MCP_HUMAN 2019

Gene Name MCP

Description Membrane cofactor protein

Length 392

9606

Sequence

>sp|P15529|MCP_HUMAN Membrane cofactor protein
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

MRGX2_HUMAN

Mas-related G-protein coupled receptor member X2

0.000

TIFAB_HUMAN

TRAF-interacting protein with FHA domain-containing protein B

0.000

UBD_HUMAN

Ubiquitin D

0.000

TA2R1_HUMAN

Taste receptor type 2 member 1

0.000

K1C27_HUMAN

Keratin, type I cytoskeletal 27

0.000

CQ078_HUMAN

Uncharacterized protein C17orf78

0.000

MRGRF_HUMAN

Mas-related G-protein coupled receptor member F

0.000

RTBDN_HUMAN

Retbindin

0.000

MNDA_HUMAN

Myeloid cell nuclear differentiation antigen

0.000

MRGX3_HUMAN

Mas-related G-protein coupled receptor member X3

0.000

CS071_HUMAN

Uncharacterized protein C19orf71

0.333

TA2R3_HUMAN

Taste receptor type 2 member 3

0.333

O52E2_HUMAN

Olfactory receptor 52E2

0.333

O52H1_HUMAN

Olfactory receptor 52H1

0.333

MT2_HUMAN

Metallothionein-2

0.333

T2R39_HUMAN

Taste receptor type 2 member 39

0.333

EPMIP_HUMAN

EPM2A-interacting protein 1

0.333

T2R40_HUMAN

Taste receptor type 2 member 40

0.333

F71F2_HUMAN

Protein FAM71F2

0.333

F71F1_HUMAN

Protein FAM71F1

0.333

CC062_HUMAN

Uncharacterized protein C3orf62

0.333

MRGX1_HUMAN

Mas-related G-protein coupled receptor member X1

0.333

O52J3_HUMAN

Olfactory receptor 52J3

0.333

K1C20_HUMAN

Keratin, type I cytoskeletal 20

0.333

SG3A2_HUMAN

Secretoglobin family 3A member 2

0.354

CI040_HUMAN

Uncharacterized protein C9orf40

0.354

OR5L2_HUMAN

Olfactory receptor 5L2

0.354

OR4B1_HUMAN

Olfactory receptor 4B1

0.354

O2AG2_HUMAN

Olfactory receptor 2AG2

0.354

CC196_HUMAN

Putative coiled-coil domain-containing protein 196

0.354

CCL22_HUMAN

C-C motif chemokine 22

0.354

O13C7_HUMAN

Olfactory receptor 13C7

0.354

O51A7_HUMAN

Olfactory receptor 51A7

0.354

MASTR_HUMAN

MEF2-activating motif and SAP domain-containing transcriptional regulator

0.354

GAPT_HUMAN

Protein GAPT

0.354

T53G5_HUMAN

TP53-target gene 5 protein

0.354

EP3A_HUMAN

Epididymal secretory protein E3-alpha

0.354

AHSP_HUMAN

Alpha-hemoglobin-stabilizing protein

0.354

S10A8_HUMAN

Protein S100-A8

0.354

ODAM_HUMAN

Odontogenic ameloblast-associated protein

0.354

OR1L6_HUMAN

Olfactory receptor 1L6

0.354

PA2GC_HUMAN

Putative inactive group IIC secretory phospholipase A2

0.354

ZNF3_HUMAN

Zinc finger protein 3

0.354

OR5A1_HUMAN

Olfactory receptor 5A1

0.354

OR5L1_HUMAN

Olfactory receptor 5L1

0.354

TCHL1_HUMAN

Trichohyalin-like protein 1

0.354

DAND5_HUMAN

DAN domain family member 5

0.354

ACTT3_HUMAN

Actin-related protein T3

0.354

MROH9_HUMAN

Maestro heat-like repeat-containing protein family member 9

0.354

CITE4_HUMAN

Cbp/p300-interacting transactivator 4

0.354

O52B4_HUMAN

Olfactory receptor 52B4

0.354

O10K2_HUMAN

Olfactory receptor 10K2

0.354

PRS42_HUMAN

Putative serine protease 42

0.354

MUC20_HUMAN

Mucin-20

0.354

STP1_HUMAN

Spermatid nuclear transition protein 1

0.354

OR5MB_HUMAN

Olfactory receptor 5M11

0.354

OR5M9_HUMAN

Olfactory receptor 5M9

0.354

COPRS_HUMAN

Coordinator of PRMT5 and differentiation stimulator

0.354

CDRT4_HUMAN

CMT1A duplicated region transcript 4 protein

0.354

S100G_HUMAN

Protein S100-G

0.354

EP3B_HUMAN

Epididymal secretory protein E3-beta

0.354

CLD9_HUMAN

Claudin-9

0.354

PAHO_HUMAN

Pancreatic prohormone

0.354

ZN641_HUMAN

Zinc finger protein 641

0.354

TSP50_HUMAN

Probable threonine protease PRSS50

0.354

C5AR2_HUMAN

C5a anaphylatoxin chemotactic receptor 2

0.354

TEX46_HUMAN

Testis-expressed protein 46

0.354

LY6H_HUMAN

Lymphocyte antigen 6H

0.354

OR4CC_HUMAN

Olfactory receptor 4C12

0.354

LAT_HUMAN

Linker for activation of T-cells family member 1

0.354

G6B_HUMAN

Megakaryocyte and platelet inhibitory receptor G6b

0.354

RNS12_HUMAN

Probable inactive ribonuclease-like protein 12

0.354

LCN1_HUMAN

Lipocalin-1

0.354

ZKSC2_HUMAN

Zinc finger protein with KRAB and SCAN domains 2

0.354

O52W1_HUMAN

Olfactory receptor 52W1

0.354

K1C26_HUMAN

Keratin, type I cytoskeletal 26

0.354

ZN697_HUMAN

Zinc finger protein 697

0.354

IL5_HUMAN

Interleukin-5

0.354

PKHH3_HUMAN

Pleckstrin homology domain-containing family H member 3

0.354

CP054_HUMAN

Transmembrane protein C16orf54

0.354

OR9A4_HUMAN

Olfactory receptor 9A4

0.354

O10G7_HUMAN

Olfactory receptor 10G7

0.354

BPIA1_HUMAN

BPI fold-containing family A member 1

0.354

M4A13_HUMAN

Membrane-spanning 4-domains subfamily A member 13

0.354

O51V1_HUMAN

Olfactory receptor 51V1

0.354

DLL3_HUMAN

Delta-like protein 3

0.354

F220A_HUMAN

Protein FAM220A

0.354

LAX1_HUMAN

Lymphocyte transmembrane adapter 1

0.354

TM202_HUMAN

Transmembrane protein 202

0.354

OR6K2_HUMAN

Olfactory receptor 6K2

0.354

OR5G3_HUMAN

Olfactory receptor 5G3

0.354

GPR31_HUMAN

12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor

0.354

OR9K2_HUMAN

Olfactory receptor 9K2

0.354

CCD54_HUMAN

Coiled-coil domain-containing protein 54

0.354

CK086_HUMAN

Uncharacterized protein C11orf86

0.354

PS1C2_HUMAN

Psoriasis susceptibility 1 candidate gene 2 protein

0.354

BPIB3_HUMAN

BPI fold-containing family B member 3

0.354

F220P_HUMAN

Putative protein FAM220BP

0.354

KRBA1_HUMAN

Protein KRBA1

0.354

ZCCHL_HUMAN

Zinc finger CCCH-type antiviral protein 1-like

0.354

O4C46_HUMAN

Olfactory receptor 4C46

0.354

ATP8_HUMAN

ATP synthase protein 8

0.354

DBND2_HUMAN

Dysbindin domain-containing protein 2

0.354

CC188_HUMAN

Coiled-coil domain-containing protein 188

0.354

OR5C1_HUMAN

Olfactory receptor 5C1

0.354

O51F2_HUMAN

Olfactory receptor 51F2

0.354

IL7_HUMAN

Interleukin-7

0.354

IL36A_HUMAN

Interleukin-36 alpha

0.354

IL1A_HUMAN

Interleukin-1 alpha

0.354

O51B6_HUMAN

Olfactory receptor 51B6

0.354

MROH8_HUMAN

Protein MROH8

0.354

FFAR1_HUMAN

Free fatty acid receptor 1

0.354

O2AG1_HUMAN

Olfactory receptor 2AG1

0.354

O2T12_HUMAN

Olfactory receptor 2T12

0.354

O10AG_HUMAN

Olfactory receptor 10AG1

0.354

CCR10_HUMAN

C-C chemokine receptor type 10

0.354

CD036_HUMAN

Uncharacterized protein C4orf36

0.354

OR8D4_HUMAN

Olfactory receptor 8D4

0.354

PRS58_HUMAN

Serine protease 58

0.354

Z286A_HUMAN

Zinc finger protein 286A

0.354

IGSF2_HUMAN

Immunoglobulin superfamily member 2

0.354

B2L10_HUMAN

Bcl-2-like protein 10

0.354

ZSC20_HUMAN

Zinc finger and SCAN domain-containing protein 20

0.354

ZSC10_HUMAN

Zinc finger and SCAN domain-containing protein 10

0.354

TM219_HUMAN

Insulin-like growth factor-binding protein 3 receptor

0.354

TNFL4_HUMAN

Tumor necrosis factor ligand superfamily member 4

0.354

ODAPH_HUMAN

Odontogenesis associated phosphoprotein

0.354

OR8G5_HUMAN

Olfactory receptor 8G5

0.354

S10A3_HUMAN

Protein S100-A3

0.354

CJ120_HUMAN

Uncharacterized protein C10orf120

0.354

CCRL2_HUMAN

C-C chemokine receptor-like 2

0.354

PRR19_HUMAN

Proline-rich protein 19

0.354

OR5MA_HUMAN

Olfactory receptor 5M10

0.354

KRA33_HUMAN

Keratin-associated protein 3-3

0.354

O13J1_HUMAN

Olfactory receptor 13J1

0.354

OR4CF_HUMAN

Olfactory receptor 4C15

0.354

TREM1_HUMAN

Triggering receptor expressed on myeloid cells 1

0.354

ZKSC5_HUMAN

Zinc finger protein with KRAB and SCAN domains 5

0.354

F229B_HUMAN

Protein FAM229B

0.354

INSL3_HUMAN

Insulin-like 3

0.354

FCERB_HUMAN

High affinity immunoglobulin epsilon receptor subunit beta

0.354

BPIB1_HUMAN

BPI fold-containing family B member 1

0.354

TIGIT_HUMAN

T-cell immunoreceptor with Ig and ITIM domains

0.354

OR4X2_HUMAN

Olfactory receptor 4X2

0.354

OR6A2_HUMAN

Olfactory receptor 6A2

0.354

GON7_HUMAN

EKC/KEOPS complex subunit GON7

0.354

OR6P1_HUMAN

Olfactory receptor 6P1

0.354

TROAP_HUMAN

Tastin

0.354

OR5P3_HUMAN

Olfactory receptor 5P3

0.354

CQ080_HUMAN

Uncharacterized protein C17orf80

0.354

OR8A1_HUMAN

Olfactory receptor 8A1

0.354

CTF1_HUMAN

Cardiotrophin-1

0.354

CK094_HUMAN

Uncharacterized protein C11orf94

0.354

RAGE_HUMAN

Advanced glycosylation end product-specific receptor

0.354

REPI1_HUMAN

Replication initiator 1

0.354

ZN672_HUMAN

Zinc finger protein 672

0.354

OR2LD_HUMAN

Olfactory receptor 2L13

0.354

O4A15_HUMAN

Olfactory receptor 4A15

0.354

K1C25_HUMAN

Keratin, type I cytoskeletal 25

0.354

TMCO2_HUMAN

Transmembrane and coiled-coil domain-containing protein 2

0.354

MRGX4_HUMAN

Mas-related G-protein coupled receptor member X4

0.354

CC116_HUMAN

Coiled-coil domain-containing protein 116

0.354

ZN746_HUMAN

Zinc finger protein 746

0.354

O2T33_HUMAN

Olfactory receptor 2T33

0.354

T2R38_HUMAN

Taste receptor type 2 member 38

0.354

ZN428_HUMAN

Zinc finger protein 428

0.354

PRND_HUMAN

Prion-like protein doppel

0.354

TMM95_HUMAN

Transmembrane protein 95

0.354

TRML2_HUMAN

Trem-like transcript 2 protein

0.354

SCND1_HUMAN

SCAN domain-containing protein 1

0.354

TM225_HUMAN

Transmembrane protein 225

0.354

TMC5A_HUMAN

Transmembrane and coiled-coil domain-containing protein 5A

0.354

CYLC2_HUMAN

Cylicin-2

0.354

CL071_HUMAN

Uncharacterized protein C12orf71

0.354

OCEL1_HUMAN

Occludin/ELL domain-containing protein 1

0.354

ZN202_HUMAN

Zinc finger protein 202

0.354

O51S1_HUMAN

Olfactory receptor 51S1

0.354

OR4C6_HUMAN

Olfactory receptor 4C6

0.354

OR8K1_HUMAN

Olfactory receptor 8K1

0.354

PRS37_HUMAN

Probable inactive serine protease 37

0.354

CS2IP_HUMAN

Casein kinase II subunit alpha-interacting protein

0.354

FCG3A_HUMAN

Low affinity immunoglobulin gamma Fc region receptor III-A

0.354

OR2V1_HUMAN

Olfactory receptor 2V1

0.354

OR5M1_HUMAN

Olfactory receptor 5M1

0.354

OR2K2_HUMAN

Olfactory receptor 2K2

0.354

OR5W2_HUMAN

Olfactory receptor 5W2

0.354

O51T1_HUMAN

Olfactory receptor 51T1

0.354

NGAL_HUMAN

Neutrophil gelatinase-associated lipocalin

0.354

SCIMP_HUMAN

SLP adapter and CSK-interacting membrane protein

0.354

O51F1_HUMAN

Olfactory receptor 51F1

0.354

O13F1_HUMAN

Olfactory receptor 13F1

0.354

SPRN_HUMAN

Shadow of prion protein

0.354

CAVN3_HUMAN

Caveolae-associated protein 3

0.354

CD70_HUMAN

CD70 antigen

0.354

EQTN_HUMAN

Equatorin

0.354

OR6K6_HUMAN

Olfactory receptor 6K6

0.354

T2R16_HUMAN

Taste receptor type 2 member 16

0.354

ZN263_HUMAN

Zinc finger protein 263

0.354

OPALI_HUMAN

Opalin

0.354

ZN496_HUMAN

Zinc finger protein 496

0.354

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CAVN3_HUMAN

Caveolae-associated protein 3

0.327

ZKSC5_HUMAN

Zinc finger protein with KRAB and SCAN domains 5

0.347

IL1A_HUMAN

Interleukin-1 alpha

0.347

KRBA1_HUMAN

Protein KRBA1

0.350

ZFP1_HUMAN

Zinc finger protein 1 homolog

0.350

ZN189_HUMAN

Zinc finger protein 189

0.350

ZN263_HUMAN

Zinc finger protein 263

0.350

TMC5A_HUMAN

Transmembrane and coiled-coil domain-containing protein 5A

0.350

OPALI_HUMAN

Opalin

0.350

TREM1_HUMAN

Triggering receptor expressed on myeloid cells 1

0.350

CC116_HUMAN

Coiled-coil domain-containing protein 116

0.350

ZN202_HUMAN

Zinc finger protein 202

0.368

LAX1_HUMAN

Lymphocyte transmembrane adapter 1

0.368

ZSC20_HUMAN

Zinc finger and SCAN domain-containing protein 20

0.368

ZNF18_HUMAN

Zinc finger protein 18

0.368

ZN496_HUMAN

Zinc finger protein 496

0.371

TMCO2_HUMAN

Transmembrane and coiled-coil domain-containing protein 2

0.371

CSF2_HUMAN

Granulocyte-macrophage colony-stimulating factor

0.371

IL5_HUMAN

Interleukin-5

0.371

LAT_HUMAN

Linker for activation of T-cells family member 1

0.371

O13C7_HUMAN

Olfactory receptor 13C7

0.371

IL2_HUMAN

Interleukin-2

0.371

ZN184_HUMAN

Zinc finger protein 184

0.371

PRS37_HUMAN

Probable inactive serine protease 37

0.371

ZN691_HUMAN

Zinc finger protein 691

0.371

DKKL1_HUMAN

Dickkopf-like protein 1

0.371

BEX3_HUMAN

Protein BEX3

0.375

ZN174_HUMAN

Zinc finger protein 174

0.375

IRGQ_HUMAN

Immunity-related GTPase family Q protein

0.375

IL33_HUMAN

Interleukin-33

0.375

BPIA3_HUMAN

BPI fold-containing family A member 3

0.375

ETV2_HUMAN

ETS translocation variant 2

0.375

ZSC25_HUMAN

Zinc finger and SCAN domain-containing protein 25

0.375

ZN445_HUMAN

Zinc finger protein 445

0.375

IL13_HUMAN

Interleukin-13

0.375

ZNF48_HUMAN

Zinc finger protein 48

0.375

TRIMM_HUMAN

Probable E3 ubiquitin-protein ligase TRIML2

0.375

PNM8A_HUMAN

Paraneoplastic antigen-like protein 8A

0.381

AKAP3_HUMAN

A-kinase anchor protein 3

0.387

GL6D1_HUMAN

Putative glycosyltransferase 6 domain-containing protein 1

0.387

GPC5D_HUMAN

G-protein coupled receptor family C group 5 member D

0.387

TSKS_HUMAN

Testis-specific serine kinase substrate

0.387

SPNDC_HUMAN

Spindlin interactor and repressor of chromatin-binding protein

0.387

DMKN_HUMAN

Dermokine

0.391

TM219_HUMAN

Insulin-like growth factor-binding protein 3 receptor

0.391

RAGE_HUMAN

Advanced glycosylation end product-specific receptor

0.391

RTBDN_HUMAN

Retbindin

0.391

ZN205_HUMAN

Zinc finger protein 205

0.391

F186B_HUMAN

Protein FAM186B

0.391

ZKSC1_HUMAN

Zinc finger protein with KRAB and SCAN domains 1

0.391

ZKSC2_HUMAN

Zinc finger protein with KRAB and SCAN domains 2

0.391

F71F1_HUMAN

Protein FAM71F1

0.391

CC196_HUMAN

Putative coiled-coil domain-containing protein 196

0.391

S10A8_HUMAN

Protein S100-A8

0.391

CQ080_HUMAN

Uncharacterized protein C17orf80

0.391

PRR3_HUMAN

Proline-rich protein 3

0.394

CD70_HUMAN

CD70 antigen

0.394

ZN200_HUMAN

Zinc finger protein 200

0.394

F229B_HUMAN

Protein FAM229B

0.394

F170A_HUMAN

Protein FAM170A

0.394

DBND2_HUMAN

Dysbindin domain-containing protein 2

0.394

SG3A2_HUMAN

Secretoglobin family 3A member 2

0.394

ZN449_HUMAN

Zinc finger protein 449

0.394

G6B_HUMAN

Megakaryocyte and platelet inhibitory receptor G6b

0.394

NGAL_HUMAN

Neutrophil gelatinase-associated lipocalin

0.394

CXL16_HUMAN

C-X-C motif chemokine 16

0.394

SHRM1_HUMAN

Protein Shroom1

0.394

IL7_HUMAN

Interleukin-7

0.394

MENT_HUMAN

Protein MENT

0.394

CJ120_HUMAN

Uncharacterized protein C10orf120

0.394

DLL3_HUMAN

Delta-like protein 3

0.394

FCG3A_HUMAN

Low affinity immunoglobulin gamma Fc region receptor III-A

0.397

NNAT_HUMAN

Neuronatin

0.397

LY66C_HUMAN

Lymphocyte antigen 6 complex locus protein G6c

0.397

TCAL8_HUMAN

Transcription elongation factor A protein-like 8

0.397

GASP2_HUMAN

G-protein coupled receptor-associated sorting protein 2

0.397

PRCA1_HUMAN

Protein PROCA1

0.397

PRS58_HUMAN

Serine protease 58

0.397

CALY_HUMAN

Neuron-specific vesicular protein calcyon

0.397

ZCCHL_HUMAN

Zinc finger CCCH-type antiviral protein 1-like

0.397

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 52 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy