MOTI_HUMAN 2019

Gene Name MOTI

Description Promotilin

Length 115

9606

Sequence

>sp|P12872|MOTI_HUMAN Promotilin
MVSRKAVAALLVVHVAAMLASQTEAFVPIFTYGELQRMQEKERNKGQKKSLSVWQRSGEEGPVDPAEPIREEENEMIKLTAPLEIGMRMNSRQLEKYPATLEGLLSEMLPQHAAK

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

T4S18_HUMAN

Transmembrane 4 L6 family member 18

0.000

CP071_HUMAN

Uncharacterized protein C16orf71

0.316

CD99_HUMAN

CD99 antigen

0.316

KLRF1_HUMAN

Killer cell lectin-like receptor subfamily F member 1

0.333

OR6C4_HUMAN

Olfactory receptor 6C4

0.333

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ZN777_HUMAN

Zinc finger protein 777

0.291

BCAS1_HUMAN

Breast carcinoma-amplified sequence 1

0.310

CD47_HUMAN

Leukocyte surface antigen CD47

0.310

CF132_HUMAN

Uncharacterized protein C6orf132

0.310

ODFP1_HUMAN

Outer dense fiber protein 1

0.312

TNFL8_HUMAN

Tumor necrosis factor ligand superfamily member 8

0.312

IL15_HUMAN

Interleukin-15

0.314

EPCR_HUMAN

Endothelial protein C receptor

0.314

IL22_HUMAN

Interleukin-22

0.331

TREM2_HUMAN

Triggering receptor expressed on myeloid cells 2

0.331

TRI14_HUMAN

Tripartite motif-containing protein 14

0.331

INLR1_HUMAN

Interferon lambda receptor 1

0.333

PML_HUMAN

Protein PML

0.333

SPERT_HUMAN

Spermatid-associated protein

0.333

VEXIN_HUMAN

Vexin

0.333

TB182_HUMAN

182 kDa tankyrase-1-binding protein

0.333

GKN2_HUMAN

Gastrokine-2

0.336

CL050_HUMAN

Uncharacterized protein C12orf50

0.336

CD1B_HUMAN

T-cell surface glycoprotein CD1b

0.341

INGR1_HUMAN

Interferon gamma receptor 1

0.346

BPIB4_HUMAN

BPI fold-containing family B member 4

0.349

CD72_HUMAN

B-cell differentiation antigen CD72

0.351

I10R1_HUMAN

Interleukin-10 receptor subunit alpha

0.351

EGLN_HUMAN

Endoglin

0.351

MYOZ3_HUMAN

Myozenin-3

0.351

TM139_HUMAN

Transmembrane protein 139

0.354

CD5_HUMAN

T-cell surface glycoprotein CD5

0.356

TM156_HUMAN

Transmembrane protein 156

0.356

OSTP_HUMAN

Osteopontin

0.356

T4S18_HUMAN

Transmembrane 4 L6 family member 18

0.359

SPT16_HUMAN

Spermatogenesis-associated protein 16

0.363

THY1_HUMAN

Thy-1 membrane glycoprotein

0.365

LIF_HUMAN

Leukemia inhibitory factor

0.368

S10AB_HUMAN

Protein S100-A11

0.368

I22R1_HUMAN

Interleukin-22 receptor subunit alpha-1

0.368

CD8B2_HUMAN

Putative T-cell surface glycoprotein CD8 beta-2 chain

0.368

ACRBP_HUMAN

Acrosin-binding protein

0.368

RESF1_HUMAN

Retroelement silencing factor 1

0.368

SIAL_HUMAN

Bone sialoprotein 2

0.370

ICOS_HUMAN

Inducible T-cell costimulator

0.370

ZN639_HUMAN

Zinc finger protein 639

0.370

XCL1_HUMAN

Lymphotactin

0.373

LSME1_HUMAN

Leucine-rich single-pass membrane protein 1

0.373

IL9R_HUMAN

Interleukin-9 receptor

0.373

CX3C1_HUMAN

CX3C chemokine receptor 1

0.373

MB214_HUMAN

Protein mab-21-like 4

0.373

K1C23_HUMAN

Keratin, type I cytoskeletal 23

0.375

LY96_HUMAN

Lymphocyte antigen 96

0.375

MISSL_HUMAN

MAPK-interacting and spindle-stabilizing protein-like

0.375

SUGP2_HUMAN

SURP and G-patch domain-containing protein 2

0.378

NFAM1_HUMAN

NFAT activation molecule 1

0.378

INAR1_HUMAN

Interferon alpha/beta receptor 1

0.378

CP071_HUMAN

Uncharacterized protein C16orf71

0.378

MILR1_HUMAN

Allergin-1

0.378

TMM40_HUMAN

Transmembrane protein 40

0.378

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.378

CLD16_HUMAN

Claudin-16

0.380

CD34_HUMAN

Hematopoietic progenitor cell antigen CD34

0.380

CD1E_HUMAN

T-cell surface glycoprotein CD1e, membrane-associated

0.381

PIANP_HUMAN

PILR alpha-associated neural protein

0.383

KCD19_HUMAN

BTB/POZ domain-containing protein KCTD19

0.383

LAPM5_HUMAN

Lysosomal-associated transmembrane protein 5

0.383

CD8B_HUMAN

T-cell surface glycoprotein CD8 beta chain

0.383

A1AG1_HUMAN

Alpha-1-acid glycoprotein 1

0.386

CKLF6_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 6

0.386

SNTAN_HUMAN

Sentan

0.386

TM52B_HUMAN

Transmembrane protein 52B

0.386

IL23R_HUMAN

Interleukin-23 receptor

0.386

CAMP_HUMAN

Cathelicidin antimicrobial peptide

0.386

INAR2_HUMAN

Interferon alpha/beta receptor 2

0.386

TPO_HUMAN

Thrombopoietin

0.388

PDCD1_HUMAN

Programmed cell death protein 1

0.388

SHSA5_HUMAN

Protein shisa-5

0.388

FYB2_HUMAN

FYN-binding protein 2

0.388

OPT_HUMAN

Opticin

0.388

CD019_HUMAN

Uncharacterized protein C4orf19

0.391

CC198_HUMAN

Uncharacterized protein CCDC198

0.391

VTDB_HUMAN

Vitamin D-binding protein

0.392

PDPN_HUMAN

Podoplanin

0.394

MROH7_HUMAN

Maestro heat-like repeat-containing protein family member 7

0.394

MTCP1_HUMAN

Protein p13 MTCP-1

0.394

CQ064_HUMAN

Uncharacterized protein C17orf64

0.396

FSHB_HUMAN

Follitropin subunit beta

0.397

SHPS1_HUMAN

Tyrosine-protein phosphatase non-receptor type substrate 1

0.397

GSG1_HUMAN

Germ cell-specific gene 1 protein

0.397

RAI3_HUMAN

Retinoic acid-induced protein 3

0.400

INGR2_HUMAN

Interferon gamma receptor 2

0.400

BRNP2_HUMAN

BMP/retinoic acid-inducible neural-specific protein 2

0.400

MMRN1_HUMAN

Multimerin-1

0.400

TAF1D_HUMAN

TATA box-binding protein-associated factor RNA polymerase I subunit D

0.400

AKND1_HUMAN

Protein AKNAD1

0.400

MFAP5_HUMAN

Microfibrillar-associated protein 5

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 9 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy