K1C40_HUMAN 2019

Gene Name K1C40

Description Keratin, type I cytoskeletal 40

Length 431

9606

Sequence

>sp|Q6A162|K1C40_HUMAN Keratin, type I cytoskeletal 40
MTSDCSSTHCSPESCGTASGCAPASSCSVETACLPGTCATSRCQTPSFLSRSRGLTGCLLPCYFTGSCNSPCLVGNCAWCEDGVFTSNEKETMQFLNDRLASYLEKVRSLEETNAELESRIQEQCEQDIPMVCPDYQRYFNTIEDLQQKILCTKAENSRLAVQLDNCKLATDDFKSKYESELSLRQLLEADISSLHGILEELTLCKSDLEAHVESLKEDLLCLKKNHEEEVNLLREQLGDRLSVELDTAPTLDLNRVLDEMRCQCETVLANNRREAEEWLAVQTEELNQQQLSSAEQLQGCQMEILELKRTASALEIELQAQQSLTESLECTVAETEAQYSSQLAQIQCLIDNLENQLAEIRCDLERQNQEYQVLLDVKARLEGEINTYWGLLDSEDSRLSCSPCSTTCTSSNTCEPCSAYVICTVENCCL

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

FM25C_HUMAN

Protein FAM25C

0.000

NRAC_HUMAN

Nutritionally-regulated adipose and cardiac enriched protein homolog

0.000

FCG2A_HUMAN

Low affinity immunoglobulin gamma Fc region receptor II-a

0.000

FM25G_HUMAN

Protein FAM25G

0.000

OR2L2_HUMAN

Olfactory receptor 2L2

0.000

PLET1_HUMAN

Placenta-expressed transcript 1 protein

0.000

O52L1_HUMAN

Olfactory receptor 52L1

0.000

TSLP_HUMAN

Thymic stromal lymphopoietin

0.000

OR2A5_HUMAN

Olfactory receptor 2A5

0.000

OR2L3_HUMAN

Olfactory receptor 2L3

0.000

OR3A1_HUMAN

Olfactory receptor 3A1

0.000

FM25A_HUMAN

Protein FAM25A

0.000

FILA2_HUMAN

Filaggrin-2

0.000

LCN9_HUMAN

Epididymal-specific lipocalin-9

0.000

OR2L5_HUMAN

Olfactory receptor 2L5

0.000

K1C39_HUMAN

Keratin, type I cytoskeletal 39

0.000

CC184_HUMAN

Coiled-coil domain-containing protein 184

0.000

CT144_HUMAN

Uncharacterized protein C20orf144

0.000

IL36G_HUMAN

Interleukin-36 gamma

0.000

TAFA3_HUMAN

Chemokine-like protein TAFA-3

0.000

KTDAP_HUMAN

Keratinocyte differentiation-associated protein

0.000

HDBP1_HUMAN

Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

0.000

KLRG2_HUMAN

Killer cell lectin-like receptor subfamily G member 2

0.000

C5AR2_HUMAN

C5a anaphylatoxin chemotactic receptor 2

0.378

TRML2_HUMAN

Trem-like transcript 2 protein

0.378

F229B_HUMAN

Protein FAM229B

0.378

ZN746_HUMAN

Zinc finger protein 746

0.378

CCL22_HUMAN

C-C motif chemokine 22

0.378

LAX1_HUMAN

Lymphocyte transmembrane adapter 1

0.378

IL36A_HUMAN

Interleukin-36 alpha

0.378

OR4B1_HUMAN

Olfactory receptor 4B1

0.378

MUC20_HUMAN

Mucin-20

0.378

O51F2_HUMAN

Olfactory receptor 51F2

0.378

FCG3A_HUMAN

Low affinity immunoglobulin gamma Fc region receptor III-A

0.378

O56A4_HUMAN

Olfactory receptor 56A4

0.378

OR8D4_HUMAN

Olfactory receptor 8D4

0.378

IL7_HUMAN

Interleukin-7

0.378

DBND2_HUMAN

Dysbindin domain-containing protein 2

0.378

CCD54_HUMAN

Coiled-coil domain-containing protein 54

0.378

ZN420_HUMAN

Zinc finger protein 420

0.378

O51V1_HUMAN

Olfactory receptor 51V1

0.378

O2T35_HUMAN

Olfactory receptor 2T35

0.378

NGAL_HUMAN

Neutrophil gelatinase-associated lipocalin

0.378

O56A3_HUMAN

Olfactory receptor 56A3

0.378

ZN202_HUMAN

Zinc finger protein 202

0.378

OPALI_HUMAN

Opalin

0.378

OR4CC_HUMAN

Olfactory receptor 4C12

0.378

OR2V1_HUMAN

Olfactory receptor 2V1

0.378

O13F1_HUMAN

Olfactory receptor 13F1

0.378

DLL3_HUMAN

Delta-like protein 3

0.378

SCIMP_HUMAN

SLP adapter and CSK-interacting membrane protein

0.378

TIGIT_HUMAN

T-cell immunoreceptor with Ig and ITIM domains

0.378

OR8U1_HUMAN

Olfactory receptor 8U1

0.378

IGSF2_HUMAN

Immunoglobulin superfamily member 2

0.378

MROH9_HUMAN

Maestro heat-like repeat-containing protein family member 9

0.378

T2R38_HUMAN

Taste receptor type 2 member 38

0.378

CJ120_HUMAN

Uncharacterized protein C10orf120

0.378

OR6K2_HUMAN

Olfactory receptor 6K2

0.378

CTF1_HUMAN

Cardiotrophin-1

0.378

O51B6_HUMAN

Olfactory receptor 51B6

0.378

OR5L1_HUMAN

Olfactory receptor 5L1

0.378

TM219_HUMAN

Insulin-like growth factor-binding protein 3 receptor

0.378

ZNF3_HUMAN

Zinc finger protein 3

0.378

CK094_HUMAN

Uncharacterized protein C11orf94

0.378

O2AG1_HUMAN

Olfactory receptor 2AG1

0.378

O4A15_HUMAN

Olfactory receptor 4A15

0.378

OR4X2_HUMAN

Olfactory receptor 4X2

0.378

ZN672_HUMAN

Zinc finger protein 672

0.378

AHSP_HUMAN

Alpha-hemoglobin-stabilizing protein

0.378

S100G_HUMAN

Protein S100-G

0.378

KRA33_HUMAN

Keratin-associated protein 3-3

0.378

FCERB_HUMAN

High affinity immunoglobulin epsilon receptor subunit beta

0.378

OR5MB_HUMAN

Olfactory receptor 5M11

0.378

OR8G5_HUMAN

Olfactory receptor 8G5

0.378

OR9K2_HUMAN

Olfactory receptor 9K2

0.378

CD036_HUMAN

Uncharacterized protein C4orf36

0.378

ZN263_HUMAN

Zinc finger protein 263

0.378

TEX46_HUMAN

Testis-expressed protein 46

0.378

TM202_HUMAN

Transmembrane protein 202

0.378

PKHH3_HUMAN

Pleckstrin homology domain-containing family H member 3

0.378

OR2F2_HUMAN

Olfactory receptor 2F2

0.378

CC116_HUMAN

Coiled-coil domain-containing protein 116

0.378

TCHL1_HUMAN

Trichohyalin-like protein 1

0.378

S10A3_HUMAN

Protein S100-A3

0.378

BPIB3_HUMAN

BPI fold-containing family B member 3

0.378

ZNF24_HUMAN

Zinc finger protein 24

0.378

OR6P1_HUMAN

Olfactory receptor 6P1

0.378

TVB31_HUMAN

T cell receptor beta variable 3-1

0.378

CITE4_HUMAN

Cbp/p300-interacting transactivator 4

0.378

OR9A4_HUMAN

Olfactory receptor 9A4

0.378

INSL3_HUMAN

Insulin-like 3

0.378

RNS12_HUMAN

Probable inactive ribonuclease-like protein 12

0.378

PRR19_HUMAN

Proline-rich protein 19

0.378

OR4C6_HUMAN

Olfactory receptor 4C6

0.378

PRND_HUMAN

Prion-like protein doppel

0.378

ZSC10_HUMAN

Zinc finger and SCAN domain-containing protein 10

0.378

TREM1_HUMAN

Triggering receptor expressed on myeloid cells 1

0.378

LCN1_HUMAN

Lipocalin-1

0.378

OR5W2_HUMAN

Olfactory receptor 5W2

0.378

O2T33_HUMAN

Olfactory receptor 2T33

0.378

OR2F1_HUMAN

Olfactory receptor 2F1

0.378

O51F1_HUMAN

Olfactory receptor 51F1

0.378

LAT_HUMAN

Linker for activation of T-cells family member 1

0.378

ATP8_HUMAN

ATP synthase protein 8

0.378

O10G7_HUMAN

Olfactory receptor 10G7

0.378

ZKSC2_HUMAN

Zinc finger protein with KRAB and SCAN domains 2

0.378

OR5C1_HUMAN

Olfactory receptor 5C1

0.378

O10K2_HUMAN

Olfactory receptor 10K2

0.378

OR5M1_HUMAN

Olfactory receptor 5M1

0.378

OR6K6_HUMAN

Olfactory receptor 6K6

0.378

CC196_HUMAN

Putative coiled-coil domain-containing protein 196

0.378

CDRT4_HUMAN

CMT1A duplicated region transcript 4 protein

0.378

GAST_HUMAN

Gastrin

0.378

IL5_HUMAN

Interleukin-5

0.378

OR2LD_HUMAN

Olfactory receptor 2L13

0.378

O13C7_HUMAN

Olfactory receptor 13C7

0.378

TNFL4_HUMAN

Tumor necrosis factor ligand superfamily member 4

0.378

O52W1_HUMAN

Olfactory receptor 52W1

0.378

K1C10_HUMAN

Keratin, type I cytoskeletal 10

0.378

S10A8_HUMAN

Protein S100-A8

0.378

Z286A_HUMAN

Zinc finger protein 286A

0.378

TMC5A_HUMAN

Transmembrane and coiled-coil domain-containing protein 5A

0.378

CLD9_HUMAN

Claudin-9

0.378

CP054_HUMAN

Transmembrane protein C16orf54

0.378

EP3A_HUMAN

Epididymal secretory protein E3-alpha

0.378

M4A13_HUMAN

Membrane-spanning 4-domains subfamily A member 13

0.378

OR5MA_HUMAN

Olfactory receptor 5M10

0.378

SG3A2_HUMAN

Secretoglobin family 3A member 2

0.378

CCRL2_HUMAN

C-C chemokine receptor-like 2

0.378

T53G5_HUMAN

TP53-target gene 5 protein

0.378

BPIB1_HUMAN

BPI fold-containing family B member 1

0.378

OR5G3_HUMAN

Olfactory receptor 5G3

0.378

OR1L6_HUMAN

Olfactory receptor 1L6

0.378

PS1C2_HUMAN

Psoriasis susceptibility 1 candidate gene 2 protein

0.378

ZCCHL_HUMAN

Zinc finger CCCH-type antiviral protein 1-like

0.378

SCND1_HUMAN

SCAN domain-containing protein 1

0.378

O13J1_HUMAN

Olfactory receptor 13J1

0.378

ODAM_HUMAN

Odontogenic ameloblast-associated protein

0.378

ZSC20_HUMAN

Zinc finger and SCAN domain-containing protein 20

0.378

CL071_HUMAN

Uncharacterized protein C12orf71

0.378

CI040_HUMAN

Uncharacterized protein C9orf40

0.378

BPIA1_HUMAN

BPI fold-containing family A member 1

0.378

TROAP_HUMAN

Tastin

0.378

ACTT3_HUMAN

Actin-related protein T3

0.378

OR5M9_HUMAN

Olfactory receptor 5M9

0.378

O51T1_HUMAN

Olfactory receptor 51T1

0.378

ZN428_HUMAN

Zinc finger protein 428

0.378

CS2IP_HUMAN

Casein kinase II subunit alpha-interacting protein

0.378

RAGE_HUMAN

Advanced glycosylation end product-specific receptor

0.378

TSP50_HUMAN

Probable threonine protease PRSS50

0.378

LY6H_HUMAN

Lymphocyte antigen 6H

0.378

OR6A2_HUMAN

Olfactory receptor 6A2

0.378

REPI1_HUMAN

Replication initiator 1

0.378

ANGL8_HUMAN

Angiopoietin-like protein 8

0.378

GPR31_HUMAN

12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor

0.378

OR2T2_HUMAN

Olfactory receptor 2T2

0.378

MRGX4_HUMAN

Mas-related G-protein coupled receptor member X4

0.378

OR4CF_HUMAN

Olfactory receptor 4C15

0.378

TMCO2_HUMAN

Transmembrane and coiled-coil domain-containing protein 2

0.378

CK086_HUMAN

Uncharacterized protein C11orf86

0.378

CYLC2_HUMAN

Cylicin-2

0.378

OCEL1_HUMAN

Occludin/ELL domain-containing protein 1

0.378

O51S1_HUMAN

Olfactory receptor 51S1

0.378

CAVN3_HUMAN

Caveolae-associated protein 3

0.378

GON7_HUMAN

EKC/KEOPS complex subunit GON7

0.378

PAHO_HUMAN

Pancreatic prohormone

0.378

KRBA1_HUMAN

Protein KRBA1

0.378

MASTR_HUMAN

MEF2-activating motif and SAP domain-containing transcriptional regulator

0.378

O4C46_HUMAN

Olfactory receptor 4C46

0.378

K1C26_HUMAN

Keratin, type I cytoskeletal 26

0.378

PRS37_HUMAN

Probable inactive serine protease 37

0.378

OR8A1_HUMAN

Olfactory receptor 8A1

0.378

CQ080_HUMAN

Uncharacterized protein C17orf80

0.378

CC188_HUMAN

Coiled-coil domain-containing protein 188

0.378

O10AG_HUMAN

Olfactory receptor 10AG1

0.378

ODAPH_HUMAN

Odontogenesis associated phosphoprotein

0.378

COPRS_HUMAN

Coordinator of PRMT5 and differentiation stimulator

0.378

CCR10_HUMAN

C-C chemokine receptor type 10

0.378

FFAR1_HUMAN

Free fatty acid receptor 1

0.378

ZN697_HUMAN

Zinc finger protein 697

0.378

PRS58_HUMAN

Serine protease 58

0.378

PRS38_HUMAN

Serine protease 38

0.378

CD70_HUMAN

CD70 antigen

0.378

OR2K2_HUMAN

Olfactory receptor 2K2

0.378

O2AG2_HUMAN

Olfactory receptor 2AG2

0.378

EP3B_HUMAN

Epididymal secretory protein E3-beta

0.378

B2L10_HUMAN

Bcl-2-like protein 10

0.378

O2T12_HUMAN

Olfactory receptor 2T12

0.378

ZN496_HUMAN

Zinc finger protein 496

0.378

K1C25_HUMAN

Keratin, type I cytoskeletal 25

0.378

OR5P3_HUMAN

Olfactory receptor 5P3

0.378

EQTN_HUMAN

Equatorin

0.378

O51A7_HUMAN

Olfactory receptor 51A7

0.378

O52B4_HUMAN

Olfactory receptor 52B4

0.378

PRS42_HUMAN

Putative serine protease 42

0.378

PA2GC_HUMAN

Putative inactive group IIC secretory phospholipase A2

0.378

ZKSC5_HUMAN

Zinc finger protein with KRAB and SCAN domains 5

0.378

ZN641_HUMAN

Zinc finger protein 641

0.378

OR5L2_HUMAN

Olfactory receptor 5L2

0.378

G6B_HUMAN

Megakaryocyte and platelet inhibitory receptor G6b

0.378

OR8K1_HUMAN

Olfactory receptor 8K1

0.378

TM225_HUMAN

Transmembrane protein 225

0.378

T2R16_HUMAN

Taste receptor type 2 member 16

0.378

IL1A_HUMAN

Interleukin-1 alpha

0.378

STP1_HUMAN

Spermatid nuclear transition protein 1

0.378

MROH8_HUMAN

Protein MROH8

0.378

SPRN_HUMAN

Shadow of prion protein

0.378

OR5A1_HUMAN

Olfactory receptor 5A1

0.378

GAPT_HUMAN

Protein GAPT

0.378

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

RAGE_HUMAN

Advanced glycosylation end product-specific receptor

0.344

CQ080_HUMAN

Uncharacterized protein C17orf80

0.344

PRS58_HUMAN

Serine protease 58

0.350

HDBP1_HUMAN

Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

0.350

ODFP4_HUMAN

Outer dense fiber protein 4

0.354

ZN202_HUMAN

Zinc finger protein 202

0.365

LAX1_HUMAN

Lymphocyte transmembrane adapter 1

0.365

PA2GF_HUMAN

Group IIF secretory phospholipase A2

0.365

BPIA1_HUMAN

BPI fold-containing family A member 1

0.368

BPIB1_HUMAN

BPI fold-containing family B member 1

0.368

LAT_HUMAN

Linker for activation of T-cells family member 1

0.368

O13C7_HUMAN

Olfactory receptor 13C7

0.368

IL36G_HUMAN

Interleukin-36 gamma

0.371

MASTR_HUMAN

MEF2-activating motif and SAP domain-containing transcriptional regulator

0.371

OR9K2_HUMAN

Olfactory receptor 9K2

0.375

KTDAP_HUMAN

Keratinocyte differentiation-associated protein

0.378

K1C39_HUMAN

Keratin, type I cytoskeletal 39

0.378

SPNDC_HUMAN

Spindlin interactor and repressor of chromatin-binding protein

0.384

IL27A_HUMAN

Interleukin-27 subunit alpha

0.384

GPC5D_HUMAN

G-protein coupled receptor family C group 5 member D

0.384

S10A8_HUMAN

Protein S100-A8

0.387

CC196_HUMAN

Putative coiled-coil domain-containing protein 196

0.387

ZKSC2_HUMAN

Zinc finger protein with KRAB and SCAN domains 2

0.387

TM219_HUMAN

Insulin-like growth factor-binding protein 3 receptor

0.387

ZKSC5_HUMAN

Zinc finger protein with KRAB and SCAN domains 5

0.387

IL1A_HUMAN

Interleukin-1 alpha

0.387

TMC5A_HUMAN

Transmembrane and coiled-coil domain-containing protein 5A

0.391

CC116_HUMAN

Coiled-coil domain-containing protein 116

0.391

DBND2_HUMAN

Dysbindin domain-containing protein 2

0.391

CP090_HUMAN

Uncharacterized protein C16orf90

0.391

CD70_HUMAN

CD70 antigen

0.391

NGAL_HUMAN

Neutrophil gelatinase-associated lipocalin

0.391

KRBA1_HUMAN

Protein KRBA1

0.391

G6B_HUMAN

Megakaryocyte and platelet inhibitory receptor G6b

0.391

CD177_HUMAN

CD177 antigen

0.397

OR4K2_HUMAN

Olfactory receptor 4K2

0.397

LCN9_HUMAN

Epididymal-specific lipocalin-9

0.397

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 6 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy