GFRA1_HUMAN 2019

Gene Name GFRA1

Description GDNF family receptor alpha-1

Length 465

9606

Sequence

>sp|P56159|GFRA1_HUMAN GDNF family receptor alpha-1
MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSPYEPVNSRLSDIFRVVPFISDVFQQVEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTTSVSNDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPNYIDSSSLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPVQTTTATTTTALRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNYEKEGLGASSHITTKSMAAPPSCGLSPLLVLVVTALSTLLSLTETS

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

LR75A_HUMAN

Leucine-rich repeat-containing protein 75A

0.295

PRDM2_HUMAN

PR domain zinc finger protein 2

0.295

MREG_HUMAN

Melanoregulin

0.295

GPR61_HUMAN

G-protein coupled receptor 61

0.295

HDX_HUMAN

Highly divergent homeobox

0.295

CC127_HUMAN

Coiled-coil domain-containing protein 127

0.295

DRAXI_HUMAN

Draxin

0.295

LAMP5_HUMAN

Lysosome-associated membrane glycoprotein 5

0.346

RET4_HUMAN

Retinol-binding protein 4

0.354

AKAP6_HUMAN

A-kinase anchor protein 6

0.354

PKR2_HUMAN

Prokineticin receptor 2

0.354

HNMT_HUMAN

Histamine N-methyltransferase

0.354

T126A_HUMAN

Transmembrane protein 126A

0.354

GEMI4_HUMAN

Gem-associated protein 4

0.354

CNMD_HUMAN

Leukocyte cell-derived chemotaxin 1

0.354

LFTY1_HUMAN

Left-right determination factor 1

0.354

B2L13_HUMAN

Bcl-2-like protein 13

0.354

NPNT_HUMAN

Nephronectin

0.354

THSD1_HUMAN

Thrombospondin type-1 domain-containing protein 1

0.354

EGFL6_HUMAN

Epidermal growth factor-like protein 6

0.354

DKK2_HUMAN

Dickkopf-related protein 2

0.354

LFTY2_HUMAN

Left-right determination factor 2

0.354

IKBZ_HUMAN

NF-kappa-B inhibitor zeta

0.354

K154L_HUMAN

UPF0606 protein KIAA1549L

0.354

FANCC_HUMAN

Fanconi anemia group C protein

0.361

GP153_HUMAN

Probable G-protein coupled receptor 153

0.361

RLF_HUMAN

Zinc finger protein Rlf

0.361

CRBA1_HUMAN

Beta-crystallin A3

0.361

HES5_HUMAN

Transcription factor HES-5

0.361

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.361

RFXAP_HUMAN

Regulatory factor X-associated protein

0.361

SMI19_HUMAN

Small integral membrane protein 19

0.361

PRLR_HUMAN

Prolactin receptor

0.361

PRLHR_HUMAN

Prolactin-releasing peptide receptor

0.361

TPA_HUMAN

Tissue-type plasminogen activator

0.361

EDNRB_HUMAN

Endothelin receptor type B

0.361

BEND5_HUMAN

BEN domain-containing protein 5

0.361

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.361

I10R2_HUMAN

Interleukin-10 receptor subunit beta

0.361

RAMP3_HUMAN

Receptor activity-modifying protein 3

0.361

GFRA2_HUMAN

GDNF family receptor alpha-2

0.361

LGI2_HUMAN

Leucine-rich repeat LGI family member 2

0.361

CJ088_HUMAN

Uncharacterized protein C10orf88

0.361

TSN18_HUMAN

Tetraspanin-18

0.361

ZN148_HUMAN

Zinc finger protein 148

0.361

EFCC1_HUMAN

EF-hand and coiled-coil domain-containing protein 1

0.361

SCG3_HUMAN

Secretogranin-3

0.361

ZN462_HUMAN

Zinc finger protein 462

0.361

PGBD5_HUMAN

PiggyBac transposable element-derived protein 5

0.361

IMPG2_HUMAN

Interphotoreceptor matrix proteoglycan 2

0.361

KNL1_HUMAN

Kinetochore scaffold 1

0.361

PTN_HUMAN

Pleiotrophin

0.361

GAK1B_HUMAN

Golgi-associated kinase 1B

0.361

EMP2_HUMAN

Epithelial membrane protein 2

0.361

LARGN_HUMAN

Protein Largen

0.361

R4RL1_HUMAN

Reticulon-4 receptor-like 1

0.361

CCDC3_HUMAN

Coiled-coil domain-containing protein 3

0.361

HBAZ_HUMAN

Hemoglobin subunit zeta

0.361

LRAD3_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 3

0.361

C2C4C_HUMAN

C2 calcium-dependent domain-containing protein 4C

0.361

PKR1_HUMAN

Prokineticin receptor 1

0.361

EURL_HUMAN

Protein EURL homolog

0.361

UR2R_HUMAN

Urotensin-2 receptor

0.361

T255A_HUMAN

Transmembrane protein 255A

0.361

PCLI1_HUMAN

PTB-containing, cubilin and LRP1-interacting protein

0.361

EDNRA_HUMAN

Endothelin-1 receptor

0.361

RET2_HUMAN

Retinol-binding protein 2

0.361

PRPH2_HUMAN

Peripherin-2

0.392

ZN407_HUMAN

Zinc finger protein 407

0.392

PCDH7_HUMAN

Protocadherin-7

0.392

USPL1_HUMAN

SUMO-specific isopeptidase USPL1

0.392

SIMC1_HUMAN

SUMO-interacting motif-containing protein 1

0.400

CTHR1_HUMAN

Collagen triple helix repeat-containing protein 1

0.400

NXPE3_HUMAN

NXPE family member 3

0.400

KTBL1_HUMAN

KATNB1-like protein 1

0.400

FNDC1_HUMAN

Fibronectin type III domain-containing protein 1

0.400

Z3H7A_HUMAN

Zinc finger CCCH domain-containing protein 7A

0.400

ZDH22_HUMAN

Palmitoyltransferase ZDHHC22

0.400

ASB7_HUMAN

Ankyrin repeat and SOCS box protein 7

0.400

LIPC_HUMAN

Hepatic triacylglycerol lipase

0.400

LIFR_HUMAN

Leukemia inhibitory factor receptor

0.400

LRRT1_HUMAN

Leucine-rich repeat transmembrane neuronal protein 1

0.400

IL6RB_HUMAN

Interleukin-6 receptor subunit beta

0.400

FANCB_HUMAN

Fanconi anemia group B protein

0.400

HRH2_HUMAN

Histamine H2 receptor

0.400

SNX10_HUMAN

Sorting nexin-10

0.400

SLAI2_HUMAN

SLAIN motif-containing protein 2

0.400

TSN15_HUMAN

Tetraspanin-15

0.400

LYAM3_HUMAN

P-selectin

0.400

GRAP2_HUMAN

GRB2-related adapter protein 2

0.400

LIPL_HUMAN

Lipoprotein lipase

0.400

BOREA_HUMAN

Borealin

0.400

SLF2_HUMAN

SMC5-SMC6 complex localization factor protein 2

0.400

CC018_HUMAN

Uncharacterized protein C3orf18

0.400

NTF3_HUMAN

Neurotrophin-3

0.400

MID51_HUMAN

Mitochondrial dynamics protein MID51

0.400

NGF_HUMAN

Beta-nerve growth factor

0.400

PDX1_HUMAN

Pancreas/duodenum homeobox protein 1

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

LAMP5_HUMAN

Lysosome-associated membrane glycoprotein 5

0.383

IL6RB_HUMAN

Interleukin-6 receptor subunit beta

0.397

LIFR_HUMAN

Leukemia inhibitory factor receptor

0.397

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 24 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy