DCST2_HUMAN 2019

Gene Name DCST2

Description DC-STAMP domain-containing protein 2

Length 773

9606

Sequence

>sp|Q5T1A1|DCST2_HUMAN DC-STAMP domain-containing protein 2
MPKVMKDVVHPLGGEEPSMARAVVRSVGGFTLGLSLATAYGLLELLVEGHSPWGCLVGTLTLAAFLSLGMGFSRQVRATVLLLLPQAFSRQGRTLLLVAAFGLVLQGPCANTLRNFTRASEAVACGAELALNQTAEVLQRAKQPLVSALNKIKAIARKTKEVADRVRKFFRSIMDGVKHIARALRNVWQWLLHIGDVCNSELGNPYLKCARVFDDAKDSCMMVIPQAYHLCYVLMPFKLALCGLASLVQVFCVIPKYIQPFLRQTIGTPVIQLLNRVRQEFEFNMTATHHFSVDLNASRSLSQVAMDLHEAVSMKLHRVREALALMGFTTPLLLVLLYLQALFYRYCYLNWDHYDNIYITSRFLRMEAVRSTAGLPTVLPLSAHEARRYIPPGSIFLSQWEKFFYILETFNLIRHLLLVLFLVFLDYAVFWVLDLARHQLQGEIVARSPVLVSLTVEGTGYAGNIYRDLVSAFDVLQQGNISILSRRCLLRPSEPDSTGYIVIGVMYGLCFFITLFGSYVSRLRRVICASYYPSREQERISYLYNVLLSRRTNLLAALHRSVRRRAADQGHRSAFLVLASRCPCLGPFVSHFWLHQAYCLGCGQPQDEGDMENTVSCSTPGCQGLYCLTCFRLLDNTCSVCASPLSYQGDLDLELDSSDEEGPQLWLAAAQRKDPEQAWLLQQQLQEVLGRSLSMESTSESSDLDEEKGPQQRKHGQQPLPEAHQPVSILTSPEPHRPPETSSATKGAPTPASEPSVPLSPPSLPDPSHPPPK

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

NR2C2_HUMAN

Nuclear receptor subfamily 2 group C member 2

0.298

DIRA2_HUMAN

GTP-binding protein Di-Ras2

0.302

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.330

FABP7_HUMAN

Fatty acid-binding protein, brain

0.330

RIPL1_HUMAN

RILP-like protein 1

0.330

ERBB2_HUMAN

Receptor tyrosine-protein kinase erbB-2

0.333

ZFHX3_HUMAN

Zinc finger homeobox protein 3

0.333

JPH2_HUMAN

Junctophilin-2

0.333

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.333

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.333

AT1B4_HUMAN

Protein ATP1B4

0.357

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.357

JPH1_HUMAN

Junctophilin-1

0.357

BARH1_HUMAN

BarH-like 1 homeobox protein

0.357

ZFHX4_HUMAN

Zinc finger homeobox protein 4

0.357

ERBB4_HUMAN

Receptor tyrosine-protein kinase erbB-4

0.361

ACK1_HUMAN

Activated CDC42 kinase 1

0.361

DACH1_HUMAN

Dachshund homolog 1

0.361

RIMS1_HUMAN

Regulating synaptic membrane exocytosis protein 1

0.361

MB211_HUMAN

Putative nucleotidyltransferase MAB21L1

0.361

CSTN1_HUMAN

Calsyntenin-1

0.361

DACH2_HUMAN

Dachshund homolog 2

0.361

UNC5C_HUMAN

Netrin receptor UNC5C

0.365

ACM5_HUMAN

Muscarinic acetylcholine receptor M5

0.365

NR1H3_HUMAN

Oxysterols receptor LXR-alpha

0.365

NDUB5_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

0.365

NFIL3_HUMAN

Nuclear factor interleukin-3-regulated protein

0.365

CASC3_HUMAN

Protein CASC3

0.365

CSTN3_HUMAN

Calsyntenin-3

0.365

RIMS3_HUMAN

Regulating synaptic membrane exocytosis protein 3

0.365

PP4P1_HUMAN

Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.365

PRDM1_HUMAN

PR domain zinc finger protein 1

0.365

ERBB3_HUMAN

Receptor tyrosine-protein kinase erbB-3

0.365

PHKG2_HUMAN

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

0.365

ACM2_HUMAN

Muscarinic acetylcholine receptor M2

0.365

SLIT1_HUMAN

Slit homolog 1 protein

0.365

KIRR1_HUMAN

Kin of IRRE-like protein 1

0.365

UNC5D_HUMAN

Netrin receptor UNC5D

0.365

ACM3_HUMAN

Muscarinic acetylcholine receptor M3

0.365

BC11B_HUMAN

B-cell lymphoma/leukemia 11B

0.365

BC11A_HUMAN

B-cell lymphoma/leukemia 11A

0.365

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.365

NRX3A_HUMAN

Neurexin-3

0.369

NPHN_HUMAN

Nephrin

0.369

RM39_HUMAN

39S ribosomal protein L39, mitochondrial

0.369

GFI1_HUMAN

Zinc finger protein Gfi-1

0.382

WLS_HUMAN

Protein wntless homolog

0.382

NKX61_HUMAN

Homeobox protein Nkx-6.1

0.386

JPH3_HUMAN

Junctophilin-3

0.386

FEM1C_HUMAN

Protein fem-1 homolog C

0.386

VANG1_HUMAN

Vang-like protein 1

0.386

ROR2_HUMAN

Tyrosine-protein kinase transmembrane receptor ROR2

0.386

HINFP_HUMAN

Histone H4 transcription factor

0.386

ITF2_HUMAN

Transcription factor 4

0.386

RN146_HUMAN

E3 ubiquitin-protein ligase RNF146

0.386

AT1B3_HUMAN

Sodium/potassium-transporting ATPase subunit beta-3

0.386

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.386

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.390

AT1B2_HUMAN

Sodium/potassium-transporting ATPase subunit beta-2

0.390

RXRA_HUMAN

Retinoic acid receptor RXR-alpha

0.390

FBX25_HUMAN

F-box only protein 25

0.390

TPD53_HUMAN

Tumor protein D53

0.390

TPD52_HUMAN

Tumor protein D52

0.390

TPD54_HUMAN

Tumor protein D54

0.390

ONEC2_HUMAN

One cut domain family member 2

0.390

SP9_HUMAN

Transcription factor Sp9

0.390

MB212_HUMAN

Protein mab-21-like 2

0.394

TNNI1_HUMAN

Troponin I, slow skeletal muscle

0.394

PROX1_HUMAN

Prospero homeobox protein 1

0.394

KIRR3_HUMAN

Kin of IRRE-like protein 3

0.394

HME2_HUMAN

Homeobox protein engrailed-2

0.394

BNC2_HUMAN

Zinc finger protein basonuclin-2

0.394

CAPON_HUMAN

Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

0.394

NR2C1_HUMAN

Nuclear receptor subfamily 2 group C member 1

0.394

SRCN1_HUMAN

SRC kinase signaling inhibitor 1

0.394

P66B_HUMAN

Transcriptional repressor p66-beta

0.394

STOX1_HUMAN

Storkhead-box protein 1

0.399

Z280D_HUMAN

Zinc finger protein 280D

0.399

DMAC2_HUMAN

Distal membrane-arm assembly complex protein 2

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CSTN1_HUMAN

Calsyntenin-1

0.361

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.366

AT1B4_HUMAN

Protein ATP1B4

0.366

BARH2_HUMAN

BarH-like 2 homeobox protein

0.367

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.368

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.374

PROX1_HUMAN

Prospero homeobox protein 1

0.375

UNC5D_HUMAN

Netrin receptor UNC5D

0.375

UNC5B_HUMAN

Netrin receptor UNC5B

0.376

HINFP_HUMAN

Histone H4 transcription factor

0.378

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.378

BC11A_HUMAN

B-cell lymphoma/leukemia 11A

0.378

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.379

AT1B3_HUMAN

Sodium/potassium-transporting ATPase subunit beta-3

0.380

MTCH2_HUMAN

Mitochondrial carrier homolog 2

0.380

5HT1A_HUMAN

5-hydroxytryptamine receptor 1A

0.383

FBX25_HUMAN

F-box only protein 25

0.383

CSTN3_HUMAN

Calsyntenin-3

0.383

KIRR3_HUMAN

Kin of IRRE-like protein 3

0.383

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.384

SYDE2_HUMAN

Rho GTPase-activating protein SYDE2

0.384

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.384

FERM2_HUMAN

Fermitin family homolog 2

0.384

WLS_HUMAN

Protein wntless homolog

0.384

RIPL1_HUMAN

RILP-like protein 1

0.386

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.386

BMP2_HUMAN

Bone morphogenetic protein 2

0.389

NDUB5_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

0.389

UNC5C_HUMAN

Netrin receptor UNC5C

0.389

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.390

MIGA2_HUMAN

Mitoguardin 2

0.390

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.391

BMP4_HUMAN

Bone morphogenetic protein 4

0.391

NUMB_HUMAN

Protein numb homolog

0.391

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.391

KIRR1_HUMAN

Kin of IRRE-like protein 1

0.391

ECSIT_HUMAN

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

0.392

SARM1_HUMAN

Sterile alpha and TIR motif-containing protein 1

0.392

ITB1_HUMAN

Integrin beta-1

0.393

IP3KB_HUMAN

Inositol-trisphosphate 3-kinase B

0.393

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.393

5HT1B_HUMAN

5-hydroxytryptamine receptor 1B

0.394

CNTP1_HUMAN

Contactin-associated protein 1

0.394

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.394

ST18_HUMAN

Suppression of tumorigenicity 18 protein

0.395

P66A_HUMAN

Transcriptional repressor p66-alpha

0.395

CSPG4_HUMAN

Chondroitin sulfate proteoglycan 4

0.395

RIMS1_HUMAN

Regulating synaptic membrane exocytosis protein 1

0.395

NFASC_HUMAN

Neurofascin

0.395

ACM2_HUMAN

Muscarinic acetylcholine receptor M2

0.396

EGFR_HUMAN

Epidermal growth factor receptor

0.396

TRIO_HUMAN

Triple functional domain protein

0.396

KPBB_HUMAN

Phosphorylase b kinase regulatory subunit beta

0.396

MTA1_HUMAN

Metastasis-associated protein MTA1

0.396

CACB4_HUMAN

Voltage-dependent L-type calcium channel subunit beta-4

0.396

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.396

FERM1_HUMAN

Fermitin family homolog 1

0.396

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.396

P66B_HUMAN

Transcriptional repressor p66-beta

0.397

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.397

PP4P1_HUMAN

Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.397

TPST1_HUMAN

Protein-tyrosine sulfotransferase 1

0.397

BICD2_HUMAN

Protein bicaudal D homolog 2

0.397

TF7L2_HUMAN

Transcription factor 7-like 2

0.398

HME2_HUMAN

Homeobox protein engrailed-2

0.399

ACK1_HUMAN

Activated CDC42 kinase 1

0.399

CSKP_HUMAN

Peripheral plasma membrane protein CASK

0.399

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.399

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.400

RIMS4_HUMAN

Regulating synaptic membrane exocytosis protein 4

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 41 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy