GLRA1_HUMAN 2019

Gene Name GLRA1

Description Glycine receptor subunit alpha-1

Length 457

9606

Sequence

>sp|P23415|GLRA1_HUMAN Glycine receptor subunit alpha-1
MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

ACHA2_HUMAN

Neuronal acetylcholine receptor subunit alpha-2

0.343

ACK1_HUMAN

Activated CDC42 kinase 1

0.350

GLRA3_HUMAN

Glycine receptor subunit alpha-3

0.350

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.374

VANG1_HUMAN

Vang-like protein 1

0.374

RIPL1_HUMAN

RILP-like protein 1

0.374

ACHA3_HUMAN

Neuronal acetylcholine receptor subunit alpha-3

0.374

GLRB_HUMAN

Glycine receptor subunit beta

0.378

TPD54_HUMAN

Tumor protein D54

0.378

SP9_HUMAN

Transcription factor Sp9

0.378

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.378

MYT1_HUMAN

Myelin transcription factor 1

0.382

RIMS4_HUMAN

Regulating synaptic membrane exocytosis protein 4

0.382

GLRA2_HUMAN

Glycine receptor subunit alpha-2

0.389

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.392

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.392

RUNX2_HUMAN

Runt-related transcription factor 2

0.392

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.396

NUMB_HUMAN

Protein numb homolog

0.396

MACOI_HUMAN

Macoilin

0.396

AT1B4_HUMAN

Protein ATP1B4

0.396

BARH1_HUMAN

BarH-like 1 homeobox protein

0.396

ROR1_HUMAN

Inactive tyrosine-protein kinase transmembrane receptor ROR1

0.396

WNT5A_HUMAN

Protein Wnt-5a

0.396

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.396

NET1_HUMAN

Netrin-1

0.396

RUND1_HUMAN

RUN domain-containing protein 1

0.396

RIMS1_HUMAN

Regulating synaptic membrane exocytosis protein 1

0.400

DACH1_HUMAN

Dachshund homolog 1

0.400

NR2C2_HUMAN

Nuclear receptor subfamily 2 group C member 2

0.400

CSTN1_HUMAN

Calsyntenin-1

0.400

ERBB4_HUMAN

Receptor tyrosine-protein kinase erbB-4

0.400

MB211_HUMAN

Putative nucleotidyltransferase MAB21L1

0.400

DACH2_HUMAN

Dachshund homolog 2

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

GLRB_HUMAN

Glycine receptor subunit beta

0.315

GLRA3_HUMAN

Glycine receptor subunit alpha-3

0.338

AHR_HUMAN

Aryl hydrocarbon receptor

0.359

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.362

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.362

NUMB_HUMAN

Protein numb homolog

0.363

MYT1_HUMAN

Myelin transcription factor 1

0.367

TPD54_HUMAN

Tumor protein D54

0.367

ACM2_HUMAN

Muscarinic acetylcholine receptor M2

0.367

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.369

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.369

GLRA2_HUMAN

Glycine receptor subunit alpha-2

0.369

RIPL1_HUMAN

RILP-like protein 1

0.370

ACK1_HUMAN

Activated CDC42 kinase 1

0.371

TPD52_HUMAN

Tumor protein D52

0.373

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.373

AT1B4_HUMAN

Protein ATP1B4

0.374

HINFP_HUMAN

Histone H4 transcription factor

0.374

MIGA2_HUMAN

Mitoguardin 2

0.374

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.375

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.375

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.375

ITB1_HUMAN

Integrin beta-1

0.378

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.378

KIRR3_HUMAN

Kin of IRRE-like protein 3

0.379

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.380

ARFP1_HUMAN

Arfaptin-1

0.380

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.380

TAOK3_HUMAN

Serine/threonine-protein kinase TAO3

0.380

EGFR_HUMAN

Epidermal growth factor receptor

0.380

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.380

TRIO_HUMAN

Triple functional domain protein

0.381

ACHA3_HUMAN

Neuronal acetylcholine receptor subunit alpha-3

0.381

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.381

TPD53_HUMAN

Tumor protein D53

0.381

TPST1_HUMAN

Protein-tyrosine sulfotransferase 1

0.382

ITAV_HUMAN

Integrin alpha-V

0.382

CSTN1_HUMAN

Calsyntenin-1

0.383

UNC5D_HUMAN

Netrin receptor UNC5D

0.383

PROX1_HUMAN

Prospero homeobox protein 1

0.383

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.384

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.384

NRCAM_HUMAN

Neuronal cell adhesion molecule

0.384

UNC5B_HUMAN

Netrin receptor UNC5B

0.384

BMP2_HUMAN

Bone morphogenetic protein 2

0.385

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.385

ARFP2_HUMAN

Arfaptin-2

0.387

CD109_HUMAN

CD109 antigen

0.387

RT25_HUMAN

28S ribosomal protein S25, mitochondrial

0.387

BMP4_HUMAN

Bone morphogenetic protein 4

0.387

BICD1_HUMAN

Protein bicaudal D homolog 1

0.388

ANLN_HUMAN

Anillin

0.388

H6ST2_HUMAN

Heparan-sulfate 6-O-sulfotransferase 2

0.389

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.389

HNF6_HUMAN

Hepatocyte nuclear factor 6

0.390

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.390

5HT1A_HUMAN

5-hydroxytryptamine receptor 1A

0.391

CSTN3_HUMAN

Calsyntenin-3

0.391

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.391

WLS_HUMAN

Protein wntless homolog

0.392

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.392

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.393

MIGA1_HUMAN

Mitoguardin 1

0.393

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.394

ACHA7_HUMAN

Neuronal acetylcholine receptor subunit alpha-7

0.394

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.394

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.394

JIP3_HUMAN

C-Jun-amino-terminal kinase-interacting protein 3

0.395

H6ST1_HUMAN

Heparan-sulfate 6-O-sulfotransferase 1

0.395

ROR1_HUMAN

Inactive tyrosine-protein kinase transmembrane receptor ROR1

0.395

SMAD5_HUMAN

Mothers against decapentaplegic homolog 5

0.395

ACHA2_HUMAN

Neuronal acetylcholine receptor subunit alpha-2

0.395

PHKG1_HUMAN

Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

0.395

CSKP_HUMAN

Peripheral plasma membrane protein CASK

0.395

RIMS4_HUMAN

Regulating synaptic membrane exocytosis protein 4

0.396

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.396

CSRN3_HUMAN

Cysteine/serine-rich nuclear protein 3

0.397

NDUB5_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

0.397

UNC5C_HUMAN

Netrin receptor UNC5C

0.397

PLXA2_HUMAN

Plexin-A2

0.397

PICK1_HUMAN

PRKCA-binding protein

0.397

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.397

ANKL2_HUMAN

Ankyrin repeat and LEM domain-containing protein 2

0.397

ITB3_HUMAN

Integrin beta-3

0.397

ERBB2_HUMAN

Receptor tyrosine-protein kinase erbB-2

0.398

ACM5_HUMAN

Muscarinic acetylcholine receptor M5

0.398

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.398

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.398

RSBN1_HUMAN

Lysine-specific demethylase 9

0.398

TMEM9_HUMAN

Transmembrane protein 9

0.399

TMM9B_HUMAN

Transmembrane protein 9B

0.399

TSN5_HUMAN

Tetraspanin-5

0.399

RUND1_HUMAN

RUN domain-containing protein 1

0.399

HTF4_HUMAN

Transcription factor 12

0.399

BARH2_HUMAN

BarH-like 2 homeobox protein

0.399

NDST1_HUMAN

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

0.400

AFAD_HUMAN

Afadin

0.400

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 47 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy