NR4A1_HUMAN 2019

Gene Name NR4A1

Description Nuclear receptor subfamily 4 group A member 1

Length 598

9606

Sequence

>sp|P22736|NR4A1_HUMAN Nuclear receptor subfamily 4 group A member 1
MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

NR4A2_HUMAN

Nuclear receptor subfamily 4 group A member 2

0.274

RORA_HUMAN

Nuclear receptor ROR-alpha

0.349

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.369

LEG8_HUMAN

Galectin-8

0.378

STOX1_HUMAN

Storkhead-box protein 1

0.378

GDF11_HUMAN

Growth/differentiation factor 11

0.378

RORB_HUMAN

Nuclear receptor ROR-beta

0.378

TMM47_HUMAN

Transmembrane protein 47

0.383

LCOR_HUMAN

Ligand-dependent corepressor

0.392

ERBB4_HUMAN

Receptor tyrosine-protein kinase erbB-4

0.394

RIMS1_HUMAN

Regulating synaptic membrane exocytosis protein 1

0.394

DACH1_HUMAN

Dachshund homolog 1

0.394

ACK1_HUMAN

Activated CDC42 kinase 1

0.394

NR2C2_HUMAN

Nuclear receptor subfamily 2 group C member 2

0.394

DACH2_HUMAN

Dachshund homolog 2

0.394

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.399

ACM3_HUMAN

Muscarinic acetylcholine receptor M3

0.399

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.399

PRDM1_HUMAN

PR domain zinc finger protein 1

0.399

ACM2_HUMAN

Muscarinic acetylcholine receptor M2

0.399

BC11A_HUMAN

B-cell lymphoma/leukemia 11A

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.356

DOXA2_HUMAN

Dual oxidase maturation factor 2

0.359

LEG8_HUMAN

Galectin-8

0.360

NR4A2_HUMAN

Nuclear receptor subfamily 4 group A member 2

0.360

PROX1_HUMAN

Prospero homeobox protein 1

0.363

CSPG4_HUMAN

Chondroitin sulfate proteoglycan 4

0.371

5HT1A_HUMAN

5-hydroxytryptamine receptor 1A

0.371

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.373

CSTN1_HUMAN

Calsyntenin-1

0.375

UNC5C_HUMAN

Netrin receptor UNC5C

0.378

NDUB5_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

0.378

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.379

AT1B4_HUMAN

Protein ATP1B4

0.379

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.379

ERBB2_HUMAN

Receptor tyrosine-protein kinase erbB-2

0.379

RYK_HUMAN

Tyrosine-protein kinase RYK

0.379

RUND1_HUMAN

RUN domain-containing protein 1

0.381

MPRIP_HUMAN

Myosin phosphatase Rho-interacting protein

0.381

DOXA1_HUMAN

Dual oxidase maturation factor 1

0.381

PRIC2_HUMAN

Prickle-like protein 2

0.382

GNRHR_HUMAN

Gonadotropin-releasing hormone receptor

0.382

CUBN_HUMAN

Cubilin

0.383

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.383

KIRR3_HUMAN

Kin of IRRE-like protein 3

0.384

FBX25_HUMAN

F-box only protein 25

0.384

TUTLB_HUMAN

Protein turtle homolog B

0.384

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.385

ACM2_HUMAN

Muscarinic acetylcholine receptor M2

0.385

PRDM1_HUMAN

PR domain zinc finger protein 1

0.385

HLF_HUMAN

Hepatic leukemia factor

0.386

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.387

OTOP1_HUMAN

Proton channel OTOP1

0.388

UNC5D_HUMAN

Netrin receptor UNC5D

0.388

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.389

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.389

NRCAM_HUMAN

Neuronal cell adhesion molecule

0.389

BMP2_HUMAN

Bone morphogenetic protein 2

0.390

SALL1_HUMAN

Sal-like protein 1

0.390

AKAP1_HUMAN

A-kinase anchor protein 1, mitochondrial

0.390

SLIT1_HUMAN

Slit homolog 1 protein

0.390

HINFP_HUMAN

Histone H4 transcription factor

0.391

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.391

ACM5_HUMAN

Muscarinic acetylcholine receptor M5

0.391

BC11A_HUMAN

B-cell lymphoma/leukemia 11A

0.391

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.392

NUMB_HUMAN

Protein numb homolog

0.392

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.392

BMP4_HUMAN

Bone morphogenetic protein 4

0.392

KIRR1_HUMAN

Kin of IRRE-like protein 1

0.392

HES1_HUMAN

Transcription factor HES-1

0.392

BARH2_HUMAN

BarH-like 2 homeobox protein

0.393

BICD1_HUMAN

Protein bicaudal D homolog 1

0.393

ANLN_HUMAN

Anillin

0.393

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.393

OSR2_HUMAN

Protein odd-skipped-related 2

0.393

RM39_HUMAN

39S ribosomal protein L39, mitochondrial

0.393

BAF_HUMAN

Barrier-to-autointegration factor

0.394

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.394

RB6I2_HUMAN

ELKS/Rab6-interacting/CAST family member 1

0.394

5HT1B_HUMAN

5-hydroxytryptamine receptor 1B

0.395

MYT1_HUMAN

Myelin transcription factor 1

0.396

RIMS1_HUMAN

Regulating synaptic membrane exocytosis protein 1

0.396

ERBB4_HUMAN

Receptor tyrosine-protein kinase erbB-4

0.396

ST18_HUMAN

Suppression of tumorigenicity 18 protein

0.396

PDC10_HUMAN

Programmed cell death protein 10

0.396

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.396

EGFR_HUMAN

Epidermal growth factor receptor

0.397

PROM1_HUMAN

Prominin-1

0.397

KPBB_HUMAN

Phosphorylase b kinase regulatory subunit beta

0.397

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.397

TRIO_HUMAN

Triple functional domain protein

0.397

FERM2_HUMAN

Fermitin family homolog 2

0.397

BNC2_HUMAN

Zinc finger protein basonuclin-2

0.398

BICD2_HUMAN

Protein bicaudal D homolog 2

0.398

TPST1_HUMAN

Protein-tyrosine sulfotransferase 1

0.398

DACH1_HUMAN

Dachshund homolog 1

0.399

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.399

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.399

FA20C_HUMAN

Extracellular serine/threonine protein kinase FAM20C

0.400

SMOC1_HUMAN

SPARC-related modular calcium-binding protein 1

0.400

SEM6A_HUMAN

Semaphorin-6A

0.400

ACK1_HUMAN

Activated CDC42 kinase 1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 38 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy