VSIG8_HUMAN 2019

Gene Name VSIG8

Description V-set and immunoglobulin domain-containing protein 8

Length 414

9606

Sequence

>sp|P0DPA2|VSIG8_HUMAN V-set and immunoglobulin domain-containing protein 8
MRVGGAFHLLLVCLSPALLSAVRINGDGQEVLYLAEGDNVRLGCPYVLDPEDYGPNGLDIEWMQVNSDPAHHRENVFLSYQDKRINHGSLPHLQQRVRFAASDPSQYDASINLMNLQVSDTATYECRVKKTTMATRKVIVTVQARPAVPMCWTEGHMTYGNDVVLKCYASGGSQPLSYKWAKISGHHYPYRAGSYTSQHSYHSELSYQESFHSSINQGLNNGDLVLKDISRADDGLYQCTVANNVGYSVCVVEVKVSDSRRIGVIIGIVLGSLLALGCLAVGIWGLVCCCCGGSGAGGARGAFGYGNGGGVGGGACGDLASEIREDAVAPGCKASGRGSRVTHLLGYPTQNVSRSLRRKYAPPPCGGPEDVALAPCTAAAACEAGPSPVYVKVKSAEPADCAEGPVQCKNGLLV

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

OR6Y1_HUMAN

Olfactory receptor 6Y1

0.000

OR6F1_HUMAN

Olfactory receptor 6F1

0.000

O13A1_HUMAN

Olfactory receptor 13A1

0.000

SPAT9_HUMAN

Spermatogenesis-associated protein 9

0.000

TM139_HUMAN

Transmembrane protein 139

0.316

SMRP1_HUMAN

Spermatid-specific manchette-related protein 1

0.316

ICOS_HUMAN

Inducible T-cell costimulator

0.316

O6C74_HUMAN

Olfactory receptor 6C74

0.316

DMRTB_HUMAN

Doublesex- and mab-3-related transcription factor B1

0.316

CC159_HUMAN

Coiled-coil domain-containing protein 159

0.316

PRS53_HUMAN

Serine protease 53

0.316

CQ064_HUMAN

Uncharacterized protein C17orf64

0.316

PRS54_HUMAN

Inactive serine protease 54

0.316

ABEC1_HUMAN

C->U-editing enzyme APOBEC-1

0.316

FXYD3_HUMAN

FXYD domain-containing ion transport regulator 3

0.316

NKG7_HUMAN

Protein NKG7

0.316

TACT_HUMAN

T-cell surface protein tactile

0.316

CX3C1_HUMAN

CX3C chemokine receptor 1

0.316

DMP1_HUMAN

Dentin matrix acidic phosphoprotein 1

0.316

OR6C1_HUMAN

Olfactory receptor 6C1

0.316

TBC21_HUMAN

TBC1 domain family member 21

0.316

AKAP4_HUMAN

A-kinase anchor protein 4

0.316

ACTT2_HUMAN

Actin-related protein T2

0.316

ARM12_HUMAN

Armadillo repeat-containing protein 12

0.316

HPIP_HUMAN

Host cell factor C1 regulator 1

0.316

NCMAP_HUMAN

Noncompact myelin-associated protein

0.316

GPSM3_HUMAN

G-protein-signaling modulator 3

0.333

IL1FA_HUMAN

Interleukin-1 family member 10

0.333

LEUK_HUMAN

Leukosialin

0.333

F186B_HUMAN

Protein FAM186B

0.333

ZKSC7_HUMAN

Zinc finger protein with KRAB and SCAN domains 7

0.333

ZN316_HUMAN

Zinc finger protein 316

0.333

CL060_HUMAN

Uncharacterized protein C12orf60

0.333

OR5T1_HUMAN

Olfactory receptor 5T1

0.333

KT33B_HUMAN

Keratin, type I cuticular Ha3-II

0.333

OR4D1_HUMAN

Olfactory receptor 4D1

0.333

LY66F_HUMAN

Lymphocyte antigen 6 complex locus protein G6f

0.333

PTCA_HUMAN

Protein tyrosine phosphatase receptor type C-associated protein

0.333

CKLF5_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 5

0.333

RAB42_HUMAN

Ras-related protein Rab-42

0.333

OR5T2_HUMAN

Olfactory receptor 5T2

0.333

F205A_HUMAN

Protein FAM205A

0.333

KT33A_HUMAN

Keratin, type I cuticular Ha3-I

0.333

K1H1_HUMAN

Keratin, type I cuticular Ha1

0.333

ZN436_HUMAN

Zinc finger protein 436

0.333

SPT25_HUMAN

Spermatogenesis-associated protein 25

0.333

ZSC29_HUMAN

Zinc finger and SCAN domain-containing protein 29

0.333

CD20_HUMAN

B-lymphocyte antigen CD20

0.333

TMG2_HUMAN

Transmembrane gamma-carboxyglutamic acid protein 2

0.333

TRML1_HUMAN

Trem-like transcript 1 protein

0.333

ZNF18_HUMAN

Zinc finger protein 18

0.333

ISG15_HUMAN

Ubiquitin-like protein ISG15

0.333

IL24_HUMAN

Interleukin-24

0.333

X3CL1_HUMAN

Fractalkine

0.333

ZN282_HUMAN

Zinc finger protein 282

0.333

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ARM12_HUMAN

Armadillo repeat-containing protein 12

0.309

DMP1_HUMAN

Dentin matrix acidic phosphoprotein 1

0.336

T53G5_HUMAN

TP53-target gene 5 protein

0.336

TRML1_HUMAN

Trem-like transcript 1 protein

0.339

SPAT9_HUMAN

Spermatogenesis-associated protein 9

0.339

PTCRA_HUMAN

Pre T-cell antigen receptor alpha

0.342

TMG2_HUMAN

Transmembrane gamma-carboxyglutamic acid protein 2

0.342

SACA1_HUMAN

Sperm acrosome membrane-associated protein 1

0.351

TBC21_HUMAN

TBC1 domain family member 21

0.356

PRS54_HUMAN

Inactive serine protease 54

0.356

CNPY1_HUMAN

Protein canopy homolog 1

0.359

AKAP3_HUMAN

A-kinase anchor protein 3

0.359

CD20_HUMAN

B-lymphocyte antigen CD20

0.359

F186B_HUMAN

Protein FAM186B

0.362

CQ080_HUMAN

Uncharacterized protein C17orf80

0.362

MENT_HUMAN

Protein MENT

0.365

T10IP_HUMAN

Testis-specific protein 10-interacting protein

0.368

DAF_HUMAN

Complement decay-accelerating factor

0.375

IGSF2_HUMAN

Immunoglobulin superfamily member 2

0.378

FNDC8_HUMAN

Fibronectin type III domain-containing protein 8

0.378

AKAP4_HUMAN

A-kinase anchor protein 4

0.378

T4S19_HUMAN

Transmembrane 4 L6 family member 19

0.378

ZNF18_HUMAN

Zinc finger protein 18

0.381

ZN202_HUMAN

Zinc finger protein 202

0.381

LAX1_HUMAN

Lymphocyte transmembrane adapter 1

0.381

IZUM3_HUMAN

Izumo sperm-egg fusion protein 3

0.384

CCR10_HUMAN

C-C chemokine receptor type 10

0.384

PRS37_HUMAN

Probable inactive serine protease 37

0.384

BPIA1_HUMAN

BPI fold-containing family A member 1

0.384

ZSC10_HUMAN

Zinc finger and SCAN domain-containing protein 10

0.384

CD5_HUMAN

T-cell surface glycoprotein CD5

0.386

CAVN3_HUMAN

Caveolae-associated protein 3

0.387

CKLF5_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 5

0.387

CA141_HUMAN

Uncharacterized protein C1orf141

0.387

TIGIT_HUMAN

T-cell immunoreceptor with Ig and ITIM domains

0.387

MTCP1_HUMAN

Protein p13 MTCP-1

0.389

FCERB_HUMAN

High affinity immunoglobulin epsilon receptor subunit beta

0.391

PSPB_HUMAN

Pulmonary surfactant-associated protein B

0.392

FSCN3_HUMAN

Fascin-3

0.392

F187B_HUMAN

Protein FAM187B

0.392

CQ064_HUMAN

Uncharacterized protein C17orf64

0.392

TROAP_HUMAN

Tastin

0.395

S10A9_HUMAN

Protein S100-A9

0.395

ZN436_HUMAN

Zinc finger protein 436

0.395

COPRS_HUMAN

Coordinator of PRMT5 and differentiation stimulator

0.395

KRT85_HUMAN

Keratin, type II cuticular Hb5

0.398

IL27A_HUMAN

Interleukin-27 subunit alpha

0.398

RAB42_HUMAN

Ras-related protein Rab-42

0.398

S10A5_HUMAN

Protein S100-A5

0.398

GPC5D_HUMAN

G-protein coupled receptor family C group 5 member D

0.398

MSTRO_HUMAN

Protein maestro

0.398

HPIP_HUMAN

Host cell factor C1 regulator 1

0.398

SPNDC_HUMAN

Spindlin interactor and repressor of chromatin-binding protein

0.398

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 9 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy