NHRF2_HUMAN 2019

Gene Name NHRF2

Description Na(+)/H(+) exchange regulatory cofactor NHE-RF2

Length 337

9606

Sequence

>sp|Q15599|NHRF2_HUMAN Na(+)/H(+) exchange regulatory cofactor NHE-RF2
MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

NHRF1_HUMAN

Na(+)/H(+) exchange regulatory cofactor NHE-RF1

0.269

NHRF3_HUMAN

Na(+)/H(+) exchange regulatory cofactor NHE-RF3

0.313

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.353

CSTN1_HUMAN

Calsyntenin-1

0.353

NHRF4_HUMAN

Na(+)/H(+) exchange regulatory cofactor NHE-RF4

0.356

MIGA2_HUMAN

Mitoguardin 2

0.357

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.357

CSTN3_HUMAN

Calsyntenin-3

0.361

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.368

BMP2_HUMAN

Bone morphogenetic protein 2

0.369

CSTN2_HUMAN

Calsyntenin-2

0.369

AT1B4_HUMAN

Protein ATP1B4

0.370

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.370

PICK1_HUMAN

PRKCA-binding protein

0.370

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.370

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.373

CSPG4_HUMAN

Chondroitin sulfate proteoglycan 4

0.374

ARFP1_HUMAN

Arfaptin-1

0.375

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.376

OFUT1_HUMAN

GDP-fucose protein O-fucosyltransferase 1

0.376

TRIO_HUMAN

Triple functional domain protein

0.376

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.376

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.378

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.381

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.382

HINFP_HUMAN

Histone H4 transcription factor

0.382

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.383

BMP4_HUMAN

Bone morphogenetic protein 4

0.383

NUMB_HUMAN

Protein numb homolog

0.383

RIMB2_HUMAN

RIMS-binding protein 2

0.383

ARFP2_HUMAN

Arfaptin-2

0.383

BICD1_HUMAN

Protein bicaudal D homolog 1

0.383

AFAD_HUMAN

Afadin

0.384

MACOI_HUMAN

Macoilin

0.384

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.384

ITB1_HUMAN

Integrin beta-1

0.385

HS2ST_HUMAN

Heparan sulfate 2-O-sulfotransferase 1

0.385

IP3KB_HUMAN

Inositol-trisphosphate 3-kinase B

0.385

HNF6_HUMAN

Hepatocyte nuclear factor 6

0.385

PCX1_HUMAN

Pecanex-like protein 1

0.386

MYT1_HUMAN

Myelin transcription factor 1

0.386

PDC10_HUMAN

Programmed cell death protein 10

0.387

CBL_HUMAN

E3 ubiquitin-protein ligase CBL

0.387

FERM2_HUMAN

Fermitin family homolog 2

0.388

MAPK2_HUMAN

MAP kinase-activated protein kinase 2

0.388

FERM1_HUMAN

Fermitin family homolog 1

0.388

CACB4_HUMAN

Voltage-dependent L-type calcium channel subunit beta-4

0.388

WLS_HUMAN

Protein wntless homolog

0.388

MTA1_HUMAN

Metastasis-associated protein MTA1

0.388

TPST1_HUMAN

Protein-tyrosine sulfotransferase 1

0.389

RHG42_HUMAN

Rho GTPase-activating protein 42

0.389

MIGA1_HUMAN

Mitoguardin 1

0.389

RIPL1_HUMAN

RILP-like protein 1

0.390

STON1_HUMAN

Stonin-1

0.390

STAU2_HUMAN

Double-stranded RNA-binding protein Staufen homolog 2

0.390

WDFY2_HUMAN

WD repeat and FYVE domain-containing protein 2

0.390

FOXO1_HUMAN

Forkhead box protein O1

0.391

PROX1_HUMAN

Prospero homeobox protein 1

0.391

H6ST1_HUMAN

Heparan-sulfate 6-O-sulfotransferase 1

0.391

ACK1_HUMAN

Activated CDC42 kinase 1

0.391

APC_HUMAN

Adenomatous polyposis coli protein

0.391

AP2B_HUMAN

Transcription factor AP-2-beta

0.391

CSKP_HUMAN

Peripheral plasma membrane protein CASK

0.391

UNC5B_HUMAN

Netrin receptor UNC5B

0.392

ROBO1_HUMAN

Roundabout homolog 1

0.393

RBCC1_HUMAN

RB1-inducible coiled-coil protein 1

0.393

ITB3_HUMAN

Integrin beta-3

0.393

ANS1A_HUMAN

Ankyrin repeat and SAM domain-containing protein 1A

0.393

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.393

WDFY1_HUMAN

WD repeat and FYVE domain-containing protein 1

0.393

MAPK3_HUMAN

MAP kinase-activated protein kinase 3

0.394

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.394

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.394

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.394

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.394

VAV2_HUMAN

Guanine nucleotide exchange factor VAV2

0.394

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.394

CASL_HUMAN

Enhancer of filamentation 1

0.395

MKNK1_HUMAN

MAP kinase-interacting serine/threonine-protein kinase 1

0.395

AT1B3_HUMAN

Sodium/potassium-transporting ATPase subunit beta-3

0.395

TSN5_HUMAN

Tetraspanin-5

0.395

BARH2_HUMAN

BarH-like 2 homeobox protein

0.395

HTF4_HUMAN

Transcription factor 12

0.395

EPHA4_HUMAN

Ephrin type-A receptor 4

0.395

TM39A_HUMAN

Transmembrane protein 39A

0.395

TTC17_HUMAN

Tetratricopeptide repeat protein 17

0.395

STK10_HUMAN

Serine/threonine-protein kinase 10

0.395

TEF_HUMAN

Thyrotroph embryonic factor

0.395

NDST1_HUMAN

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

0.395

H6ST2_HUMAN

Heparan-sulfate 6-O-sulfotransferase 2

0.396

RB6I2_HUMAN

ELKS/Rab6-interacting/CAST family member 1

0.396

SO4A1_HUMAN

Solute carrier organic anion transporter family member 4A1

0.396

LIN7C_HUMAN

Protein lin-7 homolog C

0.397

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.397

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.397

MPDZ_HUMAN

Multiple PDZ domain protein

0.397

ZSWM8_HUMAN

Zinc finger SWIM domain-containing protein 8

0.398

SAV1_HUMAN

Protein salvador homolog 1

0.398

KIRR3_HUMAN

Kin of IRRE-like protein 3

0.398

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.398

TAOK3_HUMAN

Serine/threonine-protein kinase TAO3

0.398

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.398

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.398

NAB1_HUMAN

NGFI-A-binding protein 1

0.399

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.399

PROM1_HUMAN

Prominin-1

0.399

EGFR_HUMAN

Epidermal growth factor receptor

0.399

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.399

TNIK_HUMAN

TRAF2 and NCK-interacting protein kinase

0.399

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.399

BNC2_HUMAN

Zinc finger protein basonuclin-2

0.400

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 42 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy