TNFC_HUMAN 2019

Gene Name TNFC

Description Lymphotoxin-beta

Length 244

9606

Sequence

>sp|Q06643|TNFC_HUMAN Lymphotoxin-beta
MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETADPGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLEGAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGAVMVG

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

OR2H2_HUMAN

Olfactory receptor 2H2

0.000

OR2W1_HUMAN

Olfactory receptor 2W1

0.000

OR2BB_HUMAN

Olfactory receptor 2B11

0.000

FCG3B_HUMAN

Low affinity immunoglobulin gamma Fc region receptor III-B

0.000

CYREN_HUMAN

Cell cycle regulator of non-homologous end joining

0.000

OR2H1_HUMAN

Olfactory receptor 2H1

0.000

O51D1_HUMAN

Olfactory receptor 51D1

0.333

DAF_HUMAN

Complement decay-accelerating factor

0.333

OR4E2_HUMAN

Olfactory receptor 4E2

0.333

O51I2_HUMAN

Olfactory receptor 51I2

0.333

CD69_HUMAN

Early activation antigen CD69

0.333

TARM1_HUMAN

T-cell-interacting, activating receptor on myeloid cells protein 1

0.333

POLS2_HUMAN

Polyserase-2

0.333

T4S20_HUMAN

Transmembrane 4 L6 family member 20

0.333

KISS1_HUMAN

Metastasis-suppressor KiSS-1

0.333

OSCAR_HUMAN

Osteoclast-associated immunoglobulin-like receptor

0.333

CB078_HUMAN

Uncharacterized protein C2orf78

0.333

BTNL2_HUMAN

Butyrophilin-like protein 2

0.333

C4BPA_HUMAN

C4b-binding protein alpha chain

0.333

ELNE_HUMAN

Neutrophil elastase

0.333

DPPA4_HUMAN

Developmental pluripotency-associated protein 4

0.333

T2R16_HUMAN

Taste receptor type 2 member 16

0.354

ZN263_HUMAN

Zinc finger protein 263

0.354

OPALI_HUMAN

Opalin

0.354

ZN496_HUMAN

Zinc finger protein 496

0.354

SG3A2_HUMAN

Secretoglobin family 3A member 2

0.354

CI040_HUMAN

Uncharacterized protein C9orf40

0.354

OR5L2_HUMAN

Olfactory receptor 5L2

0.354

OR4B1_HUMAN

Olfactory receptor 4B1

0.354

O2AG2_HUMAN

Olfactory receptor 2AG2

0.354

CC196_HUMAN

Putative coiled-coil domain-containing protein 196

0.354

CCL22_HUMAN

C-C motif chemokine 22

0.354

O13C7_HUMAN

Olfactory receptor 13C7

0.354

O51A7_HUMAN

Olfactory receptor 51A7

0.354

MASTR_HUMAN

MEF2-activating motif and SAP domain-containing transcriptional regulator

0.354

GAPT_HUMAN

Protein GAPT

0.354

T53G5_HUMAN

TP53-target gene 5 protein

0.354

EP3A_HUMAN

Epididymal secretory protein E3-alpha

0.354

AHSP_HUMAN

Alpha-hemoglobin-stabilizing protein

0.354

S10A8_HUMAN

Protein S100-A8

0.354

ODAM_HUMAN

Odontogenic ameloblast-associated protein

0.354

ANFB_HUMAN

Natriuretic peptides B

0.354

OR1L6_HUMAN

Olfactory receptor 1L6

0.354

GAST_HUMAN

Gastrin

0.354

PA2GC_HUMAN

Putative inactive group IIC secretory phospholipase A2

0.354

ZNF3_HUMAN

Zinc finger protein 3

0.354

OR5A1_HUMAN

Olfactory receptor 5A1

0.354

OR5L1_HUMAN

Olfactory receptor 5L1

0.354

ACTT3_HUMAN

Actin-related protein T3

0.354

TCHL1_HUMAN

Trichohyalin-like protein 1

0.354

MROH9_HUMAN

Maestro heat-like repeat-containing protein family member 9

0.354

CITE4_HUMAN

Cbp/p300-interacting transactivator 4

0.354

O52B4_HUMAN

Olfactory receptor 52B4

0.354

O10K2_HUMAN

Olfactory receptor 10K2

0.354

PRS42_HUMAN

Putative serine protease 42

0.354

MUC20_HUMAN

Mucin-20

0.354

STP1_HUMAN

Spermatid nuclear transition protein 1

0.354

OR2Y1_HUMAN

Olfactory receptor 2Y1

0.354

OR5MB_HUMAN

Olfactory receptor 5M11

0.354

OR5M9_HUMAN

Olfactory receptor 5M9

0.354

COPRS_HUMAN

Coordinator of PRMT5 and differentiation stimulator

0.354

CDRT4_HUMAN

CMT1A duplicated region transcript 4 protein

0.354

S100G_HUMAN

Protein S100-G

0.354

EP3B_HUMAN

Epididymal secretory protein E3-beta

0.354

CLD9_HUMAN

Claudin-9

0.354

PAHO_HUMAN

Pancreatic prohormone

0.354

ZN641_HUMAN

Zinc finger protein 641

0.354

TSP50_HUMAN

Probable threonine protease PRSS50

0.354

OR2W3_HUMAN

Olfactory receptor 2W3

0.354

C5AR2_HUMAN

C5a anaphylatoxin chemotactic receptor 2

0.354

TEX46_HUMAN

Testis-expressed protein 46

0.354

LY6H_HUMAN

Lymphocyte antigen 6H

0.354

OR4CC_HUMAN

Olfactory receptor 4C12

0.354

LAT_HUMAN

Linker for activation of T-cells family member 1

0.354

G6B_HUMAN

Megakaryocyte and platelet inhibitory receptor G6b

0.354

RNS12_HUMAN

Probable inactive ribonuclease-like protein 12

0.354

LCN1_HUMAN

Lipocalin-1

0.354

ZKSC2_HUMAN

Zinc finger protein with KRAB and SCAN domains 2

0.354

O52W1_HUMAN

Olfactory receptor 52W1

0.354

K1C26_HUMAN

Keratin, type I cytoskeletal 26

0.354

ZN697_HUMAN

Zinc finger protein 697

0.354

IL5_HUMAN

Interleukin-5

0.354

PKHH3_HUMAN

Pleckstrin homology domain-containing family H member 3

0.354

CP054_HUMAN

Transmembrane protein C16orf54

0.354

OR9A4_HUMAN

Olfactory receptor 9A4

0.354

O10G7_HUMAN

Olfactory receptor 10G7

0.354

BPIA1_HUMAN

BPI fold-containing family A member 1

0.354

M4A13_HUMAN

Membrane-spanning 4-domains subfamily A member 13

0.354

O51V1_HUMAN

Olfactory receptor 51V1

0.354

DLL3_HUMAN

Delta-like protein 3

0.354

LAX1_HUMAN

Lymphocyte transmembrane adapter 1

0.354

TM202_HUMAN

Transmembrane protein 202

0.354

OR6K2_HUMAN

Olfactory receptor 6K2

0.354

OR5G3_HUMAN

Olfactory receptor 5G3

0.354

GPR31_HUMAN

12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor

0.354

O56A4_HUMAN

Olfactory receptor 56A4

0.354

OR9K2_HUMAN

Olfactory receptor 9K2

0.354

CK086_HUMAN

Uncharacterized protein C11orf86

0.354

CCD54_HUMAN

Coiled-coil domain-containing protein 54

0.354

PS1C2_HUMAN

Psoriasis susceptibility 1 candidate gene 2 protein

0.354

BPIB3_HUMAN

BPI fold-containing family B member 3

0.354

Z585A_HUMAN

Zinc finger protein 585A

0.354

KRBA1_HUMAN

Protein KRBA1

0.354

OR2B2_HUMAN

Olfactory receptor 2B2

0.354

ZCCHL_HUMAN

Zinc finger CCCH-type antiviral protein 1-like

0.354

O4C46_HUMAN

Olfactory receptor 4C46

0.354

ATP8_HUMAN

ATP synthase protein 8

0.354

DBND2_HUMAN

Dysbindin domain-containing protein 2

0.354

O56A3_HUMAN

Olfactory receptor 56A3

0.354

CC188_HUMAN

Coiled-coil domain-containing protein 188

0.354

OR5C1_HUMAN

Olfactory receptor 5C1

0.354

O51F2_HUMAN

Olfactory receptor 51F2

0.354

IL7_HUMAN

Interleukin-7

0.354

IL36A_HUMAN

Interleukin-36 alpha

0.354

IL1A_HUMAN

Interleukin-1 alpha

0.354

O51B6_HUMAN

Olfactory receptor 51B6

0.354

MROH8_HUMAN

Protein MROH8

0.354

FFAR1_HUMAN

Free fatty acid receptor 1

0.354

O2AG1_HUMAN

Olfactory receptor 2AG1

0.354

O2T12_HUMAN

Olfactory receptor 2T12

0.354

O10AG_HUMAN

Olfactory receptor 10AG1

0.354

CCR10_HUMAN

C-C chemokine receptor type 10

0.354

CD036_HUMAN

Uncharacterized protein C4orf36

0.354

OR8D4_HUMAN

Olfactory receptor 8D4

0.354

PRS58_HUMAN

Serine protease 58

0.354

Z286A_HUMAN

Zinc finger protein 286A

0.354

IGSF2_HUMAN

Immunoglobulin superfamily member 2

0.354

ZSC20_HUMAN

Zinc finger and SCAN domain-containing protein 20

0.354

ZSC10_HUMAN

Zinc finger and SCAN domain-containing protein 10

0.354

TM219_HUMAN

Insulin-like growth factor-binding protein 3 receptor

0.354

TNFL4_HUMAN

Tumor necrosis factor ligand superfamily member 4

0.354

ODAPH_HUMAN

Odontogenesis associated phosphoprotein

0.354

OR8G5_HUMAN

Olfactory receptor 8G5

0.354

S10A3_HUMAN

Protein S100-A3

0.354

CJ120_HUMAN

Uncharacterized protein C10orf120

0.354

CCRL2_HUMAN

C-C chemokine receptor-like 2

0.354

PRR19_HUMAN

Proline-rich protein 19

0.354

OR5MA_HUMAN

Olfactory receptor 5M10

0.354

KRA33_HUMAN

Keratin-associated protein 3-3

0.354

O13J1_HUMAN

Olfactory receptor 13J1

0.354

OR4CF_HUMAN

Olfactory receptor 4C15

0.354

TREM1_HUMAN

Triggering receptor expressed on myeloid cells 1

0.354

F229B_HUMAN

Protein FAM229B

0.354

ZKSC5_HUMAN

Zinc finger protein with KRAB and SCAN domains 5

0.354

INSL3_HUMAN

Insulin-like 3

0.354

FCERB_HUMAN

High affinity immunoglobulin epsilon receptor subunit beta

0.354

BPIB1_HUMAN

BPI fold-containing family B member 1

0.354

TIGIT_HUMAN

T-cell immunoreceptor with Ig and ITIM domains

0.354

OR4X2_HUMAN

Olfactory receptor 4X2

0.354

OR6A2_HUMAN

Olfactory receptor 6A2

0.354

GON7_HUMAN

EKC/KEOPS complex subunit GON7

0.354

OR6P1_HUMAN

Olfactory receptor 6P1

0.354

TROAP_HUMAN

Tastin

0.354

CQ080_HUMAN

Uncharacterized protein C17orf80

0.354

OR5P3_HUMAN

Olfactory receptor 5P3

0.354

OR8A1_HUMAN

Olfactory receptor 8A1

0.354

CTF1_HUMAN

Cardiotrophin-1

0.354

CK094_HUMAN

Uncharacterized protein C11orf94

0.354

RAGE_HUMAN

Advanced glycosylation end product-specific receptor

0.354

REPI1_HUMAN

Replication initiator 1

0.354

ZN672_HUMAN

Zinc finger protein 672

0.354

OR2LD_HUMAN

Olfactory receptor 2L13

0.354

TMCO2_HUMAN

Transmembrane and coiled-coil domain-containing protein 2

0.354

O4A15_HUMAN

Olfactory receptor 4A15

0.354

K1C25_HUMAN

Keratin, type I cytoskeletal 25

0.354

CC116_HUMAN

Coiled-coil domain-containing protein 116

0.354

ZN746_HUMAN

Zinc finger protein 746

0.354

O2T33_HUMAN

Olfactory receptor 2T33

0.354

T2R38_HUMAN

Taste receptor type 2 member 38

0.354

ZN428_HUMAN

Zinc finger protein 428

0.354

TRML2_HUMAN

Trem-like transcript 2 protein

0.354

PRND_HUMAN

Prion-like protein doppel

0.354

SCND1_HUMAN

SCAN domain-containing protein 1

0.354

TM225_HUMAN

Transmembrane protein 225

0.354

CYLC2_HUMAN

Cylicin-2

0.354

TMC5A_HUMAN

Transmembrane and coiled-coil domain-containing protein 5A

0.354

CL071_HUMAN

Uncharacterized protein C12orf71

0.354

OCEL1_HUMAN

Occludin/ELL domain-containing protein 1

0.354

ZN202_HUMAN

Zinc finger protein 202

0.354

O51S1_HUMAN

Olfactory receptor 51S1

0.354

OR4C6_HUMAN

Olfactory receptor 4C6

0.354

OR8K1_HUMAN

Olfactory receptor 8K1

0.354

PRS37_HUMAN

Probable inactive serine protease 37

0.354

CS2IP_HUMAN

Casein kinase II subunit alpha-interacting protein

0.354

FCG3A_HUMAN

Low affinity immunoglobulin gamma Fc region receptor III-A

0.354

OR2V1_HUMAN

Olfactory receptor 2V1

0.354

OR5M1_HUMAN

Olfactory receptor 5M1

0.354

OR5W2_HUMAN

Olfactory receptor 5W2

0.354

OR2K2_HUMAN

Olfactory receptor 2K2

0.354

O51T1_HUMAN

Olfactory receptor 51T1

0.354

OR2W6_HUMAN

Putative olfactory receptor 2W6

0.354

NGAL_HUMAN

Neutrophil gelatinase-associated lipocalin

0.354

SCIMP_HUMAN

SLP adapter and CSK-interacting membrane protein

0.354

O51F1_HUMAN

Olfactory receptor 51F1

0.354

O13F1_HUMAN

Olfactory receptor 13F1

0.354

SPRN_HUMAN

Shadow of prion protein

0.354

CAVN3_HUMAN

Caveolae-associated protein 3

0.354

CD70_HUMAN

CD70 antigen

0.354

EQTN_HUMAN

Equatorin

0.354

OR6K6_HUMAN

Olfactory receptor 6K6

0.354

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CC196_HUMAN

Putative coiled-coil domain-containing protein 196

0.319

CQ080_HUMAN

Uncharacterized protein C17orf80

0.319

RAGE_HUMAN

Advanced glycosylation end product-specific receptor

0.319

PA2GF_HUMAN

Group IIF secretory phospholipase A2

0.342

ZN202_HUMAN

Zinc finger protein 202

0.342

LAX1_HUMAN

Lymphocyte transmembrane adapter 1

0.342

LAT_HUMAN

Linker for activation of T-cells family member 1

0.344

MASTR_HUMAN

MEF2-activating motif and SAP domain-containing transcriptional regulator

0.347

PKHH3_HUMAN

Pleckstrin homology domain-containing family H member 3

0.347

CKLF5_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 5

0.347

AMBN_HUMAN

Ameloblastin

0.356

TROAP_HUMAN

Tastin

0.359

GPC5D_HUMAN

G-protein coupled receptor family C group 5 member D

0.362

SPNDC_HUMAN

Spindlin interactor and repressor of chromatin-binding protein

0.362

IL27A_HUMAN

Interleukin-27 subunit alpha

0.362

S10A8_HUMAN

Protein S100-A8

0.365

ZKSC5_HUMAN

Zinc finger protein with KRAB and SCAN domains 5

0.365

ZKSC2_HUMAN

Zinc finger protein with KRAB and SCAN domains 2

0.365

TM219_HUMAN

Insulin-like growth factor-binding protein 3 receptor

0.365

IL1A_HUMAN

Interleukin-1 alpha

0.365

DPPA4_HUMAN

Developmental pluripotency-associated protein 4

0.365

T126B_HUMAN

Complex I assembly factor TMEM126B, mitochondrial

0.368

SHRM1_HUMAN

Protein Shroom1

0.368

PAHO_HUMAN

Pancreatic prohormone

0.368

CP090_HUMAN

Uncharacterized protein C16orf90

0.368

CD70_HUMAN

CD70 antigen

0.368

NGAL_HUMAN

Neutrophil gelatinase-associated lipocalin

0.368

CC116_HUMAN

Coiled-coil domain-containing protein 116

0.368

KRBA1_HUMAN

Protein KRBA1

0.368

DBND2_HUMAN

Dysbindin domain-containing protein 2

0.368

G6B_HUMAN

Megakaryocyte and platelet inhibitory receptor G6b

0.368

LY66C_HUMAN

Lymphocyte antigen 6 complex locus protein G6c

0.371

ENAM_HUMAN

Enamelin

0.378

GGT6_HUMAN

Glutathione hydrolase 6

0.378

FACOS_HUMAN

FANCD2 opposite strand protein

0.378

FXYD3_HUMAN

FXYD domain-containing ion transport regulator 3

0.381

T53G5_HUMAN

TP53-target gene 5 protein

0.381

SPAT9_HUMAN

Spermatogenesis-associated protein 9

0.384

ZSC20_HUMAN

Zinc finger and SCAN domain-containing protein 20

0.384

ZNF18_HUMAN

Zinc finger protein 18

0.384

NAR3_HUMAN

Ecto-ADP-ribosyltransferase 3

0.384

T4S20_HUMAN

Transmembrane 4 L6 family member 20

0.384

TRML1_HUMAN

Trem-like transcript 1 protein

0.384

CD19_HUMAN

B-lymphocyte antigen CD19

0.387

DKKL1_HUMAN

Dickkopf-like protein 1

0.387

CCR10_HUMAN

C-C chemokine receptor type 10

0.387

CCL22_HUMAN

C-C motif chemokine 22

0.387

CSF2_HUMAN

Granulocyte-macrophage colony-stimulating factor

0.387

TMCO2_HUMAN

Transmembrane and coiled-coil domain-containing protein 2

0.387

BPIB1_HUMAN

BPI fold-containing family B member 1

0.387

TNF18_HUMAN

Tumor necrosis factor ligand superfamily member 18

0.387

PRS37_HUMAN

Probable inactive serine protease 37

0.387

O13C7_HUMAN

Olfactory receptor 13C7

0.387

ZN496_HUMAN

Zinc finger protein 496

0.387

ZN691_HUMAN

Zinc finger protein 691

0.387

IL2_HUMAN

Interleukin-2

0.387

ZSC10_HUMAN

Zinc finger and SCAN domain-containing protein 10

0.387

IL5_HUMAN

Interleukin-5

0.387

BPIA1_HUMAN

BPI fold-containing family A member 1

0.387

CAVN3_HUMAN

Caveolae-associated protein 3

0.391

CLD9_HUMAN

Claudin-9

0.391

IL13_HUMAN

Interleukin-13

0.391

CDSN_HUMAN

Corneodesmosin

0.391

ZN174_HUMAN

Zinc finger protein 174

0.391

CB074_HUMAN

Uncharacterized protein C2orf74

0.391

IL36G_HUMAN

Interleukin-36 gamma

0.391

SCIMP_HUMAN

SLP adapter and CSK-interacting membrane protein

0.391

RN112_HUMAN

RING finger protein 112

0.392

TX101_HUMAN

Testis-expressed protein 101

0.394

M4A13_HUMAN

Membrane-spanning 4-domains subfamily A member 13

0.394

MROH8_HUMAN

Protein MROH8

0.394

FCERB_HUMAN

High affinity immunoglobulin epsilon receptor subunit beta

0.394

LEP_HUMAN

Leptin

0.395

PSPB_HUMAN

Pulmonary surfactant-associated protein B

0.395

PCSK1_HUMAN

ProSAAS

0.397

DMRTD_HUMAN

Doublesex- and mab-3-related transcription factor C2

0.398

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 8 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy