HEPC_HUMAN 2019

Gene Name HEPC

Description Hepcidin

Length 84

9606

Sequence

>sp|P81172|HEPC_HUMAN Hepcidin
MALSSQIWAACLLLLLLLASLTSGSVFPQQTGQLAELQPQDRAGARASWMPMFQRRRRRDTHFPICIFCCGCCHRSKCGMCCKT

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

GUC2B_HUMAN

Guanylate cyclase activator 2B

0.000

CD7_HUMAN

T-cell antigen CD7

0.316

SIM24_HUMAN

Small integral membrane protein 24

0.333

PE2R1_HUMAN

Prostaglandin E2 receptor EP1 subtype

0.333

HIDE1_HUMAN

Protein HIDE1

0.333

TM190_HUMAN

Transmembrane protein 190

0.333

OR2T4_HUMAN

Olfactory receptor 2T4

0.333

BAFL_HUMAN

Barrier-to-autointegration factor-like protein

0.333

O10V1_HUMAN

Olfactory receptor 10V1

0.333

OR6S1_HUMAN

Olfactory receptor 6S1

0.333

CC182_HUMAN

Coiled-coil domain-containing protein 182

0.333

MENT_HUMAN

Protein MENT

0.333

LY66C_HUMAN

Lymphocyte antigen 6 complex locus protein G6c

0.333

TEX38_HUMAN

Testis-expressed protein 38

0.333

OSTB_HUMAN

Organic solute transporter subunit beta

0.333

O52A5_HUMAN

Olfactory receptor 52A5

0.333

IZUM3_HUMAN

Izumo sperm-egg fusion protein 3

0.333

CF201_HUMAN

Uncharacterized protein C6orf201

0.333

CM046_HUMAN

Uncharacterized protein C13orf46

0.333

UPK3L_HUMAN

Uroplakin-3b-like protein 1

0.333

ERIC5_HUMAN

Glutamate-rich protein 5

0.333

IL27A_HUMAN

Interleukin-27 subunit alpha

0.333

MSTRO_HUMAN

Protein maestro

0.333

TEX29_HUMAN

Testis-expressed protein 29

0.333

OR4N5_HUMAN

Olfactory receptor 4N5

0.333

OR9I1_HUMAN

Olfactory receptor 9I1

0.333

DMRTD_HUMAN

Doublesex- and mab-3-related transcription factor C2

0.333

TNFL9_HUMAN

Tumor necrosis factor ligand superfamily member 9

0.333

TMM92_HUMAN

Transmembrane protein 92

0.333

CH058_HUMAN

Uncharacterized protein C8orf58

0.333

CCDC7_HUMAN

Coiled-coil domain-containing protein 7

0.333

OR9G4_HUMAN

Olfactory receptor 9G4

0.333

OR5I1_HUMAN

Olfactory receptor 5I1

0.333

CD27_HUMAN

CD27 antigen

0.333

OR9G1_HUMAN

Olfactory receptor 9G1

0.333

AMTN_HUMAN

Amelotin

0.333

SSMM1_HUMAN

Serine-rich single-pass membrane protein 1

0.333

SPT19_HUMAN

Spermatogenesis-associated protein 19, mitochondrial

0.333

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

IL7_HUMAN

Interleukin-7

0.267

LY66C_HUMAN

Lymphocyte antigen 6 complex locus protein G6c

0.270

PRCA1_HUMAN

Protein PROCA1

0.270

ERIC4_HUMAN

Glutamate-rich protein 4

0.272

TMCO2_HUMAN

Transmembrane and coiled-coil domain-containing protein 2

0.296

LAT_HUMAN

Linker for activation of T-cells family member 1

0.296

IL5_HUMAN

Interleukin-5

0.296

TRIMM_HUMAN

Probable E3 ubiquitin-protein ligase TRIML2

0.299

TMM89_HUMAN

Transmembrane protein 89

0.302

IL27A_HUMAN

Interleukin-27 subunit alpha

0.319

TSKS_HUMAN

Testis-specific serine kinase substrate

0.319

SPT19_HUMAN

Spermatogenesis-associated protein 19, mitochondrial

0.322

IL1A_HUMAN

Interleukin-1 alpha

0.322

ZKSC5_HUMAN

Zinc finger protein with KRAB and SCAN domains 5

0.322

RAGE_HUMAN

Advanced glycosylation end product-specific receptor

0.322

ZN263_HUMAN

Zinc finger protein 263

0.324

NGAL_HUMAN

Neutrophil gelatinase-associated lipocalin

0.324

T126B_HUMAN

Complex I assembly factor TMEM126B, mitochondrial

0.324

F229B_HUMAN

Protein FAM229B

0.324

ZFP1_HUMAN

Zinc finger protein 1 homolog

0.324

CC116_HUMAN

Coiled-coil domain-containing protein 116

0.324

OPALI_HUMAN

Opalin

0.324

DBND2_HUMAN

Dysbindin domain-containing protein 2

0.324

CXL16_HUMAN

C-X-C motif chemokine 16

0.324

G6B_HUMAN

Megakaryocyte and platelet inhibitory receptor G6b

0.324

ZN189_HUMAN

Zinc finger protein 189

0.324

NNAT_HUMAN

Neuronatin

0.327

TCAL8_HUMAN

Transcription elongation factor A protein-like 8

0.327

PRS58_HUMAN

Serine protease 58

0.327

PATE2_HUMAN

Prostate and testis expressed protein 2

0.330

FNDC8_HUMAN

Fibronectin type III domain-containing protein 8

0.342

ZN202_HUMAN

Zinc finger protein 202

0.344

PA2GF_HUMAN

Group IIF secretory phospholipase A2

0.344

ZSC20_HUMAN

Zinc finger and SCAN domain-containing protein 20

0.344

LAX1_HUMAN

Lymphocyte transmembrane adapter 1

0.344

NKG7_HUMAN

Protein NKG7

0.344

ZNF18_HUMAN

Zinc finger protein 18

0.344

IL2_HUMAN

Interleukin-2

0.347

O13C7_HUMAN

Olfactory receptor 13C7

0.347

OR2F1_HUMAN

Olfactory receptor 2F1

0.347

TM270_HUMAN

Transmembrane protein 270

0.347

DKKL1_HUMAN

Dickkopf-like protein 1

0.347

TNF18_HUMAN

Tumor necrosis factor ligand superfamily member 18

0.347

CP086_HUMAN

Uncharacterized protein C16orf86

0.347

ZN496_HUMAN

Zinc finger protein 496

0.347

PRS37_HUMAN

Probable inactive serine protease 37

0.347

CCL22_HUMAN

C-C motif chemokine 22

0.347

ZN691_HUMAN

Zinc finger protein 691

0.347

TEX38_HUMAN

Testis-expressed protein 38

0.347

CSF2_HUMAN

Granulocyte-macrophage colony-stimulating factor

0.347

CKLF5_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 5

0.350

SCIMP_HUMAN

SLP adapter and CSK-interacting membrane protein

0.350

BPIA3_HUMAN

BPI fold-containing family A member 3

0.350

IL33_HUMAN

Interleukin-33

0.350

CDSN_HUMAN

Corneodesmosin

0.350

LY6D_HUMAN

Lymphocyte antigen 6D

0.350

PKHH3_HUMAN

Pleckstrin homology domain-containing family H member 3

0.350

ZN445_HUMAN

Zinc finger protein 445

0.350

IRGQ_HUMAN

Immunity-related GTPase family Q protein

0.350

ZNF48_HUMAN

Zinc finger protein 48

0.350

ZSC25_HUMAN

Zinc finger and SCAN domain-containing protein 25

0.350

BEX3_HUMAN

Protein BEX3

0.350

IL13_HUMAN

Interleukin-13

0.350

TM262_HUMAN

Transmembrane protein 262

0.350

CLD9_HUMAN

Claudin-9

0.350

ZN174_HUMAN

Zinc finger protein 174

0.350

CAVN3_HUMAN

Caveolae-associated protein 3

0.350

MASTR_HUMAN

MEF2-activating motif and SAP domain-containing transcriptional regulator

0.350

ONCM_HUMAN

Oncostatin-M

0.354

CA185_HUMAN

Uncharacterized protein C1orf185

0.354

CI131_HUMAN

Uncharacterized protein C9orf131

0.354

BEX2_HUMAN

Protein BEX2

0.354

CC184_HUMAN

Coiled-coil domain-containing protein 184

0.354

CASK_HUMAN

Kappa-casein

0.354

ZN689_HUMAN

Zinc finger protein 689

0.354

M4A13_HUMAN

Membrane-spanning 4-domains subfamily A member 13

0.354

GON7_HUMAN

EKC/KEOPS complex subunit GON7

0.357

CF015_HUMAN

Uncharacterized protein C6orf15

0.357

FWCH2_HUMAN

FLYWCH family member 2

0.357

DMRTD_HUMAN

Doublesex- and mab-3-related transcription factor C2

0.362

ZFP37_HUMAN

Zinc finger protein 37 homolog

0.363

AKAP3_HUMAN

A-kinase anchor protein 3

0.365

APOA2_HUMAN

Apolipoprotein A-II

0.365

S10A5_HUMAN

Protein S100-A5

0.365

HPIP_HUMAN

Host cell factor C1 regulator 1

0.365

SIT1_HUMAN

Signaling threshold-regulating transmembrane adapter 1

0.365

GL6D1_HUMAN

Putative glycosyltransferase 6 domain-containing protein 1

0.365

HIDE1_HUMAN

Protein HIDE1

0.365

GPC5D_HUMAN

G-protein coupled receptor family C group 5 member D

0.365

SPNDC_HUMAN

Spindlin interactor and repressor of chromatin-binding protein

0.365

MSTRO_HUMAN

Protein maestro

0.365

DMKN_HUMAN

Dermokine

0.368

F186B_HUMAN

Protein FAM186B

0.368

CQ080_HUMAN

Uncharacterized protein C17orf80

0.368

ZN205_HUMAN

Zinc finger protein 205

0.368

ZKSC1_HUMAN

Zinc finger protein with KRAB and SCAN domains 1

0.368

CC196_HUMAN

Putative coiled-coil domain-containing protein 196

0.368

ZKSC2_HUMAN

Zinc finger protein with KRAB and SCAN domains 2

0.368

TM219_HUMAN

Insulin-like growth factor-binding protein 3 receptor

0.368

S10A8_HUMAN

Protein S100-A8

0.368

IQCF6_HUMAN

IQ domain-containing protein F6

0.368

TREM1_HUMAN

Triggering receptor expressed on myeloid cells 1

0.371

CD70_HUMAN

CD70 antigen

0.371

PRR3_HUMAN

Proline-rich protein 3

0.371

AMTN_HUMAN

Amelotin

0.371

SG3A2_HUMAN

Secretoglobin family 3A member 2

0.371

ZN200_HUMAN

Zinc finger protein 200

0.371

KRBA1_HUMAN

Protein KRBA1

0.371

MENT_HUMAN

Protein MENT

0.371

F170A_HUMAN

Protein FAM170A

0.371

SHRM1_HUMAN

Protein Shroom1

0.371

CP090_HUMAN

Uncharacterized protein C16orf90

0.371

ZN449_HUMAN

Zinc finger protein 449

0.371

TMC5A_HUMAN

Transmembrane and coiled-coil domain-containing protein 5A

0.371

CJ120_HUMAN

Uncharacterized protein C10orf120

0.371

LY66F_HUMAN

Lymphocyte antigen 6 complex locus protein G6f

0.371

ZCCHL_HUMAN

Zinc finger CCCH-type antiviral protein 1-like

0.375

ZN446_HUMAN

Zinc finger protein 446

0.375

CD320_HUMAN

CD320 antigen

0.375

CALY_HUMAN

Neuron-specific vesicular protein calcyon

0.375

CD036_HUMAN

Uncharacterized protein C4orf36

0.375

MCEM1_HUMAN

Mast cell-expressed membrane protein 1

0.375

LY6H_HUMAN

Lymphocyte antigen 6H

0.375

CL12A_HUMAN

C-type lectin domain family 12 member A

0.378

C4BPB_HUMAN

C4b-binding protein beta chain

0.378

LY65C_HUMAN

Lymphocyte antigen 6 complex locus protein G5c

0.378

S10A3_HUMAN

Protein S100-A3

0.378

ZNF23_HUMAN

Zinc finger protein 23

0.378

ZNF81_HUMAN

Zinc finger protein 81

0.378

ENHO_HUMAN

Adropin

0.378

CST9L_HUMAN

Cystatin-9-like

0.378

TMM95_HUMAN

Transmembrane protein 95

0.378

GUC2B_HUMAN

Guanylate cyclase activator 2B

0.381

TCAL9_HUMAN

Transcription elongation factor A protein-like 9

0.381

ZN483_HUMAN

Zinc finger protein 483

0.381

ZN655_HUMAN

Zinc finger protein 655

0.381

T53G5_HUMAN

TP53-target gene 5 protein

0.384

T4S19_HUMAN

Transmembrane 4 L6 family member 19

0.384

PRIC4_HUMAN

Prickle-like protein 4

0.384

TM210_HUMAN

Transmembrane protein 210

0.385

ERIC5_HUMAN

Glutamate-rich protein 5

0.387

SPAT9_HUMAN

Spermatogenesis-associated protein 9

0.387

UPK3B_HUMAN

Uroplakin-3b

0.387

ACKR1_HUMAN

Atypical chemokine receptor 1

0.387

SSMM1_HUMAN

Serine-rich single-pass membrane protein 1

0.387

CH058_HUMAN

Uncharacterized protein C8orf58

0.387

TRML1_HUMAN

Trem-like transcript 1 protein

0.387

IL9_HUMAN

Interleukin-9

0.387

NAR3_HUMAN

Ecto-ADP-ribosyltransferase 3

0.387

SPT25_HUMAN

Spermatogenesis-associated protein 25

0.391

MEFV_HUMAN

Pyrin

0.391

ZN296_HUMAN

Zinc finger protein 296

0.391

CD19_HUMAN

B-lymphocyte antigen CD19

0.391

ZN184_HUMAN

Zinc finger protein 184

0.391

ZSC10_HUMAN

Zinc finger and SCAN domain-containing protein 10

0.391

BPIA1_HUMAN

BPI fold-containing family A member 1

0.391

IZUM3_HUMAN

Izumo sperm-egg fusion protein 3

0.391

ACTT3_HUMAN

Actin-related protein T3

0.391

SPIN4_HUMAN

Spindlin-4

0.391

BPIB1_HUMAN

BPI fold-containing family B member 1

0.391

XIRP1_HUMAN

Xin actin-binding repeat-containing protein 1

0.391

NRK_HUMAN

Nik-related protein kinase

0.391

GPVI_HUMAN

Platelet glycoprotein VI

0.391

CCR10_HUMAN

C-C chemokine receptor type 10

0.391

CP074_HUMAN

Uncharacterized protein C16orf74

0.391

MEPE_HUMAN

Matrix extracellular phosphoglycoprotein

0.394

ODAM_HUMAN

Odontogenic ameloblast-associated protein

0.394

ETV2_HUMAN

ETS translocation variant 2

0.394

CB074_HUMAN

Uncharacterized protein C2orf74

0.394

ZN317_HUMAN

Zinc finger protein 317

0.394

BAFL_HUMAN

Barrier-to-autointegration factor-like protein

0.394

TEX35_HUMAN

Testis-expressed protein 35

0.394

PRR19_HUMAN

Proline-rich protein 19

0.394

ZN768_HUMAN

Zinc finger protein 768

0.394

SYNE4_HUMAN

Nesprin-4

0.394

IL36G_HUMAN

Interleukin-36 gamma

0.394

TM202_HUMAN

Transmembrane protein 202

0.397

MUC20_HUMAN

Mucin-20

0.397

Z354A_HUMAN

Zinc finger protein 354A

0.397

CF222_HUMAN

Uncharacterized protein C6orf222

0.397

OCEL1_HUMAN

Occludin/ELL domain-containing protein 1

0.397

K2C78_HUMAN

Keratin, type II cytoskeletal 78

0.397

FCERB_HUMAN

High affinity immunoglobulin epsilon receptor subunit beta

0.397

PEG3_HUMAN

Paternally-expressed gene 3 protein

0.397

ZN394_HUMAN

Zinc finger protein 394

0.397

CK086_HUMAN

Uncharacterized protein C11orf86

0.397

ZN597_HUMAN

Zinc finger protein 597

0.397

IZUM4_HUMAN

Izumo sperm-egg fusion protein 4

0.397

TX101_HUMAN

Testis-expressed protein 101

0.397

LEP_HUMAN

Leptin

0.398

FSCN3_HUMAN

Fascin-3

0.398

ARM12_HUMAN

Armadillo repeat-containing protein 12

0.398

AMBN_HUMAN

Ameloblastin

0.398

PSPB_HUMAN

Pulmonary surfactant-associated protein B

0.398

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 8 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy