ACHD_HUMAN 2019

Gene Name ACHD

Description Acetylcholine receptor subunit delta

Length 517

9606

Sequence

>sp|Q07001|ACHD_HUMAN Acetylcholine receptor subunit delta
MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

5HT3A_HUMAN

5-hydroxytryptamine receptor 3A

0.209

ENC1_HUMAN

Ectoderm-neural cortex protein 1

0.302

ACHG_HUMAN

Acetylcholine receptor subunit gamma

0.302

ACHA_HUMAN

Acetylcholine receptor subunit alpha

0.392

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

5HT3A_HUMAN

5-hydroxytryptamine receptor 3A

0.286

ACHG_HUMAN

Acetylcholine receptor subunit gamma

0.323

OLFM4_HUMAN

Olfactomedin-4

0.354

PRDM5_HUMAN

PR domain zinc finger protein 5

0.366

ZBT18_HUMAN

Zinc finger and BTB domain-containing protein 18

0.366

ZBTB1_HUMAN

Zinc finger and BTB domain-containing protein 1

0.366

VCAM1_HUMAN

Vascular cell adhesion protein 1

0.366

KDF1_HUMAN

Keratinocyte differentiation factor 1

0.370

MPZL1_HUMAN

Myelin protein zero-like protein 1

0.370

ZN217_HUMAN

Zinc finger protein 217

0.370

ZN638_HUMAN

Zinc finger protein 638

0.370

MFA3L_HUMAN

Microfibrillar-associated protein 3-like

0.378

ZN131_HUMAN

Zinc finger protein 131

0.378

CO8A_HUMAN

Complement component C8 alpha chain

0.378

PDGFC_HUMAN

Platelet-derived growth factor C

0.378

LEG1_HUMAN

Galectin-1

0.378

VSTM4_HUMAN

V-set and transmembrane domain-containing protein 4

0.378

OCLN_HUMAN

Occludin

0.378

ZN644_HUMAN

Zinc finger protein 644

0.378

ADNP_HUMAN

Activity-dependent neuroprotector homeobox protein

0.378

SYBU_HUMAN

Syntabulin

0.378

NEXMI_HUMAN

Neurite extension and migration factor

0.378

ZPLD1_HUMAN

Zona pellucida-like domain-containing protein 1

0.378

MYZAP_HUMAN

Myocardial zonula adherens protein

0.378

P33MX_HUMAN

Putative monooxygenase p33MONOX

0.378

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.378

GHR_HUMAN

Growth hormone receptor

0.378

PRL_HUMAN

Prolactin

0.378

NPY_HUMAN

Pro-neuropeptide Y

0.378

MERB1_HUMAN

bMERB domain-containing protein 1

0.378

PENK_HUMAN

Proenkephalin-A

0.378

TM182_HUMAN

Transmembrane protein 182

0.380

AKA12_HUMAN

A-kinase anchor protein 12

0.380

MIME_HUMAN

Mimecan

0.380

JCAD_HUMAN

Junctional protein associated with coronary artery disease

0.380

SYNEM_HUMAN

Synemin

0.380

ACKR3_HUMAN

Atypical chemokine receptor 3

0.380

GPC5C_HUMAN

G-protein coupled receptor family C group 5 member C

0.380

ERRFI_HUMAN

ERBB receptor feedback inhibitor 1

0.380

K1107_HUMAN

AP2-interacting clathrin-endocytosis protein

0.380

SCF_HUMAN

Kit ligand

0.380

F131A_HUMAN

Protein FAM131A

0.380

ZBT20_HUMAN

Zinc finger and BTB domain-containing protein 20

0.380

CCPG1_HUMAN

Cell cycle progression protein 1

0.380

REST_HUMAN

RE1-silencing transcription factor

0.380

CC126_HUMAN

Coiled-coil domain-containing protein 126

0.380

UIMC1_HUMAN

BRCA1-A complex subunit RAP80

0.382

RN214_HUMAN

RING finger protein 214

0.382

ZBT25_HUMAN

Zinc finger and BTB domain-containing protein 25

0.382

RELL2_HUMAN

RELT-like protein 2

0.384

SUSD5_HUMAN

Sushi domain-containing protein 5

0.386

ACHA_HUMAN

Acetylcholine receptor subunit alpha

0.387

ZN142_HUMAN

Zinc finger protein 142

0.389

GCR_HUMAN

Glucocorticoid receptor

0.389

CD166_HUMAN

CD166 antigen

0.389

CEP55_HUMAN

Centrosomal protein of 55 kDa

0.389

CCD80_HUMAN

Coiled-coil domain-containing protein 80

0.389

KLH42_HUMAN

Kelch-like protein 42

0.389

NLRX1_HUMAN

NLR family member X1

0.391

FMOD_HUMAN

Fibromodulin

0.391

ABEC2_HUMAN

C->U-editing enzyme APOBEC-2

0.391

LYRIC_HUMAN

Protein LYRIC

0.391

NAIF1_HUMAN

Nuclear apoptosis-inducing factor 1

0.391

LUR1L_HUMAN

Leucine rich adaptor protein 1-like

0.391

GDNF_HUMAN

Glial cell line-derived neurotrophic factor

0.391

SPIN1_HUMAN

Spindlin-1

0.391

CCSE2_HUMAN

Serine-rich coiled-coil domain-containing protein 2

0.391

LUZP1_HUMAN

Leucine zipper protein 1

0.391

TMM51_HUMAN

Transmembrane protein 51

0.391

F1711_HUMAN

Protein FAM171A1

0.391

PHAG1_HUMAN

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

0.391

TANK_HUMAN

TRAF family member-associated NF-kappa-B activator

0.391

TF_HUMAN

Tissue factor

0.391

ZN335_HUMAN

Zinc finger protein 335

0.391

AZI2_HUMAN

5-azacytidine-induced protein 2

0.391

ANGT_HUMAN

Angiotensinogen

0.391

CAD17_HUMAN

Cadherin-17

0.391

CCR7_HUMAN

C-C chemokine receptor type 7

0.391

ITGBL_HUMAN

Integrin beta-like protein 1

0.391

LEPR_HUMAN

Leptin receptor

0.391

AKA11_HUMAN

A-kinase anchor protein 11

0.391

CKLF3_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 3

0.391

PALMD_HUMAN

Palmdelphin

0.391

CXD2_HUMAN

Gap junction delta-2 protein

0.391

M3K8_HUMAN

Mitogen-activated protein kinase kinase kinase 8

0.391

CXCR4_HUMAN

C-X-C chemokine receptor type 4

0.391

TEFF1_HUMAN

Tomoregulin-1

0.391

BFSP1_HUMAN

Filensin

0.391

ZP3_HUMAN

Zona pellucida sperm-binding protein 3

0.391

CDCP1_HUMAN

CUB domain-containing protein 1

0.391

FPRP_HUMAN

Prostaglandin F2 receptor negative regulator

0.391

F131B_HUMAN

Protein FAM131B

0.391

ZBTB2_HUMAN

Zinc finger and BTB domain-containing protein 2

0.391

EDAR_HUMAN

Tumor necrosis factor receptor superfamily member EDAR

0.391

SKA3_HUMAN

Spindle and kinetochore-associated protein 3

0.391

SCG3_HUMAN

Secretogranin-3

0.391

MBP_HUMAN

Myelin basic protein

0.391

MNAR1_HUMAN

Major intrinsically disordered Notch2-binding receptor 1

0.391

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.391

PTHR_HUMAN

Parathyroid hormone-related protein

0.391

NYAP2_HUMAN

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

0.391

ZBT16_HUMAN

Zinc finger and BTB domain-containing protein 16

0.391

ZN276_HUMAN

Zinc finger protein 276

0.391

SMS_HUMAN

Somatostatin

0.391

CLD11_HUMAN

Claudin-11

0.391

RAG2_HUMAN

V(D)J recombination-activating protein 2

0.391

C99L2_HUMAN

CD99 antigen-like protein 2

0.393

ZBT24_HUMAN

Zinc finger and BTB domain-containing protein 24

0.393

IL12B_HUMAN

Interleukin-12 subunit beta

0.393

CABP1_HUMAN

Calcium-binding protein 1

0.393

ZBT14_HUMAN

Zinc finger and BTB domain-containing protein 14

0.393

ZBT46_HUMAN

Zinc finger and BTB domain-containing protein 46

0.393

CCKN_HUMAN

Cholecystokinin

0.393

NXPH1_HUMAN

Neurexophilin-1

0.393

ESM1_HUMAN

Endothelial cell-specific molecule 1

0.393

INSY1_HUMAN

Inhibitory synaptic factor 1

0.393

ZBT41_HUMAN

Zinc finger and BTB domain-containing protein 41

0.393

SETBP_HUMAN

SET-binding protein

0.393

CLCF1_HUMAN

Cardiotrophin-like cytokine factor 1

0.393

BFSP2_HUMAN

Phakinin

0.393

MYOZ2_HUMAN

Myozenin-2

0.393

LBH_HUMAN

Protein LBH

0.393

SDF1_HUMAN

Stromal cell-derived factor 1

0.393

MAL2_HUMAN

Protein MAL2

0.393

GEMC1_HUMAN

Geminin coiled-coil domain-containing protein 1

0.395

TM114_HUMAN

Transmembrane protein 114

0.395

CSTOS_HUMAN

Protein CUSTOS

0.395

VIP_HUMAN

VIP peptides

0.395

FASTK_HUMAN

Fas-activated serine/threonine kinase

0.395

VTM2A_HUMAN

V-set and transmembrane domain-containing protein 2A

0.395

TM108_HUMAN

Transmembrane protein 108

0.395

CXCR5_HUMAN

C-X-C chemokine receptor type 5

0.399

CCG1_HUMAN

Voltage-dependent calcium channel gamma-1 subunit

0.400

BORG2_HUMAN

Cdc42 effector protein 3

0.400

RIC3_HUMAN

Protein RIC-3

0.400

GAK1B_HUMAN

Golgi-associated kinase 1B

0.400

EURL_HUMAN

Protein EURL homolog

0.400

ZBT44_HUMAN

Zinc finger and BTB domain-containing protein 44

0.400

CXAR_HUMAN

Coxsackievirus and adenovirus receptor

0.400

CC127_HUMAN

Coiled-coil domain-containing protein 127

0.400

LEGL_HUMAN

Galectin-related protein

0.400

STXB6_HUMAN

Syntaxin-binding protein 6

0.400

STC2_HUMAN

Stanniocalcin-2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 91 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy