DLX6_HUMAN 2019

Gene Name DLX6

Description Homeobox protein DLX-6

Length 175

9606

Sequence

>sp|P56179|DLX6_HUMAN Homeobox protein DLX-6
MSHSQHSPYLQSYHNSSAAAQTRGDDTDQQKTTVIENGEIRFNGKGKKIRKPRTIYSSLQLQALNHRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLLKQGSNPHESDPLQGSAALSPRSPALPPVWDVSASAKGVSMPPNSYMPGYSHWYSSPHQDTMQRPQMM

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

CELR1_HUMAN

Cadherin EGF LAG seven-pass G-type receptor 1

0.218

DLX1_HUMAN

Homeobox protein DLX-1

0.261

NFASC_HUMAN

Neurofascin

0.298

NCHL1_HUMAN

Neural cell adhesion molecule L1-like protein

0.337

PITX1_HUMAN

Pituitary homeobox 1

0.337

CELR3_HUMAN

Cadherin EGF LAG seven-pass G-type receptor 3

0.337

AT1B4_HUMAN

Protein ATP1B4

0.357

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.357

HLF_HUMAN

Hepatic leukemia factor

0.357

PO4F3_HUMAN

POU domain, class 4, transcription factor 3

0.361

MSX1_HUMAN

Homeobox protein MSX-1

0.361

AVR2B_HUMAN

Activin receptor type-2B

0.361

DACH2_HUMAN

Dachshund homolog 2

0.361

BTBD7_HUMAN

BTB/POZ domain-containing protein 7

0.361

APC_HUMAN

Adenomatous polyposis coli protein

0.361

RIMS1_HUMAN

Regulating synaptic membrane exocytosis protein 1

0.361

DACH1_HUMAN

Dachshund homolog 1

0.361

K2013_HUMAN

Uncharacterized protein KIAA2013

0.365

ACM2_HUMAN

Muscarinic acetylcholine receptor M2

0.365

S12A8_HUMAN

Solute carrier family 12 member 8

0.365

ACM3_HUMAN

Muscarinic acetylcholine receptor M3

0.365

PAR3L_HUMAN

Partitioning defective 3 homolog B

0.365

FBX32_HUMAN

F-box only protein 32

0.365

TSN17_HUMAN

Tetraspanin-17

0.365

EVX1_HUMAN

Homeobox even-skipped homolog protein 1

0.369

APLP1_HUMAN

Amyloid-like protein 1

0.369

NEGR1_HUMAN

Neuronal growth regulator 1

0.369

GFI1_HUMAN

Zinc finger protein Gfi-1

0.382

NLK_HUMAN

Serine/threonine-protein kinase NLK

0.382

WLS_HUMAN

Protein wntless homolog

0.382

TGFR1_HUMAN

TGF-beta receptor type-1

0.382

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.386

FOXO1_HUMAN

Forkhead box protein O1

0.386

HINFP_HUMAN

Histone H4 transcription factor

0.386

ZO1_HUMAN

Tight junction protein ZO-1

0.386

TEF_HUMAN

Thyrotroph embryonic factor

0.386

AP2A_HUMAN

Transcription factor AP-2-alpha

0.386

NFIA_HUMAN

Nuclear factor 1 A-type

0.386

ITF2_HUMAN

Transcription factor 4

0.386

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.386

FOXO3_HUMAN

Forkhead box protein O3

0.386

AP2B_HUMAN

Transcription factor AP-2-beta

0.386

VANG1_HUMAN

Vang-like protein 1

0.386

ROR2_HUMAN

Tyrosine-protein kinase transmembrane receptor ROR2

0.386

NFIB_HUMAN

Nuclear factor 1 B-type

0.386

E41L5_HUMAN

Band 4.1-like protein 5

0.386

FABP7_HUMAN

Fatty acid-binding protein, brain

0.386

RIPL1_HUMAN

RILP-like protein 1

0.386

TSN5_HUMAN

Tetraspanin-5

0.386

ONEC2_HUMAN

One cut domain family member 2

0.390

NRCAM_HUMAN

Neuronal cell adhesion molecule

0.390

RXRA_HUMAN

Retinoic acid receptor RXR-alpha

0.390

HMX3_HUMAN

Homeobox protein HMX3

0.390

ANLN_HUMAN

Anillin

0.390

PEBB_HUMAN

Core-binding factor subunit beta

0.390

AT1B2_HUMAN

Sodium/potassium-transporting ATPase subunit beta-2

0.390

TPD52_HUMAN

Tumor protein D52

0.390

GFI1B_HUMAN

Zinc finger protein Gfi-1b

0.390

DAG1_HUMAN

Dystroglycan

0.390

FBX25_HUMAN

F-box only protein 25

0.390

HME2_HUMAN

Homeobox protein engrailed-2

0.394

NAB1_HUMAN

NGFI-A-binding protein 1

0.394

NR2C1_HUMAN

Nuclear receptor subfamily 2 group C member 1

0.394

L1CAM_HUMAN

Neural cell adhesion molecule L1

0.394

HAND2_HUMAN

Heart- and neural crest derivatives-expressed protein 2

0.394

SKT_HUMAN

Sickle tail protein homolog

0.394

MED24_HUMAN

Mediator of RNA polymerase II transcription subunit 24

0.394

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.394

CRYA2_HUMAN

Alpha-crystallin A2 chain

0.394

DAB2_HUMAN

Disabled homolog 2

0.394

EFNB1_HUMAN

Ephrin-B1

0.399

E41LB_HUMAN

Band 4.1-like protein 4B

0.399

EFNB2_HUMAN

Ephrin-B2

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

AT1B4_HUMAN

Protein ATP1B4

0.359

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.359

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.373

ANLN_HUMAN

Anillin

0.373

NFASC_HUMAN

Neurofascin

0.376

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.378

HLF_HUMAN

Hepatic leukemia factor

0.379

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.381

BMP2_HUMAN

Bone morphogenetic protein 2

0.382

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.383

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.383

HINFP_HUMAN

Histone H4 transcription factor

0.383

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.384

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.384

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.384

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.384

TEF_HUMAN

Thyrotroph embryonic factor

0.385

TSN5_HUMAN

Tetraspanin-5

0.385

ZO1_HUMAN

Tight junction protein ZO-1

0.386

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.387

ITB1_HUMAN

Integrin beta-1

0.387

DAB1_HUMAN

Disabled homolog 1

0.388

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.389

PAR3L_HUMAN

Partitioning defective 3 homolog B

0.389

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.389

WLS_HUMAN

Protein wntless homolog

0.389

TRIO_HUMAN

Triple functional domain protein

0.389

OFUT1_HUMAN

GDP-fucose protein O-fucosyltransferase 1

0.389

NCHL1_HUMAN

Neural cell adhesion molecule L1-like protein

0.390

CSTN1_HUMAN

Calsyntenin-1

0.391

RIPL1_HUMAN

RILP-like protein 1

0.391

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.391

NLK_HUMAN

Serine/threonine-protein kinase NLK

0.391

NRCAM_HUMAN

Neuronal cell adhesion molecule

0.393

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.394

DAB2_HUMAN

Disabled homolog 2

0.395

NUMB_HUMAN

Protein numb homolog

0.395

BICD1_HUMAN

Protein bicaudal D homolog 1

0.396

AT1B3_HUMAN

Sodium/potassium-transporting ATPase subunit beta-3

0.396

HTF4_HUMAN

Transcription factor 12

0.396

AFAD_HUMAN

Afadin

0.397

BMP7_HUMAN

Bone morphogenetic protein 7

0.397

MACOI_HUMAN

Macoilin

0.397

PRIC2_HUMAN

Prickle-like protein 2

0.397

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.398

PO4F3_HUMAN

POU domain, class 4, transcription factor 3

0.398

TAOK1_HUMAN

Serine/threonine-protein kinase TAO1

0.399

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.399

ZSWM8_HUMAN

Zinc finger SWIM domain-containing protein 8

0.399

SAV1_HUMAN

Protein salvador homolog 1

0.399

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 41 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy