ANKR1_HUMAN 2019

Gene Name ANKR1

Description Ankyrin repeat domain-containing protein 1

Length 319

9606

Sequence

>sp|Q15327|ANKR1_HUMAN Ankyrin repeat domain-containing protein 1
MMVLKVEELVTGKKNGNGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQWKSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

CXA8_HUMAN

Gap junction alpha-8 protein

0.400

CXG1_HUMAN

Gap junction gamma-1 protein

0.400

CXA1_HUMAN

Gap junction alpha-1 protein

0.400

MYPC1_HUMAN

Myosin-binding protein C, slow-type

0.400

CXB1_HUMAN

Gap junction beta-1 protein

0.400

FLRT2_HUMAN

Leucine-rich repeat transmembrane protein FLRT2

0.400

TM121_HUMAN

Transmembrane protein 121

0.400

IKZF2_HUMAN

Zinc finger protein Helios

0.400

CLD10_HUMAN

Claudin-10

0.400

MYPC3_HUMAN

Myosin-binding protein C, cardiac-type

0.400

CXA10_HUMAN

Gap junction alpha-10 protein

0.400

ZBT44_HUMAN

Zinc finger and BTB domain-containing protein 44

0.400

FABP6_HUMAN

Gastrotropin

0.400

TNNC1_HUMAN

Troponin C, slow skeletal and cardiac muscles

0.400

CLD8_HUMAN

Claudin-8

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ZBT44_HUMAN

Zinc finger and BTB domain-containing protein 44

0.354

NEXN_HUMAN

Nexilin

0.365

ZN142_HUMAN

Zinc finger protein 142

0.367

CD166_HUMAN

CD166 antigen

0.367

LEPR_HUMAN

Leptin receptor

0.369

ZBT18_HUMAN

Zinc finger and BTB domain-containing protein 18

0.369

TANK_HUMAN

TRAF family member-associated NF-kappa-B activator

0.369

GDNF_HUMAN

Glial cell line-derived neurotrophic factor

0.369

MBP_HUMAN

Myelin basic protein

0.369

ZBTB1_HUMAN

Zinc finger and BTB domain-containing protein 1

0.369

VCAM1_HUMAN

Vascular cell adhesion protein 1

0.369

ZBT24_HUMAN

Zinc finger and BTB domain-containing protein 24

0.370

CXB1_HUMAN

Gap junction beta-1 protein

0.378

BORG2_HUMAN

Cdc42 effector protein 3

0.378

STXB6_HUMAN

Syntaxin-binding protein 6

0.378

FABP6_HUMAN

Gastrotropin

0.378

STC2_HUMAN

Stanniocalcin-2

0.378

RIC3_HUMAN

Protein RIC-3

0.378

ADNP_HUMAN

Activity-dependent neuroprotector homeobox protein

0.380

MYZAP_HUMAN

Myocardial zonula adherens protein

0.380

NEXMI_HUMAN

Neurite extension and migration factor

0.380

MYPC3_HUMAN

Myosin-binding protein C, cardiac-type

0.380

PENK_HUMAN

Proenkephalin-A

0.380

PRL_HUMAN

Prolactin

0.380

NPY_HUMAN

Pro-neuropeptide Y

0.380

FAKD2_HUMAN

FAST kinase domain-containing protein 2, mitochondrial

0.380

ZN131_HUMAN

Zinc finger protein 131

0.380

OCLN_HUMAN

Occludin

0.380

ZPLD1_HUMAN

Zona pellucida-like domain-containing protein 1

0.380

JAM3_HUMAN

Junctional adhesion molecule C

0.380

MFA3L_HUMAN

Microfibrillar-associated protein 3-like

0.380

LEG1_HUMAN

Galectin-1

0.380

GHR_HUMAN

Growth hormone receptor

0.380

CALD1_HUMAN

Caldesmon

0.380

P33MX_HUMAN

Putative monooxygenase p33MONOX

0.380

ZN644_HUMAN

Zinc finger protein 644

0.380

PDGFC_HUMAN

Platelet-derived growth factor C

0.380

EPYC_HUMAN

Epiphycan

0.380

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.380

MERB1_HUMAN

bMERB domain-containing protein 1

0.380

VSTM4_HUMAN

V-set and transmembrane domain-containing protein 4

0.380

SYBU_HUMAN

Syntabulin

0.380

K1107_HUMAN

AP2-interacting clathrin-endocytosis protein

0.382

GP176_HUMAN

G-protein coupled receptor 176

0.382

REST_HUMAN

RE1-silencing transcription factor

0.382

GTF2I_HUMAN

General transcription factor II-I

0.382

OLFM4_HUMAN

Olfactomedin-4

0.382

CCPG1_HUMAN

Cell cycle progression protein 1

0.382

ZBT20_HUMAN

Zinc finger and BTB domain-containing protein 20

0.382

APOH_HUMAN

Beta-2-glycoprotein 1

0.382

SCF_HUMAN

Kit ligand

0.382

CADH2_HUMAN

Cadherin-2

0.387

NET4_HUMAN

Netrin-4

0.389

STC1_HUMAN

Stanniocalcin-1

0.389

NECT1_HUMAN

Nectin-1

0.389

FBLN7_HUMAN

Fibulin-7

0.390

IKZF2_HUMAN

Zinc finger protein Helios

0.390

CCD80_HUMAN

Coiled-coil domain-containing protein 80

0.390

GCR_HUMAN

Glucocorticoid receptor

0.390

TPA_HUMAN

Tissue-type plasminogen activator

0.390

TSN12_HUMAN

Tetraspanin-12

0.390

CEP55_HUMAN

Centrosomal protein of 55 kDa

0.390

MYPC1_HUMAN

Myosin-binding protein C, slow-type

0.390

CXG1_HUMAN

Gap junction gamma-1 protein

0.390

T150A_HUMAN

Transmembrane protein 150A

0.390

PRDM5_HUMAN

PR domain zinc finger protein 5

0.392

MNAR1_HUMAN

Major intrinsically disordered Notch2-binding receptor 1

0.392

LUR1L_HUMAN

Leucine rich adaptor protein 1-like

0.392

RAG2_HUMAN

V(D)J recombination-activating protein 2

0.392

ZN276_HUMAN

Zinc finger protein 276

0.392

F1711_HUMAN

Protein FAM171A1

0.392

CDCP1_HUMAN

CUB domain-containing protein 1

0.392

ABEC2_HUMAN

C->U-editing enzyme APOBEC-2

0.392

BFSP1_HUMAN

Filensin

0.392

CCSE2_HUMAN

Serine-rich coiled-coil domain-containing protein 2

0.392

ZP3_HUMAN

Zona pellucida sperm-binding protein 3

0.392

CCR7_HUMAN

C-C chemokine receptor type 7

0.392

SKA3_HUMAN

Spindle and kinetochore-associated protein 3

0.392

MUC18_HUMAN

Cell surface glycoprotein MUC18

0.392

LUZP1_HUMAN

Leucine zipper protein 1

0.392

ZBTB2_HUMAN

Zinc finger and BTB domain-containing protein 2

0.392

M3K8_HUMAN

Mitogen-activated protein kinase kinase kinase 8

0.392

SMS_HUMAN

Somatostatin

0.392

LYRIC_HUMAN

Protein LYRIC

0.392

PHAG1_HUMAN

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

0.392

EDAR_HUMAN

Tumor necrosis factor receptor superfamily member EDAR

0.392

TMM51_HUMAN

Transmembrane protein 51

0.392

AKA11_HUMAN

A-kinase anchor protein 11

0.392

CKLF3_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 3

0.392

NAIF1_HUMAN

Nuclear apoptosis-inducing factor 1

0.392

CXCR4_HUMAN

C-X-C chemokine receptor type 4

0.392

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.392

PTHR_HUMAN

Parathyroid hormone-related protein

0.392

FPRP_HUMAN

Prostaglandin F2 receptor negative regulator

0.392

SPIN1_HUMAN

Spindlin-1

0.392

ZN335_HUMAN

Zinc finger protein 335

0.392

CLD11_HUMAN

Claudin-11

0.392

TEFF1_HUMAN

Tomoregulin-1

0.392

NLRX1_HUMAN

NLR family member X1

0.392

CXD2_HUMAN

Gap junction delta-2 protein

0.392

ZBT16_HUMAN

Zinc finger and BTB domain-containing protein 16

0.392

PALMD_HUMAN

Palmdelphin

0.392

NYAP2_HUMAN

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

0.392

TF_HUMAN

Tissue factor

0.392

AZI2_HUMAN

5-azacytidine-induced protein 2

0.392

ITGBL_HUMAN

Integrin beta-like protein 1

0.392

F131B_HUMAN

Protein FAM131B

0.392

FMOD_HUMAN

Fibromodulin

0.392

CAD17_HUMAN

Cadherin-17

0.392

ANGT_HUMAN

Angiotensinogen

0.392

CLD10_HUMAN

Claudin-10

0.392

CAVN4_HUMAN

Caveolae-associated protein 4

0.394

IL12B_HUMAN

Interleukin-12 subunit beta

0.394

K1671_HUMAN

Uncharacterized protein KIAA1671

0.394

T4S4_HUMAN

Transmembrane 4 L6 family member 4

0.394

LBH_HUMAN

Protein LBH

0.394

TECTB_HUMAN

Beta-tectorin

0.394

BFSP2_HUMAN

Phakinin

0.394

ZBT14_HUMAN

Zinc finger and BTB domain-containing protein 14

0.394

ZBT41_HUMAN

Zinc finger and BTB domain-containing protein 41

0.394

DCSTP_HUMAN

Dendritic cell-specific transmembrane protein

0.394

PD1L1_HUMAN

Programmed cell death 1 ligand 1

0.394

WIZ_HUMAN

Protein Wiz

0.394

MYOZ2_HUMAN

Myozenin-2

0.394

APC16_HUMAN

Anaphase-promoting complex subunit 16

0.394

GLHA_HUMAN

Glycoprotein hormones alpha chain

0.396

SCAR3_HUMAN

Scavenger receptor class A member 3

0.396

CEP68_HUMAN

Centrosomal protein of 68 kDa

0.396

I20RB_HUMAN

Interleukin-20 receptor subunit beta

0.396

PANX1_HUMAN

Pannexin-1

0.399

ZBT37_HUMAN

Zinc finger and BTB domain-containing protein 37

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 25 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy