CLD2_HUMAN 2019

Gene Name CLD2

Description Claudin-2

Length 230

9606

Sequence

>sp|P57739|CLD2_HUMAN Claudin-2
MASLGLQLVGYILGLLGLLGTLVAMLLPSWKTSSYVGASIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIISVVGMRCTVFCQESRAKDRVAVAGGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLIAGIILCFSCSSQRNRSNYYDAYQAQPLATRSSPRPGQPPKVKSEFNSYSLTGYV

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

DMA_HUMAN

HLA class II histocompatibility antigen, DM alpha chain

0.289

HRG_HUMAN

Histidine-rich glycoprotein

0.289

CENPA_HUMAN

Histone H3-like centromeric protein A

0.289

CD72_HUMAN

B-cell differentiation antigen CD72

0.289

I10R1_HUMAN

Interleukin-10 receptor subunit alpha

0.289

S10AB_HUMAN

Protein S100-A11

0.289

DMB_HUMAN

HLA class II histocompatibility antigen, DM beta chain

0.289

NXPH3_HUMAN

Neurexophilin-3

0.289

CLBA1_HUMAN

Uncharacterized protein CLBA1

0.289

TREM2_HUMAN

Triggering receptor expressed on myeloid cells 2

0.392

CK091_HUMAN

Uncharacterized protein C11orf91

0.392

O11A1_HUMAN

Olfactory receptor 11A1

0.392

ACRBP_HUMAN

Acrosin-binding protein

0.392

TM52B_HUMAN

Transmembrane protein 52B

0.392

CXA4_HUMAN

Gap junction alpha-4 protein

0.392

OPT_HUMAN

Opticin

0.392

INAR2_HUMAN

Interferon alpha/beta receptor 2

0.392

BPIB4_HUMAN

BPI fold-containing family B member 4

0.392

MYOZ3_HUMAN

Myozenin-3

0.392

K2C75_HUMAN

Keratin, type II cytoskeletal 75

0.392

PRIO_HUMAN

Major prion protein

0.392

PSPC_HUMAN

Pulmonary surfactant-associated protein C

0.392

CD8A_HUMAN

T-cell surface glycoprotein CD8 alpha chain

0.392

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

BPIB4_HUMAN

BPI fold-containing family B member 4

0.281

THY1_HUMAN

Thy-1 membrane glycoprotein

0.302

RESF1_HUMAN

Retroelement silencing factor 1

0.303

S10AB_HUMAN

Protein S100-A11

0.303

INGR1_HUMAN

Interferon gamma receptor 1

0.320

CF132_HUMAN

Uncharacterized protein C6orf132

0.322

I10R1_HUMAN

Interleukin-10 receptor subunit alpha

0.324

CD72_HUMAN

B-cell differentiation antigen CD72

0.324

ACRBP_HUMAN

Acrosin-binding protein

0.342

LIF_HUMAN

Leukemia inhibitory factor

0.342

TAF1D_HUMAN

TATA box-binding protein-associated factor RNA polymerase I subunit D

0.342

TREM2_HUMAN

Triggering receptor expressed on myeloid cells 2

0.342

ZN777_HUMAN

Zinc finger protein 777

0.344

INLR1_HUMAN

Interferon lambda receptor 1

0.344

CD6_HUMAN

T-cell differentiation antigen CD6

0.351

SUGP2_HUMAN

SURP and G-patch domain-containing protein 2

0.354

INAR1_HUMAN

Interferon alpha/beta receptor 1

0.354

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.354

CLD16_HUMAN

Claudin-16

0.356

CD34_HUMAN

Hematopoietic progenitor cell antigen CD34

0.356

PIANP_HUMAN

PILR alpha-associated neural protein

0.358

CD47_HUMAN

Leukocyte surface antigen CD47

0.358

ODFP1_HUMAN

Outer dense fiber protein 1

0.360

TM171_HUMAN

Transmembrane protein 171

0.360

MYOZ3_HUMAN

Myozenin-3

0.360

TNFL8_HUMAN

Tumor necrosis factor ligand superfamily member 8

0.360

INAR2_HUMAN

Interferon alpha/beta receptor 2

0.360

TM52B_HUMAN

Transmembrane protein 52B

0.360

EPCR_HUMAN

Endothelial protein C receptor

0.363

PDCD1_HUMAN

Programmed cell death protein 1

0.363

VTDB_HUMAN

Vitamin D-binding protein

0.369

CO8A1_HUMAN

Collagen alpha-1(VIII) chain

0.373

GSG1_HUMAN

Germ cell-specific gene 1 protein

0.373

VWCE_HUMAN

von Willebrand factor C and EGF domain-containing protein

0.376

I22R1_HUMAN

Interleukin-22 receptor subunit alpha-1

0.376

INGR2_HUMAN

Interferon gamma receptor 2

0.376

RAI3_HUMAN

Retinoic acid-induced protein 3

0.376

BRNP2_HUMAN

BMP/retinoic acid-inducible neural-specific protein 2

0.376

IL22_HUMAN

Interleukin-22

0.376

VEXIN_HUMAN

Vexin

0.378

TB182_HUMAN

182 kDa tankyrase-1-binding protein

0.378

SPERT_HUMAN

Spermatid-associated protein

0.378

ICOS_HUMAN

Inducible T-cell costimulator

0.378

CA094_HUMAN

Uncharacterized protein C1orf94

0.378

ZN639_HUMAN

Zinc finger protein 639

0.378

CD28_HUMAN

T-cell-specific surface glycoprotein CD28

0.380

RARR2_HUMAN

Retinoic acid receptor responder protein 2

0.380

IL9R_HUMAN

Interleukin-9 receptor

0.380

CL050_HUMAN

Uncharacterized protein C12orf50

0.380

PRIO_HUMAN

Major prion protein

0.380

TRI29_HUMAN

Tripartite motif-containing protein 29

0.383

SCG1_HUMAN

Secretogranin-1

0.383

CE57L_HUMAN

Centrosomal protein CEP57L1

0.383

TNF15_HUMAN

Tumor necrosis factor ligand superfamily member 15

0.383

C1S_HUMAN

Complement C1s subcomponent

0.383

AREG_HUMAN

Amphiregulin

0.383

F166A_HUMAN

Protein FAM166A

0.385

CD40L_HUMAN

CD40 ligand

0.385

BPIB6_HUMAN

BPI fold-containing family B member 6

0.386

HXD13_HUMAN

Homeobox protein Hox-D13

0.387

ICAM5_HUMAN

Intercellular adhesion molecule 5

0.387

ZN654_HUMAN

Zinc finger protein 654

0.387

AMGO2_HUMAN

Amphoterin-induced protein 2

0.390

TM215_HUMAN

Transmembrane protein 215

0.390

LAPM5_HUMAN

Lysosomal-associated transmembrane protein 5

0.390

BCAS1_HUMAN

Breast carcinoma-amplified sequence 1

0.390

I13R1_HUMAN

Interleukin-13 receptor subunit alpha-1

0.390

EMP1_HUMAN

Epithelial membrane protein 1

0.390

O51E2_HUMAN

Olfactory receptor 51E2

0.390

EGLN_HUMAN

Endoglin

0.392

CAMP_HUMAN

Cathelicidin antimicrobial peptide

0.392

SNTAN_HUMAN

Sentan

0.392

MALL_HUMAN

MAL-like protein

0.392

IL6_HUMAN

Interleukin-6

0.393

K2C75_HUMAN

Keratin, type II cytoskeletal 75

0.395

OPT_HUMAN

Opticin

0.395

IL15_HUMAN

Interleukin-15

0.395

TM139_HUMAN

Transmembrane protein 139

0.395

ODF2L_HUMAN

Protein BCAP

0.395

FYB2_HUMAN

FYN-binding protein 2

0.395

ETV3_HUMAN

ETS translocation variant 3

0.396

BCLA3_HUMAN

BCLAF1 and THRAP3 family member 3

0.396

CD5_HUMAN

T-cell surface glycoprotein CD5

0.397

CENPA_HUMAN

Histone H3-like centromeric protein A

0.397

IL17B_HUMAN

Interleukin-17B

0.398

BCLF1_HUMAN

Bcl-2-associated transcription factor 1

0.398

IL5RA_HUMAN

Interleukin-5 receptor subunit alpha

0.398

HMGN1_HUMAN

Non-histone chromosomal protein HMG-14

0.400

S10AG_HUMAN

Protein S100-A16

0.400

NXPH3_HUMAN

Neurexophilin-3

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 12 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy