0.387

TREM1_HUMAN

Triggering receptor expressed on myeloid cells 1

0.387

CJ120_HUMAN

Uncharacterized protein C10orf120

0.387

ZN746_HUMAN

Zinc finger protein 746

0.387

ZN449_HUMAN

Zinc finger protein 449

0.387

ZN263_HUMAN

Zinc finger protein 263

0.387

CC116_HUMAN

Coiled-coil domain-containing protein 116

0.387

ZN200_HUMAN

Zinc finger protein 200

0.387

SHRM1_HUMAN

Protein Shroom1

0.387

PRR3_HUMAN

Proline-rich protein 3

0.387

TMC5A_HUMAN

Transmembrane and coiled-coil domain-containing protein 5A

0.387

G6B_HUMAN

Megakaryocyte and platelet inhibitory receptor G6b

0.387

CD70_HUMAN

CD70 antigen

0.387

K2C71_HUMAN

Keratin, type II cytoskeletal 71

0.391

NNAT_HUMAN

Neuronatin

0.391

MCEM1_HUMAN

Mast cell-expressed membrane protein 1

0.391

MRAP_HUMAN

Melanocortin-2 receptor accessory protein

0.391

CD320_HUMAN

CD320 antigen

0.391

TCAL8_HUMAN

Transcription elongation factor A protein-like 8

0.391

PRCA1_HUMAN

Protein PROCA1

0.391

LY6H_HUMAN

Lymphocyte antigen 6H

0.391

ENHO_HUMAN

Adropin

0.394

ZBT32_HUMAN

Zinc finger and BTB domain-containing protein 32

0.394

RNF39_HUMAN

RING finger protein 39

0.394

ZFP90_HUMAN

Zinc finger protein 90 homolog

0.394

GUC2B_HUMAN

Guanylate cyclase activator 2B

0.395

CK042_HUMAN

Uncharacterized protein C11orf42

0.395

NUTM1_HUMAN

NUT family member 1

0.395

AKAP4_HUMAN

A-kinase anchor protein 4

0.398

FAIM3_HUMAN

Fas apoptotic inhibitory molecule 3

0.398

I27RA_HUMAN

Interleukin-27 receptor subunit alpha

0.398

T4S19_HUMAN

Transmembrane 4 L6 family member 19

0.398

PRIC4_HUMAN

Prickle-like protein 4

0.398

DMP1_HUMAN

Dentin matrix acidic phosphoprotein 1

0.398

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 7 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy