T2FA_HUMAN 2019

Gene Name T2FA

Description General transcription factor IIF subunit 1

Length 517

9606

Sequence

>sp|P35269|T2FA_HUMAN General transcription factor IIF subunit 1
MAALGPSSQNVTEYVVRVPKNTTKKYNIMAFNAADKVNFATWNQARLERDLSNKKIYQEEEMPESGAGSEFNRKLREEARRKKYGIVLKEFRPEDQPWLLRVNGKSGRKFKGIKKGGVTENTSYYIFTQCPDGAFEAFPVHNWYNFTPLARHRTLTAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDAVRRYLTRKPMTTKDLLKKFQTKKTGLSSEQTVNVLAQILKRLNPERKMINDKMHFSLKE

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

AT1B4_HUMAN

Protein ATP1B4

0.316

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.316

RIMS1_HUMAN

Regulating synaptic membrane exocytosis protein 1

0.319

WLS_HUMAN

Protein wntless homolog

0.343

GFI1_HUMAN

Zinc finger protein Gfi-1

0.343

RIPL1_HUMAN

RILP-like protein 1

0.346

VANG1_HUMAN

Vang-like protein 1

0.346

FABP7_HUMAN

Fatty acid-binding protein, brain

0.346

HINFP_HUMAN

Histone H4 transcription factor

0.346

LIPA1_HUMAN

Liprin-alpha-1

0.346

ITF2_HUMAN

Transcription factor 4

0.346

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.346

AT1B2_HUMAN

Sodium/potassium-transporting ATPase subunit beta-2

0.350

SYT1_HUMAN

Synaptotagmin-1

0.367

FERM1_HUMAN

Fermitin family homolog 1

0.367

FERM2_HUMAN

Fermitin family homolog 2

0.367

RUNX2_HUMAN

Runt-related transcription factor 2

0.367

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.367

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.370

HTF4_HUMAN

Transcription factor 12

0.370

WNT5A_HUMAN

Protein Wnt-5a

0.370

RUND1_HUMAN

RUN domain-containing protein 1

0.370

NUMB_HUMAN

Protein numb homolog

0.370

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.370

JPH1_HUMAN

Junctophilin-1

0.370

JIP3_HUMAN

C-Jun-amino-terminal kinase-interacting protein 3

0.370

NET1_HUMAN

Netrin-1

0.370

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.370

BARH1_HUMAN

BarH-like 1 homeobox protein

0.370

PO4F3_HUMAN

POU domain, class 4, transcription factor 3

0.374

MB211_HUMAN

Putative nucleotidyltransferase MAB21L1

0.374

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.374

NFASC_HUMAN

Neurofascin

0.374

DACH1_HUMAN

Dachshund homolog 1

0.374

DACH2_HUMAN

Dachshund homolog 2

0.374

NR2C2_HUMAN

Nuclear receptor subfamily 2 group C member 2

0.374

CSTN1_HUMAN

Calsyntenin-1

0.374

LIPA2_HUMAN

Liprin-alpha-2

0.374

ACK1_HUMAN

Activated CDC42 kinase 1

0.374

BC11A_HUMAN

B-cell lymphoma/leukemia 11A

0.378

BC11B_HUMAN

B-cell lymphoma/leukemia 11B

0.378

RIMS3_HUMAN

Regulating synaptic membrane exocytosis protein 3

0.378

RASF8_HUMAN

Ras association domain-containing protein 8

0.378

LMBR1_HUMAN

Limb region 1 protein homolog

0.381

NPHN_HUMAN

Nephrin

0.382

INT13_HUMAN

Integrator complex subunit 13

0.389

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.389

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.389

BMP2_HUMAN

Bone morphogenetic protein 2

0.392

NLK_HUMAN

Serine/threonine-protein kinase NLK

0.392

CTNA1_HUMAN

Catenin alpha-1

0.392

TGFR1_HUMAN

TGF-beta receptor type-1

0.392

DVL2_HUMAN

Segment polarity protein dishevelled homolog DVL-2

0.392

CPEB3_HUMAN

Cytoplasmic polyadenylation element-binding protein 3

0.392

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.392

FGOP2_HUMAN

FGFR1 oncogene partner 2

0.392

IRX4_HUMAN

Iroquois-class homeodomain protein IRX-4

0.392

FOXO3_HUMAN

Forkhead box protein O3

0.396

AP2B_HUMAN

Transcription factor AP-2-beta

0.396

NFIB_HUMAN

Nuclear factor 1 B-type

0.396

JPH3_HUMAN

Junctophilin-3

0.396

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.396

TFE2_HUMAN

Transcription factor E2-alpha

0.396

AP2A_HUMAN

Transcription factor AP-2-alpha

0.396

FOXO1_HUMAN

Forkhead box protein O1

0.396

ZO1_HUMAN

Tight junction protein ZO-1

0.396

FEM1C_HUMAN

Protein fem-1 homolog C

0.396

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.396

TSN5_HUMAN

Tetraspanin-5

0.396

NFIA_HUMAN

Nuclear factor 1 A-type

0.396

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.396

ROR2_HUMAN

Tyrosine-protein kinase transmembrane receptor ROR2

0.396

RN146_HUMAN

E3 ubiquitin-protein ligase RNF146

0.396

FA8A1_HUMAN

Protein FAM8A1

0.396

STON1_HUMAN

Stonin-1

0.396

AT1B3_HUMAN

Sodium/potassium-transporting ATPase subunit beta-3

0.396

E41L5_HUMAN

Band 4.1-like protein 5

0.396

NKX61_HUMAN

Homeobox protein Nkx-6.1

0.396

EMX2_HUMAN

Homeobox protein EMX2

0.396

PTPRN_HUMAN

Receptor-type tyrosine-protein phosphatase-like N

0.396

ONEC2_HUMAN

One cut domain family member 2

0.400

LIPA3_HUMAN

Liprin-alpha-3

0.400

HMX3_HUMAN

Homeobox protein HMX3

0.400

GFI1B_HUMAN

Zinc finger protein Gfi-1b

0.400

VANG2_HUMAN

Vang-like protein 2

0.400

TPD54_HUMAN

Tumor protein D54

0.400

JPH2_HUMAN

Junctophilin-2

0.400

FBX25_HUMAN

F-box only protein 25

0.400

AHR_HUMAN

Aryl hydrocarbon receptor

0.400

NRCAM_HUMAN

Neuronal cell adhesion molecule

0.400

TPD52_HUMAN

Tumor protein D52

0.400

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.400

SP9_HUMAN

Transcription factor Sp9

0.400

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.400

ANLN_HUMAN

Anillin

0.400

ZFHX3_HUMAN

Zinc finger homeobox protein 3

0.400

DLX1_HUMAN

Homeobox protein DLX-1

0.400

TPD53_HUMAN

Tumor protein D53

0.400

RXRA_HUMAN

Retinoic acid receptor RXR-alpha

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

HNF4A_HUMAN

Hepatocyte nuclear factor 4-alpha

0.375

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.376

AT1B4_HUMAN

Protein ATP1B4

0.388

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.388

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.389

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.391

ITB1_HUMAN

Integrin beta-1

0.391

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.391

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.393

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.394

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.394

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.396

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.397

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.397

BMP2_HUMAN

Bone morphogenetic protein 2

0.398

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.399

HINFP_HUMAN

Histone H4 transcription factor

0.399

CASP7_HUMAN

Caspase-7

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 47 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy