GRM3_HUMAN 2019

Gene Name GRM3

Description Metabotropic glutamate receptor 3

Length 879

9606

Sequence

>sp|Q14832|GRM3_HUMAN Metabotropic glutamate receptor 3
MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

GRM2_HUMAN

Metabotropic glutamate receptor 2

0.330

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.357

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.362

IP3KB_HUMAN

Inositol-trisphosphate 3-kinase B

0.366

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.366

TRIO_HUMAN

Triple functional domain protein

0.368

CACB4_HUMAN

Voltage-dependent L-type calcium channel subunit beta-4

0.368

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.372

BMP2_HUMAN

Bone morphogenetic protein 2

0.373

HINFP_HUMAN

Histone H4 transcription factor

0.374

AT1B4_HUMAN

Protein ATP1B4

0.374

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.375

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.375

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.375

AFAD_HUMAN

Afadin

0.376

ITB1_HUMAN

Integrin beta-1

0.377

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.379

ARFP1_HUMAN

Arfaptin-1

0.379

WLS_HUMAN

Protein wntless homolog

0.380

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.380

MTA1_HUMAN

Metastasis-associated protein MTA1

0.380

STON1_HUMAN

Stonin-1

0.381

RIPL1_HUMAN

RILP-like protein 1

0.381

CAPS1_HUMAN

Calcium-dependent secretion activator 1

0.382

AP2B_HUMAN

Transcription factor AP-2-beta

0.382

H6ST1_HUMAN

Heparan-sulfate 6-O-sulfotransferase 1

0.382

CSKP_HUMAN

Peripheral plasma membrane protein CASK

0.383

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.384

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.385

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.385

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.385

RIMB2_HUMAN

RIMS-binding protein 2

0.386

RSBN1_HUMAN

Lysine-specific demethylase 9

0.386

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.386

VAV2_HUMAN

Guanine nucleotide exchange factor VAV2

0.386

NUMB_HUMAN

Protein numb homolog

0.386

RUND1_HUMAN

RUN domain-containing protein 1

0.386

BICD1_HUMAN

Protein bicaudal D homolog 1

0.386

TSN5_HUMAN

Tetraspanin-5

0.386

HTF4_HUMAN

Transcription factor 12

0.386

FA8A1_HUMAN

Protein FAM8A1

0.387

RUNX2_HUMAN

Runt-related transcription factor 2

0.387

MACOI_HUMAN

Macoilin

0.387

HS2ST_HUMAN

Heparan sulfate 2-O-sulfotransferase 1

0.388

TMOD3_HUMAN

Tropomodulin-3

0.388

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.389

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.390

TAOK3_HUMAN

Serine/threonine-protein kinase TAO3

0.390

CBL_HUMAN

E3 ubiquitin-protein ligase CBL

0.390

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.390

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.390

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.390

FERM1_HUMAN

Fermitin family homolog 1

0.390

FERM2_HUMAN

Fermitin family homolog 2

0.390

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.391

MIGA1_HUMAN

Mitoguardin 1

0.391

ZC4H2_HUMAN

Zinc finger C4H2 domain-containing protein

0.392

BCL7B_HUMAN

B-cell CLL/lymphoma 7 protein family member B

0.392

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.392

CSTN1_HUMAN

Calsyntenin-1

0.392

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.392

UNC79_HUMAN

Protein unc-79 homolog

0.392

TMOD1_HUMAN

Tropomodulin-1

0.393

AHR_HUMAN

Aryl hydrocarbon receptor

0.393

APC_HUMAN

Adenomatous polyposis coli protein

0.393

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.394

SYT1_HUMAN

Synaptotagmin-1

0.394

AP2A_HUMAN

Transcription factor AP-2-alpha

0.394

ARRB1_HUMAN

Beta-arrestin-1

0.394

TMOD2_HUMAN

Tropomodulin-2

0.394

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.394

AIPL1_HUMAN

Aryl-hydrocarbon-interacting protein-like 1

0.395

ANKL2_HUMAN

Ankyrin repeat and LEM domain-containing protein 2

0.395

PICK1_HUMAN

PRKCA-binding protein

0.395

MIGA2_HUMAN

Mitoguardin 2

0.395

IGF1R_HUMAN

Insulin-like growth factor 1 receptor

0.395

MAPK3_HUMAN

MAP kinase-activated protein kinase 3

0.396

RT25_HUMAN

28S ribosomal protein S25, mitochondrial

0.396

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.396

BMP4_HUMAN

Bone morphogenetic protein 4

0.396

ARFP2_HUMAN

Arfaptin-2

0.396

NUDT9_HUMAN

ADP-ribose pyrophosphatase, mitochondrial

0.396

AT1B3_HUMAN

Sodium/potassium-transporting ATPase subunit beta-3

0.397

TEF_HUMAN

Thyrotroph embryonic factor

0.397

ANLN_HUMAN

Anillin

0.397

NDUAA_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

0.397

H6ST2_HUMAN

Heparan-sulfate 6-O-sulfotransferase 2

0.398

TFAP4_HUMAN

Transcription factor AP-4

0.398

HERP2_HUMAN

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

0.398

PACS1_HUMAN

Phosphofurin acidic cluster sorting protein 1

0.398

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.399

MPDZ_HUMAN

Multiple PDZ domain protein

0.399

TAOK1_HUMAN

Serine/threonine-protein kinase TAO1

0.399

PCX1_HUMAN

Pecanex-like protein 1

0.399

CSTN3_HUMAN

Calsyntenin-3

0.400

IP3KA_HUMAN

Inositol-trisphosphate 3-kinase A

0.400

PDC10_HUMAN

Programmed cell death protein 10

0.400

SPRY7_HUMAN

SPRY domain-containing protein 7

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 55 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy