MK04_HUMAN 2019

Gene Name MK04

Description Mitogen-activated protein kinase 4

Length 587

9606

Sequence

>sp|P31152|MK04_HUMAN Mitogen-activated protein kinase 4
MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSRYPVSLSSDLEWRPDRCQDASEVQRDPRAGSAPLAEDVQVDPRKDSHSSSERFLEQSHSSMERAFEADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAAGAPPTATGLADTGAREDEPASLFLEIAQWVKSTQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLDVFISRALKLCTKPEDLPDNKLGDLNGACIPEHPGDLVQTEAFSKERW

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

MK06_HUMAN

Mitogen-activated protein kinase 6

0.209

AFAP1_HUMAN

Actin filament-associated protein 1

0.289

CAR14_HUMAN

Caspase recruitment domain-containing protein 14

0.295

CCHCR_HUMAN

Coiled-coil alpha-helical rod protein 1

0.295

F167A_HUMAN

Protein FAM167A

0.346

PAWR_HUMAN

PRKC apoptosis WT1 regulator protein

0.346

AF1L1_HUMAN

Actin filament-associated protein 1-like 1

0.354

SLF2_HUMAN

SMC5-SMC6 complex localization factor protein 2

0.354

CB050_HUMAN

Uncharacterized protein C2orf50

0.354

CCD18_HUMAN

Coiled-coil domain-containing protein 18

0.354

F199X_HUMAN

Protein FAM199X

0.354

MATR3_HUMAN

Matrin-3

0.354

CTHR1_HUMAN

Collagen triple helix repeat-containing protein 1

0.354

KTBL1_HUMAN

KATNB1-like protein 1

0.354

AF1L2_HUMAN

Actin filament-associated protein 1-like 2

0.354

CF062_HUMAN

Uncharacterized protein C6orf62

0.354

MID51_HUMAN

Mitochondrial dynamics protein MID51

0.354

ARG33_HUMAN

Rho guanine nucleotide exchange factor 33

0.361

TTC22_HUMAN

Tetratricopeptide repeat protein 22

0.361

FP100_HUMAN

Fanconi anemia core complex-associated protein 100

0.361

TALD3_HUMAN

Protein TALPID3

0.361

TNF14_HUMAN

Tumor necrosis factor ligand superfamily member 14

0.369

LRAT2_HUMAN

Protein LRATD2

0.369

LRC28_HUMAN

Leucine-rich repeat-containing protein 28

0.392

MTBP_HUMAN

Mdm2-binding protein

0.392

OIT3_HUMAN

Oncoprotein-induced transcript 3 protein

0.392

CC171_HUMAN

Coiled-coil domain-containing protein 171

0.400

SLAI1_HUMAN

SLAIN motif-containing protein 1

0.400

PCD20_HUMAN

Protocadherin-20

0.400

HGFL_HUMAN

Hepatocyte growth factor-like protein

0.400

HAUS8_HUMAN

HAUS augmin-like complex subunit 8

0.400

CNTLN_HUMAN

Centlein

0.400

KNDC1_HUMAN

Kinase non-catalytic C-lobe domain-containing protein 1

0.400

SFRP3_HUMAN

Secreted frizzled-related protein 3

0.400

TM168_HUMAN

Transmembrane protein 168

0.400

NCOA4_HUMAN

Nuclear receptor coactivator 4

0.400

AKNA_HUMAN

Microtubule organization protein AKNA

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

MK06_HUMAN

Mitogen-activated protein kinase 6

0.300

F199X_HUMAN

Protein FAM199X

0.343

MID51_HUMAN

Mitochondrial dynamics protein MID51

0.343

F167A_HUMAN

Protein FAM167A

0.352

CF062_HUMAN

Uncharacterized protein C6orf62

0.355

DRA_HUMAN

HLA class II histocompatibility antigen, DR alpha chain

0.355

A0A0G2JMH6_HUMAN

HLA-DRA

0.355

MTFR1_HUMAN

Mitochondrial fission regulator 1

0.359

USPL1_HUMAN

SUMO-specific isopeptidase USPL1

0.365

CAR14_HUMAN

Caspase recruitment domain-containing protein 14

0.368

AF1L1_HUMAN

Actin filament-associated protein 1-like 1

0.370

AF1L2_HUMAN

Actin filament-associated protein 1-like 2

0.370

MASP1_HUMAN

Mannan-binding lectin serine protease 1

0.372

TNR19_HUMAN

Tumor necrosis factor receptor superfamily member 19

0.372

ENDD1_HUMAN

Endonuclease domain-containing 1 protein

0.372

MTBP_HUMAN

Mdm2-binding protein

0.376

PAWR_HUMAN

PRKC apoptosis WT1 regulator protein

0.378

MOONR_HUMAN

Protein moonraker

0.380

TM196_HUMAN

Transmembrane protein 196

0.382

CTHR1_HUMAN

Collagen triple helix repeat-containing protein 1

0.382

SFRP3_HUMAN

Secreted frizzled-related protein 3

0.382

KTBL1_HUMAN

KATNB1-like protein 1

0.383

DERM_HUMAN

Dermatopontin

0.383

CIKS_HUMAN

Adapter protein CIKS

0.383

CAR11_HUMAN

Caspase recruitment domain-containing protein 11

0.383

MIEAP_HUMAN

Mitochondria-eating protein

0.385

DSE_HUMAN

Dermatan-sulfate epimerase

0.385

TGFB2_HUMAN

Transforming growth factor beta-2 proprotein

0.385

GP161_HUMAN

G-protein coupled receptor 161

0.387

STXB6_HUMAN

Syntaxin-binding protein 6

0.387

BORG2_HUMAN

Cdc42 effector protein 3

0.387

FAKD2_HUMAN

FAST kinase domain-containing protein 2, mitochondrial

0.389

TR19L_HUMAN

Tumor necrosis factor receptor superfamily member 19L

0.389

CCHCR_HUMAN

Coiled-coil alpha-helical rod protein 1

0.389

CNTLN_HUMAN

Centlein

0.390

AFAP1_HUMAN

Actin filament-associated protein 1

0.392

TCO2_HUMAN

Transcobalamin-2

0.392

BCL10_HUMAN

B-cell lymphoma/leukemia 10

0.394

SNX10_HUMAN

Sorting nexin-10

0.394

SLAI1_HUMAN

SLAIN motif-containing protein 1

0.394

GSDME_HUMAN

Gasdermin-E

0.394

HPLN1_HUMAN

Hyaluronan and proteoglycan link protein 1

0.396

HNMT_HUMAN

Histamine N-methyltransferase

0.396

I17RA_HUMAN

Interleukin-17 receptor A

0.396

HAUS8_HUMAN

HAUS augmin-like complex subunit 8

0.396

KCMB2_HUMAN

Calcium-activated potassium channel subunit beta-2

0.396

TALD3_HUMAN

Protein TALPID3

0.396

PCDH7_HUMAN

Protocadherin-7

0.396

MATR3_HUMAN

Matrin-3

0.396

CK053_HUMAN

Uncharacterized protein C11orf53

0.397

EFC4B_HUMAN

EF-hand calcium-binding domain-containing protein 4B

0.398

TM168_HUMAN

Transmembrane protein 168

0.399

CENPM_HUMAN

Centromere protein M

0.399

TXD16_HUMAN

Thioredoxin domain-containing protein 16

0.399

MAG_HUMAN

Myelin-associated glycoprotein

0.399

IL27B_HUMAN

Interleukin-27 subunit beta

0.399

EMP3_HUMAN

Epithelial membrane protein 3

0.399

FBLN7_HUMAN

Fibulin-7

0.400

CD166_HUMAN

CD166 antigen

0.400

ZN142_HUMAN

Zinc finger protein 142

0.400

CEP55_HUMAN

Centrosomal protein of 55 kDa

0.400

BEND3_HUMAN

BEN domain-containing protein 3

0.400

LR75A_HUMAN

Leucine-rich repeat-containing protein 75A

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 22 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy